Chemotherapy for transarterial chemoembolization in patients with unresectable hepatocellular carcinoma.

Abstract:

AIM:To compare the efficacy of different chemotherapeutic agents during conventional transarterial chemoembolization (cTACE) in the treatment of unresectable hepatocellular carcinoma (HCC). METHODS:A retrospective review was undertaken of patients with unresectable HCC undergoing cTACE from May 2003 to November 2011. A total of 107 patients were treated with at least one cTACE session. Irinotecan (CPT-11) was used as a chemotherapeutic agent in 24 patients, gemcitabine (GEM) in 24 and doxorubicin in 59. RESULTS:The time to progression and overall survival rates were significantly superior in patients treated with CPT-11 compared with the GEM or doxorubicin treated groups (11.4, 8.2, 9.5 mo, P = 0.02 and 21.7, 12.7, 14.5 mo, P = 0.004, respectively). Subgroup analysis showed that for intermediate-stage HCC, CPT-11 resulted in a significantly longer time to progression and overall survival compared with the GEM or doxorubicin treated groups (P = 0.022; P = 0.003, respectively). There were no significant differences in adverse events among the three groups (P > 0.05). CONCLUSION:For patients treated with cTACE, the chemotherapeutic agent CPT-11 was significantly associated with improved overall survival and delayed tumor progression compared with GEM or doxorubicin. There were no significant differences in clinical adverse events between the three agents. CPT-11 thus appears to be a promising agent when combined with cTACE for the treatment of HCC.

journal_name

World J Gastroenterol

authors

Wu J,Song L,Zhao DY,Guo B,Liu J

doi

10.3748/wjg.v20.i31.10960

subject

Has Abstract

pub_date

2014-08-21 00:00:00

pages

10960-8

issue

31

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章
  • Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an.

    abstract:AIM:To analyze the association of tobacco smoking polymorphism of CYP1A1 (7th exon) and GSTM1 genotype and esophageal cancer(EC) in Xi'an. METHODS:A hospital based case-control study, with molecular epidemiological method, was carried out. Polymorphism of CYP1A1 and GSTM1 of samples from 127 EC cases and 101 controls ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i1.49

    authors: Wang AH,Sun CS,Li LS,Huang JY,Chen QS

    更新日期:2002-02-01 00:00:00

  • Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma.

    abstract:AIM:To explore the correlation between expression of somatostatin (SS), gastrin (GAS) and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma. METHODS:Sixty-two large intestine cancer tissue samples were randomly and retrospectively selected from patients with large intestine carcinoma. Immunohistoch...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i5.721

    authors: Mao JD,Wu P,Xia XH,Hu JQ,Huang WB,Xu GQ

    更新日期:2005-02-07 00:00:00

  • When combination therapy isn't working: emerging therapies for the management of inflammatory bowel disease.

    abstract::Although antagonists of tumor necrosis factor have resulted in major therapeutic benefits in inflammatory bowel disease, the magnitude and durability of response are variable. Similar to previously available drugs such as 5-aminosalicylates and immunomodulators, the therapeutic effect is not universal leaving many peo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i5.1139

    authors: Krishnareddy S,Swaminath A

    更新日期:2014-02-07 00:00:00

  • Gastroesophageal reflux: the features in elderly patients.

    abstract::AIM:To compare the features of gastroesophageal reflux disease between elderly and younger patients.METHODS:Twenty-four hour pH-monitoring and endoscopy were performed for the 66 elderly patients with typical gastroesophageal reflux symptoms, and the results were compared with 112 symptomatic younger patients.RESULTS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v5.i5.421

    authors: Huang X,Zhu HM,Deng CZ,Porro GB,Sangaletti O,Pace F

    更新日期:1999-10-01 00:00:00

  • Small intestinal vascular malformation bleeding: a case report with imaging findings.

    abstract::The small intestine is approximately 5-6 m long and occupies a large area in the abdominal cavity. These factors preclude the use of ordinary endoscopy and X-ray to thoroughly examine the small intestine for bleeding of vascular malformations. Thus, the diagnosis of intestinal bleeding is very difficult. A 47-year-old...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i38.14076

    authors: Cui J,Huang LY,Lin SJ,Yi LZ,Wu CR,Zhang B

    更新日期:2014-10-14 00:00:00

  • Role of Salmonella enterica exposure in Chilean Crohn's disease patients.

    abstract:AIM:To study the association between exposure to Salmonella enterica (SE) and Crohn's disease (CD) and its clinical implications in Chilean patients. METHODS:Ninety-four unrelated Chilean CD patients from CAREI (Active Cohort Registry of Inflammatory Bowel Disease) presenting to a single inflammatory bowel disease (IB...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i35.5855

    authors: Alvarez-Lobos M,Pizarro DP,Palavecino CE,Espinoza A,Sebastián VP,Alvarado JC,Ibañez P,Quintana C,Díaz O,Kalergis AM,Bueno SM

    更新日期:2013-09-21 00:00:00

  • Multiple small bowel ruptures due to ischemic enteritis: a case report.

    abstract::A rare case of multiple small bowel ruptures due to ischemic enteritis (ISE) is reported. The patient was admitted to the hospital with acute abdominal pain followed by bloody diarrhoeas. Preoperative colonoscopic findings were similar to those presented in Crohn's disease. Intraoperatively, ischemic lesions and multi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i26.4262

    authors: Delikoukos S,Christodoulidis G,Zacharoulis D,Poultsidi A,Hatzitheofilou C

    更新日期:2006-07-14 00:00:00

  • Chinese guidelines on the management of liver cirrhosis (abbreviated version).

    abstract::Based on reviews of the literature and experts' consensus, the Chinese Society of Hepatology developed guidelines for the diagnosis and treatment of liver cirrhosis, in order to improve clinical practice. In addition to what has been covered in previously published guidelines on the management of cirrhosis complicatio...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i45.7088

    authors: Xu XY,Ding HG,Li WG,Xu JH,Han Y,Jia JD,Wei L,Duan ZP,Ling-Hu EQ,Zhuang H

    更新日期:2020-12-07 00:00:00

  • Role of MGST1 in reactive intermediate-induced injury.

    abstract::Microsomal glutathione transferase (MGST1, EC 2.5.1.18) is a membrane bound glutathione transferase extensively studied for its ability to detoxify reactive intermediates, including metabolic electrophile intermediates and lipophilic hydroperoxides through its glutathione dependent transferase and peroxidase activitie...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i20.2552

    authors: Schaffert CS

    更新日期:2011-05-28 00:00:00

  • Translational pancreatic cancer research: A comparative study on patient-derived xenograft models.

    abstract:AIM:To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice. METHODS:This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i7.794

    authors: Rubio-Manzanares Dorado M,Marín Gómez LM,Aparicio Sánchez D,Pereira Arenas S,Praena-Fernández JM,Borrero Martín JJ,Farfán López F,Gómez Bravo MÁ,Muntané Relat J,Padillo Ruiz J

    更新日期:2018-02-21 00:00:00

  • Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma.

    abstract:AIM:To detect linc00675 expression in pancreatic ductal adenocarcinoma (PDAC), to analyze the relationship between the expression level of linc00675 and the clinical pathological characteristics, to explore the biological functions of linc00675, and to determine whether linc00675 has independent prognostic value in PDA...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i31.9348

    authors: Li DD,Fu ZQ,Lin Q,Zhou Y,Zhou QB,Li ZH,Tan LP,Chen RF,Liu YM

    更新日期:2015-08-21 00:00:00

  • Post-partum reactivation of chronic hepatitis B virus infection among hepatitis B e-antigen-negative women.

    abstract:AIM:To investigate the frequency and timing of post-partum chronic hepatitis B virus (HBV) reactivation and identify its pre-partum predictors. METHODS:Forty-one hepatitis B e antigen (HBeAg)-negative chronic HBV infected pregnant women were prospectively evaluated between the 28th and the 32nd week of gestation. Subj...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i4.1261

    authors: Elefsiniotis I,Vezali E,Vrachatis D,Hatzianastasiou S,Pappas S,Farmakidis G,Vrioni G,Tsakris A

    更新日期:2015-01-28 00:00:00

  • Ischemic colitis and large bowel infarction: a case report.

    abstract::Ischemic bowel disease results from an acute or chronic drop in the blood supply to the bowel and may have various clinical presentations, such as intestinal angina, ischemic colitis or intestinal infarction. Elderly patients with systemic atherosclerosis who are symptomatic for the disease in two or more vascular bed...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i39.5640

    authors: Georgescu EF,Carstea D,Dumitrescu D,Teodorescu R,Carstea A

    更新日期:2012-10-21 00:00:00

  • Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis.

    abstract:AIM:To investigate whether composite yogurt with acacia dietary fiber and Bifidobacterium lactis (B. lactis) has additive effects in irritable bowel syndrome (IBS). METHODS:A total of 130 patients were randomly allocated to consume, twice daily for 8 wk, either the composite yogurt or the control product. The composit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v18.i33.4563

    authors: Min YW,Park SU,Jang YS,Kim YH,Rhee PL,Ko SH,Joo N,Kim SI,Kim CH,Chang DK

    更新日期:2012-09-07 00:00:00

  • Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes.

    abstract::Mesenteric venous thrombosis (MVT) is a rare but life threatening form of bowel ischemia. It is implicated in 6%-9% of all cases of acute mesenteric ischemia. The proportion of patients with primary (or idiopathic) MVT varies from 0% to 49%, with a decrease in frequency secondary to more recent availability of newer i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i43.7813

    authors: Karmacharya P,Aryal MR,Donato A

    更新日期:2013-11-21 00:00:00

  • Can mean platelet volume play a role in evaluating the severity of acute pancreatitis?

    abstract:AIM:To investigate serum mean platelet volume (MPV) levels in acute pancreatitis (AP) patients and assess whether MPV effectively predicts the disease severity of AP. METHODS:We included 117 consecutive patients with AP as the AP group and 34 consecutive patients with colorectal polyps (before endoscopic treatment) as...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i13.2404

    authors: Lei JJ,Zhou L,Liu Q,Xiong C,Xu CF

    更新日期:2017-04-07 00:00:00

  • Improved technique of vascular anastomosis for small intestinal transplantation in rats.

    abstract::AIM:To establish a new improved vascular anastomotic technique to simplify the surgical technique and increase the survival rate of small intestinal transplantation in rats.METHODS:The graft removed en bloc consisted of entire small intestine, portal vein and aortic segment with superior mesenteric artery. The graft w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v6.i2.259

    authors: Li YX,Li JS,Li N

    更新日期:2000-04-01 00:00:00

  • The effect pathway of retinoic acid through regulation of retinoic acid receptor alpha in gastric cancer cells.

    abstract:AIM:To evaluate the role of RARalpha gene in mediating the growth inhibitory effect of all-trans retinoic acid (ATRA) on gastric cancer cells. METHODS:The expression levels of retinoic acid receptors (RARs) in gastric cancer cells were detected by Northern blot. Transient transfection and chlorophenicol acetyl transfe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i5.662

    authors: Liu S,Wu Q,Chen ZM,Su WJ

    更新日期:2001-10-01 00:00:00

  • Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.

    abstract::Desmoid tumor is a locally invasive, myofibroblastic, nonmetastatic tumor. Its pathogenesis remains unclear and it may involve genetic abnormalities, sex hormones and traumatic injury, including surgery. Postoperative intra-abdominal desmoid tumor is rare, especially in the retroperitoneum. We report a case of postope...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i42.6172

    authors: Shih LY,Wei CK,Lin CW,Tseng CE

    更新日期:2012-11-14 00:00:00

  • Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis.

    abstract::Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative stress. Dubin-Johnson syndrome is a rare, autosomal recessive, inherited disorder characterized by biphasic, predominantly conjugated hyperbilirubinemia with no progression to end-stage liver ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i6.946

    authors: Sticova E,Elleder M,Hulkova H,Luksan O,Sauer M,Wunschova-Moudra I,Novotny J,Jirsa M

    更新日期:2013-02-14 00:00:00

  • Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis.

    abstract:AIM:To assess the value of magnetic resonance elastography (MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis (AIH). METHODS:In this retrospective study, 36 patients (19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a te...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i5.859

    authors: Wang J,Malik N,Yin M,Smyrk TC,Czaja AJ,Ehman RL,Venkatesh SK

    更新日期:2017-02-07 00:00:00

  • Clear cell colitis: a form of microscopic colitis in children.

    abstract:AIM:To describe a new clinical and pathological subtype of microscopic colitis in children. METHODS:A selected group of children with abdominal pain, constipation and/or diarrhoea showing discrete or no macroscopic abnormalities on endoscopy was described. RESULTS:Multiple biopsies of colon showed large mononuclear c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.231

    authors: Józefczuk J,Wozniewicz BM

    更新日期:2008-01-14 00:00:00

  • Full-thickness myotomy is associated with higher rate of postoperative gastroesophageal reflux disease.

    abstract:AIM:To compare long-term occurrence of gastroesophageal reflux disease (GERD) between two different types of peroral endoscopic myotomy (POEM) for achalasia. METHODS:We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation with ≥ 3 yea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i42.9419

    authors: Wang XH,Tan YY,Zhu HY,Li CJ,Liu DL

    更新日期:2016-11-14 00:00:00

  • Complications after ileal pouch-anal anastomosis in Korean patients with ulcerative colitis.

    abstract:AIM:To investigate the outcomes of treatments for complications after ileal pouch-anal anastomosis (IPAA) in Korean patients with ulcerative colitis. METHODS:Between March 1998 and February 2013, 72 patients (28 male and 44 female, median age 43.0 years ± 14.0 years) underwent total proctocolectomy with IPAA. The stud...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i23.7488

    authors: Ryoo SB,Oh HK,Han EC,Ha HK,Moon SH,Choe EK,Park KJ

    更新日期:2014-06-21 00:00:00

  • Quantification of choline concentration following liver cell apoptosis using 1H magnetic resonance spectroscopy.

    abstract:AIM:To evaluate the feasibility of quantifying liver choline concentrations in both normal and apoptotic rabbit livers in vivo, using 1H magnetic resonance spectroscopy (1H-MRS). METHODS:1H-MRS was performed in 18 rabbits using a 1.5T GE MR system with an eight-channel head/neck receiving coil. Fifteen rabbits were in...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i10.1130

    authors: Shen ZW,Cao Z,You KZ,Yang ZX,Xiao YY,Cheng XF,Chen YW,Wu RH

    更新日期:2012-03-14 00:00:00

  • Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes.

    abstract::Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by the intake of pyrrolizidine alkaloids (PAs). To date, PAs-induced HSOS has not been extensively studied. In view of the difference in etiology of HSOS between the West and China, clinical profiles, imaging findings, treatment, and outcomes of HSOS associa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i28.3753

    authors: Yang XQ,Ye J,Li X,Li Q,Song YH

    更新日期:2019-07-28 00:00:00

  • Multivariate analysis of the risk for pulmonary complication after gastrointestinal surgery.

    abstract:AIM:To identify the risk factors for postoperative pulmonary complications (PPC) after gastrointestinal surgery. METHODS:A total of 1 002 patients undergoing gastrointestinal surgery in the Second Affiliated Hospital, Sun Yat-Sen University, during December 1999 and December 2003, were retrospectively studied. RESULT...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i24.3735

    authors: Jiang SP,Li ZY,Huang LW,Zhang W,Lu ZQ,Zheng ZY

    更新日期:2005-06-28 00:00:00

  • Impact of comorbidities on the severity of chronic hepatitis B at presentation.

    abstract:AIM:To evaluate the clinical relevance of each cofactor on clinical presentation of chronic hepatitis B. METHODS:Out of 1366 hepatitis B surface antigen (HBsAg) positive subjects consecutively observed in 79 Italian hospitals, 53 (4.3%) showed as the only cofactor hepatitis D virus (HDV) infection [hepatitis B virus (...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v18.i14.1616

    authors: Sagnelli E,Stroffolini T,Mele A,Imparato M,Sagnelli C,Coppola N,Almasio PL

    更新日期:2012-04-14 00:00:00

  • Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006.

    abstract:AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.1237

    authors: Roman F,Hawotte K,Struck D,Ternes AM,Servais JY,Arendt V,Hoffman P,Hemmer R,Staub T,Seguin-Devaux C,Schmit JC

    更新日期:2008-02-28 00:00:00

  • Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis.

    abstract:AIM:To investigate the effect of moxibustion on intestinal flora and release of interleukin-12 (IL-12) and tumor necrosis factor-α (TNF-α) from the colon in rat with ulcerative colitis (UC). METHODS:A rat model of UC was established by local stimulation of the intestine with supernatant from colonic contents harvested...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i46.6819

    authors: Wang XM,Lu Y,Wu LY,Yu SG,Zhao BX,Hu HY,Wu HG,Bao CH,Liu HR,Wang JH,Yao Y,Hua XG,Guo HY,Shen LR

    更新日期:2012-12-14 00:00:00