Close link between development and function of gamma-delta T cells.

Abstract:

:Murine γδ T cells develop as the first T-cell lineage within the fetal thymus and disproportionately localize in mucosal tissues such as lung, skin, uterus, and intestine of adult mice. These unique developmental features and distribution patterns of γδ T cells enable rapid functioning against various insults from pathogens. γδ T cells are also able to respond to local inflammation and consequently regulate the pathogenesis of autoimmune disorders and development of tumors in mice and humans. Hence, it is clinically important to understand the mechanisms that regulate γδ T cell functions. Recent evidence has shown that generations of effector γδ T cell subsets producing IFN-γ, IL-4, and IL-17 are programmed in the murine thymus before their migration to peripheral tissues. This review outlines our current understanding of the development and function of γδ T cells as they influence both innate and acquired immunity.

journal_name

Microbiol Immunol

authors

Shibata K

doi

10.1111/j.1348-0421.2012.00435.x

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

217-27

issue

4

eissn

0385-5600

issn

1348-0421

journal_volume

56

pub_type

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