Abstract：
OBJECTIVES:To evaluate the association between the genetic polymorphism of the tumor necrosis factor-alpha (TNF-α) gene and the development of sepsis and septic shock in Thai pediatric patients and to investigate the clinical impacts of TNF-α polymorphisms in this population. METHODS:To perform this genetic association study, a prospective analysis of pediatric patients (age < 18 years) with clinical sepsis/septic shock was conducted. All clinical data were collected by pediatric intensive care experts, and genetic analyses were performed at a central laboratory. A single nucleotide polymorphism (SNP) located in the 5'-promoter region at position -308 was genotyped and the results were associated with clinical phenotypes. RESULTS:A total of 167 Thai individuals were investigated, 66 of which were pediatric patients with sepsis/septic shock and 101 were healthy controls. Interestingly, we could not identify an association between sepsis and -308 (G/A) polymorphism, which have previously been demonstrated to be a major SNP associated with sepsis in several Caucasian populations, since there was no frequency difference between cases and controls. CONCLUSIONS:In this report, the major TNF-α polymorphism (-308) was not associated with clinical sepsis/septic shock in Thais. This information will be important for future analyses to identify the role of TNF-α as a genetic risk for the development of immunopathology underlying several diseases in Asia.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Phumeetham S,Chat-Uthai N,Manavathongchai M,Viprakasit Vdoi
10.2223/JPED.2216subject
Has Abstractpub_date
2012-09-01 00:00:00pages
417-22issue
5eissn
0021-7557issn
1678-4782journal_volume
88pub_type
杂志文章abstract：OBJECTIVES:To evaluate the motor performance of premature neonates using the Alberta Infant Motor Scale (AIMS) and to investigate the influence of birth weight on motor acquisition. METHODS:A cross-sectional study was carried out of a prospective cohort of 44 premature newborn infants with gestational ages from 32 to ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1741
更新日期：2008-01-01 00:00:00
abstract：:Immediate skin test reactions are the hallmark of atopic diseases. EMLA (eutectic mixture of local anesthetics) is a local anesthetic that reduces the pain and apprehension for skin testing. We studied EMLA effects on the skin prick test with allergen and histamine. Reactions were evaluated by means of wheal and flare...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.613
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVE:To meta-analyze health-related quality of life in pediatric patients with chronic kidney disease in comparison to healthy patients according to the dimensions of the PedsQL instrument. SOURCES OF DATA:A systematic review was performed with meta-analysis for the mean difference in each of the health-related q...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2020.10.013
更新日期：2020-12-17 00:00:00
abstract：OBJECTIVE:To report the results of open challenge tests performed in children fed with cow's milk-free diet. DESCRIPTION:Cross-sectional study evaluating cow's milk open challenge performed under supervision in a hospital setting during 2.5 hours and ambulatory follow-up for 30 days when no immediate reaction occurred...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1967
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Evaluate the prevalence of retinopathy of prematurity (ROP) in very low birthweight infants (birthweight<1500 g). METHOD:A prospective examination was conducted on 102 neonates with very low birthweight admitted to the BAM-HC (FMUSP) between 01/01/92 and 12/31/93. The mapping of the retina with scleral depre...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.564
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:We sought to describe the prevalence of microcephaly and to compare the different cutoff points established by the Brazilian Ministry of Health (MoH) at various times during a Zika virus epidemic. As a secondary aim, we investigated the possible etiology of the microcephaly. METHOD:This retrospective study u...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2020.08.010
更新日期：2020-10-18 00:00:00
abstract：OBJECTIVE:To describe the main predictors for excess birth weight in Brazilian children. DATA SOURCES:Systematic review carried out in the bibliographic databases: PubMed/MEDLINE, Cochrane, Scopus, Web of Science, and LILACS. The research in the gray literature was performed using the Google Scholar database. The bias...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.04.006
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. METHODS:Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate th...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.08.012
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To present an updated review of the most common upper respiratory infections (URI) in children seen by the pediatrician in outpatient clinics, for better diagnostic and therapeutic decisions. SOURCES:References from Medline database were reviewed. The most relevant articles were selected. SUMMARY OF THE FIN...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/jped.1002
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:This article presents a review of the main aspects related to lung transplant in children and shows the experience of the first medical team to perform this procedure in Latin America. SOURCES:Literature review of scientific articles, using the MEDLINE and Lilacs databases. SUMMARY OF THE FINDINGS:The artic...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness of salbutamol administration by metered-dose inhaler with a home-made spacer versus jet nebulizer in children with moderate wheezing attacks. MATERIAL AND METHODS:A randomized, single-blinded trial was performed with a convenience sample of children presenting wheezing. The child...
journal_title：Jornal de pediatria
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:To characterize the deaths of 193 children with sickle cell disease screened by a neonatal program from 1998 to 2012 and contrast the initial years with the final years. METHODS:Deaths were identified by active surveillance of children absent to scheduled appointments in Blood Bank Clinical Centers (Hemomina...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.08.006
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:To review the literature for clinical data on infants with allergic or eosinophilic colitis. DATA SOURCE:MEDLINE search of all indexes was performed using the words "colitis or proctocolitis and eosinophilic" or "colitis or proctocolitis and allergic" between 1966 and February of 2013. All articles that desc...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2013.03.024
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To report the case of two siblings with chronic granulomatous disease. Chronic granulomatous disease is a primary immunodeficiency disorder characterized by abnormal microbicidal activity. Mutations in the p47-phox gene (NCF-1) are present in about 30% of the patients with chronic granulomatous disease; this ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:This study investigates the nutritional factors that determine the absence of anemia in infants from families with a low socioeconomic background submitted to a nutrition intervention program, as well as iron intake according to recommendations. METHODS:The study included 369 children from a cohort of inhabi...
journal_title：Jornal de pediatria
pub_type： 杂志文章,随机对照试验
doi：10.2223/JPED.1577
更新日期：2007-01-01 00:00:00
abstract：:Iron deficiency is the most frequent form of nutritional anemia, and infants represent one of the major risk groups. The present study was meant to evaluate the iron content of infant diets cooked in iron utensils and in aluminum utensils prepared by volunteer mothers at home. The iron content was analyzed by atomic a...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.706
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To assess the applicability of salivary C-reactive protein, mean platelet volume, neutrophil-lymphocyte ratio, and platelet lymphocyte ratio in the diagnosis of neonatal sepsis. METHODS:Prospective case-control study of 70 full-term neonates, 35 with sepsis (20 with proven sepsis and 15 with clinical sepsis)...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.03.006
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To present, in an essay form, two distinct views on well-child care. METHODS:Using several different methods of historical analysis, the two most common views on well-child care are presented: the positivist one, whose foundation is essentially based upon historical facts, and that of social criticism, conce...
journal_title：Jornal de pediatria
pub_type： 历史文章,杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to identify the causes of congenital microcephaly in Rio Grande do Sul, a state in southern Brazil, where no ZIKV outbreak was detected, from December 2015 to December 2016, which was the period when ZIKV infection was at its peak in northeast Brazil. METHODS:This was a cross-sectio...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.05.013
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To present the characteristics of pediatric patients with chronic and irreversible diseases submitted to palliative extubation. METHOD:This is a descriptive analysis of a series of patients admitted to a public pediatric hospital, with chronic and irreversible diseases, permanently dependent on ventilatory s...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2019.07.005
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:This article reviews the clinical and epidemiological aspects of anxiety disorders in youngsters, as well as current medical and psychological treatment strategies. The role of the neurobiological models possibly involved in the etiology of these disorders is also discussed. SOURCES OF DATA:MEDLINE search of...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/1166
更新日期：2004-04-01 00:00:00
abstract：:OBJECTIVE: To present and discuss the indications, the endoscopic and histologic findings and the complications of upper digestive endoscopies carried out in children and adolescents.METHODS: We have done 228 endoscopies in pediatric patients with ages between 3 months to 19 years (x=5.7 y) during a period of 8 months...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.410
更新日期：1998-01-01 00:00:00
abstract：:OBJECTIVE: To review and discuss different contraceptive methods currently used by adolescents, and also discuss adolescent pregnancy, including the associated risks and the importance of prenatal care. METHODS: Review of literature and clinical experience with different contraceptive methods and with adolescent pregn...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.305
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVES:Functional echocardiography is a valuable tool in the neonatal intensive care unit, but training programs are not standardized. The aim was to report an functional echocardiography training program for neonatologists and to describe the agreement of their measurements with the pediatric cardiologist. METHOD...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2019.04.006
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:To investigate the immune response of preterm infants to hepatitis B vaccination. METHODS:Three doses of recombinant hepatitis B vaccine (5 micro g dose) were administered to 35 preterm and 21 full-term infants within 24 hours after birth and at one and six months of postnatal age. RESULTS:A protective anti...
journal_title：Jornal de pediatria
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:To describe the increased risk of acquiring infectious diseases associated with out-of-home childcare and the effectiveness of measures for the control and prevention of diseases transmission at daycare and preschool education centers. SOURCES:A review of literature in the MEDLINE, LILACS and Cochrane Librar...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.1649
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To analyze the influence of obesity status on immune cell count and concentration of the hormones cortisol and leptin, in order to establish a relationship among the variables analyzed. METHODS:We recruited 27 obese [body mass index (BMI) > or = 95th percentile] and 21 non-obese (BMI < or = 75th percentile) ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1845
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:To carry out a systematic review on the relationship of bullying with type 1 diabetes in children and adolescents. METHODS:Systematic review, according to the PRISMA methodology, in which the databases PubMed, Web of Science, Scopus, Thomson Reuters, Eighteenth Century Collections Online, Begell House Digita...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.10.003
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To describe the clinical and demographic characteristics of non-Hodgkin's lymphoma patients diagnosed at the Pediatric Oncology Unit at the Instituto Materno-Infantil Professor Fernando Figueira (IMIP) over a 9-year period, and also to describe their survival rates and possible associations between the surviv...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1726
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of pathologic gastroesophageal reflux in a group of regurgitant infants attended at Helena Moura Hospital, Recife, State of Pernambuco, Brazil. The clinical criteria employed were based on Rome II criteria. METHOD:The study design was transversal. The patients were all children of...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
