Abstract：
:OBJECTIVE: To study plasma levels of IL-1beta and IL-6 in order to distinguish the presence of bacterial infection in newborn infants with fever. METHODS: A cohort of 117 newborn infants with postnatal age equal to or less than 5 days, with no previous use of antibiotic therapy, and with clinical suspicion of bacterial infection was studied from July 1995 through August 1996. Those with definite criteria for sepsis were considered infected. Fever was defined as axillar temperature > 37.5 degrees C in three independent measurements. The patients were classified in four different groups: Group 1: infected with fever; Group 2: infected without fever; Group 3: not infected with fever; Group 4: not infected without fever. Complete blood count, platelet count, blood or other fluid cultures, and plasmatic levels of IL-1beta and IL-6 were collected before the beginning of antibiotic therapy. RESULTS: Of the 117 newborn infants studied were 66 infected and 51 not infected. Fever was present in 45 (38.46%). The median values of IL-1beta and IL-6 were significantly higher in newborn infants with fever than in those with no fever. There were significant differences between groups 1 and 2, 1 and 4, and 2 and 3 for IL-1beta. There were no significant differences between groups 2 and 4, and 1 and 3 for IL-1beta. Eight (72%) newborn infants with no infection and no fever had environment heating, and 3 had dehydration. There were no differences in median IL-6 levels between groups 1 and 2, and 3 and 4. There were significant differences in the median IL-6 levels between groups 1 and 3, and 1 and 4. CONCLUSIONS: IL- 6 is a marker of early neonatal sepsis. IL-1beta is related to neonatal fever response independently of the presence of bacterial infection.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Silveira RC,Procianoy RSdoi
10.2223/jped.253keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
29-33issue
1eissn
0021-7557issn
1678-4782journal_volume
75pub_type
杂志文章abstract：OBJECTIVE:Sedation is an important step in the management of patients with hypercyanotic spells associated with tetralogy of Fallot (TOF) to ameliorate and prevent recurrence of cyanosis. This case report illustrates the effectiveness of dexmedetomidine-induced sedation in the management of hypercyanotic spells in a ne...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1794
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVE:End-stage renal disease is a health problem that consumes public and private resources. This study aimed to identify the cost of hemodialysis (either daily or conventional hemodialysis) and transplantation in children and adolescents. METHODS:This was a retrospective cohort of pediatric patients with End-sta...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.05.004
更新日期：2018-01-01 00:00:00
abstract：:In order to better understand the natural history of chronic functional constipation, a questionnaire was applied to 163 children and infants, before beginning standardized treatment. Median age (range) at start was 3 mo(0-108 mo) but age at arrival at the Pediatric Gastroenterology Unit was 53 mo(2-146 mo). In 62.4% ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.688
更新日期：1994-09-01 00:00:00
abstract：:OBJECTIVE: To present current concepts about the diagnosis of recurrent abdominal pain and to review the basis of the therapeutic approach for this disease in children and adolescents. METHODS: References were obtained from the Medline, from recent review articles, and from personal files. Books and dissertations were...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.150
更新日期：2000-07-01 00:00:00
abstract：:OBJECTIVE: To present and discuss the indications, the endoscopic and histologic findings and the complications of upper digestive endoscopies carried out in children and adolescents.METHODS: We have done 228 endoscopies in pediatric patients with ages between 3 months to 19 years (x=5.7 y) during a period of 8 months...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.410
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:Several reports claim that blood pressure (BP) in the radial artery may underestimate the accurate BP in critically ill patients. Here, the authors evaluated differences in mean blood pressure (MBP) between the radial and femoral artery during pediatric cardiac surgery to determine the effectiveness of femora...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.03.011
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:This study reviews clinical features, evolution, comorbidity and suicidal behavior in childhood and adolescence depression. Its objective is to provide clear information on this common, severe and not very easily recognized pathology. SOURCES:Literature searches were performed through Medline (1991-2000), wi...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVE:To assess the applicability of salivary C-reactive protein, mean platelet volume, neutrophil-lymphocyte ratio, and platelet lymphocyte ratio in the diagnosis of neonatal sepsis. METHODS:Prospective case-control study of 70 full-term neonates, 35 with sepsis (20 with proven sepsis and 15 with clinical sepsis)...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.03.006
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To present an updated review of the most common upper respiratory infections (URI) in children seen by the pediatrician in outpatient clinics, for better diagnostic and therapeutic decisions. SOURCES:References from Medline database were reviewed. The most relevant articles were selected. SUMMARY OF THE FIN...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/jped.1002
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVES:To describe the prevalence of and factors associated with overweight in children under 4 years of age in Feira de Santana, state of Bahia, Brazil. METHODS:Cross-sectional study nested within a birth cohort of 793 children born in Feira de Santana, Brazil. Independent variables were related to infant charact...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2009
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To assess the health-related quality of life (HRQoL) of children surviving to pediatric intensive care discharge. METHODS:A prospective evaluation of HRQoL at admission and 6 months later was carried out with children aged 6 years or more, admitted to three tertiary pediatric intensive care units (PICUs) fro...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2151
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To carry out a systematic review on the relationship of bullying with type 1 diabetes in children and adolescents. METHODS:Systematic review, according to the PRISMA methodology, in which the databases PubMed, Web of Science, Scopus, Thomson Reuters, Eighteenth Century Collections Online, Begell House Digita...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.10.003
更新日期：2019-01-01 00:00:00
abstract：:OBJECTIVES: To present the clinical outcome of a newborn with severe respiratory distress secondary to meconium aspiration syndrome and treated by extracorporeal membrane oxygenation (ECMO); and to present the effect of the use of exogenous surfactant in this case and the cost of the procedure. METHODS: Case report of...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.212
更新日期：2001-05-01 00:00:00
abstract：:OBJECTIVE: Evaluation of epidemiological, clinical and laboratory features of Plasmodium vivax malaria in children and adolescents. METHODS: This study was carried out in the Malaria Program of the Evandro Chagas Institute (Belém, Pará), from January 1995 to November 1996. 100 children and adolescents with the diagnos...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.295
更新日期：1999-05-01 00:00:00
abstract：:OBJECTIVE: Describe the hemodynamic response with rebound of pulmonary hypertension after withdrawal of inhaled nitric oxide (NO) in a pediatric patient with acute respiratory distress syndrome (ARDS). METHODS: Case report of a child with ARDS and pulmonary hypertension evaluated through ecocardiografic with dopller, ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.59
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:To compare two groups of school age girls from different social strata were compared in terms of their perception and knowledge about breastfeeding. METHODS:A structured questionnaire was applied to all 346 4th to 8th grade girls attending two schools, a private one, whose students belonged to the upper clas...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVE:Total bilirubin is beneficial for protecting cardiovascular diseases in adults. The authors aimed to investigate the association of total bilirubin, red blood cell, and hemoglobin levels with the prevalence of high blood pressure in children and adolescents. METHODS:A total of 3776 students (aged from 6 to 1...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.07.018
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To identify risk factors for neonatal mortality, focusing on factors related to assistance care during the prenatal period, childbirth, and maternal reproductive history. METHODS:This was a case-control study conducted in Maceió, Northeastern Brazil. The sample consisted of 136 cases and 272 controls selecte...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2012.11.005
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. METHODS:Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate th...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.08.012
更新日期：2016-05-01 00:00:00
abstract：:Iron deficiency is the most frequent form of nutritional anemia, and infants represent one of the major risk groups. The present study was meant to evaluate the iron content of infant diets cooked in iron utensils and in aluminum utensils prepared by volunteer mothers at home. The iron content was analyzed by atomic a...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.706
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To study the etiology of exanthema cases, with or without fever, in children seen in the emergency room of a hospital located in a region where dengue is endemic. METHODS:Enrollment took place between 21/09/2001 and 20/09/2002 and included 95.9% (71/74) of children presenting with exanthema at the emergency ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1522
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:To present, in an essay form, two distinct views on well-child care. METHODS:Using several different methods of historical analysis, the two most common views on well-child care are presented: the positivist one, whose foundation is essentially based upon historical facts, and that of social criticism, conce...
journal_title：Jornal de pediatria
pub_type： 历史文章,杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:OBJECTIVE: Neonatal tetanus is an infection with high mortality, constituting a problem in underdeveloped countries, where there is faulty prenatal attendance. In spite of this and of the decreasing incidence of the disease in the state of Rio Grande do Sul, we report a case of neonatal tetanus identified in 1997. MET...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.80
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To assess the carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease. MATERIAL AND METHODS:Observational, cross-sectional study carried out at the Universidade Federal de São Paulo (chronic kidney disease outpatient clinics) w...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.06.010
更新日期：2019-01-01 00:00:00
abstract：:OBJECTIVE: To report four cases of myositis ossificans progressiva, its form of presentation, in addition to new control and treatment options. DESCRIPTION: The authors describe four cases of myositis ossificans progressiva, presenting its clinical manifestations, evolution, and available forms of control and treatmen...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.287
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the peak inspiratory pressure, tidal volume and respiratory rate achieved during manual ventilation of premature lambs, using a self-inflating bag. METHODS:In this descriptive, experimental study, five pairs of physicians, selected at random among 35 neonatologists working at a neonatal intensive...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1517
更新日期：2006-07-01 00:00:00
abstract：:OBJECTIVE: To assess the prevalence of prenatal exposure to cocaine in a sample of newborns using two methods: fluorescence polarization immunoassay and interview with the mother. METHODS: This cross-sectional study was carried out in a university teaching hospital. The population included all live births between Marc...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.277
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the association of intimate partner violence during the gestational period and the development of externalizing and internalizing behavioral problems in children and adolescents. SOURCE OF DATA:A meta-analysis of cohort and case-control studies was performed, using studies selected from electroni...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2018.01.007
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To present a wide-ranging review of the literature on broncopulmonary dysplasia, covering new definitions, pathophysiology, prevention, treatment, prognosis and progression. SOURCES OF DATA:The most relevant articles published on the subject since it was first described in 1967 were selected from MEDLINE sea...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To provide recent guidelines to reduce the incidence of diarrheal diseases. We discuss the definition, clinical aspects, pathophysiology, diagnosis, management, and prevention of persistent diarrhea. SOURCES:Electronic search of the MEDLINE database, Google search. SUMMARY OF THE FINDINGS:Acute diarrhea may...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.2087
更新日期：2011-05-01 00:00:00
