Contraception, Venous Thromboembolism, and Inflammatory Bowel Disease: What Clinicians (and Patients) Should Know.

abstract：:Corticosteroids, and more recently biologics, have been the mainstay of therapy for patients with inflammatory bowel disease. Unfortunately, both are fraught with side effects and limited by lack of efficacy or loss of response. Many patients ultimately succumb to medically refractory disease and require an operation....

journal_title：Inflammatory bowel diseases

authors： Lightner AL

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) have demonstrated significant potentials for the treatment of inflammatory bowel disease. Clinical feasible methods to individually document the MSC recruitment to intestinal mucosa is lacking. Here, we proposed that endomicroscopy could noninvasively track MSCs in vivo at cellu...

journal_title：Inflammatory bowel diseases

authors： Li M,Zhang YX,Zhang Z,Zhou XY,Zuo XL,Cong Y,Li YQ

更新日期：2015-09-01 00:00:00

abstract：:: Crohn's disease (CD) is a lifelong inflammatory condition with underlying environmental and genetic components. CD affects multiple parts of the gastrointestinal tract, and it has a growing incidence in Western societies. IL-23 receptor variants have been identified as susceptibility or resistance factors for CD in ...

journal_title：Inflammatory bowel diseases

authors： Eken A,Singh AK,Oukka M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Evaluating structural damage using imaging is essential for the evaluation of small intestinal Crohn's disease (CD), but it is limited by potential interobserver variation. We compared the agreement of enterography-based bowel damage measurements collected by experienced radiologists and a semi-automated ima...

journal_title：Inflammatory bowel diseases

authors： Stidham RW,Enchakalody B,Waljee AK,Higgins PDR,Wang SC,Su GL,Wasnik AP,Al-Hawary M

更新日期：2020-04-11 00:00:00

abstract：BACKGROUND:This study compared the efficacy of an elemental formula (EF) to a polymeric formula (PF) in inducing remission for pediatric Crohn's disease (CD). METHODS:Newly diagnosed CD children were randomized to EF or PF for 6 weeks. Change in the Pediatric Crohn's Disease Activity Index (PCDAI), fecal calprotectin,...

journal_title：Inflammatory bowel diseases

authors： Grogan JL,Casson DH,Terry A,Burdge GC,El-Matary W,Dalzell AM

更新日期：2012-02-01 00:00:00

abstract：Background:In Crohn's disease (CD) a small bowel study-in addition to colonoscopy-is considered necessary for diagnosis/staging. In this study we re-examined the role of capsule endoscopy (CE), colonoscopy, imaging tests [magnetic resonance enterography/computed tomographic enterography (MRE/CTE)], and inflammatory mar...

journal_title：Inflammatory bowel diseases

authors： Sorrentino D,Nguyen VQ

更新日期：2018-06-08 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy is effective in treating some Crohn's disease (CD) patients and protects mice from colitis induced by dextran sulfate sodium (DSS) administration. However, its mechanisms of action remain elusive. We hypothesized that GM-CSF affects intestinal...

journal_title：Inflammatory bowel diseases

authors： Bernasconi E,Favre L,Maillard MH,Bachmann D,Pythoud C,Bouzourene H,Croze E,Velichko S,Parkinson J,Michetti P,Velin D

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The postpartum period is marked by physiological and psychological stresses that may impact activity in inflammatory bowel disease. The predictors and outcomes of disease activity during this period have not been well characterized. METHODS:We performed a retrospective review of inflammatory bowel disease p...

journal_title：Inflammatory bowel diseases

authors： Yu A,Friedman S,Ananthakrishnan AN

更新日期：2020-11-19 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic remitting disorder with increasing incidence worldwide. The intestinal epithelial barrier plays a major role in IBD, contributing to its pathogenesis, evolution, and perpetuation over time. Until recently, studies focused on exploring the role of the intestinal epithelium ...

journal_title：Inflammatory bowel diseases

authors： Dotti I,Salas A

更新日期：2018-11-29 00:00:00

abstract：:There is no standard practice in the induction of colitis by 2,4,6-trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6-trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease and give recommendat...

journal_title：Inflammatory bowel diseases

authors： te Velde AA,Verstege MI,Hommes DW

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The immediate early response gene X-1 (IEX-1) is a stress-inducible gene involved in the regulation of cell growth, apoptosis and inflammation. METHODS:Acute colitis was induced by treatment of IEX-1 knockout (KO) and wild type (WT) control mice with dextran sulfate sodium (DSS), whereas chronic colitis was...

journal_title：Inflammatory bowel diseases

authors： Ustyugova IV,Zhi L,Wu MX

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:A common feature of preclinical models of colitis is that the time-course, magnitude, and persistence of inflammation vary considerably within the experimental animal group. Accordingly, noninvasive, serial quantification of colonic inflammation could advantageously guide dosing regimens and assess drug effi...

journal_title：Inflammatory bowel diseases

authors： Pohlmann A,Tilling LC,Robinson A,Woolmer O,McCleary S,Kruidenier L,Warnock LC,Lewis HD,Hobson AR,James MF

更新日期：2009-04-01 00:00:00

abstract：:After colectomy and ileal pouch-rectal anastomosis, pouchitis may occur. Pouchitis is a poorly defined condition with unknown etiology. The aim of this study was to develop an animal model of pouchitis. Ileal pouch-rectal anastomosis was created in Lewis and Sprague-Dawley rats. Rats were studied 4 and 8 weeks after s...

journal_title：Inflammatory bowel diseases

authors： Lichtman SN,Wang J,Hummel B,Lacey S,Sartor RB

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Endoscopic balloon dilation (EBD) is widely used to manage Crohn's disease-associated strictures. However, most studies of the safety and efficacy are small and heterogenous. We performed a combined analysis of published studies and evaluated 676 comprehensive individual participant data sets to determine th...

journal_title：Inflammatory bowel diseases

authors： Bettenworth D,Gustavsson A,Atreja A,Lopez R,Tysk C,van Assche G,Rieder F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-S-methyltransferase (TPMT) deficiency. Azathioprine is known to induce glutathione depletion and consumption of glutathione is greater in cells with high glut...

journal_title：Inflammatory bowel diseases

authors： Stocco G,Martelossi S,Barabino A,Decorti G,Bartoli F,Montico M,Gotti A,Ventura A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk, fate, and ideal management of colorectal dysplasia in inflammatory bowel disease (IBD) remain debated. We estimated the incidence, long-term outcome, and risk factors for progression of colorectal dysplasia (adenomas [adenoma-associated lesions or masses (ALMs)], flat dysplasia, and dyspla...

journal_title：Inflammatory bowel diseases

authors： Jess T,Loftus EV Jr,Velayos FS,Harmsen WS,Zinsmeister AR,Smyrk TC,Tremaine WJ,Melton LJ 3rd,Munkholm P,Sandborn WJ

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD)-associated dysbiosis is characterized by a loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect. However, the anti-inflammatory substances in F. prausnitzii supernatant and the mechanism in ameliorating colitis in IBD have not yet been fu...

journal_title：Inflammatory bowel diseases

authors： Zhou L,Zhang M,Wang Y,Dorfman RG,Liu H,Yu T,Chen X,Tang D,Xu L,Yin Y,Pan Y,Zhou Q,Zhou Y,Yu C

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous disease, and several classification systems have been developed to classify the patients in more homogeneous groups. Our aim was to assess the intra- and interobserver variation when classifying patients according to the widely used Vifenna classification. METHODS:Ten rand...

journal_title：Inflammatory bowel diseases

authors： Riis L,Munkholm P,Binder V,Skovgaard LT,Langholz E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Iron is an important nutrient for both the host and colonizing bacteria. Oral iron supplementation may impact the composition of the microbiota and can be particularly damaging to patients suffering from inflammatory bowel disease (IBD). However, patients with IBD may require iron supplementation to treat th...

journal_title：Inflammatory bowel diseases

authors： Constante M,Fragoso G,Lupien-Meilleur J,Calvé A,Santos MM

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Many chronic illnesses are accompanied by impaired cognitive functioning. In people with Inflammatory Bowel Disease (IBD), there is some research to suggest a decrement in verbal IQ (VIQ), when compared to people with Irritable Bowel Syndrome (IBS) and healthy controls. Although this is an important finding,...

journal_title：Inflammatory bowel diseases

authors： Dancey CP,Attree EA,Stuart G,Wilson C,Sonnet A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Female patients receiving immunosuppressive therapy may be at increased risk for human papillomavirus (HPV) infection and cervical neoplasia. METHODS:We administered the 3-dose HPV vaccine Gardasil to 37 females aged 9 to 26 years with inflammatory bowel disease (IBD) prescribed immunosuppressive therapy (p...

journal_title：Inflammatory bowel diseases

authors： Jacobson DL,Bousvaros A,Ashworth L,Carey R,Shrier LA,Burchett SK,Renna H,Lu Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Mesalamine is the first-line drug for the treatment of ulcerative colitis (UC). We directly compared the efficacy and safety of two mesalamine formulations for the induction of remission in patients with UC. METHODS:In a multicenter, double-blind, randomized study, 229 patients with mild-to-moderate active ...

journal_title：Inflammatory bowel diseases

authors： Ito H,Iida M,Matsumoto T,Suzuki Y,Sasaki H,Yoshida T,Takano Y,Hibi T

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Infliximab is an effective therapy for inflammatory bowel disease (IBD). However, more than 50% of patients lose response. Empiric dose intensification is not effective for all patients because not all patients have objective disease activity or subtherapeutic drug level. The aim was to determine how an obje...

journal_title：Inflammatory bowel diseases

authors： Huang VW,Prosser C,Kroeker KI,Wang H,Shalapay C,Dhami N,Fedorak DK,Halloran B,Dieleman LA,Goodman KJ,Fedorak RN

更新日期：2015-06-01 00:00:00

abstract：:Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

journal_title：Inflammatory bowel diseases

authors： Palmer MT,Weaver CT

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Flavaglines are a family of natural compounds shown to have anti-inflammatory and cytoprotective effects in neurons and cardiomyocytes. Flavaglines target prohibitins as ligands, which are scaffold proteins that regulate mitochondrial function, cell survival, and transcription. This study tested the therapeu...

journal_title：Inflammatory bowel diseases

authors： Han J,Zhao Q,Basmadjian C,Désaubry L,Theiss AL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of t...

journal_title：Inflammatory bowel diseases

authors： Yang SK,Hong M,Choi H,Zhao W,Jung Y,Haritunians T,Ye BD,Kim KJ,Park SH,Lee I,Kim WH,Cheon JH,Kim YH,Jang BI,Kim HS,Choi JH,Koo JS,Lee JH,Jung SA,Shin HD,Kang D,Youn HS,Taylor KD,Rotter JI,Liu J,McGovern

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Poor sleep quality in Crohn's disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. METHODS:Clinical data were collected for CD subjects including ...

journal_title：Inflammatory bowel diseases

authors： Sofia MA,Lipowska AM,Zmeter N,Perez E,Kavitt R,Rubin DT

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:Ulcerative colitis is associated with increased colon permeability resulting in bacterial translocation into the lamina propria. We investigate the importance of the Toll-like receptor (TLR) regulating protein IL-1 receptor-associated kinase M (IRAK-M) using the erosive dextran sulfate sodium (DSS)-induced m...

journal_title：Inflammatory bowel diseases

authors： Berglund M,Melgar S,Kobayashi KS,Flavell RA,Hörnquist EH,Hultgren OH

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Though vedolizumab has received regulatory approval for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) in adults, there is increasing off-label use in children. AIMS:To describe the experience with vedolizumab in pediatric inflammatory bowel disease (IBD) patients at 3 tertiary IBD center...

journal_title：Inflammatory bowel diseases

authors： Singh N,Rabizadeh S,Jossen J,Pittman N,Check M,Hashemi G,Phan BL,Hyams JS,Dubinsky MC

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. METHODS:Inflammatory bowel disease pa...

journal_title：Inflammatory bowel diseases

authors： Carney H,Marrie RA,Bolton JM,Patten SB,Graff LA,Bernstein CN,Kowalec K

更新日期：2021-01-01 00:00:00