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A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee.

Abstract：

INTRODUCTION:Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. METHODS:In total, 394 older men and women (mean age, 63 years; range, 52 to 79) were measured at baseline and approximately 2.7 years later. BMLs were determined by using T2-weighted fat-saturation magnetic resonance imaging (MRI) by measuring the maximal area of the lesion. Nutrient intake (total energy, fat, carbohydrate, protein, and sugar) and serum lipids were assessed at baseline. RESULTS:Cross-sectionally, dietary factors and lipids were not significantly associated with BMLs. Energy, carbohydrate, and sugar intake (but not fat) were positively associated with a change in BML size (β = 15.44 to 19.27 mm2 per 1 SD increase; all P < 0.05). High-density lipoprotein (HDL) cholesterol tended to be negatively associated with BML change (β = -11.66 mm2 per 1 SD increase; P = 0.088). CONCLUSIONS:Energy, carbohydrate, and sugar intake may be risk factors for BML development and progression. HDL cholesterol seems protective against BMLs. These results suggest that macronutrients and lipids may be important in BML etiology and that dietary modification may alter BML natural history.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Doré D,de Hoog J,Giles G,Ding C,Cicuttini F,Jones G

doi

10.1186/ar3689

subject

Has Abstract

pub_date

2012-01-18 00:00:00

pages

R13

issue

1

eissn

1478-6354

issn

1478-6362

pii

ar3689

journal_volume

14

pub_type

杂志文章

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