Abstract:
OBJECTIVE:To review the new options in insulin therapy for controlling diabetes mellitus in children and adolescents. SOURCES:Articles indexed in PubMed were located using the search terms insulin analogs in children and adolescents and reviewed. Information was also obtained from American Diabetes Association and Sociedade Brasileira de Diabetes consensus documents. SUMMARY OF THE FINDINGS:Information is presented on new analogs of insulin and, for purposes of comparison, the other insulin modalities currently available are also reviewed, focusing on insulin therapies which attempt to approximate basal-bolus treatment strategies to physiology. With the objective of obtaining improved metabolic control, more and more children are being put on multiple daily injection regimes or using continuous subcutaneous insulin infusion. It is difficult to achieve optimum glycemic control in children due to the increased risk of hypoglycemia resulting from the great variability in dietary intake habits and in physical activity levels. With diabetes type 1, if rapid-acting analogs are given subcutaneously in bolus, they generally reduce hypoglycemia episodes and postprandial glycemia levels, compared with regular human insulin, while basal analogs tend to reduce particularly the number of episodes of nocturnal hypoglycemia. CONCLUSIONS:Although the benefits to individual metabolic and clinical outcomes appear modest, the majority of studies demonstrate benefits when insulin analogs are used in the treatment of diabetes type 1 or 2.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Schmid Hdoi
10.2223/JPED.1712subject
Has Abstractpub_date
2007-11-01 00:00:00pages
S146-55issue
5 Suppleissn
0021-7557issn
1678-4782journal_volume
83pub_type
杂志文章,评审abstract:OBJECTIVE:Plastic bronchitis is an unusual condition in children, associated with formation of mucofibrinous casts and mucous plugging of the tracheobronchial tree. Given that this illness is part of the differential diagnosis of acute respiratory failure, early treatment is important for improved prognosis. The aim of...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1425
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:To present evidence-based recommendations for the use of antibiotics for the treatment of the most common acute respiratory infections (ARI) and the available information on the importance of this type of management. SOURCES:MEDLINE and LILACS databases, technical publications by international organizations...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1548
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of pain, musculoskeletal syndromes, orthopedic disorders and using computers and playing videogames among obese adolescents. METHODS:This was a cross-sectional study that investigated 100 consecutive obese adolescents and 100 healthy-weight controls using a confidential, self-repo...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.2111
更新日期:2011-07-01 00:00:00
abstract::Symptoms of psoas muscular abscess in children are nonspecific and differential diagnosis is made among diseases included in childreńs acute hip pain syndrome, imaging tests being necessary for diagnostic confirmation. During the first semester of 1995, 48,550 children were examined in Pronto Socorro do Instituto da C...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.632
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Several reports claim that blood pressure (BP) in the radial artery may underestimate the accurate BP in critically ill patients. Here, the authors evaluated differences in mean blood pressure (MBP) between the radial and femoral artery during pediatric cardiac surgery to determine the effectiveness of femora...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2017.03.011
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To describe the increased risk of acquiring infectious diseases associated with out-of-home childcare and the effectiveness of measures for the control and prevention of diseases transmission at daycare and preschool education centers. SOURCES:A review of literature in the MEDLINE, LILACS and Cochrane Librar...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1649
更新日期:2007-07-01 00:00:00
abstract::OBJECTIVE: To establish the nutritional diagnosis of children living in a low-income community through anthropometric evaluation, detecting insufficient nutrition (low weight-for-age, wasting and stunting) and excessive nutrition (overweight and obesity). METHODS: A community-based survey identified children below 11 ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.236
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To measure the prevalence of children with adequate weight who feel fat and to examine the factors associated with this perception. METHODS:Cross-sectional study with 901 schoolchildren aged 8-11 years selected by cluster sampling. The children had their weight and height measured, and answered a questionnai...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1477
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To carry out a systematic review on the relationship of bullying with type 1 diabetes in children and adolescents. METHODS:Systematic review, according to the PRISMA methodology, in which the databases PubMed, Web of Science, Scopus, Thomson Reuters, Eighteenth Century Collections Online, Begell House Digita...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.10.003
更新日期:2019-01-01 00:00:00
abstract::OBJECTIVE: The association between cryptosporidiosis and persistent diarrhea has been studied in many countries. The aim of this study was to verify the incidence of this parasite in children with persistent diarrhea. Children infected or not with protozoan cryptosporidium were compared in relation to laboratory and c...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.425
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the peak inspiratory pressure and ventilation rate achieved by physicians when using a neonatal self-inflating bag on a lung model. METHODS:Fifteen physicians ventilated full term and preterm infant lung simulators while the outcomes were captured by a ventilation monitor. RESULTS:Median peak pr...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1524
更新日期:2006-09-01 00:00:00
abstract::OBJECTIVE: This paper is a review on the topic of adolescent-onset anorexia nervosa. According to the literature, this disorder presents high morbidity and mortality, with increasing incidence over the last decades, thus enhancing the importance of scientific investigation on the subject. METHODS: The authors performe...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.170
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To investigate the immune response of preterm infants to hepatitis B vaccination. METHODS:Three doses of recombinant hepatitis B vaccine (5 micro g dose) were administered to 35 preterm and 21 full-term infants within 24 hours after birth and at one and six months of postnatal age. RESULTS:A protective anti...
journal_title:Jornal de pediatria
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::Iron deficiency is the most frequent form of nutritional anemia, and infants represent one of the major risk groups. The present study was meant to evaluate the iron content of infant diets cooked in iron utensils and in aluminum utensils prepared by volunteer mothers at home. The iron content was analyzed by atomic a...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.706
更新日期:1995-03-01 00:00:00
abstract::OBJECTIVE: To verify the effects of malnutrition and nutritional rehabilitation regarding seizure threshold, body weight and brain weight in rats. METHODS: Pregnant Wistar rats and their pups were used. Part of the rat pups were submitted to a malnutrition protocol and the rest served as nourished controls. At P15, ma...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To analyze calcium intake in adolescents according to sociodemographic variables, health-related behaviors, morbidities, and body mass index. METHODS:This was a cross-sectional population-based study, with a two-stage cluster sampling that used data from a survey conducted in Campinas, São Paulo, Brazil, bet...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2015.09.004
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the peak inspiratory pressure, tidal volume and respiratory rate achieved during manual ventilation of premature lambs, using a self-inflating bag. METHODS:In this descriptive, experimental study, five pairs of physicians, selected at random among 35 neonatologists working at a neonatal intensive...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1517
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To analyze the evolution of pediatric patients chosen for hepatic transplantation. METHODS:A review was made of the clinical charts of the first 65 children and adolescents with chronic liver disease, aged 5 months to 19 years (X = 6.8%), chosen for liver transplantation during the period of August 1994 to M...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.511
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. METHODS:Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate th...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2015.08.012
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the presence of insulin resistance and its association with other metabolic abnormalities in obese children and adolescents. METHODS:Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometric measurements were performed (weight, height, and waist circumference) and clinic...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2014.03.005
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To describe the clinical and demographic characteristics of non-Hodgkin's lymphoma patients diagnosed at the Pediatric Oncology Unit at the Instituto Materno-Infantil Professor Fernando Figueira (IMIP) over a 9-year period, and also to describe their survival rates and possible associations between the surviv...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1726
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To evaluate retinol concentration in colostrum samples collected with a 24 hour interval. METHOD:Colostrum was collected from 24 recently-delivered mothers at two points in time, 0 hours (T0) and 24 hours later (T24), and a pooled sample of colostrum from T0 and T24 was also analyzed. Fat content was determi...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1646
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:This study of Terena Indian children less than 10 years old was undertaken in order to compare weight and height in 1995 and 2002 and to evaluate anemia prevalence in 2002. METHODS:This was a cross-sectional study of the Limão Verde and Córrego Seco tribes, located in Aquidauana, Mato Gosso do Sul, Brazil. T...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1389
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the trend of pneumonia mortality in Brazilian children aged 4 years and younger from 1991 to 2007. METHODS:We conducted a retrospective study based on the database of the IT Department of the Brazilian Unified Health System (DATASUS), from which we obtained the number of deaths from pneumonia and...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2070
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of intimate partner violence during the gestational period and the development of externalizing and internalizing behavioral problems in children and adolescents. SOURCE OF DATA:A meta-analysis of cohort and case-control studies was performed, using studies selected from electroni...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2018.01.007
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To analyze acute splenic sequestration (ASS) in children with sickle cell anemia diagnosed through a newborn screening program in the state of Minas Gerais, Brazil, and followed up at the hematology center in the city of Belo Horizonte, Minas Gerais, Brazil. METHODS:Retrospective cohort of 255 children with ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1885
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To assess the frequency of baked egg tolerance in IgE-mediated egg allergy patients through the oral food challenge and to assess the tolerance predictability of different skin prick tests, as well as specific serum IgE measurement to egg proteins. METHODS:In this cross-sectional study, 42 patients with a di...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2019.08.002
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To analyze the trend in mortality due to diarrhea among children under 5 in the town of Osasco (SP), Brazil, between 1980 and 2000. METHODS:This is a descriptive observational study with two different designs, the first using individuals as the unit of study, and the other ecological, using groups of individ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1856
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation. METHODS:This was a retrospective observational cohort study of children ventil...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2013.02.008
更新日期:2013-01-01 00:00:00
abstract::OBJECTIVE: Neonatal tetanus is an infection with high mortality, constituting a problem in underdeveloped countries, where there is faulty prenatal attendance. In spite of this and of the decreasing incidence of the disease in the state of Rio Grande do Sul, we report a case of neonatal tetanus identified in 1997. MET...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.80
更新日期:2000-09-01 00:00:00