当前位置： SCI文献检索 > Jornal de Pediatria期刊下所有文献 > [Oropharyngeal carriage of Streptococcus pneumoniae by children attending day care centers in Taubate, SP: correlation between serotypes and the conjugated heptavalent pneumococcal vaccine].

[Oropharyngeal carriage of Streptococcus pneumoniae by children attending day care centers in Taubate, SP: correlation between serotypes and the conjugated heptavalent pneumococcal vaccine].

Abstract：

OBJECTIVE:Streptococcus pneumoniae usually colonizes the oropharynx of healthy people. Oropharyngeal carriage is related to the invasion of adjacent structures and to the development of invasive disease. A descriptive cross-sectional study was performed aiming at verifying the prevalence of oropharyngeal colonization by S. pneumoniae in children attending day care centers in the city of Taubaté - SP; verifying the frequency of S. pneumoniae serotypes in isolated strains; and relating the most frequent serotypes to the composition of the conjugated heptavalent pneumococcal vaccine currently in use. METHODS:From June 29 to December 15 1998, samples of oropharyngeal material were collected from 987 children, ranging from 8 to 71 months old, enrolled in day care centers in Taubaté - SP. The identification of S. pneumoniae was based on the observation of the colonies that presented partial hemolysis in agar-blood and agar-blood with gentamycin plates and on the observation of inhibited growth around the optochin disc. Serotyping was performed by the Quellung reaction, using specific antiserum, provided by the Centers for Disease Control and Prevention (Atlanta, GA/USA), and the Danish nomenclature system. RESULTS:S. pneumoniae was isolated from the oropharynx in 209 out of 987 children (colonization rate of 21.2%). Twenty eight serotypes were identified. The seven most frequent serotypes were: 6A/6B (21.5%), 19F (14.8%), 18C (7.4%), 23F (7.4%), 9V (6.7%), 14 (5.2%), 10A (4.4%). Except for serotype 10A, all the other six are included in the vaccine. The only vaccine serotype which was not found was serotype 4. CONCLUSION:Agreement of 63% between the oropharynx colonizer serotypes and the serotypes present in the vaccine was found.

journal_name

J Pediatr (Rio J)

journal_title

Jornal de pediatria

authors

Lucarevschi BR,Baldacci ER,Bricks LF,Bertoli CJ,Teixeira LM,Mendes CM,Oplustil C

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

215-20

issue

eissn

0021-7557

issn

1678-4782

journal_volume

pub_type

杂志文章

在线工具

[Oropharyngeal carriage of Streptococcus pneumoniae by children attending day care centers in Taubate, SP: correlation between serotypes and the conjugated heptavalent pneumococcal vaccine].