Abstract:
:Previous studies demonstrate significant roles for passive water channels (aquaporins, AQPs) in maintaining water homeostasis in cell membranes of endometrial cells during decidualisation and embryo implantation. However, there is little information regarding the role of AQPs in the human fallopian tube, specifically their role in human tubal ectopic pregnancy. In this study we took tissue samples from the site of implantation of tubal ectopic pregnancy (group 1, N = 30, mean age 32 years, range 23-42) and the corresponding non-implantation site in women undergoing salpingectomy for tubal pregnancy (group 2). Ampullary fallopian tubes during mid-secretory phase were collected as control group (group 3, N = 17, mean age 37 years, range 30-50). Thin sections were prepared and stained with anti-AQP9, and, for estrogen and progesterone receptors in each group. Immunohistochemical studies showed that AQP9 proteins localize in the cytoplasm of epithelial cells of Fallopian tube. Expression of AQP9 was significantly reduced during tubal pregnancy compared to controls (group 1 vs. group 3, P = 0.036; group 2 vs. group 3, P = 0.029), and, this reduced expression was not related to estrogen receptor or progesterone receptor status (group 2, ER vs. AQP9, Pearson r = 0.173, P = 0.361; PR vs. AQP9, Pearson r = 0.124, P = 0.514, respectively). Similarly, there is no correlation between AQP9 and estrogen receptor or progesterone receptor status in the normal group (group 3, ER vs. AQP9, Pearson r = -0.026, P = 0.923; PR vs. AQP9, Pearson r = -0.292, P = 0.255, respectively). Reduced expression of AQP9 in human fallopian tube may contribute to aspects of pathophysiology of tubal ectopic pregnancy.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Ji YF,Chen LY,Xu KH,Yao JF,Shi YF,Shanguan XJdoi
10.1007/s10735-012-9471-6subject
Has Abstractpub_date
2013-04-01 00:00:00pages
167-73issue
2eissn
1567-2379issn
1567-2387journal_volume
44pub_type
杂志文章abstract::Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-019-09822-2
更新日期:2019-06-01 00:00:00
abstract::Prostate cancer is the most common cancer in American men and the second leading cause of cancer deaths in this group. Both growth hormone (GH) and the inflammatory cytokine interleukin 6 (IL-6) have been implicated in prostate cancer progression. Studies in other systems have shown that an increase in GH results in a...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-006-9027-8
更新日期:2006-01-01 00:00:00
abstract::Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized tha...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9496-5
更新日期:2013-08-01 00:00:00
abstract::Sphingosine-1-phosphate receptor 1 (S1P(1)), a receptor for sphingosine-1-phosphate, has been shown to play an important role in the migration, proliferation, and survival of several types of cell including endothelial cells. Given that S1P(1) signaling could serve as a therapeutic target, we evaluate the expression o...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-008-9193-y
更新日期:2008-10-01 00:00:00
abstract::Microscopy is advancing at a rapid pace, enabling high-speed, high-resolution analyses to be conducted in a wide range of cellular contexts. For example, the capacity to quickly capture high-resolution images from multiple optical sections over multiple channels with confocal microscopy has allowed researchers to gain...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-019-09850-y
更新日期:2019-12-01 00:00:00
abstract::TGF-β1, SNAI1 and MMP-9 are implicated in tumor invasion and metastasis. The purpose of this study was to examine TGF-β1, SNAI1 and MMP-9 expression in papillary thyroid carcinoma (PTC), and to assess association of TGF-β1, SNAI1 and MMP-9 expression with several clinicopathological indicators of PTC. TGF-β1, SNAI1 an...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9557-9
更新日期:2014-08-01 00:00:00
abstract::Nickel nanoparticles (Ni NPs) have been applied in various fields along with the rapid development of nanotechnology. However, the potential adverse health effects of the Ni NPs are unclear. To investigate the cyto- and genotoxicity and compare the differences between the Ni NPs and the nickel fine particles (Ni FPs),...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-016-9671-6
更新日期:2016-06-01 00:00:00
abstract::Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...
journal_title:Journal of molecular histology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10735-008-9195-9
更新日期:2008-10-01 00:00:00
abstract::The incidence of chronic renal diseases is increasing worldwide, and there is a great need to identify therapies capable of arresting or reducing disease progression. The current treatment of chronic nephropathies is limited to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, but increasing ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-011-9336-4
更新日期:2011-08-01 00:00:00
abstract::The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-020-09903-7
更新日期:2020-10-01 00:00:00
abstract::The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-011-9323-9
更新日期:2011-04-01 00:00:00
abstract::Inpp5f-v3 is a transcriptional variant of Inpp5f (inositol polyphosphate-5-phosphatase F) and locates in distal mouse chromosome 7. It is a paternally expressed imprinted gene in mouse. In this study, we examined the spatiotemporal patterns of Inpp5f-v3 gene during the mouse development. The northern blotting analysis...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-011-9321-y
更新日期:2011-04-01 00:00:00
abstract::Wnt signaling plays important roles in skeletal development. However, the activation and function of canonical Wnt signaling in joint development remains unclear. We analyzed the lineage identity and developmental changes of the Wnt-responsive cells during synovial joint formation as well as adulthood in the Wnt signa...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-009-9242-1
更新日期:2009-08-01 00:00:00
abstract::Dentin is a major component of teeth that protects dental pulp and maintains tooth health. Bone morphogenetic protein (BMP) signaling is required for the formation of dentin. Mice lacking a BMP type I receptor, activin A receptor type 1 (ACVR1), in the neural crest display a deformed mandible. Acvr1 is known to be exp...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-018-9806-z
更新日期:2019-02-01 00:00:00
abstract::Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for the repair of the injured heart, but optimal cell production in a fully chemically defined and cost-effective system is essential for the efficacy and safety of cell transplantation therapies. In this study, we provided a simple and...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-020-09926-0
更新日期:2021-02-01 00:00:00
abstract::MT1-MMP and TIMP-2 are well known for their roles in remodelling of extracellular matrix components. However, reports are emerging on the involvement of these molecules in cell kinetics. In the rat incisor tooth, a shortening treatment increases the eruption and cell proliferation rates. However, the role of MT1-MMP a...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-010-9295-1
更新日期:2010-12-01 00:00:00
abstract::Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-012-9458-3
更新日期:2013-02-01 00:00:00
abstract::Histochemical and morphological research increasingly relies upon quantification of complex biological systems. For such investigations to be meaningful, quantification techniques must meet the seemingly conflicting requirements of being theoretically robust, yet sufficiently practical to facilitate widespread applica...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-004-2187-5
更新日期:2004-08-01 00:00:00
abstract::Low muscle strength is observed during the peri-and postmenopausal periods, when the secretion of ovarian hormones is drastically reduced. It is also a predictive of adverse health events as well as incident mobility limitation and disability. The objective of the present study is to study the biochemical and the hist...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-011-9326-6
更新日期:2011-06-01 00:00:00
abstract::Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-014-9592-1
更新日期:2014-12-01 00:00:00
abstract::Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-019-09810-6
更新日期:2019-04-01 00:00:00
abstract::In in vitro and in vivo systems, understanding localization and the functional role of ATP is essential, but effective methods to monitor ATP in cells and tissues are limited. Although quinacrine dihydrochloride is a well-known fluorescent dye used to detect ATP, it is limited in its use because it shows non-specific ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-012-9474-3
更新日期:2013-04-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is an important angiogenic factor in the pituitary gland. The objective of this study was to unveil the VEGF subcellular localisation in different pituitary cell types and to evaluate changes in its expression at different time intervals after oestrogen stimulation. A relevant...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-005-9012-7
更新日期:2005-10-01 00:00:00
abstract::S100A8 and S100A9 are calcium-binding proteins expressed in myeloid cells and are markers of numerous inflammatory diseases in humans. S100A9 has been associated with dystrophic calcification in human atherosclerosis. Here we demonstrate S100A8 and S100A9 expression in murine and human bone and cartilage cells. Only S...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-007-9117-2
更新日期:2007-10-01 00:00:00
abstract::This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9553-0
更新日期:2014-06-01 00:00:00
abstract:AIM:To compare the expression of p57 as indirect marker of genomic imprinting of CDKN1C in a series of infantile hemangiomas (IH) of patients with and without Beckwith-Wiedemann syndrome. MATERIALS AND METHODS:Cases of mammary, salivary gland, liver (one each), and placental (2 cases) capillary hemangiomas all with hi...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-005-2255-5
更新日期:2005-03-01 00:00:00
abstract::The goal of this study was to investigate whether sub-chronic anti-oxidant treatment with ascorbic acid (Vit C) is able to protect the heart against myocardial infarction. The effects of Vit C treatment on the histopatological changes and immunohistochemistry for p53, COX-2 and iNOS were evaluated in rats submitted to...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-009-9218-1
更新日期:2009-04-01 00:00:00
abstract::Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopathy in rats. Rats divided into six groups; normal-control, diabetic-control, dia...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-020-09930-4
更新日期:2021-01-03 00:00:00
abstract::Pulp regeneration using human dental pulp stem cells (hDPSCs) maintains tooth vitality compared with conventional root canal therapy. Our previous study demonstrated that preameloblast-conditioned medium (PA-CM) from murine apical bud cells induces the odontogenic differentiation of hDPSCs and promoted dentin formatio...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9513-8
更新日期:2013-12-01 00:00:00
abstract::Tissue microarrays have become an essential tool in translational pathology. They are used to confirm results from other experimental platforms, such as expression microarrays, as well as a primary tool to explore the expression profile of proteins by immunohistochemical analysis. Tissue microarrays are routinely used...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-006-9049-2
更新日期:2007-05-01 00:00:00