Abstract：
OBJECTIVE:Interleukin 8 protein promotes inflammatory responses, even in airways. The presence of interleukin 8 gene variants causes altered inflammatory responses and possibly varied responses to inhaled bronchodilators. Thus, this study analyzed the interleukin 8 variants (rs4073, rs2227306, and rs2227307) and their association with the response to inhaled bronchodilators in cystic fibrosis patients. METHODS:Analysis of interleukin 8 gene variants was performed by restriction fragment length polymorphism of polymerase chain reaction. The association between spirometry markers and the response to inhaled bronchodilators was evaluated by Mann-Whitney and Kruskal-Wallis tests. The analysis included all cystic fibrosis patients, and subsequently patients with two mutations in the cystic fibrosis transmembrane conductance regulator gene belonging to classes I to III. RESULTS:This study included 186 cystic fibrosis patients. There was no association of the rs2227307 variant with the response to inhaled bronchodilators. The rs2227306 variant was associated with FEF50% in the dominant group and in the group with two identified mutations in the cystic fibrosis transmembrane conductance regulator gene. The rs4073 variant was associated with spirometry markers in four genetic models: co-dominant (FEF25-75% and FEF75%), dominant (FEV1, FEF50%, FEF75%, and FEF25-75%), recessive (FEF75% and FEF25-75%), and over-dominant (FEV1/FVC). CONCLUSIONS:This study highlighted the importance of the rs4073 variant of the interleukin 8 gene, regarding response to inhaled bronchodilators, and of the assessment of mutations in the cystic fibrosis transmembrane conductance regulator gene.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Furlan LL,Ribeiro JD,Bertuzzo CS,Salomão Junior JB,Souza DRS,Marson FALdoi
10.1016/j.jped.2017.03.005subject
Has Abstractpub_date
2017-01-01 00:00:00pages
639-648issue
6eissn
0021-7557issn
1678-4782pii
S0021-7557(17)30634-4journal_volume
93pub_type
杂志文章abstract：OBJECTIVE:To assess the applicability of salivary C-reactive protein, mean platelet volume, neutrophil-lymphocyte ratio, and platelet lymphocyte ratio in the diagnosis of neonatal sepsis. METHODS:Prospective case-control study of 70 full-term neonates, 35 with sepsis (20 with proven sepsis and 15 with clinical sepsis)...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.03.006
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:End-stage renal disease is a health problem that consumes public and private resources. This study aimed to identify the cost of hemodialysis (either daily or conventional hemodialysis) and transplantation in children and adolescents. METHODS:This was a retrospective cohort of pediatric patients with End-sta...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.05.004
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:The incidence of abnormal breathing and its consequences on craniofacial development is increasing, and is not limited to children with adenoid faces. The objective of this study was to evaluate the cephalometric differences in craniofacial structures and head posture between nasal breathing and oral breathin...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.05.007
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:Plastic bronchitis is an unusual condition in children, associated with formation of mucofibrinous casts and mucous plugging of the tracheobronchial tree. Given that this illness is part of the differential diagnosis of acute respiratory failure, early treatment is important for improved prognosis. The aim of...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1425
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to evaluate the agreement between the most used skinfold thickness equations with multi-frequency bioimpedance analysis in the prediction of body fat levels in children. METHOD:A cross-sectional study of healthy Brazilian community-dwelling individuals. The anthropometric ass...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2019.12.006
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:To determine if the number of involved anatomic areas can modify the standard risk groups in pediatric Hodgkin's lymphoma, identifying children who would benefit from a reduction in treatment intensity. METHODS:Retrospective study evaluating age, sex, histology, Ann-Arbor stage, presence of B symptoms, numb...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1891
更新日期：2009-05-01 00:00:00
abstract：:Epidemiologic principles and methods have been widely employed in clinical research. The purpose of this paper is to discuss basic epidemiological concepts applied to the investigation of the determinants of infant diseases. The theoretical framework outlines the hypothesis of the investigation. The design of the stud...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.742
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To study bone density as a concomitant factor for obesity in post-pubertal adolescents, controlling for other variables that may interfere in such a relation. METHODS:Study comprising 83 overweight and obese adolescents (BMI > or = P85) and 89 non obese ones (P5 < or = BMI < or = P85). Cases and controls wer...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVES:To identify the prevalence of iron deficiency in the population studied, as well as verifying if such deprivation is associated with vitamin A deficiency. METHODS:One hundred seventy-nine children, > or = 24 months and < 72 months of age, with no diarrhea and/or fever at collection were studied. Vitamin A d...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:The use of whole-cell pertussis vaccine has led to a significant decline in incidence of the disease among children. This change in the epidemiological profile led to an increased number of cases among teenagers and adults, as a result of loss of immunity to the disease or vaccine after approximately 10 year...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.1491
更新日期：2006-07-01 00:00:00
abstract：:OBJECTIVES: The aims of this review are to present research data about aerosoltherapy and to discuss the optimization of this form of drug administration.METHOD: Review of the literature, covering some of the most important studies about aerosoltherapy, inhaler devices, pharmacokinetics and pharmacodynamics of inhaled...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.428
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. METHODS:Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate th...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.08.012
更新日期：2016-05-01 00:00:00
abstract：:OBJECTIVE: To determine ASO titer profile by establishing ARF differential diagnoses of other diseases with high levels of ASO antibodies. METHODS: We investigated 78 patients with ARF at onset and follow-up, 22 with isolated chorea at onset, 45 with recurrent oropharyngeal tonsillitis, and 23 with recent flare of juv...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.185
更新日期：2001-03-01 00:00:00
abstract：:OBJECTIVE: Describe the morbidity associated with a rare disease due to an embryological defect. METHODS: Retrospective revision of medical and necropsy reports. Bibliographic research using MEDLINE, LILACS and Index Medicus databases. RESULTS: 1 year-old male patient, admitted with generalized tonic-clonic seizures, ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.320
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:To report the results of open challenge tests performed in children fed with cow's milk-free diet. DESCRIPTION:Cross-sectional study evaluating cow's milk open challenge performed under supervision in a hospital setting during 2.5 hours and ambulatory follow-up for 30 days when no immediate reaction occurred...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1967
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:To generate prediction equations for spirometry in 4- to 6-year-old children. METHODS:Forced vital capacity, forced expiratory volume in 0.5s, forced expiratory volume in one second, peak expiratory flow, and forced expiratory flow at 25-75% of the forced vital capacity were assessed in 195 healthy children ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.10.005
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:To assess the occurrence of an aggregate risk to cardiometabolic and musculoskeletal health of Brazilian adolescents in the period 2008/09 and 2013/14 and to identify whether there are differences in risk between the genders and in these periods. METHODS:This was a trend epidemiological study with a quantita...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.04.006
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to identify the causes of congenital microcephaly in Rio Grande do Sul, a state in southern Brazil, where no ZIKV outbreak was detected, from December 2015 to December 2016, which was the period when ZIKV infection was at its peak in northeast Brazil. METHODS:This was a cross-sectio...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.05.013
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To determine the thyroid stimulating hormone (TSH) secretion in children with Down syndrome (DS), who do not present clinical and laboratory evidence of classical hypothyroidism and concomitant undetectable antibodies. METHODS:Fourteen children with DS with a mean age of 3.4 (+/- 1.8) years were studied. Pat...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To analyze the available evidence regarding the efficacy of interventions on parents whose children were aged 2-5 years to promote parental competence and skills for children's healthy lifestyles. SOURCE:Articles published in English and Spanish, available at PubMed, Psycinfo, CINAHL, Web of Science, Eric, a...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2017.07.019
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To investigate risk factors for anemia in infants assisted by public health services. METHODS:In a cross-sectional study carried out in Viçosa, state of Minas Gerais, Brazil, 205 children from 6 to 12 months were evaluated. Socioeconomic, environmental and biological data were collected, as well as informati...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1603
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:Exposure to sunlight in childhood is often more intense than in adults. Literature data unequivocally show the association between this social behavior and the risk for developing malignant melanoma and non-melanoma skin cancer, even in adulthood. Furthermore, skin photoaging begins already in childhood throu...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/jped.2194
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:To analyze the evolution of pediatric patients chosen for hepatic transplantation. METHODS:A review was made of the clinical charts of the first 65 children and adolescents with chronic liver disease, aged 5 months to 19 years (X = 6.8%), chosen for liver transplantation during the period of August 1994 to M...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.511
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:To investigate the immune response of preterm infants to hepatitis B vaccination. METHODS:Three doses of recombinant hepatitis B vaccine (5 micro g dose) were administered to 35 preterm and 21 full-term infants within 24 hours after birth and at one and six months of postnatal age. RESULTS:A protective anti...
journal_title：Jornal de pediatria
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:To review well-known aspects of exogenous surfactant therapy, and to discuss controversial points regarding the current state of research. SOURCES:Review of the literature, using Medline and Cochrane Database Library, in association with the authors' experience in relation to exogenous surfactant replacement...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.900
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To contribute with information about the adequate administration of drugs during breastfeeding. SOURCES OF DATA:MEDLINE articles from 1993 to 2004, and Lilacs articles from 1995 to 2004 were selected in Portuguese, Spanish and English, by including the following keywords: breastfeeding, lactation, drugs and ...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/1246
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:To analyze the occurrence of anemia and iron deficiency in children aged 1 to 5 years and the association of these events and retinol deficiency. METHODS:This was an observational analytic cross-sectional study conducted in Vitoria, ES, Brazil, between April and August of 2008, with healthy children aged 1 t...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.03.003
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation. METHODS:This was a retrospective observational cohort study of children ventil...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2013.02.008
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:This study investigates the nutritional factors that determine the absence of anemia in infants from families with a low socioeconomic background submitted to a nutrition intervention program, as well as iron intake according to recommendations. METHODS:The study included 369 children from a cohort of inhabi...
journal_title：Jornal de pediatria
pub_type： 杂志文章,随机对照试验
doi：10.2223/JPED.1577
更新日期：2007-01-01 00:00:00
abstract：:OBJECTIVE: To study plasma levels of IL-1beta and IL-6 in order to distinguish the presence of bacterial infection in newborn infants with fever. METHODS: A cohort of 117 newborn infants with postnatal age equal to or less than 5 days, with no previous use of antibiotic therapy, and with clinical suspicion of bacteria...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.253
更新日期：1999-01-01 00:00:00
