Contraception, Venous Thromboembolism, and Inflammatory Bowel Disease: What Clinicians (and Patients) Should Know.


:The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed preconceptual care, increased risk of preterm birth, low birth weight, and adverse maternal and neonatal outcomes. Increased IBD activity during pregnancy is also associated with adverse pregnancy-related outcomes, such as miscarriage, intrauterine growth retardation, and preterm birth. Furthermore, the increased risk of venous thromboembolism (VTE) conferred by active IBD may be potentially augmented by hormonal contraceptives. Recent literature suggests that women with IBD seek counseling on contraception from gastroenterologists in preference to their primary care physicians. Meanwhile, attitudes and awareness regarding contraception counseling remain suboptimal, underpinning the importance and need for physician and patient education in this area. We discuss the association between contraception and IBD, benefits and risks associated with various contraceptive methods in women with IBD, and practical recommendations for clinicians caring for women with IBD. 10.1093/ibd/izz025_video1 izz025.video1 6014727518001 10.1093/ibd/izz025_video2 izz025.video2 6014726992001.


Inflamm Bowel Dis


Limdi JK,Farraye J,Cannon R,Woodhams E,Farraye FA




Has Abstract


2019-09-18 00:00:00














  • Extracorporeal photopheresis (ECP) in patients with steroid-dependent Crohn's disease: an open-label, multicenter, prospective trial.

    abstract:BACKGROUND:Extracorporeal photopheresis (ECP) involves ex vivo leukocyte treatment with methoxsalen and UVA light to generate a tolerogenic response. A previous trial demonstrated that ECP permits corticosteroid withdrawal in steroid-dependent Crohn's disease (CD) patients who were in clinical remission. We studied the...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Reinisch W,Knobler R,Rutgeerts PJ,Ochsenkühn T,Anderson F,von Tirpitz C,Kaatz M,Janneke van der Woude C,Parenti D,Mannon PJ

    更新日期:2013-02-01 00:00:00

  • Development of an internet-based cohort of patients with inflammatory bowel diseases (CCFA Partners): methodology and initial results.

    abstract:BACKGROUND:The widespread use of the Internet allows for unique research opportunities. We aimed to develop and follow an Internet-based cohort (e-cohort) of patients with self-reported inflammatory bowel diseases (IBD) over time. METHODS:We established an e-cohort of adults with IBD (CCFA Partners) by recruiting thro...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Long MD,Kappelman MD,Martin CF,Lewis JD,Mayer L,Kinneer PM,Sandler RS

    更新日期:2012-11-01 00:00:00

  • Acute pancreatitis in patients with Crohn's disease: clinical features and outcomes.

    abstract:BACKGROUND:Acute pancreatitis has occasionally been associated with Crohn's disease (CD), but whether a causal association exists remains unclear. We sought to determine the frequency of etiologies in a consecutive series of patients with CD with acute pancreatitis. METHODS:A centralized diagnostic index was used to i...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Moolsintong P,Loftus EV Jr,Chari ST,Egan LJ,Tremaine WJ,Sandborn WJ

    更新日期:2005-12-01 00:00:00

  • Feasibility of endoscopic assessment and treating to target to achieve mucosal healing in ulcerative colitis.

    abstract:BACKGROUND:Mucosal healing (MH) as a treatment target for ulcerative colitis is of growing interest because it is associated with improved clinical outcomes. However, the feasibility and probability of reaching MH in clinical practice is unknown. We therefore evaluated the feasibility of "treating to target" according ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bouguen G,Levesque BG,Pola S,Evans E,Sandborn WJ

    更新日期:2014-02-01 00:00:00

  • Gender Differences and Other Factors Associated with Weight Gain Following Initiation of Infliximab: A Post Hoc Analysis of Clinical Trials.

    abstract:BACKGROUND:In our clinical practice, women often report excess weight gain with infliximab (IFX) use. There are currently no studies investigating weight gain after antitumor necrosis factor therapy in patients with inflammatory bowel disease. The objective of this study was to evaluate the association of clinical fact...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Christian KE,Russman KM,Rajan DP,Barr EA,Cross RK

    更新日期:2020-01-01 00:00:00

  • Endocytosis of Intestinal Tight Junction Proteins: In Time and Space.

    abstract::Eukaryotic cells take up macromolecules and particles from the surrounding milieu and also internalize membrane proteins via a precise process of endocytosis. The role of endocytosis in diverse physiological processes such as cell adhesion, cell signaling, tissue remodeling, and healing is well recognized. The epithel...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Nighot P,Ma T

    更新日期:2021-01-19 00:00:00

  • Socioeconomic and psychological factors associated with nonadherence to treatment in inflammatory bowel disease patients: results of the ISSEO survey.

    abstract:BACKGROUND:Adherence to treatment is a key condition in preventing relapses in inflammatory bowel disease (IBD). The aims of this study were specifically to study socioeconomic and psychological factors and adherence to treatment in a large cohort of patients. METHODS:A questionnaire concerning demographic, clinical, ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Nahon S,Lahmek P,Saas C,Durance C,Olympie A,Lesgourgues B,Gendre JP

    更新日期:2011-06-01 00:00:00

  • Differential role of tumor necrosis factor receptors in TNBS colitis.

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored. METHODS:Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacki...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Ebach DR,Newberry R,Stenson WF

    更新日期:2005-06-01 00:00:00

  • Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays.

    abstract::Potential biomarkers for Crohn's disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray and PharmArray DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Dooley TP,Curto EV,Reddy SP,Davis RL,Lambert GW,Wilborn TW,Elson CO

    更新日期:2004-01-01 00:00:00

  • Guide to endoscopy of the ileo-anal pouch following restorative proctocolectomy with ileal pouch-anal anastomosis; indications, technique, and management of common findings.

    abstract::Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the surgical procedure of choice for patients with ulcerative colitis (UC). It is also performed in selected patients with familial adenomatous polyposis (FAP). A significant proportion of patients will develop pouch dysfunction. Flexible pouchosco...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,实务指引,评审


    authors: McLaughlin SD,Clark SK,Thomas-Gibson S,Tekkis PP,Ciclitira PJ,Nicholls RJ

    更新日期:2009-08-01 00:00:00

  • The Natural History, Treatments, and Outcomes of Portal Vein Thrombosis in Patients With Inflammatory Bowel Disease.

    abstract:BACKGROUND:Portal vein thrombosis (PVT) is a poorly described complication of inflammatory bowel disease (IBD). We sought to better characterize presentations, compare treatments, and assess outcomes in IBD-related PVT. METHODS:We conducted a retrospective investigation of IBD-related PVT at our institution. Multivari...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Naymagon L,Tremblay D,Zubizarreta N,Moshier E,Naymagon S,Mascarenhas J,Schiano T

    更新日期:2021-01-19 00:00:00

  • Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis.

    abstract:BACKGROUND/AIMS:The plant sterol guggulsterone has been shown to have anti-inflammatory properties. It remains unknown, however, whether guggulsterone is effective for the treatment of inflammatory bowel disease (IBD). Therefore, we investigated anti-inflammatory effects of guggulsterone on intestinal epithelial cells ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Cheon JH,Kim JS,Kim JM,Kim N,Jung HC,Song IS

    更新日期:2006-12-01 00:00:00

  • Glucocorticoid bioactivity does not predict response to steroid therapy in severe pediatric ulcerative colitis.

    abstract:BACKGROUND:The pathophysiological basis for corticosteroid (CS) failure in ulcerative colitis (UC) is unknown. A transactivation glucocorticoid bioassay (GBA) was developed to measure the biological activity of CS by quantifying glucocorticoid response elements. This approach eliminates differences in bioavailability, ...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Turner D,Kolho KL,Mack DR,Raivio T,Leleiko N,Crandall W,Markowitz J,Silverberg MS,Jänne OA,Stempak J,Hyams J,Griffiths AM

    更新日期:2010-03-01 00:00:00

  • Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study.

    abstract:BACKGROUND:Genetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies and genetic variants associated with the disease have been identified. The aim of our study was to determine the concordance rates for IBD in German twin pairs and to evaluate clinical charac...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Spehlmann ME,Begun AZ,Burghardt J,Lepage P,Raedler A,Schreiber S

    更新日期:2008-07-01 00:00:00

  • Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms.

    abstract::Crohn's disease is associated with an excessive T helper (TH) type 1 inflammatory immune response. Reducing the influx of disease-associated CD4+ TH1 cells into the inflamed intestine is likely to be beneficial in preventing a disease flare-up and even possibly in reducing the effect of acute disease. Thiazolidenedion...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Schaefer KL,Denevich S,Ma C,Cooley SR,Nakajima A,Wada K,Schlezinger J,Sherr D,Saubermann LJ

    更新日期:2005-03-01 00:00:00

  • Apical Periodontitis in Patients With Inflammatory Bowel Disease: A Puppet Master?

    abstract::Focal infection theory posits that periodontal pathobionts play a causal role in initiating or exacerbating diseases. Periodontal disease is a common inflammatory, multifactorial disease of the periodontal tissues. The main factor for inflammation is mature dental plaque with the presence of pathogens in the microbial...

    journal_title:Inflammatory bowel diseases

    pub_type: 评论,社论


    authors: Barta Z

    更新日期:2020-01-06 00:00:00

  • Effects of fistula on healthcare costs and utilization for patients with Crohn's disease treated in a managed care environment.

    abstract:BACKGROUND:Fistulas are a common complication of Crohn's disease (CD) and are difficult to treat effectively. This study aimed to assess the effects of fistula on annual costs of healthcare and resource utilization for patients with CD. METHODS:A retrospective analysis, using the PharMetrics database, of patients with...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Cohen RD,Waters HC,Tang B,Rahman MI

    更新日期:2008-12-01 00:00:00

  • A genome-wide search identifies potential new susceptibility loci for Crohn's disease.

    abstract::Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susc...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Ma Y,Ohmen JD,Li Z,Bentley LG,McElree C,Pressman S,Targan SR,Fischel-Ghodsian N,Rotter JI,Yang H

    更新日期:1999-11-01 00:00:00

  • Chemoprophylaxis of colorectal cancer in inflammatory bowel disease: current concepts.

    abstract::Ulcerative colitis and Crohn's disease both confer an increased risk of developing colorectal cancer. The use of 5-aminosalicylate as a remission-inducing agent has been long accepted. Its use as a potential chemoprophylactic agent has been proposed and is used by some practitioners. This review examines the most rece...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Levine JS,Burakoff R

    更新日期:2007-10-01 00:00:00

  • Inflammatory bowel disease in Chinese children: a multicenter analysis over a decade from Shanghai.

    abstract:BACKGROUND:The purpose was to estimate the incidence and characteristics of childhood inflammatory bowel disease (IBD) during 2000-2010 in Shanghai, China. METHODS:IBD patients between the ages of 0 and 18 years old were identified by survey of computerized medical information. Relevant data were extracted from their ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Wang XQ,Zhang Y,Xu CD,Jiang LR,Huang Y,Du HM,Wang XJ

    更新日期:2013-02-01 00:00:00

  • Are sTWEAK and IL-17A Levels in Inflammatory Bowel Disease Associated with Disease Activity and Etiopathogenesis?

    abstract:BACKGROUND:We aimed to identify the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin 17A (IL-17A) in inflammatory bowel disease (IBD) and to examine their relationship with disease activity. METHODS:A total of 92 patients with IBD, in which 54 patients were diagnosed with...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Kaplan M,Yuksel M,Ates I,Yaln Kilic ZM,Kilic H,Ates H,Kayacetin E

    更新日期:2016-03-01 00:00:00

  • Dipeptidyl peptidase expression during experimental colitis in mice.

    abstract:BACKGROUND:We have previously demonstrated that inhibition of dipeptidyl peptidase (DP) activity partially attenuates dextran sulfate sodium (DSS) colitis in mice. The aim of this study was to further investigate the mechanisms of this protection. MATERIALS AND METHODS:Wildtype (WT) and DPIV(-/-) mice consumed 2% DSS ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Yazbeck R,Sulda ML,Howarth GS,Bleich A,Raber K,von Hörsten S,Holst JJ,Abbott CA

    更新日期:2010-08-01 00:00:00

  • Immunogenicity and tolerability to human papillomavirus-like particle vaccine in girls and young women with inflammatory bowel disease.

    abstract:BACKGROUND:Female patients receiving immunosuppressive therapy may be at increased risk for human papillomavirus (HPV) infection and cervical neoplasia. METHODS:We administered the 3-dose HPV vaccine Gardasil to 37 females aged 9 to 26 years with inflammatory bowel disease (IBD) prescribed immunosuppressive therapy (p...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Jacobson DL,Bousvaros A,Ashworth L,Carey R,Shrier LA,Burchett SK,Renna H,Lu Y

    更新日期:2013-06-01 00:00:00

  • Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease.

    abstract::Tolerance, the regulated inability to respond to a specific immunologic stimulant, is a physiological event important to normal immune function. Just as loss of tolerance to self-proteins results in autoimmune diseases, we assert that loss of tolerance to commensal flora in the intestinal lumen leads to inflammatory b...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Jump RL,Levine AD

    更新日期:2004-07-01 00:00:00

  • Approach to corticosteroid-dependent and corticosteroid-refractory Crohn's disease.

    abstract::Corticosteroids are considered a drug of choice for the treatment of patients with moderately to severely active Crohn's disease (CD), an inflammatory bowel disease characterized by chronic recurrent flares of disease activity. However, among patients receiving corticosteroid therapy for induction of remission, 20% ha...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Lichtenstein GR

    更新日期:2001-05-01 00:00:00

  • Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.

    abstract:BACKGROUND:Activation of cannabinoid (CB)(1) receptors results in attenuation of experimental colitis. Our aim was to examine the role of CB(2) receptors in experimental colitis using agonists (JWH133, AM1241) and an antagonist (AM630) in trinitrobenzene sulfonic acid (TNBS)-induced colitis in wildtype and CB(2) recept...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Storr MA,Keenan CM,Zhang H,Patel KD,Makriyannis A,Sharkey KA

    更新日期:2009-11-01 00:00:00

  • Treatment patterns, complications, and disease relapse in a real-world population of patients with moderate-to-severe ulcerative colitis initiating immunomodulator therapy.

    abstract:BACKGROUND:Immunomodulator (IM) treatments in ulcerative colitis (UC) are not curative and carry increased risk of complications, sometimes leading to therapy changes, reduced treatment benefits, and eventual relapse. We assessed patterns of IM utilization and therapy changes, complications, and disease relapse in a re...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Loftus EV Jr,Davis KL,Wang CC,Dastani H,Luo A

    更新日期:2014-08-01 00:00:00

  • Male issues of the ileal pouch.

    abstract::: Restorative proctocolectomy with ileal pouch-anal anastomosis is the standard surgical treatment modality for patients with ulcerative colitis who require colectomy. There are special issues related to male gender. We performed systemic literature review on the topic, incorporating the experience in our specialized ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Kani HT,Shen B

    更新日期:2015-03-01 00:00:00

  • Characterization of cecal gene expression in a differentially susceptible mouse model of bacterial-induced inflammatory bowel disease.

    abstract:BACKGROUND:A/JCr mice develop typhlitis in response to Helicobacter hepaticus infection, whereas C57BL/6 mice coexist with this bacterium in a "commensal" relationship and do not develop disease even during prolonged colonization. METHODS:To determine mechanisms that control this balance between responsiveness and non...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Myles MH,Dieckgraefe BK,Criley JM,Franklin CL

    更新日期:2007-07-01 00:00:00

  • Intra- and interobserver variation in the use of the Vienna classification of Crohn's disease.

    abstract:BACKGROUND:Crohn's disease is a heterogeneous disease, and several classification systems have been developed to classify the patients in more homogeneous groups. Our aim was to assess the intra- and interobserver variation when classifying patients according to the widely used Vifenna classification. METHODS:Ten rand...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Riis L,Munkholm P,Binder V,Skovgaard LT,Langholz E

    更新日期:2005-07-01 00:00:00