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Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus.

Abstract：

OBJECTIVE:to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV). DATA SOURCE:the key words "bronchiolitis", "risk factor", "genetics" and "respiratory syncytial virus", and all combinations among them were used to perform a search in the PubMed, SciELO, and Lilacs databases, of articles published after the year 2000 that included individuals younger than 2 years of age. DATA SYNTHESIS:a total of 1,259 articles were found, and their respective summaries were read. Of these, 81 were selected, which assessed risk factors for the severity of AVB, and were read in full; the 60 most relevant studies were included. The epidemiologic factors associated with AVB severity by RSV were prematurity, passive smoking, young age, lack of breastfeeding, chronic lung disease, congenital heart disease, male gender, ethnicity, viral coinfection, low weight at admission, maternal smoking during pregnancy, atopic dermatitis, mechanical ventilation in the neonatal period, maternal history of atopy and/or asthma during pregnancy, season of birth, low socioeconomic status, Down syndrome, environmental pollution, living at an altitude > 2,500 meters above sea level, and cesarean section birth. Conversely, some children with severe AVB did not present any of these risk factors. In this regard, recent studies have verified the influence of genetic factors on the severity of AVB by RSV. Polymorphisms of the TLRs, RANTES, JUN, IFNA5, NOS2, CX3CR1, ILs, and VDR genes have been shown to be associated with more severe evolution of AVB by RSV. CONCLUSION:the severity of AVB by RSV is a phenomenon that depends on the varying degrees of interaction among epidemiological, environmental, and genetic variables.

journal_name

J Pediatr (Rio J)

journal_title

Jornal de pediatria

authors

Alvarez AE,Marson FA,Bertuzzo CS,Arns CW,Ribeiro JD

doi

10.1016/j.jped.2013.02.022

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

531-43

issue

eissn

0021-7557

issn

1678-4782

pii

S0021-7557(13)00163-0

journal_volume

pub_type

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Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus.