Baked egg tolerance: is it possible to predict?

Abstract:

OBJECTIVE:To assess the frequency of baked egg tolerance in IgE-mediated egg allergy patients through the oral food challenge and to assess the tolerance predictability of different skin prick tests, as well as specific serum IgE measurement to egg proteins. METHODS:In this cross-sectional study, 42 patients with a diagnosis of egg allergy were submitted to different skin prick tests with egg (in natura, boiled, muffin, ovalbumin, and ovomucoid), and specific IgE to egg white, ovalbumin, and ovomucoid; as well as to the oral food challenge with food containing egg, extensively baked in a wheat matrix. RESULTS:Of the total, 66.6% of patients tolerated the ingestion of egg-containing foods in the oral food challenge. A comparative analysis with positive and negative oral food challenge found no significant differences regarding age, gender, other food allergies, or even specific skin prick tests and IgE values between the groups. CONCLUSIONS:The study demonstrated an elevated frequency of baked egg food-tolerant individuals among egg allergy patients. None of the tested markers, skin prick tests, or specific IgE, were shown to be good predictors for identifying baked egg-tolerant patients. The oral food challenge with egg baked in a matrix is central to demonstrate tolerance and the early introduction of baked foods, improving patients' and families' quality of life and nutrient intake.

journal_name

J Pediatr (Rio J)

journal_title

Jornal de pediatria

authors

Vilar LK,Rolins Neto PR,Abdo MA,Cheik MFA,Afonso CPES,Segundo GRS

doi

10.1016/j.jped.2019.08.002

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

725-731

issue

6

eissn

0021-7557

issn

1678-4782

pii

S0021-7557(19)30287-6

journal_volume

96

pub_type

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