[Epidemiology applied to the investigation of infant health determinants: basic concepts and methods].

Abstract:

:Epidemiologic principles and methods have been widely employed in clinical research. The purpose of this paper is to discuss basic epidemiological concepts applied to the investigation of the determinants of infant diseases. The theoretical framework outlines the hypothesis of the investigation. The design of the study is chosen accordingly. Exposure and outcome are defined, and the sampling criteria and the strategies for its implementation are specified. The researcher can be an observer (as in cross-sectional, cohort and case-control studies) or can determine who will be exposed in the experimental studies (clinical trials). Cross-sectional study is the easiest one to conduct, since exposure and outcome are assessed simultaneously in a well-defined population. In a cohort study, a group of people is assembled according to the exposure and followed over time to detect who will develop the outcome. In a case-control study,people are selected based on disease status. Then, they are investigated about previous exposures which could be associated with the development of the disease. The investigator allocates the exposure and then follows the participants to assess the outcome in clinical trials. Contrasting with the experiment developed in laboratory, the subjects are human beings.

journal_name

J Pediatr (Rio J)

journal_title

Jornal de pediatria

authors

Fuchs SC

doi

10.2223/jped.742

keywords:

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

132-8

issue

3

eissn

0021-7557

issn

1678-4782

journal_volume

71

pub_type

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