Probing the Association of Pancreatitis in Inflammatory Bowel Disease.


:Inflammatory bowel disease (IBD) has been increasingly diagnosed in children and adults. Similarly, acute and chronic pancreatitis are increasingly prevalent conditions with potentially devastating consequences. There is a growing body of literature linking these 2 conditions. The purpose of this review is to provide a comprehensive outline of the association between IBD and pancreatitis and to explore their putative pathophysiology. Based on the collective reports, 2 outstanding reasons for pancreatitis in patients with IBD are medications and IBD complications.


Inflamm Bowel Dis


Srinath AI,Gupta N,Husain SZ




Has Abstract


2016-02-01 00:00:00












  • IL-1 receptor-associated kinase M downregulates DSS-induced colitis.

    abstract:BACKGROUND:Ulcerative colitis is associated with increased colon permeability resulting in bacterial translocation into the lamina propria. We investigate the importance of the Toll-like receptor (TLR) regulating protein IL-1 receptor-associated kinase M (IRAK-M) using the erosive dextran sulfate sodium (DSS)-induced m...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Berglund M,Melgar S,Kobayashi KS,Flavell RA,Hörnquist EH,Hultgren OH

    更新日期:2010-10-01 00:00:00

  • A Critical Role for Monocytes/Macrophages During Intestinal Inflammation-associated Lymphangiogenesis.

    abstract:BACKGROUND:Inflammation-associated lymphangiogenesis (IAL) is frequently observed in inflammatory bowel diseases. IAL is believed to limit inflammation by enhancing fluid and immune cell clearance. Although monocytes/macrophages (MΦ) are known to contribute to intestinal pathology in inflammatory bowel disease, their r...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Becker F,Kurmaeva E,Gavins FN,Stevenson EV,Navratil AR,Jin L,Tsunoda I,Orr AW,Alexander JS,Ostanin DV

    更新日期:2016-06-01 00:00:00

  • Practice of gastroenterologists in treating flaring inflammatory bowel disease patients with clostridium difficile: antibiotics alone or combined antibiotics/immunomodulators?

    abstract:BACKGROUND:The optimal management of Clostridium difficile infection (CDI) in flaring inflammatory bowel disease (IBD) patients has not been defined. Limited data suggest that coadministration of immunomodulators (IM) with antibiotics (AB) results in a worse outcome. We investigated the prevalent practice among North A...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Yanai H,Nguyen GC,Yun L,Lebwohl O,Navaneethan U,Stone CD,Ghazi L,Moayyedi P,Brooks J,Bernstein CN,Ben-Horin S

    更新日期:2011-07-01 00:00:00

  • Thiazolidinedione use and ulcerative colitis-related flares: an exploratory analysis of administrative data.

    abstract:BACKGROUND:Recent animal studies and clinical trials suggest that thiazolidinediones, a class of oral antidiabetic agents, are efficacious in reducing inflammation, yet no studies have evaluated their effectiveness in preventing flares. We examined the association between thiazolidinedione use and ulcerative colitis (U...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Lund JL,Stürmer T,Porter CQ,Sandler RS,Kappelman MD

    更新日期:2011-03-01 00:00:00

  • Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation.

    abstract::Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the balance between tolerance and active immunity. The regulatory role of DC is of particular importance in the gut where the immune system lies in intimate contact with the hig...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Ng SC,Kamm MA,Stagg AJ,Knight SC

    更新日期:2010-10-01 00:00:00

  • Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis.

    abstract:BACKGROUND:The efficacy of anti-tumor necrosis factor monoclonal antibody (anti-TNF mAb) for Crohn's disease (CD) is well established, and anti-interleukin-6 receptor (anti-IL-6R) mAb has also been reported to be effective in CD. It is, however, unclear if the efficacy and mechanisms of both agents are different in CD ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Terabe F,Fujimoto M,Serada S,Shinzaki S,Iijima H,Tsujii M,Hayashi N,Nomura S,Kawahata H,Jang MH,Miyasaka M,Mihara M,Ohsugi Y,Kishimoto T,Naka T

    更新日期:2011-02-01 00:00:00

  • Association of Biomarker Cutoffs and Endoscopic Outcomes in Crohn's Disease: A Post Hoc Analysis From the CALM Study.

    abstract:BACKGROUND:CALM was a randomized phase 3 trial in patients with Crohn's disease (CD) that demonstrated improved endoscopic outcomes when treatment was escalated based on cutoffs for inflammatory biomarkers, fecal calprotectin (FC), C-reactive protein (CRP), and CD Activity Index (CDAI) remission vs CDAI response alone....

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Reinisch W,Panaccione R,Bossuyt P,Baert F,Armuzzi A,Hébuterne X,Travis S,Danese S,Sandborn WJ,Schreiber S,Berg S,Zhou Q,Kligys K,Neimark E,Suleiman AA,D'Haens G,Colombel JF

    更新日期:2020-09-18 00:00:00

  • Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.

    abstract:BACKGROUND:Genetic variants of nucleotide-binding oligomerization domain 2 (NOD2) lead to aberrant microbial recognition and can cause chronic inflammatory diseases in patients with Crohn's disease (CD). METHODS:We utilized gene-specific siRNA mediated knockdown and expression of guanine nucleotide exchange factor H1 ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Zhao Y,Alonso C,Ballester I,Song JH,Chang SY,Guleng B,Arihiro S,Murray PJ,Xavier R,Kobayashi KS,Reinecker HC

    更新日期:2012-04-01 00:00:00

  • A Controlled Study of a Group Mindfulness Intervention for Individuals Living With Inflammatory Bowel Disease.

    abstract:BACKGROUND:This study aimed to evaluate the feasibility, acceptability, and effectiveness of a mindfulness-based intervention for patients with inflammatory bowel disease (MI-IBD). DESIGN:Treatment-as-usual control versus mindfulness-based stress reduction intervention. METHODS:Sixty patients participated in either t...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Neilson K,Ftanou M,Monshat K,Salzberg M,Bell S,Kamm MA,Connell W,Knowles SR,Sevar K,Mancuso SG,Castle D

    更新日期:2016-03-01 00:00:00

  • Enterotoxigenic bacteroides fragilis: a potential instigator of colitis.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) is proposed to result from a dysregulated mucosal immune response to the colonic flora in genetically susceptible individuals. Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has been associated with IBD. This stud...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Rabizadeh S,Rhee KJ,Wu S,Huso D,Gan CM,Golub JE,Wu X,Zhang M,Sears CL

    更新日期:2007-12-01 00:00:00

  • Endothelial ligands and homing of mucosal leukocytes in extraintestinal manifestations of IBD.

    abstract::Crohn's disease and ulcerative colitis are quite often complicated with manifestations in extraintestinal organs like joints, eye, and skin. Although the etiopathogenesis of these nonmucosal complications remains unsettled, they all share the characteristic feature of inappropriate leukocyte recruitment in nonlymphati...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Salmi M,Jalkanen S

    更新日期:1998-05-01 00:00:00

  • Aneuploidy-associated gene expression signatures characterize malignant transformation in ulcerative colitis.

    abstract:BACKGROUND:Malignant transformation in ulcerative colitis (UC) is associated with pronounced chromosomal instability, reflected by aneuploidy. Although aneuploidy can precede primary cancer diagnosis in UC for more than a decade, little is known of its cellular consequences. METHODS:Whole-genome gene expression analys...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Gerling M,Nousiainen K,Hautaniemi S,Krüger S,Fritzsche B,Homann N,Bruch HP,Auer G,Roblick UJ,Ried T,Habermann JK

    更新日期:2013-03-01 00:00:00

  • Adalimumab therapy in Crohn's disease of the ileal pouch.

    abstract:BACKGROUND:Crohn's disease (CD) of the pouch can develop in patients with ileal pouch-anal anastomosis, resulting in significant morbidities, even pouch failure. The aim of this study was to evaluate short- and long-term outcome of adalimumab (ADA) in treating these patients. METHODS:A total of 48 patients who receive...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章


    authors: Li Y,Lopez R,Queener E,Shen B

    更新日期:2012-12-01 00:00:00

  • Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease.

    abstract:BACKGROUND:Recent studies have suggested that the downregulation of pregnane X receptor (PXR) may contribute to the susceptibility and exacerbation of Crohn's disease (CD). Because bile acid malabsorption is one of the features of CD and bile acids are potential activators of PXR, we explored the relationship between b...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Iwamoto J,Saito Y,Honda A,Miyazaki T,Ikegami T,Matsuzaki Y

    更新日期:2013-05-01 00:00:00

  • A Cell-Based Approach to the Treatment of Inflammatory Bowel Disease-Entering an Era of Regenerative Medicine.

    abstract::Corticosteroids, and more recently biologics, have been the mainstay of therapy for patients with inflammatory bowel disease. Unfortunately, both are fraught with side effects and limited by lack of efficacy or loss of response. Many patients ultimately succumb to medically refractory disease and require an operation....

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Lightner AL

    更新日期:2018-07-12 00:00:00

  • The Role of Citrullination in Inflammatory Bowel Disease: A Neglected Player in Triggering Inflammation and Fibrosis?

    abstract::Citrullination is a posttranslational modification of proteins mediated by a specific family of enzymes called peptidylarginine deiminases (PAD). Dysregulation of these enzymes is involved in the etiology of various diseases, from cancer to autoimmune disorders. In inflammatory bowel disease (IBD), data for a role of ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Dragoni G,De Hertogh G,Vermeire S

    更新日期:2021-01-01 00:00:00

  • Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study.

    abstract:BACKGROUND:Genetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies and genetic variants associated with the disease have been identified. The aim of our study was to determine the concordance rates for IBD in German twin pairs and to evaluate clinical charac...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Spehlmann ME,Begun AZ,Burghardt J,Lepage P,Raedler A,Schreiber S

    更新日期:2008-07-01 00:00:00

  • Incidence of and impact of medications on colectomy in newly diagnosed ulcerative colitis in the era of biologics.

    abstract:BACKGROUND:The cumulative incidence of colectomy and the impact of 5-aminosalicylates (5-ASA), azathioprine, and antitumor necrosis factor (TNF) treatment on the long-term need for surgery are unknown in ulcerative colitis (UC) in the era of biologics. METHODS:This was an observational study of a referral center cohor...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Williet N,Pillot C,Oussalah A,Billioud V,Chevaux JB,Bresler L,Bigard MA,Gueant JL,Peyrin-Biroulet L

    更新日期:2012-09-01 00:00:00

  • Elevated IL-13Ralpha2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway.

    abstract:BACKGROUND:Chronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin-13 (IL-13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine. METHODS:Expression o...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,收录出版


    authors: Mandal D,Levine AD

    更新日期:2010-05-01 00:00:00

  • Dipeptidyl peptidase expression during experimental colitis in mice.

    abstract:BACKGROUND:We have previously demonstrated that inhibition of dipeptidyl peptidase (DP) activity partially attenuates dextran sulfate sodium (DSS) colitis in mice. The aim of this study was to further investigate the mechanisms of this protection. MATERIALS AND METHODS:Wildtype (WT) and DPIV(-/-) mice consumed 2% DSS ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Yazbeck R,Sulda ML,Howarth GS,Bleich A,Raber K,von Hörsten S,Holst JJ,Abbott CA

    更新日期:2010-08-01 00:00:00

  • Cell Trafficking Interference in Inflammatory Bowel Disease: Therapeutic Interventions Based on Basic Pathogenesis Concepts.

    abstract::After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based on several decades of advances in understanding the pathogenesis of IBD. The targeting of molecules involved in leukocyte traffic has recently become a safe and effectiv...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Pérez-Jeldres T,Tyler CJ,Boyer JD,Karuppuchamy T,Bamias G,Dulai PS,Boland BS,Sandborn WJ,Patel DR,Rivera-Nieves J

    更新日期:2019-01-10 00:00:00

  • High Patient Activation Is Associated With Remission in Patients With Inflammatory Bowel Disease.

    abstract:BACKGROUND:High levels of patient activation (having the knowledge, skills, and confidence to effectively manage one's care), have been associated with improved outcomes in many chronic conditions. There have been few studies of the effects of activation in patients with inflammatory bowel disease (IBD). We performed a...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Barnes EL,Long MD,Kappelman MD,Martin CF,Sandler RS

    更新日期:2019-06-18 00:00:00

  • Short pediatric Crohn's disease activity index for quality improvement and observational research.

    abstract:BACKGROUND:Practical and objective instruments to assess pediatric Crohn's disease (CD) activity are required for observational research and quality improvement. The objectives were: 1) to determine the feasibility of completing the Pediatric Crohn's Disease Activity Index (PCDAI) and the Abbreviated PCDAI (APCDAI); an...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Kappelman MD,Crandall WV,Colletti RB,Goudie A,Leibowitz IH,Duffy L,Milov DE,Kim SC,Schoen BT,Patel AS,Grunow J,Larry E,Fairbrother G,Margolis P

    更新日期:2011-01-01 00:00:00

  • Cost-effectiveness and Clinical Outcomes of Early Anti-Tumor Necrosis Factor-α Intervention in Pediatric Crohn's Disease.

    abstract:BACKGROUND:Anti-tumor necrosis factor-α (anti-TNF-α) treatments are increasingly used to treat pediatric Crohn's disease, even without a prior trial of immunomodulators, but the cost-effectiveness of such treatment algorithms has not been formally examined. Drug plan decision-makers require evidence of cost-effectivene...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bashir NS,Walters TD,Griffiths AM,Ito S,Ungar WJ

    更新日期:2020-07-17 00:00:00

  • Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease.

    abstract::Tolerance, the regulated inability to respond to a specific immunologic stimulant, is a physiological event important to normal immune function. Just as loss of tolerance to self-proteins results in autoimmune diseases, we assert that loss of tolerance to commensal flora in the intestinal lumen leads to inflammatory b...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Jump RL,Levine AD

    更新日期:2004-07-01 00:00:00

  • Multi-Center Experience of Vedolizumab Effectiveness in Pediatric Inflammatory Bowel Disease.

    abstract:BACKGROUND:Though vedolizumab has received regulatory approval for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) in adults, there is increasing off-label use in children. AIMS:To describe the experience with vedolizumab in pediatric inflammatory bowel disease (IBD) patients at 3 tertiary IBD center...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Singh N,Rabizadeh S,Jossen J,Pittman N,Check M,Hashemi G,Phan BL,Hyams JS,Dubinsky MC

    更新日期:2016-09-01 00:00:00

  • Antibodies against infliximab are associated with de novo development of antibodies to adalimumab and therapeutic failure in infliximab-to-adalimumab switchers with IBD.

    abstract:BACKGROUND:A notable proportion of patients with inflammatory bowel disease (IBD) are switched from infliximab (IFX) to adalimumab (ADL). We investigated if immunogenicity of IFX influenced immunogenicity and clinical outcomes of later ADL therapy. METHODS:Single-center cohort study including all patients with IBD ass...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章


    authors: Frederiksen MT,Ainsworth MA,Brynskov J,Thomsen OO,Bendtzen K,Steenholdt C

    更新日期:2014-10-01 00:00:00

  • Oral mesalazine (5-ASA) treatment may protect against proximal extension of mucosal inflammation in ulcerative proctitis.

    abstract:OBJECTIVES:Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis....

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Pica R,Paoluzi OA,Iacopini F,Marcheggiano A,Crispino P,Rivera M,Bella A,Consolazio A,Paoluzi P

    更新日期:2004-11-01 00:00:00

  • The position of the amino group on the benzene ring is critical for mesalamine's improvement of replication fidelity.

    abstract:BACKGROUND:Individuals with ulcerative colitis are at high risk of developing colitis-associated cancer. 5-Aminosalicylate (5-ASA) protects from cancer by its antiinflammatory activity as well as by altering cell growth, inducing apoptosis, and reducing replication errors. So far neither 5-ASA's structural specificity ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Campregher C,Luciani MG,Biesenbach P,Evstatiev R,Lyakhovich A,Gasche C

    更新日期:2010-04-01 00:00:00

  • Use of Social Media for Health-Related Tasks by Adolescents With Inflammatory Bowel Disease: A Step in the Pathway of Transition.

    abstract:Background:Social media is commonly used among the adolescent and young adult population, including those with chronic diseases. For adults, these platforms have been shown to be a major source of health information. Our aims were to explore how youth with inflammatory bowel disease (IBD) use social media for (1) disea...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Szeto W,van der Bent A,Petty CR,Reich J,Farraye F,Fishman LN

    更新日期:2018-05-18 00:00:00