Asymmetrically expressed axin required for anterior development in Tribolium.

abstract：:Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao W,Komar HM,Hart PA,Conwell DL,Lesinski GB,Friedman A

更新日期：2017-05-09 00:00:00

abstract：:Hox genes are conserved transcription factor-encoding genes that specify the identity of body regions in bilaterally symmetrical animals. In the cricket Gryllus bimaculatus, a member of the hemimetabolous insect group Orthoptera, the induction of a subset of mesodermal cells to form the primordial germ cells (PGCs) is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett AA,Nakamura T,Extavour CG

更新日期：2019-08-13 00:00:00

abstract：:Schizosaccharomyces pombe cells were transformed with an S. pombe expression vector containing a full-length cDNA of the Chlorella hexose transporter. The transformed cells accumulated 3-O-methylglucose up to 10-fold, whereas wild-type S. pombe and control transformants could only equilibrate this sugar analogue. In a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauer N,Caspari T,Klebl F,Tanner W

更新日期：1990-10-01 00:00:00

abstract：:Aphids maintain mutualistic symbioses involving consortia of coinherited organisms. All possess a primary endosymbiont, Buchnera, which compensates for dietary deficiencies; many also contain secondary symbionts, such as Hamiltonella defensa, which confers defense against natural enemies. Genome sequences of uncultiva...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moran NA,Degnan PH,Santos SR,Dunbar HE,Ochman H

更新日期：2005-11-22 00:00:00

abstract：:Genome duplication followed by massive gene loss has permanently shaped the genomes of many higher eukaryotes, particularly angiosperms. It has long been believed that a primary advantage of genome duplication is the opportunity for the evolution of genes with new functions by modification of duplicated genes. If so, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chapman BA,Bowers JE,Feltus FA,Paterson AH

更新日期：2006-02-21 00:00:00

abstract：:Parts of the primary structure of the NAD-specific glutamate dehydrogenase [L-glutamate:NAD oxidoreductase (deaminating), EC 1.4.1.2] from Neurospora crassa are presented. Segments of the sequence representing 886 unique amino-acid residues have been determined; the largest contains 267 residues. There are only short ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austen BM,Nyc JF,Degani Y,Smith EL

更新日期：1975-12-01 00:00:00

abstract：:Aggression is a universal social behavior important for the acquisition of food, mates, territory, and social status. Aggression in Drosophila is context-dependent and can thus be expected to involve inputs from multiple sensory modalities. Here, we use mechanical disruption and genetic approaches in Drosophila melano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Versteven M,Vanden Broeck L,Geurten B,Zwarts L,Decraecker L,Beelen M,Göpfert MC,Heinrich R,Callaerts P

更新日期：2017-02-21 00:00:00

abstract：:Identified over a dozen years ago in the brain and pancreatic islet, βIV-spectrin is critical for the local organization of protein complexes throughout the nervous system. βIV-Spectrin targets ion channels and adapter proteins to axon initial segments and nodes of Ranvier in neurons, and βIV-spectrin dysfunction unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kline CF,Wright PJ,Koval OM,Zmuda EJ,Johnson BL,Anderson ME,Hai T,Hund TJ,Mohler PJ

更新日期：2013-10-22 00:00:00

abstract：:The colony-stimulating factors (CSFs) greatly influence mature macrophage function in vitro: macrophage (M)-CSF induces maturation of monocytes and enhances differentiated cell function; granulocyte-macrophage (GM)-CSF stimulates a variety of antimicrobial functions. In vivo M-CSF is thought to promote differentiation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Nichilo MO,Burns GF

更新日期：1993-03-15 00:00:00

abstract：:In diabetes, the death of insulin-producing beta-cells by apoptosis leads to insulin deficiency. The lower prevalence of diabetes in females suggests that female sex steroids protect from beta-cell injury. Consistent with this hypothesis, 17beta-estradiol (estradiol) manifests antidiabetic actions in humans and rodent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le May C,Chu K,Hu M,Ortega CS,Simpson ER,Korach KS,Tsai MJ,Mauvais-Jarvis F

更新日期：2006-06-13 00:00:00

abstract：:Amphibians are a bellwether for environmental degradation, even in natural ecosystems such as Yellowstone National Park in the western United States, where species have been actively protected longer than anywhere else on Earth. We document that recent climatic warming and resultant wetland desiccation are causing sev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMenamin SK,Hadly EA,Wright CK

更新日期：2008-11-04 00:00:00

abstract：:Two approaches have been explored for the synthesis of double-stranded DNA from single-stranded DNA template complementary to rabbit 9S globin mRNA (cDNA). (i) cDNA was elongated with dCMP or dTMP homopolymeric tracts using terminal deoxynucleotidyltransferase (EC 2.7.7.31; nucleosidetriphosphate:DNA deoxynucleotidyle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rougeon F,Mach B

更新日期：1976-10-01 00:00:00

abstract：:Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure. Antiepileptic drugs (AEDs), used to treat seizures in children, infants, and pregnant women, cause cognitive impairment, microcephaly, and birth defects. The cause of unwan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bittigau P,Sifringer M,Genz K,Reith E,Pospischil D,Govindarajalu S,Dzietko M,Pesditschek S,Mai I,Dikranian K,Olney JW,Ikonomidou C

更新日期：2002-11-12 00:00:00

abstract：:Fibronectin mediates the adhesion of cells to collagen by first binding to the collagen substrate, followed by attachment of the cells to the fibronectin-collagen complex. Bovine brain gangliosides were found to block fibronectin-mediated cell adhesion to collagen in a concentration-dependent manner. The gangliosides ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinman HK,Martin GR,Fishman PH

更新日期：1979-07-01 00:00:00

abstract：:Intramembrane proteolysis is a new paradigm in biology that controls signaling events throughout evolution. Hydrolysis of peptide bonds is thought to occur within the normally hydrophobic membrane environment, but insights into this unusual activity have been lacking because of difficulty in recapitulating activity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urban S,Wolfe MS

更新日期：2005-02-08 00:00:00

abstract：:Duplication of the genome during the S phase of the cell cycle does not occur simultaneously; rather, different sequences are replicated at different times. The replication timing of specific sequences can change during development; however, the determinants of this dynamic process are poorly understood. To gain insig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White EJ,Emanuelsson O,Scalzo D,Royce T,Kosak S,Oakeley EJ,Weissman S,Gerstein M,Groudine M,Snyder M,Schübeler D

更新日期：2004-12-21 00:00:00

abstract：:We have previously shown that surfactant protein A (SP-A) mediates in vitro killing of mycoplasmas by alveolar macrophages (AMs) from resistant C57BL/6 mice through a nitric oxide (.NO)-dependent mechanism. Herein, SP-A-deficient [SP-A(-/-)] and inducible.NO synthase-deficient [iNOS(-/-)] mice were infected intranasal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickman-Davis J,Gibbs-Erwin J,Lindsey JR,Matalon S

更新日期：1999-04-27 00:00:00

abstract：:Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination. However, mechanisms involved in p53-mediated control of cell motility and invasion remain poorly understood. By using the primary ovarian surface epithelium cell culture, we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CI,Matoso A,Corney DC,Flesken-Nikitin A,Körner S,Wang W,Boccaccio C,Thorgeirsson SS,Comoglio PM,Hermeking H,Nikitin AY

更新日期：2011-08-23 00:00:00

abstract：:A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25-OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haussler MR,Boyce DW,Littledike ET,Rasmussen H

更新日期：1971-01-01 00:00:00

abstract：:Septins assemble into filaments and higher-order structures that act as scaffolds for diverse cell functions including cytokinesis, cell polarity, and membrane remodeling. Despite their conserved role in cell organization, little is known about how septin filaments elongate and are knitted together into higher-order a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridges AA,Zhang H,Mehta SB,Occhipinti P,Tani T,Gladfelter AS

更新日期：2014-02-11 00:00:00

abstract：:The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in metabolic defense against O2 toxicity in Drosophila is examined through the properties of a mutant strain carrying a cSOD-null mutation, cSODn108. Homozygotes are viable as larvae, which indicates that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips JP,Campbell SD,Michaud D,Charbonneau M,Hilliker AJ

更新日期：1989-04-01 00:00:00

abstract：:Mammalian centromere function depends upon a specialized chromatin organization where distinct domains of CENP-A and dimethyl K4 histone H3, forming centric chromatin, are uniquely positioned on or near the surface of the chromosome. These distinct domains are embedded in pericentric heterochromatin (characterized by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greaves IK,Rangasamy D,Ridgway P,Tremethick DJ

更新日期：2007-01-09 00:00:00

abstract：:Studies on the structure-function relationship of diphtheria toxin are reported. New methods are described for the preparation of pure intact ("unnicked") toxin and for the preparation of the individual A and B chains. A biological assay method for the B chain is also presented, as well as a method for the labelling o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Everse J,Lappi DA,Beglau JM,Lee CL,Kaplan NO

更新日期：1977-02-01 00:00:00

abstract：:Encoding activity in the medial temporal lobe, presumably evoked by the presentation of stimuli (postonset activity), is known to predict subsequent memory. However, several independent lines of research suggest that preonset activity also affects subsequent memory. We investigated the role of preonset and postonset s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urgolites ZJ,Wixted JT,Goldinger SD,Papesh MH,Treiman DM,Squire LR,Steinmetz PN

更新日期：2020-06-16 00:00:00

abstract：:Current evidence suggests that the length of poly(A) tails of bacterial mRNAs result from a competition between poly(A) polymerase and exoribonucleases that attack the 3' ends of RNAs. Here, we show that host factor Hfq is also involved in poly(A) tail metabolism. Inactivation of the hfq gene reduces the length of pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hajnsdorf E,Régnier P

更新日期：2000-02-15 00:00:00

abstract：:Biosynthesis of sucrose-6-P catalyzed by sucrose-phosphate synthase (SPS), and the presence of sucrose-phosphate phosphatase (SPP) leading to the formation of sucrose, have both been ascertained in a prokaryotic organism: Anabaena 7119, a filamentous heterocystic cyanobacterium. Two SPS activities (SPS-I and SPS-II) w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porchia AC,Salerno GL

更新日期：1996-11-26 00:00:00

abstract：:The matrix-2 (M2) protein from influenza A virus is a tetrameric, integral transmembrane (TM) protein that plays a vital role in viral replication by proton flux into the virus. The His37 tetrad is a pH sensor in the center of the M2 TM helix that activates the channel in response to the low endosomal pH. M2 consists ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torabifard H,Panahi A,Brooks CL 3rd

更新日期：2020-02-18 00:00:00

abstract：:Upon stimulation with anti-CD3, suppressor T-cell (Ts) hybridomas and homologous transfectants of T-cell receptor a (TCRalpha) cDNA in the T-cell hybridoma formed a 55-kDa TCRalpha chain derivative that bound both the monoclonal anti-TCRalpha chain and polyclonal antibodies against glycosylation inhibiting factor (GIF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii Y,Nakano T,Ishizaka K

更新日期：1996-07-09 00:00:00

abstract：:We present a comparative study of calorimetrically derived thermodynamic profiles for the binding of a series of drugs with selected DNA host duplexes. We use these data to demonstrate that comparisons between complete thermodynamic profiles (delta G zero, delta H zero, delta S zero, delta Cp) are required before drug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breslauer KJ,Remeta DP,Chou WY,Ferrante R,Curry J,Zaunczkowski D,Snyder JG,Marky LA

更新日期：1987-12-01 00:00:00

abstract：:In a genetic screen of available T-DNA-mutagenized Arabidopsis populations for loci potentially involved in phytochrome (phy) signaling, we identified a mutant that displayed reduced seedling deetiolation under continuous red light, but little if any change in responsiveness to continuous far-red light. This behavior ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huq E,Tepperman JM,Quail PH

更新日期：2000-08-15 00:00:00