Abstract:
:Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment. The model is represented by a system of partial differential equations. The model is used to explore in silico potential drugs that could slow the progression of the disease, for example infliximab (anti-TNF-[Formula: see text]) and tocilizumab or siltuximab (anti-IL-6/IL-6R).
journal_name
Proc Natl Acad Sci U S Aauthors
Hao W,Komar HM,Hart PA,Conwell DL,Lesinski GB,Friedman Adoi
10.1073/pnas.1620264114subject
Has Abstractpub_date
2017-05-09 00:00:00pages
5011-5016issue
19eissn
0027-8424issn
1091-6490pii
1620264114journal_volume
114pub_type
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