Abstract:
OBJECTIVE:To review well-known aspects of exogenous surfactant therapy, and to discuss controversial points regarding the current state of research. SOURCES:Review of the literature, using Medline and Cochrane Database Library, in association with the authors' experience in relation to exogenous surfactant replacement therapy. SUMMARY OF THE FINDINGS:The main aspects of surfactant characteristics: composition, pool, metabolism, inactivation and immediate effects after its administration are well established. However, there are some doubts related to the use of exogenous surfactants that need to be cleared up: choice of surfactant type, most appropriate length of treatment, adequate dose and number of doses, best administration route and complications associated with its use. Currently, the research about exogenous surfactant therapy focuses on two aspects: the use of surfactant in other pathologies besides the respiratory distress syndrome of the newborn, and the development of new surfactants through the addition of proteins or analogous proteins, with the aim of improving its action and reducing its inactivation. CONCLUSIONS:The use of exogenous surfactant has become a routine in neonatal intensive care units, but both clinical and experimental research is still necessary.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Rebello CM,Proença RS,Troster EJ,Jobe AHdoi
10.2223/jped.900keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
S215-26eissn
0021-7557issn
1678-4782journal_volume
78 Suppl 2pub_type
杂志文章abstract::OBJECTIVES: Air pollution has been a significant worldwide problem with repercussions in the respiratory tract, along the years. The main objectives of this review are to present results from studies on the harmful effects of allergens as well as of pollutants over the respiratory tract.METHOD: Published studies were ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.481
更新日期:1998-07-01 00:00:00
abstract::OBJECTIVES: To present the clinical outcome of a newborn with severe respiratory distress secondary to meconium aspiration syndrome and treated by extracorporeal membrane oxygenation (ECMO); and to present the effect of the use of exogenous surfactant in this case and the cost of the procedure. METHODS: Case report of...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.212
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:Using a wide and representative sample of adolescents from 37 countries, this study aimed to analyze how age changes adolescents' healthy lifestyle. METHODS:The study included 148,839 adolescents who participated in the Health Behavior in School-aged Children 2010 survey. A composite score of a healthy lifes...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.09.002
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To assess the frequency of baked egg tolerance in IgE-mediated egg allergy patients through the oral food challenge and to assess the tolerance predictability of different skin prick tests, as well as specific serum IgE measurement to egg proteins. METHODS:In this cross-sectional study, 42 patients with a di...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2019.08.002
更新日期:2020-01-01 00:00:00
abstract::Immediate skin test reactions are the hallmark of atopic diseases. EMLA (eutectic mixture of local anesthetics) is a local anesthetic that reduces the pain and apprehension for skin testing. We studied EMLA effects on the skin prick test with allergen and histamine. Reactions were evaluated by means of wheal and flare...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.613
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To evaluate retinol concentration in colostrum samples collected with a 24 hour interval. METHOD:Colostrum was collected from 24 recently-delivered mothers at two points in time, 0 hours (T0) and 24 hours later (T24), and a pooled sample of colostrum from T0 and T24 was also analyzed. Fat content was determi...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1646
更新日期:2007-07-01 00:00:00
abstract::OBJECTIVE: Describe the hemodynamic response with rebound of pulmonary hypertension after withdrawal of inhaled nitric oxide (NO) in a pediatric patient with acute respiratory distress syndrome (ARDS). METHODS: Case report of a child with ARDS and pulmonary hypertension evaluated through ecocardiografic with dopller, ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.59
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To investigate determinants of physical inactivity among adolescents aged 15 to 19 years in the city of Recife, northeastern Brazil. METHOD:This case-control study involved 597 private school students aged 15 to 19 years selected by convenience sampling. Exclusion criteria were adolescents with diseases that...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2047
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:To perform a bibliometric analysis of theses and dissertations on prematurity in the Capes database from 1987 to 2009. METHODS:This is a descriptive study that used the bibliometric approach for the production of indicators of scientific production. Operationally, the methodology was developed in four steps...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2232
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To review the main causes of new bronchopulmonary dysplasia and the strategies utilized to decrease its incidence in extremely low birth weight infants. SOURCES OF DATA:For this review a MEDLINE search from 1966 to October 2004, the Cochrane Database, abstracts from the Society for Pediatric Research and rec...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/1304
更新日期:2005-03-01 00:00:00
abstract::OBJECTIVE: Evaluation of epidemiological, clinical and laboratory features of Plasmodium vivax malaria in children and adolescents. METHODS: This study was carried out in the Malaria Program of the Evandro Chagas Institute (Belém, Pará), from January 1995 to November 1996. 100 children and adolescents with the diagnos...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.295
更新日期:1999-05-01 00:00:00
abstract::BCG-test reaction was carried out in 91 non-tuberculous children between 2 and 11 years old, who had received BCG vaccination during the first six months of life to critically evaluate the usefulness of this test in Pediatric practice. The BCG-test profile of the vaccinated group was shown to have a unimodal distribut...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.678
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To report the results of open challenge tests performed in children fed with cow's milk-free diet. DESCRIPTION:Cross-sectional study evaluating cow's milk open challenge performed under supervision in a hospital setting during 2.5 hours and ambulatory follow-up for 30 days when no immediate reaction occurred...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1967
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To estimate the frequency and describe the clinical characteristics and respective treatments of previous history of wheezing. METHODS:Infants aged 6-23 months with upper respiratory tract complaints and reporting previous wheezing were followed-up retrospectively. Data were registered on a validated standar...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2187
更新日期:2012-07-01 00:00:00
abstract::OBJECTIVE: To report four cases of myositis ossificans progressiva, its form of presentation, in addition to new control and treatment options. DESCRIPTION: The authors describe four cases of myositis ossificans progressiva, presenting its clinical manifestations, evolution, and available forms of control and treatmen...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.287
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:Children's differences in moderate-to-vigorous physical activity levels are not at random. This study investigates the relevance of individual- and school-level characteristics in explaining these differences. METHODS:In total, 307 children (154 girls) aged 5-10 years, from 19 Portuguese schools, were sample...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.10.013
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To guide the diagnostic and therapeutic management of severe forms of food allergy. DATA SOURCES:Search in the Medline database using the terms "severe food allergy," "anaphylaxis and food allergy," "generalized urticaria and food allergy," and "food protein-induced enterocolitis syndrome" in the last ten y...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2017.06.021
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To measure the main risk factors associated with the occurrence of accidental injuries in children aged 4-5 years. METHODS:The study included a prospective cohort of children whose parents filled in a diary recording accidents and injuries during a period of one-month. The children represented a systematic s...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::In order to better understand the natural history of chronic functional constipation, a questionnaire was applied to 163 children and infants, before beginning standardized treatment. Median age (range) at start was 3 mo(0-108 mo) but age at arrival at the Pediatric Gastroenterology Unit was 53 mo(2-146 mo). In 62.4% ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.688
更新日期:1994-09-01 00:00:00
abstract::OBJECTIVES: To characterize primitive neuroectodermal tumor of the kidney as a differential diagnosis for Wilms tumor, and to emphasize the severity of the disease. METHODS: We report the case of a patient with a diagnosis of primitive neuroectodermal tumor of the kidney who underwent nephrectomy and complete tumor re...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.111
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To evaluate sleep architecture in children and adolescents with both cystic fibrosis (CF) and a clinical suspicion of sleep-disordered breathing (SDB), and to identify the respiratory polysomnographic profile of these patients. METHODS:Parents or guardians of children with CF filled out a questionnaire desi...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2055
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To describe the clinical and demographic characteristics of non-Hodgkin's lymphoma patients diagnosed at the Pediatric Oncology Unit at the Instituto Materno-Infantil Professor Fernando Figueira (IMIP) over a 9-year period, and also to describe their survival rates and possible associations between the surviv...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1726
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. METHODS:This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening d...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2016.07.006
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To analyze the parents' perception of their infants hospitalization in a neonatal intensive care unit (NICU) and suggest a more humane and individualized care in this highly stressful environment. METHODS:We recorded and analyzed the interview of 20 young, low socioeconomic class couples having their first b...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.543
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To analyze the influence of obesity status on immune cell count and concentration of the hormones cortisol and leptin, in order to establish a relationship among the variables analyzed. METHODS:We recruited 27 obese [body mass index (BMI) > or = 95th percentile] and 21 non-obese (BMI < or = 75th percentile) ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1845
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To observe the behavior of the plotted vectors on the RXc (R - resistance - and Xc - reactance corrected for body height/length) graph through bioelectrical impedance analysis (BIVA) and phase angle (PA) values in stable premature infants, considering the hypothesis that preterm infants present vector behavio...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2016.04.005
更新日期:2012-05-01 00:00:00
abstract::OBJECTIVE: To verify the effects of malnutrition and nutritional rehabilitation regarding seizure threshold, body weight and brain weight in rats. METHODS: Pregnant Wistar rats and their pups were used. Part of the rat pups were submitted to a malnutrition protocol and the rest served as nourished controls. At P15, ma...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the peak inspiratory pressure and ventilation rate achieved by physicians when using a neonatal self-inflating bag on a lung model. METHODS:Fifteen physicians ventilated full term and preterm infant lung simulators while the outcomes were captured by a ventilation monitor. RESULTS:Median peak pr...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1524
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To review current concepts related to the procedure of tracheal intubation in children. SOURCES:Relevant articles published from 1968 to 2006 were selected from the MEDLINE, LILACS and SciELO databases, using the keywords intubation, tracheal intubation, child, rapid sequence intubation and pediatric airway....
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1626
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the prevalence of infection versus the prevalence of contamination in infants less than 60 days old who had blood cultures positive for CoNS. MATERIAL AND METHODS:Between February and June - 1993, a number of 45 blood cultures positive for CoNS from 41 patients were stu...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.524
更新日期:1997-05-01 00:00:00