Abstract：
OBJECTIVE:To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. METHODS:Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate the results, parental impressions the Childhood Autism Rating Scale (CARS) and the Clinical Global Impression (CGI) Scale. Each child underwent a new peptide cycle after two weeks. The children were followed for four weeks after the end of the infusions. RESULTS:The gastrin-releasing peptide was well tolerated and no child had adverse effects. Two children had improved social interaction, with a slight improvement in joint attention and the interaction initiatives. Two showed reduction of stereotypes and improvement in verbal language. One child lost his compulsion to bathe, an effect that lasted two weeks after each infusion cycle. Average reduction in CARS score was 2.8 points. CGI was "minimally better" in two children and "much better" in one. CONCLUSIONS:This study suggests that the gastrin-releasing peptide is safe and may be effective in improving key symptoms of autism spectrum disorder, but its results should be interpreted with caution. Controlled clinical trials-randomized, double-blinded, and with more children-are needed to better evaluate the possible therapeutic effects of gastrin-releasing peptide in autism.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Becker MM,Bosa C,Oliveira-Freitas VL,Goldim JR,Ohlweiler L,Roesler R,Schwartsmann G,Riesgo Rdos Sdoi
10.1016/j.jped.2015.08.012subject
Has Abstractpub_date
2016-05-01 00:00:00pages
302-6issue
3eissn
0021-7557issn
1678-4782pii
S0021-7557(16)00016-4journal_volume
92pub_type
杂志文章abstract：OBJECTIVE:End-stage renal disease is a health problem that consumes public and private resources. This study aimed to identify the cost of hemodialysis (either daily or conventional hemodialysis) and transplantation in children and adolescents. METHODS:This was a retrospective cohort of pediatric patients with End-sta...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.05.004
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:To describe the prevalence of and factors associated with overweight in children under 4 years of age in Feira de Santana, state of Bahia, Brazil. METHODS:Cross-sectional study nested within a birth cohort of 793 children born in Feira de Santana, Brazil. Independent variables were related to infant charact...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2009
更新日期：2010-07-01 00:00:00
abstract：:OBJECTIVE: To determine the presence of antimeasles antibodies in children perinatally infected with HIV and properly immunized. METHODS: A retrospective cohort study conducted in Belo Horizonte by the Universidade Federal de Minas Gerais, between 1995 and 1996. Twenty one children perinatally infected with HIV and 29...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.360
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV). DATA SOURCE:the key words "bronchiolitis", "risk factor", "genetics" and "respiratory syncytial virus", and all combinations among them were used to perform a se...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2013.02.022
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the presence of insulin resistance and its association with other metabolic abnormalities in obese children and adolescents. METHODS:Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometric measurements were performed (weight, height, and waist circumference) and clinic...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.03.005
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To report the case of two siblings with chronic granulomatous disease. Chronic granulomatous disease is a primary immunodeficiency disorder characterized by abnormal microbicidal activity. Mutations in the p47-phox gene (NCF-1) are present in about 30% of the patients with chronic granulomatous disease; this ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To report the results of open challenge tests performed in children fed with cow's milk-free diet. DESCRIPTION:Cross-sectional study evaluating cow's milk open challenge performed under supervision in a hospital setting during 2.5 hours and ambulatory follow-up for 30 days when no immediate reaction occurred...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1967
更新日期：2010-03-01 00:00:00
abstract：:OBJECTIVE: This paper is a review on the topic of adolescent-onset anorexia nervosa. According to the literature, this disorder presents high morbidity and mortality, with increasing incidence over the last decades, thus enhancing the importance of scientific investigation on the subject. METHODS: The authors performe...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.170
更新日期：2000-11-01 00:00:00
abstract：:OBJECTIVE: Review the theoretical bases on the maintenance of the acid-basic balance, the pathophysiology of the disturbances and its therapeutics in the child.METHODS: References were obtained from computerized searches on the National Library of Medicine (Medline), recent review articles and personal files.RESULTS: ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.393
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:Total bilirubin is beneficial for protecting cardiovascular diseases in adults. The authors aimed to investigate the association of total bilirubin, red blood cell, and hemoglobin levels with the prevalence of high blood pressure in children and adolescents. METHODS:A total of 3776 students (aged from 6 to 1...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.07.018
更新日期：2018-01-01 00:00:00
abstract：:OBJECTIVES: To identify rubella prevalence in different ages and population groups and rubella susceptibility of pregnant and postpartum women according to age, number of children and spontaneous abortion. METHODS: Cross-sectional study of sero-survey type. Children and students were selected in day-care centers and s...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.470
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation. METHODS:This was a retrospective observational cohort study of children ventil...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2013.02.008
更新日期：2013-01-01 00:00:00
abstract：:OBJECTIVE: Morbidity and mortality of premature infants have decreased considerably over the last decades, therefore, adequate nutrition of the premature is a major concern. Enteral feeding is the route of choice, but when it is not possible the parenteral route, which contains glucose as one of its main components, i...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.463
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:Assess the maternal socio-demographic factors associated with the frequency of use of child care services by low income families. METHODS:Cross-sectional analysis of 393 children between 12 and 16 months old who participated in a randomized field trial during their first year of life in a program of nutritio...
journal_title：Jornal de pediatria
pub_type： 杂志文章,随机对照试验
doi：10.2223/JPED.1966
更新日期：2010-01-01 00:00:00
abstract：:OBJECTIVE: To establish the nutritional diagnosis of children living in a low-income community through anthropometric evaluation, detecting insufficient nutrition (low weight-for-age, wasting and stunting) and excessive nutrition (overweight and obesity). METHODS: A community-based survey identified children below 11 ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.236
更新日期：2001-07-01 00:00:00
abstract：:OBJECTIVE: The aim of this article is to review and update the knowledge about sleep disorders in childhood. SOURCES: Normal sleep ontogenesis and therapeutics for the most prevalent sleep disorders were reviewed. The text was based on classical articles and books and on Medline (publications from 2000 and 2001) using...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.852
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To determine the thyroid stimulating hormone (TSH) secretion in children with Down syndrome (DS), who do not present clinical and laboratory evidence of classical hypothyroidism and concomitant undetectable antibodies. METHODS:Fourteen children with DS with a mean age of 3.4 (+/- 1.8) years were studied. Pat...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact of heptavalent pneumococcal conjugate vaccine in invasive pneumococcal diseases in the United States, and to analyze the potential impact of this vaccine in Brazil. SOURCES OF DATA:MEDLINE, LILACS, Cochrane Database Reviews, as well as the websites of the Centers for Disease Control a...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.1475
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:The objective of this review of genetic counseling (GC) is to describe the current concepts and philosophical and ethical principles accepted by the great majority of countries and recommended by the World Health Organization, the stages of the process, its results and the psychological impact that a genetic ...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.1782
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To describe the linear growth and growth velocity of preterm infants born small for gestational age according to variables such as weight, length and head circumference, from birth to three months of corrected age. METHODS:Prospective study of one hundred preterm infants born small for gestational age from 2...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVES:To evaluate the possible effects of the introduction of the pneumococcal conjugate 10-valent vaccine schedule in the state of Parana on pneumococcal meningitis cases and to assess the distribution of serotypes among cases. METHOD:Cross-sectional study with retrospective data collection of cases of pneumococ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.07.002
更新日期：2015-03-01 00:00:00
abstract：:OBJECTIVE: To review and discuss different contraceptive methods currently used by adolescents, and also discuss adolescent pregnancy, including the associated risks and the importance of prenatal care. METHODS: Review of literature and clinical experience with different contraceptive methods and with adolescent pregn...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.305
更新日期：2001-11-01 00:00:00
abstract：:OBJECTIVE: Aiming a better understanding of the distribution of enteropathogens in Brazil, we have investigated the prevalence of enteropathogens in acute infantile diarrhea in children of low economic level from São José do Rio Preto, SP.METHODS: A prospective study with 196 children under age five, all with diarrhea...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.444
更新日期：1998-07-01 00:00:00
abstract：:OBJECTIVE: Describe the morbidity associated with a rare disease due to an embryological defect. METHODS: Retrospective revision of medical and necropsy reports. Bibliographic research using MEDLINE, LILACS and Index Medicus databases. RESULTS: 1 year-old male patient, admitted with generalized tonic-clonic seizures, ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.320
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:To generate prediction equations for spirometry in 4- to 6-year-old children. METHODS:Forced vital capacity, forced expiratory volume in 0.5s, forced expiratory volume in one second, peak expiratory flow, and forced expiratory flow at 25-75% of the forced vital capacity were assessed in 195 healthy children ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.10.005
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:To analyze the influence of obesity status on immune cell count and concentration of the hormones cortisol and leptin, in order to establish a relationship among the variables analyzed. METHODS:We recruited 27 obese [body mass index (BMI) > or = 95th percentile] and 21 non-obese (BMI < or = 75th percentile) ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1845
更新日期：2008-11-01 00:00:00
abstract：:OBJECTIVE: To verify the effects of malnutrition and nutritional rehabilitation regarding seizure threshold, body weight and brain weight in rats. METHODS: Pregnant Wistar rats and their pups were used. Part of the rat pups were submitted to a malnutrition protocol and the rest served as nourished controls. At P15, ma...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:OBJECTIVES: To describe the characteristics of the patients not resuscitated in a university affiliated pediatric hospital. To characterize the data registered in the chart regarding the resuscitation and evaluate ethical and legal aspects of CPR (cardiopulmonary resuscitation). METHODS: Retrospective study of 176 dea...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.89
更新日期：2000-11-01 00:00:00
abstract：:The authors interviewed 76.2% of the pediatricians from the Pediatric Department-School of Medical Sciences-Campinas University-UNICAMP, to analyse the difficulties of this professional group in the evaluation of the domestic violence against children. From the group of professionals, 86.7% had already attended a situ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.798
更新日期：1995-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the prevalence of intestinal parasitoses in Native Brazilian children from 2 to 9 years old. METHODS:A search for ova and parasites was conducted in the stools of children between 2 to 9 years old living in six indigenous villages located in the Middle and Lower Xingu River, to wit: Pavuru, Moygu...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2036
更新日期：2010-11-01 00:00:00
