Reduction of DNA primase activity in aging but still proliferating cells.

abstract：:Conditioned medium from Sertoli cells, prepared from testes of 20-day-old rats, contains component(s) that inhibit the incorporation of [3H]-thymidine into DNA of peritubular myoid cells (PMC) and inhibit the proliferation of PMC. These components are trypsin-resistant, heat-stable compounds having a molecular weight ...

journal_title：Journal of cellular physiology

authors： Tung PS,Fritz IB

更新日期：1991-06-01 00:00:00

abstract：:Fas, which functions to initiate a signal causing apoptosis, is expressed in epithelia, thus, suggesting a role in controlling cell number during states of cell and matrix turnover. In view of this, we hypothesized that cell-matrix interactions may be an important determinant of Fas expression in epithelial cells. To ...

journal_title：Journal of cellular physiology

authors： Fine A,Miranda K,Farmer SR,Anderson NL

更新日期：1998-03-01 00:00:00

abstract：:Increased oxidative stress contributes to pathogenesis of Parkinson's disease (PD). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is the oxidation product most frequently measured as an indicator of oxidative DNA damage. Several studies have shown increased 8-OHdG in PD patients. There are few basic laboratory data examining 8...

journal_title：Journal of cellular physiology

authors： Kikuchi Y,Yasuhara T,Agari T,Kondo A,Kuramoto S,Kameda M,Kadota T,Baba T,Tajiri N,Wang F,Tayra JT,Liang H,Miyoshi Y,Borlongan CV,Date I

更新日期：2011-05-01 00:00:00

abstract：:Apoptosis of matrix producing cells is common among many inflammatory diseases. The goal of the present study was to examine the apoptotic effects of tumor necrosis factor-alpha (TNF-alpha) on fibroblastic cells in vivo and to investigate the role of different caspases in this process. This was accomplished in vivo by...

journal_title：Journal of cellular physiology

authors： Alikhani M,Alikhani Z,Raptis M,Graves DT

更新日期：2004-12-01 00:00:00

abstract：:The present study was to investigate the effects and action mechanisms of digoxin and ouabain on steroidogenesis in human adrenocortical NCI-H295 cells. Administration of digoxin or ouabain for 24 h decreased the basal and angiotensin II (Ang II)-stimulated release of aldosterone by NCI-H295 cells. The conversions of ...

journal_title：Journal of cellular physiology

authors： Kau MM,Kan SF,Wang JR,Wang PS

更新日期：2005-12-01 00:00:00

abstract：:Interleukin (IL)-37 diminishes a variety of inflammatory responses through ligation to its receptor IL-1R8/Sigirr. Sigirr is a Toll like receptor/IL-1R family member. We have shown that Sigirr is not stable in response to IL-37 treatment. IL-37-induced Sigirr degradation is mediated by the ubiquitin-proteasome system,...

journal_title：Journal of cellular physiology

authors： Li L,Wei J,Suber TL,Ye Q,Miao J,Li S,Taleb SJ,Tran KC,Tamaskar AS,Zhao J,Zhao Y

更新日期：2021-01-05 00:00:00

abstract：:The vascular isoform of ATP-sensitive K(+) (KATP ) channels regulates blood flow to all organs. The KATP channel is strongly inhibited by reactive oxygen and carbonyl species produced in diabetic tissue inflammation. To address how such channel inhibition impacts vascular regulation as well as tissue viability, we per...

journal_title：Journal of cellular physiology

authors： Li SS,Cui N,Yang Y,Trower TC,Wei YM,Wu Y,Zhang S,Jin X,Jiang C

更新日期：2015-12-01 00:00:00

abstract：:For malignant cells cultured from a human astrocytoma, electrophysiological characteristics of the plasma membrane included specific resistivity of 446.82 +/- 279.5 ohm . cm2, specific capacitance of 0.758 +/- 0.52 microfarads/cm2, time constant 0.318 +/- 0.10 msec. The resting membrane potential averaged--14.07 +/- 7...

journal_title：Journal of cellular physiology

authors： Black PM,Kornblith PL

更新日期：1980-12-01 00:00:00

abstract：:Studies on a normal human diploid cell strain revealed that the specific activity of the cell protein, for each of the three enzymes of the Leloir pathway, changed significantly as the cells grew. The kinetics of change in specific activity varied according to the enzyme being studied, and the kinetics for each enzyme...

journal_title：Journal of cellular physiology

authors： Stern ES,Krooth RS

更新日期：1975-08-01 00:00:00

abstract：:Ischemia is a situation occurring in several diseases including myocardial infarction and organ transplantation in which oxygenated blood supply is impaired. Ischemia leads to many cellular and tissue modifications, the most important one being cell death. Several explanations have been proposed to account for these m...

journal_title：Journal of cellular physiology

authors： Arnould T,Michiels C,Alexandre I,Remacle J

更新日期：1992-07-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) are small noncoding RNAs that play critical roles in muscle cell proliferation and differentiation via post-transcriptional regulation of gene expression. Here, based on our previous high-throughput sequencing results, we evaluated miRNA-499 (miR-499) functions during myoblast proliferation ...

journal_title：Journal of cellular physiology

authors： Wu J,Yue B,Lan X,Wang Y,Fang X,Ma Y,Bai Y,Qi X,Zhang C,Chen H

更新日期：2019-03-01 00:00:00

abstract：:Osteoclasts differentiate from cells that share some phenotypes with mature macrophages and monocytes, but early precursors for osteoclasts still remain obscure. To characterize osteoclast precursors, using monoclonal anti-c-Fms and anti-c-Kit antibodies, bone marrow cells were separated and the frequency of clonogeni...

journal_title：Journal of cellular physiology

authors： Hayashi S,Miyamoto A,Yamane T,Kataoka H,Ogawa M,Sugawara S,Nishikawa S,Nishikawa S,Sudo T,Yamazaki H,Kunisada T

更新日期：1997-03-01 00:00:00

abstract：:The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial cells (HAECs) and smooth muscle cells (HASMCs) were treated with ...

journal_title：Journal of cellular physiology

authors： Millar SA,Anderson SI,O'sullivan SE

更新日期：2019-11-01 00:00:00

abstract：:The mechanism(s) by which heparin influences the biological activities of acidic and basic fibroblast growth factors (aFGF and bFGF) is not completely understood. One mechanism by which heparin could alter the biological activities of aFGF and bFGF is by altering their biological half-lives. We investigated the possib...

journal_title：Journal of cellular physiology

authors： Damon DH,Lobb RR,D'Amore PA,Wagner JA

更新日期：1989-02-01 00:00:00

abstract：:Male breast cancer (MBC) is an uncommon malignancy. We have previously reported that the expression of the Hippo transducers TAZ/YAP and their target CTGF was associated with inferior survival in MBC patients. Preclinical evidence demonstrated that Axl is a transcriptional target of TAZ/YAP. Thus, we herein assessed A...

journal_title：Journal of cellular physiology

authors： Di Benedetto A,Mottolese M,Sperati F,Ercolani C,Di Lauro L,Pizzuti L,Vici P,Terrenato I,Shaaban AM,Humphries MP,Sundara-Rajan S,Barba M,Speirs V,De Maria R,Maugeri-Saccà M

更新日期：2017-08-01 00:00:00

abstract：:Although the role of several protooncogenes, including sis, myc, and myb in the regulation of growth and differentiation of vascular cells has been examined in some detail, limited information is available on the contribution of ras genes to these processes. In the present studies the influence of oncogenic ras transf...

journal_title：Journal of cellular physiology

authors： Sadhu DN,Lundberg MS,Burghardt RC,Ramos KS

更新日期：1994-12-01 00:00:00

abstract：:Colon cancer stem cells (CCSCs) stand for a critical subpopulation of colon cancer cells that possess self-renewal and multilineage differentiation potentials and drive tumorigenicity. Due to their impact on treatment tolerance, CCSCs have been a hot research topic in the past few years. We have previously reported th...

journal_title：Journal of cellular physiology

authors： Ma X,Liu J,Li J,Li Y,Le VM,Li S,Liang X,Liu L,Liu J

更新日期：2019-12-01 00:00:00

abstract：:Cells of confluent cultures of the established pig renal epithelial line, LLC-PK1, accumulate alpha-methyl-D-glucoside against a concentration gradient. This transport system is strongly inhibited by phlorizin and 6-deoxy-D-glucose, moderately inhibited by phloretin, and only weakly inhibited by 3-0-methyl-D-glucose, ...

journal_title：Journal of cellular physiology

authors： Mullin JM,Weibel J,Diamond L,Kleinzeller A

更新日期：1980-09-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are enzymes that are involved in the detoxification of harmful electrophilic endogenous and exogenous compounds by conjugating with glutathione (GSH). The liver fluke GSTs have multifunctional roles in the host-parasite interaction, such as general detoxification and bile acid sequest...

journal_title：Journal of cellular physiology

authors： Kalita J,Shukla R,Tripathi T

更新日期：2019-04-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy in head and neck cancer and a global cause of cancer-related death. Due to the poor survival rates associated with OSCC, there is a growing need to develop novel technologies and predictive biomarkers to improve disease diagnosis. The identification of ...

journal_title：Journal of cellular physiology

authors： Wang Q,Zhi Y,Ren W,Li S,Dou Z,Xing X,Quan X,Wang Y,Jiang C,Liang X,Gao L,Zhi K

更新日期：2019-01-28 00:00:00

abstract：:A method for killing dividing cells (Puck and Kao, '67) was adapted for the elimination of dividing heart muscle cells (myoblasts) in cultures. We have used this method to demonstrate their presence and to estimate their number as well as the number of nondividing heart muscle cells (myocytes) in the neo-natal rat hea...

journal_title：Journal of cellular physiology

authors： Masse MJ,Harary I

更新日期：1980-11-01 00:00:00

abstract：:The calcium-sensitive fluorescent indicator fura-2 and a microscope equipped for rapidly changing excitation wavelengths were used to look at the effects of growth factors on cytosolic free calcium ([Ca2+]i) in NRK-49F cells. In these cells bradykinin induced a rapid increase in [Ca2+]i, which generally decayed to nea...

journal_title：Journal of cellular physiology

authors： Marks PW,Kruskal BA,Maxfield FR

更新日期：1988-09-01 00:00:00

abstract：:The human cervical cancer (CC) has been identified as one of the most common tumors in women, and the molecular regulation in CC still remains unclear. The dysregulation of periostin has been found in a variety of cancers, but whether it is involved in the regulation of CC is unknown. The present study aimed to invest...

journal_title：Journal of cellular physiology

authors： Han X,Wang Q,Wang Y,Hu B,Dong X,Zhang H,Wang W

更新日期：2019-08-01 00:00:00

abstract：:A sensitive serum-free culture system was used to demonstrate that cells derived from normal human skin release soluble mediators which can modulate keratinocyte, melanocyte, and fibroblast growth in vitro. In M199 supplemented with epidermal growth factor, hydrocortisone, insulin, transferrin, triidothyronine, bovine...

journal_title：Journal of cellular physiology

authors： Gilchrest BA,Karassik RL,Wilkins LM,Vrabel MA,Maciag T

更新日期：1983-11-01 00:00:00

abstract：:O-linked N-acetylglucosamine (O-GlcNAc) protein modification has been implicated in the regulation of signaling pathways, cell function, and gene expression. Glutamine:fructose-6-phosphate amidotransferase-1 (GFAT-1) is the rate-limiting enzyme in the hexosamine biosynthetic pathway (HBP), which generates the sugar nu...

journal_title：Journal of cellular physiology

authors： Hsieh TJ,Lin T,Hsieh PC,Liao MC,Shin SJ

更新日期：2012-01-01 00:00:00

abstract：:Melanoma as the most major skin malignancy has attracted much attention, so far. Although a successful therapeutic strategy requires an accurate understanding of the precise mechanisms for the initiation and progression of the melanoma. Several types of cell death mechanisms have recently been identified along with co...

journal_title：Journal of cellular physiology

authors： Ashrafizadeh M,Mohammadinejad R,Tavakol S,Ahmadi Z,Roomiani S,Katebi M

更新日期：2019-11-01 00:00:00

abstract：:Our understanding of the mechanism of cell fate transition during the direct reprogramming of fibroblasts into various central nervous system (CNS) neural cell types has been limited by the lack of a comprehensive analysis on generated cells, independently and in comparison with other CNS neural cell types. Here, we a...

journal_title：Journal of cellular physiology

authors： Khazaei N,Rastegar-Pouyani S,O'Toole N,Wee P,Mohammadnia A,Yaqubi M

更新日期：2018-04-01 00:00:00

abstract：:The p53 protein directly regulates the expression of the WAF1 (wild-type p53-activated fragment 1) protein which is a cyclin-dependent kinase inhibitor (CDK1). DNA damaging agents such as ionizing or UV radiation, and some chemical agents induce WAF1 in wild-type p53 containing cells, thereby halting cell cycle progre...

journal_title：Journal of cellular physiology

authors： Shiohara M,Akashi M,Gombart AF,Yang R,Koeffler HP

更新日期：1996-03-01 00:00:00

abstract：:Short term, carrier mediated transport of D-glucose, L-leucine and L-lysine by guinea pig peritoneal macrophages was characterized. Analysis of the amino acid transport demonstrated two-limbed double reciprocal plots suggesting two transport systems for each amino acid. The low concentration limb of the curves establi...

journal_title：Journal of cellular physiology

authors： Straus DC,Imhoff JG,Bonventre PF

更新日期：1977-10-01 00:00:00

abstract：:Anti-angiogenic agents regulate tumor growth by inhibiting endothelial cell proliferation and invasion. Carboxyamido-triazole (CAI), an inhibitor of non-voltage-operated calcium entry and calcium influx-mediated pathways, has angiogenesis and invasion inhibitory activity. We hypothesized that CAI may express its anti-...

journal_title：Journal of cellular physiology

authors： Oliver VK,Patton AM,Desai S,Lorang D,Libutti SK,Kohn EC

更新日期：2003-10-01 00:00:00