Abstract：
OBJECTIVE:To determine the prevalence of celiac disease in patients with myocarditis and dilated cardiomyopathy. METHODS:Fifty-six patients between 1 and 18 years old with dilated cardiomyopathy or myocarditis were evaluated and followed up at Instituto de Medicina Integral Professor Fernando Figueira. Patients with previous diagnosis of celiac disease were excluded. The functional classification was determined according to the American Heart Association criteria (classes I, II, III and IV). Diagnosis of myocarditis was reported in the patients' medical records. Dilated cardiomyopathy was diagnosed by echocardiogram with systolic dysfunction of one or both ventricles, ejection fraction lower than 55%, ventricular dilatation, and left ventricular diastolic diameter bigger than 112%. Patients answered a questionnaire about gastrointestinal and cardiac symptoms; next, anti-tissue transglutaminase (tTG) and anti-endomysial (EMA) antibodies were dosed. Those with positive antibody results were referred to intestinal biopsy and histological evaluation to detect celiac disease according to Marsh classification. RESULTS:One of the 56 children (1.8%) had positive tTG antibody level, but negative EMA. Intestinal histological evaluation showed total villous atrophy. Approximately, 30% of patients had heart failure. Gastrointestinal symptoms and signs were frequent, especially abdominal pain (70%, 39/56). CONCLUSION:Celiac disease prevalence in pediatric patients with dilated cardiomyopathy or myocarditis was 1.8%. It is important to investigate celiac disease in patients with these conditions to avoid the progression of such diseases and patients' clinical deterioration.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Menezes TM,Motta MEdoi
10.2223/JPED.2219subject
Has Abstractpub_date
2012-09-01 00:00:00pages
439-42issue
5eissn
0021-7557issn
1678-4782journal_volume
88pub_type
杂志文章abstract：OBJECTIVE:To assess the occurrence of an aggregate risk to cardiometabolic and musculoskeletal health of Brazilian adolescents in the period 2008/09 and 2013/14 and to identify whether there are differences in risk between the genders and in these periods. METHODS:This was a trend epidemiological study with a quantita...
journal_title：Jornal de pediatria
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Jornal de pediatria
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abstract：OBJECTIVES:To guide the diagnostic and therapeutic management of severe forms of food allergy. DATA SOURCES:Search in the Medline database using the terms "severe food allergy," "anaphylaxis and food allergy," "generalized urticaria and food allergy," and "food protein-induced enterocolitis syndrome" in the last ten y...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV). DATA SOURCE:the key words "bronchiolitis", "risk factor", "genetics" and "respiratory syncytial virus", and all combinations among them were used to perform a se...
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更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.jped.2013.03.014
更新日期：2013-03-01 00:00:00
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更新日期：2007-03-01 00:00:00
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doi：10.2223/jped.305
更新日期：2001-11-01 00:00:00
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更新日期：1997-11-01 00:00:00
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更新日期：2013-05-01 00:00:00
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更新日期：2016-05-01 00:00:00
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更新日期：2010-11-01 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：2007-07-01 00:00:00
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更新日期：2005-03-01 00:00:00
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更新日期：2013-01-01 00:00:00
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更新日期：2018-01-01 00:00:00
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journal_title：Jornal de pediatria
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doi：10.2223/jped.543
更新日期：1997-09-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.09.004
更新日期：2016-05-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章,随机对照试验
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更新日期：2010-01-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2019.08.002
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to investigate what effect the ingestion of sardines, rich in omega-3 series polyunsaturated fatty acids, has on the composition of breastmilk. METHODS:This was a prospective study of 31 nursing mothers under observation at the Hospital Guilherme Alvaro. Each was given 2 kg of ...
journal_title：Jornal de pediatria
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更新日期：2006-01-01 00:00:00
