Abstract：
OBJECTIVE:To evaluate the presence of insulin resistance and its association with other metabolic abnormalities in obese children and adolescents. METHODS:Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometric measurements were performed (weight, height, and waist circumference) and clinical (gender, age, pubertal stage, and degree of obesity) and biochemical (glucose, insulin, total cholesterol, and fractions, triglycerides) data were analyzed. Insulin resistance was identified by the homeostasis model assessment for insulin resistance (HOMA-IR) index. The analysis of the differences between the variables of interest and the HOMA-IR quartiles was performed by ANOVA or Kruskal-Wallis tests. RESULTS:Insulin resistance was diagnosed in 33.20% of the sample. It was associated with low levels of high-density lipoprotein cholesterol (HDL-C; p=0.044), waist circumference measurement (p=0.030), and the set of clinical and metabolic (p=0.000) alterations. Insulin-resistant individuals had higher mean age (p=0.000), body mass index (BMI; p=0.000), abdominal circumference (p=0.000), median triglycerides (p=0.001), total cholesterol (p≤0.042), and low-density lipoprotein cholesterol (LDL-C; p≤0.027); and lower HDL-C levels (p=0.005). There was an increase in mean BMI (p=0.000), abdominal circumference (p=0.000), and median triglycerides (p=0.002) as the values of HOMA -IR increased, with the exception of HDL-C, which decreased (p=0.001). Those with the highest number of simultaneous alterations were between the second and third quartiles of the HOMA-IR index (p=0.000). CONCLUSION:The results confirmed that insulin resistance is present in many obese children and adolescents, and that this condition is associated with alterations that represent an increased risk for developing metabolic disorders in adulthood.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Romualdo MC,Nóbrega FJ,Escrivão MAdoi
10.1016/j.jped.2014.03.005subject
Has Abstractpub_date
2014-11-01 00:00:00pages
600-7issue
6eissn
0021-7557issn
1678-4782pii
S0021-7557(14)00097-7journal_volume
90pub_type
杂志文章abstract：OBJECTIVE:To identify risk factors for neonatal mortality, focusing on factors related to assistance care during the prenatal period, childbirth, and maternal reproductive history. METHODS:This was a case-control study conducted in Maceió, Northeastern Brazil. The sample consisted of 136 cases and 272 controls selecte...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2012.11.005
更新日期：2013-05-01 00:00:00
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journal_title：Jornal de pediatria
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doi：10.1016/j.jped.2020.03.005
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journal_title：Jornal de pediatria
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2013.04.002
更新日期：2013-11-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.410
更新日期：1998-01-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1741
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journal_title：Jornal de pediatria
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更新日期：2006-05-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2013.03.002
更新日期：2013-03-01 00:00:00
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journal_title：Jornal de pediatria
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doi：10.2223/JPED.1765
更新日期：2008-03-01 00:00:00
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doi：
更新日期：2004-05-01 00:00:00
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pub_type： 杂志文章
doi：10.2223/JPED.1856
更新日期：2009-01-01 00:00:00
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journal_title：Jornal de pediatria
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doi：
更新日期：2004-09-01 00:00:00
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doi：10.2223/JPED.2232
更新日期：2012-11-01 00:00:00
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pub_type： 杂志文章
doi：10.2223/jped.425
更新日期：1998-03-01 00:00:00
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pub_type： 杂志文章
doi：10.2223/JPED.1524
更新日期：2006-09-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.776
更新日期：1995-07-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1845
更新日期：2008-11-01 00:00:00
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更新日期：2017-01-01 00:00:00
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doi：
更新日期：2002-01-01 00:00:00
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更新日期：2001-05-01 00:00:00
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更新日期：2019-01-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
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更新日期：2020-10-18 00:00:00
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journal_title：Jornal de pediatria
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doi：10.2223/jped.185
更新日期：2001-03-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2047
更新日期：2010-11-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.202
更新日期：2001-05-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.852
更新日期：2002-07-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
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更新日期：2004-04-01 00:00:00
