Abstract:
OBJECTIVE:To present a new branch of scientific knowledge, known as the developmental origins of health and disease (DOHaD), covering its concepts, study methods and ethical considerations in addition to the prospects for this area of knowledge. SOURCES:A non-systematic review of the biomedical literature intended to identify historical and current references related to the subject under discussion. SUMMARY OF THE FINDINGS:Recent studies demonstrate associations between aggressions suffered during the initial phases of somatic development and amplified risk of chronic diseases throughout life, such as obesity, diabetes and cardiovascular diseases. A variety of models have been proposed in attempts to better explain these associations, such as the thrifty phenotype, programming and predictive adaptive response theories and the concept of match or mismatch. Some of the mechanisms possibly involved in these processes are: effects of the environment on gene expression, through epigenetic mechanisms; effects of hormonal signals transmitted to the fetus via the placenta or the newborn via lactation. CONCLUSIONS:DOHaD draws together information originating from many different areas of knowledge, proposing new investigative methodologies to elucidate the influence of adverse events that occur during early phases of human development on the pattern of health and disease throughout life. This new scientific field proposes new models of causality and of the mechanisms involved in the emergence and development of chronic diseases. The results of these investigations may result in a significant impact on the prevention of chronic diseases, and also on health promotion in different phases of life.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Silveira PP,Portella AK,Goldani MZ,Barbieri MAdoi
10.2223/JPED.1728subject
Has Abstractpub_date
2007-11-01 00:00:00pages
494-504issue
6eissn
0021-7557issn
1678-4782journal_volume
83pub_type
杂志文章,评审abstract:OBJECTIVE:to evaluate neonatal sepsis as a risk factor for abnormal neuromotor and cognitive development in very low birth weight preterm infants at 12 months of corrected age. METHODS:this was a prospective cohort study that followed the neuromotor and cognitive development of 194 very low birth weight preterm infant...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2013.09.006
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To review the main causes of new bronchopulmonary dysplasia and the strategies utilized to decrease its incidence in extremely low birth weight infants. SOURCES OF DATA:For this review a MEDLINE search from 1966 to October 2004, the Cochrane Database, abstracts from the Society for Pediatric Research and rec...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/1304
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of celiac disease and to describe the histological alterations, clinical manifestations, and conditions associated with a group of first-degree relatives of celiac disease patients in the municipality of Recife, Northeast Brazil. METHOD:The study was conducted in outpatient clinic...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2013
更新日期:2010-07-01 00:00:00
abstract::OBJECTIVE: This paper is a review on the topic of adolescent-onset anorexia nervosa. According to the literature, this disorder presents high morbidity and mortality, with increasing incidence over the last decades, thus enhancing the importance of scientific investigation on the subject. METHODS: The authors performe...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.170
更新日期:2000-11-01 00:00:00
abstract::OBJECTIVE: Describe the morbidity associated with a rare disease due to an embryological defect. METHODS: Retrospective revision of medical and necropsy reports. Bibliographic research using MEDLINE, LILACS and Index Medicus databases. RESULTS: 1 year-old male patient, admitted with generalized tonic-clonic seizures, ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.320
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:To rescue medical genetics concepts that are necessary to understand the advances in the genetic-molecular characterization of primary immunodeficiencies, to help in the understanding and adequate interpretation of their results. SOURCE OF DATA:Non-systematic literature review, searching for articles since ...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2020.09.007
更新日期:2020-10-26 00:00:00
abstract:OBJECTIVE:To describe intubation procedures in two pediatric and two neonatal intensive care units in the city of Porto Alegre. METHODS:Cross-sectional study divided into a retrospective and a prospective phase. All intubations performed in these units during a 6-month period were considered. Data were collected by in...
journal_title:Jornal de pediatria
pub_type: 杂志文章,多中心研究
doi:
更新日期:2004-09-01 00:00:00
abstract::OBJECTIVE: Review the theoretical bases on the maintenance of the acid-basic balance, the pathophysiology of the disturbances and its therapeutics in the child.METHODS: References were obtained from computerized searches on the National Library of Medicine (Medline), recent review articles and personal files.RESULTS: ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.393
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Streptococcus pneumoniae usually colonizes the oropharynx of healthy people. Oropharyngeal carriage is related to the invasion of adjacent structures and to the development of invasive disease. A descriptive cross-sectional study was performed aiming at verifying the prevalence of oropharyngeal colonization b...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To compare two groups of school age girls from different social strata were compared in terms of their perception and knowledge about breastfeeding. METHODS:A structured questionnaire was applied to all 346 4th to 8th grade girls attending two schools, a private one, whose students belonged to the upper clas...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To review well-known aspects of exogenous surfactant therapy, and to discuss controversial points regarding the current state of research. SOURCES:Review of the literature, using Medline and Cochrane Database Library, in association with the authors' experience in relation to exogenous surfactant replacement...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.900
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the age at menarche of girls, with or without weight excess, attending private and public schools in a city in Southeastern Brazil. METHODS:This was a cross-sectional study comparing the age at menarche of 750 girls from private schools with 921 students from public schools, aged between 7 and 18...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2014.05.008
更新日期:2015-01-01 00:00:00
abstract::Immediate skin test reactions are the hallmark of atopic diseases. EMLA (eutectic mixture of local anesthetics) is a local anesthetic that reduces the pain and apprehension for skin testing. We studied EMLA effects on the skin prick test with allergen and histamine. Reactions were evaluated by means of wheal and flare...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.613
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To investigate the extent to which sexual orientation-based bullying relates to self-reported feelings of loneliness and sleeping difficulty among Brazilian middle school students. METHOD:This is a cross-sectional study using data from the 2015 PeNSE (Pesquisa Nacional de Saúde do Escolar), a survey designed...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2020.03.005
更新日期:2020-04-15 00:00:00
abstract:OBJECTIVE:This study of Terena Indian children less than 10 years old was undertaken in order to compare weight and height in 1995 and 2002 and to evaluate anemia prevalence in 2002. METHODS:This was a cross-sectional study of the Limão Verde and Córrego Seco tribes, located in Aquidauana, Mato Gosso do Sul, Brazil. T...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1389
更新日期:2005-09-01 00:00:00
abstract::The author describes television as a factor of influence in the sexual (mis)education in adolescence. He considers the role of eroticism in television as a dysfunctional factor in the sexual education of youth. In accordance with its pervasion, accessibility and attractive and seductive contents TV may be considered a...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.786
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To report a case of an infant with endstage renal failure caused by primary hyperoxaluria. METHODS:The review of the literature showed the rarity of the disease. In France, the prevalence is about 1.05/million and the incidence rate is 0.12/million/year. A survey, performed in international specialized cente...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::A prospective study of acute diarrhoeal diseases was carried out from April 1990 to September 1992 with the purpose of assessing the immunogenicity, safety and efficacy of a Rhesus-human reassortant rotavirus ("RRV-TV") vaccine, involving 540 children living in Belém, Pará, Brazil. As half of the children received pla...
journal_title:Jornal de pediatria
pub_type: 临床试验,杂志文章
doi:10.2223/jped.714
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To present the characteristics of pediatric patients with chronic and irreversible diseases submitted to palliative extubation. METHOD:This is a descriptive analysis of a series of patients admitted to a public pediatric hospital, with chronic and irreversible diseases, permanently dependent on ventilatory s...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2019.07.005
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The predisposing factors for pericarditis recurrence in the pediatric population have not yet been established. This study aimed to define the risk factors for the unfavorable prognosis of pediatric acute pericarditis. METHODS:This was a retrospective study that included all patients with acute pericarditis ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2020.06.007
更新日期:2020-07-29 00:00:00
abstract:OBJECTIVE:To assess the frequency of baked egg tolerance in IgE-mediated egg allergy patients through the oral food challenge and to assess the tolerance predictability of different skin prick tests, as well as specific serum IgE measurement to egg proteins. METHODS:In this cross-sectional study, 42 patients with a di...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2019.08.002
更新日期:2020-01-01 00:00:00
abstract::OBJECTIVES: To present the clinical outcome of a newborn with severe respiratory distress secondary to meconium aspiration syndrome and treated by extracorporeal membrane oxygenation (ECMO); and to present the effect of the use of exogenous surfactant in this case and the cost of the procedure. METHODS: Case report of...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.212
更新日期:2001-05-01 00:00:00
abstract::OBJECTIVE: To determine ASO titer profile by establishing ARF differential diagnoses of other diseases with high levels of ASO antibodies. METHODS: We investigated 78 patients with ARF at onset and follow-up, 22 with isolated chorea at onset, 45 with recurrent oropharyngeal tonsillitis, and 23 with recent flare of juv...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.185
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To evaluate retinol concentration in colostrum samples collected with a 24 hour interval. METHOD:Colostrum was collected from 24 recently-delivered mothers at two points in time, 0 hours (T0) and 24 hours later (T24), and a pooled sample of colostrum from T0 and T24 was also analyzed. Fat content was determi...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1646
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To describe the main predictors for excess birth weight in Brazilian children. DATA SOURCES:Systematic review carried out in the bibliographic databases: PubMed/MEDLINE, Cochrane, Scopus, Web of Science, and LILACS. The research in the gray literature was performed using the Google Scholar database. The bias...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.04.006
更新日期:2019-01-01 00:00:00
abstract::OBJECTIVE: To verify the effects of malnutrition and nutritional rehabilitation regarding seizure threshold, body weight and brain weight in rats. METHODS: Pregnant Wistar rats and their pups were used. Part of the rat pups were submitted to a malnutrition protocol and the rest served as nourished controls. At P15, ma...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The use of whole-cell pertussis vaccine has led to a significant decline in incidence of the disease among children. This change in the epidemiological profile led to an increased number of cases among teenagers and adults, as a result of loss of immunity to the disease or vaccine after approximately 10 year...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1491
更新日期:2006-07-01 00:00:00
abstract::The acute inflammatory demyelinating polyneuropathy (Guillain-Barré Syndrome) might have a severe presentation but a good prognosis in children. It is an immune-mediated and inflammatory disorder of the peripheral nervous system. This retrospective study observed that GBS is frequently complicated by hypertension and ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.579
更新日期:1996-01-01 00:00:00
abstract::OBJECTIVES: To identify rubella prevalence in different ages and population groups and rubella susceptibility of pregnant and postpartum women according to age, number of children and spontaneous abortion. METHODS: Cross-sectional study of sero-survey type. Children and students were selected in day-care centers and s...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.470
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:To describe the association between electronic devices in the bedroom with sedentary time and physical activity, both assessed by accelerometry, in addition to body mass index in children from São Caetano do Sul. METHODS:The sample consisted of 441 children. The presence of electronic equipment (television, ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2015.01.009
更新日期:2015-11-01 00:00:00