Identification of effective siRNA against K-ras in human pancreatic cancer cell line MiaPaCa-2 by siRNA expression cassette.

abstract：:Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyz...

journal_title：World journal of gastroenterology

authors： Daher R,Chouillard E,Panis Y

更新日期：2014-12-28 00:00:00

abstract：AIM:To determine the immune-modulatory and the hepatoprotective effects of oral administration of two soy extracts in immune mediated liver injury and non-alcoholic steatohepatitis (NASH). METHODS:Two soy extracts, M1 and OS, were orally administered to mice with concanavalin A (ConA) immune-mediated hepatitis, to hig...

journal_title：World journal of gastroenterology

authors： Khoury T,Ben Ya'acov A,Shabat Y,Zolotarovya L,Snir R,Ilan Y

更新日期：2015-06-28 00:00:00

abstract：AIM:To observe the kinetics of D (-)-lactate alteration in both portal and systemic circulation systems, and its relationship with intestinal injury in rats subjected to acute intestinal ischemia-reperfusion. METHODS:Anesthetized rats underwent a 75-min superior mesenteric artery occlusion followed by a 6-h reperfusio...

journal_title：World journal of gastroenterology

authors： Yao YM,Yu Y,Wu Y,Lu LR,Sheng ZY

更新日期：1997-12-15 00:00:00

abstract：BACKGROUND:Although previous studies have confirmed the feasibility of magnetic compression anastomosis (MCA), there is still a risk of long-term anastomotic stenosis. For traditional MCA devices, a large device is associated with great pressure, and eventually increased leakage. AIM:To develop a novel MCA device to s...

journal_title：World journal of gastroenterology

authors： Chen H,Ma T,Wang Y,Zhu HY,Feng Z,Wu RQ,Lv Y,Dong DH

更新日期：2020-11-14 00:00:00

abstract：AIM:To determine the expression of toll-like receptor 9 (TLR9) in pancreatic tumor and the effects of cytosine phosphate-guanosine oligodeoxynucleotides 2216 (CPG ODN2216) on biological behavior of pancreatic carcinoma cell line PANC-1 and explore their clinical significance. METHODS:The immunohistochemistry and Weste...

journal_title：World journal of gastroenterology

authors： Wu HQ,Wang B,Zhu SK,Tian Y,Zhang JH,Wu HS

更新日期：2011-02-28 00:00:00

abstract：AIM:To investigate the relationship of serum levels of polyunsaturated fatty acid (PUFA) with kinds of cytokines in colorectal cancer (CRC). METHODS:Serum samples of 100 CRC patients were collected. The concentration of total n-3 PUFA which included C18:3 n-3, C20:5 n-3, C22:5 n-3, C22:6 n-3 and the total n-6 PUFA inc...

journal_title：World journal of gastroenterology

authors： Jia HJ,Zhang PJ,Liu YL,Jiang CG,Zhu X,Tian YP

更新日期：2016-02-28 00:00:00

abstract：AIM:H101, an E1B 55 kD gene deleted adenovirus, has been shown to possess oncolysis activity experimentally and proved to be safe in preliminary phase I study. The current study was designed to evaluate its anti-tumor activity and toxicity in combination with chemotherapy in patients with late stage cancers. METHODS:H...

journal_title：World journal of gastroenterology

authors： Lu W,Zheng S,Li XF,Huang JJ,Zheng X,Li Z

更新日期：2004-12-15 00:00:00

abstract：:Microsatellite instability (MSI) is a prognostic factor and a marker of deficient mismatch repair (MMR) in colorectal adenocarcinomas (CRC). However, a proper application of this marker requires understanding the following: (1) The MSI concept: The PCR approach must amplify the correct locus and accurately identify th...

journal_title：World journal of gastroenterology

authors： Blanes A,Diaz-Cano SJ

更新日期：2006-10-07 00:00:00

abstract：AIM:To describe a three-dimensional model (3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas (HCCs). METHODS:From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed ...

journal_title：World journal of gastroenterology

authors： Tian F,Wu JX,Rong WQ,Wang LM,Wu F,Yu WB,An SL,Liu FQ,Feng L,Bi C,Liu YH

更新日期：2015-04-21 00:00:00

abstract：AIM:To investigate the expression frequency of endocan in colorectal cancer and analyze the relationship between endocan expression and clinical parameters and to study the role of endocan in colorectal carcinogenesis. METHODS:Expression of endocan in 72 tumor tissue samples of colorectal cancer as well as in 27 norma...

journal_title：World journal of gastroenterology

authors： Zuo L,Zhang SM,Hu RL,Zhu HQ,Zhou Q,Gui SY,Wu Q,Wang Y

更新日期：2008-07-28 00:00:00

abstract：:It has been reported that host defense responses, such as phagocytic function of neutrophils and natural killer (NK) cell activity of lymphocytes, are impaired in cirrhotic patients. This review will concentrate on the impairment of innate immune responses in decompensated cirrhotic patients and the effect of the trea...

journal_title：World journal of gastroenterology

authors： Nakamura I

更新日期：2014-06-21 00:00:00

abstract：AIM:To evaluate the inhibition effect of HCV NS5A on p53 transactivation on p21 promoter and explore its possible mechanism for influencing p53 function. METHODS:p53 function of transactivation on p21 promoter was studied with a luciferase reporter system in which the luciferase gene is driven by p21 promoter, and the...

journal_title：World journal of gastroenterology

authors： Gong GZ,Jiang YF,He Y,Lai LY,Zhu YH,Su XS

更新日期：2004-08-01 00:00:00

abstract：AIM:To evaluate the association of pre-treatment (13)C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers. METHODS:One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori d...

journal_title：World journal of gastroenterology

authors： Lai YC,Yang JC,Huang SH

更新日期：2004-04-01 00:00:00

abstract：AIM:To investigate the proportion of patients with moderate-severe erosive esophagitis (EE) who will have Barrett's esophagus (BE) after healing of inflammation. METHODS:Patients with EE of Los Angeles (LA) class B, C and D who underwent follow-up endoscopy documenting complete mucosal healing. RESULTS:A total of 86/...

journal_title：World journal of gastroenterology

authors： Gilani N,Gerkin RD,Ramirez FC,Hakim S,Randolph AC

更新日期：2008-06-14 00:00:00

abstract：:We report a case of a patient presenting with clinical, radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed, which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwa...

journal_title：World journal of gastroenterology

authors： Fass G,Hossey D,Nyst M,Smets D,Saligheh EN,Duttmann R,Claes K,da Costa PM

更新日期：2007-11-07 00:00:00

abstract：:Neuroendocrine carcinoma (NEC) of the extrahepatic bile duct is rare, and only 22 cases have been reported. Only two of these were large-cell NEC (LCNEC); the vast majority were small-cell NEC. Here, we report a third case of LCNEC of the extrahepatic bile duct. A 76-year-old male presented to a local hospital with pa...

journal_title：World journal of gastroenterology

authors： Sasatomi E,Nalesnik MA,Marsh JW

更新日期：2013-07-28 00:00:00

abstract：:As among persons with normal anatomy, occasional patients with situs inversus develop malignant tumors. Recently, several laparoscopic operations have been reported in patients with situs inversus. We describe laparoscopic hemicolectomy with radical lymphadenectomy in such a patient. Careful consideration of the mirro...

journal_title：World journal of gastroenterology

authors： Fujiwara Y,Fukunaga Y,Higashino M,Tanimura S,Takemura M,Tanaka Y,Osugi H

更新日期：2007-10-07 00:00:00

abstract：:Two major types of cancer occur in the esophagus: squamous cell carcinoma, which is associated with chronic smoking and alcohol consumption, and adenocarcinoma, which typically arises in gastric reflux-associated Barrett's esophagus. Although there is increasing incidence of esophageal adenocarcinoma in Western counti...

journal_title：World journal of gastroenterology

authors： Sasaki Y,Tamura M,Koyama R,Nakagaki T,Adachi Y,Tokino T

更新日期：2016-02-21 00:00:00

abstract：AIM:To compare the efficacy of different chemotherapeutic agents during conventional transarterial chemoembolization (cTACE) in the treatment of unresectable hepatocellular carcinoma (HCC). METHODS:A retrospective review was undertaken of patients with unresectable HCC undergoing cTACE from May 2003 to November 2011. ...

journal_title：World journal of gastroenterology

authors： Wu J,Song L,Zhao DY,Guo B,Liu J

更新日期：2014-08-21 00:00:00

abstract：:AIM:It is well known that colonoscopy can be difficult due to abdominal pain induced during colonoscope insertion, if sedative agents are not given. Recently, an extra-flexible, small-diameter colonoscope (CF-SV, Olympus Inc.Japan) was developed in order to improve safety and comfort. The aim of this study was to acce...

journal_title：World journal of gastroenterology

authors： Han Y,Uno Y,Munakata A

更新日期：2000-10-01 00:00:00

abstract：AIM:To assess the clinical outcomes of pre-, pro- and synbiotics therapy in patients with acute pancreatitis. METHODS:The databases including Medline, Embase, the Cochrane Library, Web of Science and Chinese Biomedicine Database were searched for all relevant randomized controlled trials that studied the effects of pr...

journal_title：World journal of gastroenterology

authors： Zhang MM,Cheng JQ,Lu YR,Yi ZH,Yang P,Wu XT

更新日期：2010-08-21 00:00:00

abstract：:AIM:To construct Hsp90 antisense RNA eukaryotic expression vector, transfect it into SGC7901 and SGC7901/VCR of MDR-type human gastric cancer cell lines, HCC7402 of human hepatic cancer and Ec109 of human esophageal cancer cell lines, and to study the cell cycle distribution of the gene transected cells and their resp...

journal_title：World journal of gastroenterology

authors： Liu XL,Xiao B,Yu ZC,Guo JC,Zhao QC,Xu L,Shi YQ,Fan DM

更新日期：1999-06-01 00:00:00

abstract：AIM:To establish a new, reliable vomit model of minks. METHODS:Adult male minks were randomly divided into 8 groups (n=6): cisplatin (7.5 mg/kg) intraperitoneal injection (i.p.) group, copper sulfate (40 mg/kg) intragastric injection (i.g.) group, apomorphine (1.6 mg/kg) subcutaneous injection (s.c.) group, and 18 Gy ...

journal_title：World journal of gastroenterology

authors： Zhang F,Wang L,Yang ZH,Liu ZT,Yue W

更新日期：2006-02-28 00:00:00

abstract：:Two-dimensional shear wave elastography (2D-SWE) is a rapid, simple and novel noninvasive method that has been proposed for assessing hepatic fibrosis in patients with chronic liver diseases (CLDs) based on measurements of liver stiffness. 2D-SWE can be performed easily at the bedside or in an outpatient clinic and yi...

journal_title：World journal of gastroenterology

authors： Xie LT,Yan CH,Zhao QY,He MN,Jiang TA

更新日期：2018-03-07 00:00:00

abstract：AIM:To investigate the relationship between exercise-provoked esophageal motility disorders and the prognosis for patients with chest pain. METHODS:The study involved 63 subjects with recurrent angina-like chest pain non-responsive to empirical therapy with proton pump inhibitor (PPI). In all, a coronary artery angiog...

journal_title：World journal of gastroenterology

authors： Budzyński J

更新日期：2010-09-21 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids in the form of triglycerides in hepatocytes. It is most prevalent in western countries and includes a wide range of clinical and histopathological findings, namely from simple steatosis to steatohepatitis and fibrosis, which...

journal_title：World journal of gastroenterology

authors： Katsarou A,Moustakas II,Pyrina I,Lembessis P,Koutsilieris M,Chatzigeorgiou A

更新日期：2020-05-07 00:00:00

abstract：AIM:To study the inhibitory effects of a Shuangling Fuzheng anticancer preparation (SFAP) on the human gastric cancer cell line SGC-7901 in vitro as well as its immune-modulated effects in a cyclophosphamide-treated murine model. METHODS:MTT experiments and immunocytochemistry ABC experiments were performed for detect...

journal_title：World journal of gastroenterology

authors： Chen HS,Chen J,Cui DL,Zheng YY,Xu AH,Chen G,Jia LC

更新日期：2007-12-28 00:00:00

abstract：:Colorectal cancer (CRC) represents one of the leading causes of tumor-related deaths worldwide. Among the various tools at physicians' disposal for the diagnostic management of the disease, tomographic imaging (e.g., CT, MRI, and hybrid PET imaging) is considered essential. The qualitative and subjective evaluation of...

journal_title：World journal of gastroenterology

authors： Mainenti PP,Stanzione A,Guarino S,Romeo V,Ugga L,Romano F,Storto G,Maurea S,Brunetti A

更新日期：2019-09-21 00:00:00

abstract：AIM:To globally compare the gene expression profiles during the capillary morphogenesis of human microvascular endothelial cells (HMVECs) in an in vitro angiogenesis system with affymetrix oligonucleotide array. METHODS:A microcarrier-based in vitro angiogenesis system was developed, in which ECs migrated into the mat...

journal_title：World journal of gastroenterology

authors： Sun XT,Zhang MY,Shu C,Li Q,Yan XG,Cheng N,Qiu YD,Ding YT

更新日期：2005-04-21 00:00:00

abstract：AIM:To evaluate a laparoscopic approach to gallbladder lesions including polyps, wall-thickening lesions, and suspected T1 and T2 gallbladder cancer (GBC). METHODS:We performed 50 cases of laparoscopic whole-layer cholecystectomy (LCWL) and 13 cases of laparoscopic gallbladder bed resection (LCGB) for those gallbladde...

journal_title：World journal of gastroenterology

authors： Ome Y,Hashida K,Yokota M,Nagahisa Y,Okabe M,Kawamoto K

更新日期：2017-04-14 00:00:00