Entry of hepatitis C virus into the cell: a therapeutic target.

abstract：AIM:We shall construct the small interfering RNA (siRNA) expression cassette (SEC) targeting activated K-ras gene sequence, identify more effective siRNA sequence against K-ras gene in human pancreatic cancer cell line MiaPaCa-2 by SEC and reveal the anti-cancer effects of RNA interference (RNAi) and its therapeutic po...

journal_title：World journal of gastroenterology

authors： Wang W,Wang CY,Dong JH,Chen X,Zhang M,Zhao G

更新日期：2005-04-07 00:00:00

abstract：:Gastroduodenal disease (GDD) was initially thought to be uncommon in Africa. Amongst others, lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world. Following the increasing availa...

journal_title：World journal of gastroenterology

authors： Archampong TN,Asmah RH,Richards CJ,Martin VJ,Bayliss CD,Botão E,David L,Beleza S,Carrilho C

更新日期：2019-07-14 00:00:00

abstract：:Adult to adult living donor liver transplantation (AALDLT) was first preformed in the United States in 1997. The procedure was rapidly integrated into clinical practice, but in 2002, possibly due to the first widely publicized donor death, the number of living liver donors plummeted. The number of donors has since rea...

journal_title：World journal of gastroenterology

authors： Carlisle EM,Testa G

更新日期：2012-12-14 00:00:00

abstract：:Cholangiocarcinoma (CC) is rare malignant tumors composed of cells that resemble those of the biliary tract. It is notoriously difficult to diagnose, and is associated with a high mortality. Traditionally, CC is divided into intrahepatic and extrahepatic disease according to its location within the biliary tree. Intra...

journal_title：World journal of gastroenterology

authors： Shimoda M,Kubota K

更新日期：2007-03-14 00:00:00

abstract：:Leiomyomas are the most common benign tumors of the esophagus. They usually occur as a single lesion or as two or three nodules. Only two cases of esophageal multiple leiomyomas comprising more than 10 nodules have been reported previously. Moreover, there have been few reports of esophageal squamous cell carcinoma ov...

journal_title：World journal of gastroenterology

authors： Iwaya T,Maesawa C,Uesugi N,Kimura T,Ikeda K,Kimura Y,Mitomo S,Ishida K,Sato N,Wakabayashi G

更新日期：2006-07-28 00:00:00

abstract：AIM:To determine the immune-modulatory and the hepatoprotective effects of oral administration of two soy extracts in immune mediated liver injury and non-alcoholic steatohepatitis (NASH). METHODS:Two soy extracts, M1 and OS, were orally administered to mice with concanavalin A (ConA) immune-mediated hepatitis, to hig...

journal_title：World journal of gastroenterology

authors： Khoury T,Ben Ya'acov A,Shabat Y,Zolotarovya L,Snir R,Ilan Y

更新日期：2015-06-28 00:00:00

abstract：AIM:To elucidate the efficacy and safety of a split dose of midazolam in combination with meperidine for colonoscopy. METHODS:Eighty subjects undergoing outpatient colonoscopy were randomly assigned to group A or B. Group A (n = 40) received a split dose of midazolam in combination with meperidine. Group B (n = 40) re...

journal_title：World journal of gastroenterology

authors： Lee H,Kim JH

更新日期：2009-08-14 00:00:00

abstract：:AIM:To prepare valaciclovir polybutylcyan_oacrylate nanoparticles (VACV-PBCA-NP) with liver targeting and hepatocyte permeable charateristics.METHODS: Emulsion polymerization method was employed to prepare VACV-PBCA-NP.The formula and preparation conditions were optimized by using the uniform design. The organ distrib...

journal_title：World journal of gastroenterology

authors： Zhang ZR,He Q

更新日期：1999-08-01 00:00:00

abstract：AIM:To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes, osmotic gap and pH. METHODS:Seventy-six patients were included: 51 with microscopic colitis (MC) (40 with lymphocytic colitis (LC); 11 with collagenous colitis (CC)); 7 with MC without diarrhea and 18 as a cont...

journal_title：World journal of gastroenterology

authors： Protic M,Jojic N,Bojic D,Milutinovic S,Necic D,Bojic B,Svorcan P,Krstic M,Popovic O

更新日期：2005-09-21 00:00:00

abstract：AIM:To investigate the role of reactive oxygen species (ROS) in ethanol-mediated cell death of polarized hepatic (WIF-B) cells. METHODS:In this work, WIF-B cultures were treated with pyrazole (inducer of cytochrome P4502E1, CYP2E1) and/or L-buthionine sulfoximine (BSO), a known inhibitor of hepatic glutathione (GSH), ...

journal_title：World journal of gastroenterology

authors： McVicker BL,Tuma PL,Kharbanda KK,Lee SM,Tuma DJ

更新日期：2009-06-07 00:00:00

abstract：AIM:To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy. METHODS:A cross-sectional study examining the results of upper endoscopy and colonoscopy in adults with dermatomyositis at an urban, university hospital over a te...

journal_title：World journal of gastroenterology

authors： Kidambi TD,Schmajuk G,Gross AJ,Ostroff JW,Terdiman JP,Lee JK

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:The prognosis of gastric cancer continues to remain poor, and epigenetic drugs like histone deacetylase inhibitors (HDACi) have been envisaged as potential therapeutic agents. Nevertheless, clinical trials are facing issues with toxicity and efficacy against solid tumors, which may be partly due to the lack ...

journal_title：World journal of gastroenterology

authors： Amnekar RV,Khan SA,Rashid M,Khade B,Thorat R,Gera P,Shrikhande SV,Smoot DT,Ashktorab H,Gupta S

更新日期：2020-02-14 00:00:00

abstract：AIM:To transfer hepatitis E virus (HEV) ORF2 partial gene to tomato plants, to investigate its expression in transformants and the immunoactivity of expression products, and to explore the feasibility of developing a new type of plant-derived HEV oral vaccine. METHODS:Plant binary expression vector p1301E2, carrying a...

journal_title：World journal of gastroenterology

authors： Ma Y,Lin SQ,Gao Y,Li M,Luo WX,Zhang J,Xia NS

更新日期：2003-10-01 00:00:00

abstract：AIM:To study the induction of T cellular immune responses in BALB/c mice immunized with uric acid and dendritic cells (DCs) pulsed with hepatitis B virus surface antigen (HBsAg). METHODS:DCs were generated from bone-marrow cells of BABL/c mice, and then pulsed or unpulsed with HBsAg protein (HBsAg-pulsed-DCs or unpuls...

journal_title：World journal of gastroenterology

authors： Ma XJ,Tian DY,Xu D,Yang DF,Zhu HF,Liang ZH,Zhang ZG

更新日期：2007-02-21 00:00:00

abstract：:A 41-year-old man with a continuous-flow left ventricular assist device presented for evaluation of dysphagia and dark urine. He was found to have a significantly elevated L-lactate dehydrogenase and an elevated plasma free hemoglobin consistent with intravascular hemolysis. After the hemolysis ceased, both the black ...

journal_title：World journal of gastroenterology

authors： Wuschek A,Iqbal S,Estep J,Quigley E,Richards D

更新日期：2015-05-14 00:00:00

abstract：AIM:To determine the genotype distribution of hepatitis B virus (HBV) with a newly oligonucleotide chip assay among the HBV carriers in Eastern China. METHODS:An assay using oligonucleotide chip was developed for detection of HBV genotypes in serum samples from HBV DNA-positive patients in Eastern China. This method i...

journal_title：World journal of gastroenterology

authors： Tang XR,Zhang JS,Zhao H,Gong YH,Wang YZ,Zhao JL

更新日期：2007-04-07 00:00:00

abstract：:To review the underlying pathophysiology and currently available treatments for pruritis associated with jaundice. English language literature was reviewed using MEDLINE, PubMed, EMBASE and clinicaltrials.gov for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with jau...

journal_title：World journal of gastroenterology

authors： Bassari R,Koea JB

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:The digestive tract is the maximal immunizing tissue in the body, and mucosal integrity and functional status of the gut is very important to maintain a healthy organism. Severe infection is one of the most common causes of gastrointestinal dysfunction, and the pathogenesis is closely related to endotoxemia ...

journal_title：World journal of gastroenterology

authors： Wang W,Sun M,Zheng YL,Sun LY,Qu SQ

更新日期：2019-06-21 00:00:00

abstract：AIM:To develop a novel method for the rapid and efficient extraction of exosomes secreted by tumor cells. METHODS:Unlike the traditional extraction method, the supernatants of cell cultures were concentrated, and the exosomes were isolated promptly and effectively using a novel nanomaterial called ExoQuick. Coomassie ...

journal_title：World journal of gastroenterology

authors： Zhu L,Qu XH,Sun YL,Qian YM,Zhao XH

更新日期：2014-06-07 00:00:00

abstract：:Smoking of tobacco products continues to be a major cause of worldwide health problems. Epidemiological studies have shown that tobacco smoking is the greatest risk factor for the development of pancreatic cancer. Smokers who are able to quit smoking can reduce their risk of pancreatic cancer by nearly 50% within two ...

journal_title：World journal of gastroenterology

authors： MacLeod SL,Chowdhury P

更新日期：2006-12-14 00:00:00

abstract：:Unidimensional transient elastography (TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. This paper focuses on reviewing the existing data on the use of TE in the diagnosis of fibrosis and in monitoring disease progression in alcoholic liver disease, on the f...

journal_title：World journal of gastroenterology

authors： Lupsor-Platon M,Badea R

更新日期：2015-11-14 00:00:00

abstract：AIM:To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS:A prospective, non-comparative, and non-randomized trial was performed and registered on Eudra CT database (2011-002953-80) and on www.trial.gov (NCT01398098). All patients had a validated indication for colonoscopy a...

journal_title：World journal of gastroenterology

authors： Coriat R,Polin V,Oudjit A,Henri F,Dhooge M,Leblanc S,Delchambre C,Esch A,Tabouret T,Barret M,Prat F,Chaussade S

更新日期：2014-10-07 00:00:00

abstract：AIM:To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters within the E1 region, and combines the advantages of oncolytic virus and gene therapies for hepatocellular carcinoma (HCC). METHODS:CNHK500-p53 was constructed by using human telomerase reverse transcr...

journal_title：World journal of gastroenterology

authors： Zhao HC,Zhang Q,Yang Y,Lu MQ,Li H,Xu C,Chen GH

更新日期：2007-02-07 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly invasive tumor that metastasizes hematogenously and lymphogenously to distant site. Frequent sites are lung, regional lymph node, bone, and adrenal gland. But metastasis to the gastrointestinal (GI) tract is rare, and most common site is stomach. Metastasis to the small intes...

journal_title：World journal of gastroenterology

authors： Kim HS,Shin JW,Kim GY,Kim YM,Cha HJ,Jeong YK,Jeong ID,Bang SJ,Kim DH,Park NH

更新日期：2006-03-28 00:00:00

abstract：:Treatment of chronic pancreatitis has been exclusively surgical for a long time. Recently, endoscopic therapy has become widely used as a primary therapeutic option. Initially performed for drainage of pancreatic cysts and pseudocysts, endoscopic treatments were adapted to biliary and pancreatic ducts stenosis. Pancre...

journal_title：World journal of gastroenterology

authors： Heyries L,Sahel J

更新日期：2007-12-14 00:00:00

abstract：AIM:To investigate the effect and mechanism of action of the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on invasion and metastasis of human colorectal cancer cell line SL-174T. METHODS:Human colorectal cancer cell line SL-174T was cultured and treated separately with four different...

journal_title：World journal of gastroenterology

authors： Yu LB,Dong XS,Sun WZ,Zhao DL,Yang Y

更新日期：2005-10-28 00:00:00

abstract：AIM:To estimate the incidence of catheter tract implantation metastasis among patients undergoing percutaneous transhepatic biliary drainage (PTBD) for extrahepatic cholangiocarcinoma, and to provide data regarding the management of this unusual complication of PTBD by reviewing cases reported in the literature. METHO...

journal_title：World journal of gastroenterology

authors： Sakata J,Shirai Y,Wakai T,Nomura T,Sakata E,Hatakeyama K

更新日期：2005-11-28 00:00:00

abstract：AIM:To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics. METHODS:The study was carried on 40 patients with liver cirrhosis and ascites treated with diure...

journal_title：World journal of gastroenterology

authors： El-Bokl MA,Senousy BE,El-Karmouty KZ,Mohammed Iel K,Mohammed SM,Shabana SS,Shalaby H

更新日期：2009-08-07 00:00:00

abstract：:The treatment of chronic hepatitis C (CHC) is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-alpha (IFNalpha) plus ribavirin. Although in some cases the use of higher doses or longer treatment periods may be effective, these approac...

journal_title：World journal of gastroenterology

authors： Moreno-Otero R,Trapero-Marugán M,Gómez-Domínguez E,García-Buey L,Moreno-Monteagudo JA

更新日期：2006-05-07 00:00:00

abstract：AIM:To highlight the intestinal perforation (IP), an uncommon and catastrophic complication after combined liver-kidney transplantation. METHODS:Combined liver-kidney transplantation (LKTx) with left kidney excision and a cyst fenestration procedure on the right kidney were performed on a case of 46-year-old female wi...

journal_title：World journal of gastroenterology

authors： Peng T,Peng MH,Li LQ,Deng YL,Yang DH,Lu BY,Chen XG,Guo Y,Xiao KY,Chen B,Zhong Q,Wei MY

更新日期：2004-09-15 00:00:00