Abstract：
OBJECTIVES:To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. METHODS:This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening database for all live births from January 1, 2010, to December 31, 2012, assessed using the Newborn Screening Program of a Brazilian state, Brazil. The infants were divided into two groups: I - Control: infants with normal newborn screening tests and II - Study: infants with congenital hypothyroidism. Analysis included comparing the TSHneo levels from both groups. A receiver operating characteristic (ROC) curve was constructed to assess the TSHneo cutoff values. RESULTS:Using a TSHneo cutoff value of 5.0μIU/mL, 50 out of 111,705 screened infants had diagnosis of congenital hypothyroidism (prevalence 1:2234 live births). The ROC curve showed that TSHneo value of 5.03μIU/mL had 100% sensitivity and the greatest associated specificity (93.7%). The area under the curve was 0.9898 (p<0.0001). CONCLUSIONS:The ROC curve confirmed that the TSHneo cutoff value of 5.0μIU/mL adopted by the Newborn Screening Program of a Brazilian state was the most appropriate for detecting congenital hypothyroidism and most likely explains the high prevalence that was found.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Silvestrin SM,Leone C,Leone CRdoi
10.1016/j.jped.2016.07.006subject
Has Abstractpub_date
2017-01-01 00:00:00pages
274-280issue
3eissn
0021-7557issn
1678-4782pii
S0021-7557(16)30388-6journal_volume
93pub_type
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journal_title：Jornal de pediatria
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更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV). DATA SOURCE:the key words "bronchiolitis", "risk factor", "genetics" and "respiratory syncytial virus", and all combinations among them were used to perform a se...
journal_title：Jornal de pediatria
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abstract：OBJECTIVE:Streptococcus pneumoniae usually colonizes the oropharynx of healthy people. Oropharyngeal carriage is related to the invasion of adjacent structures and to the development of invasive disease. A descriptive cross-sectional study was performed aiming at verifying the prevalence of oropharyngeal colonization b...
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journal_title：Jornal de pediatria
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doi：10.2223/jped.524
更新日期：1997-05-01 00:00:00
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journal_title：Jornal de pediatria
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更新日期：2016-05-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.1529
更新日期：2006-09-01 00:00:00
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更新日期：2004-05-01 00:00:00
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更新日期：2012-05-01 00:00:00
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journal_title：Jornal de pediatria
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更新日期：2013-05-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
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journal_title：Jornal de pediatria
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更新日期：2011-09-01 00:00:00
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doi：10.2223/jped.185
更新日期：2001-03-01 00:00:00
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更新日期：1998-01-01 00:00:00
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doi：10.2223/JPED.1914
更新日期：2009-07-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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更新日期：2009-09-01 00:00:00
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doi：10.1016/j.jped.2017.03.005
更新日期：2017-01-01 00:00:00
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更新日期：2013-09-01 00:00:00
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更新日期：2002-11-01 00:00:00
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更新日期：2007-11-01 00:00:00
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2010-01-01 00:00:00
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更新日期：2014-07-01 00:00:00
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更新日期：2014-07-01 00:00:00
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更新日期：2001-09-01 00:00:00
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journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/1166
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:End-stage renal disease is a health problem that consumes public and private resources. This study aimed to identify the cost of hemodialysis (either daily or conventional hemodialysis) and transplantation in children and adolescents. METHODS:This was a retrospective cohort of pediatric patients with End-sta...
journal_title：Jornal de pediatria
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更新日期：2018-01-01 00:00:00
