The meniscus, calcification and osteoarthritis: a pathologic team.

Abstract:

:Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition by OA menisci is inhibited by phosphocitrate. This study should catalyse further work examining the pathological contribution or otherwise of calcium crystals in OA. This would significantly aid the development of potential disease modifying agents in OA, which are currently unavailable.

journal_name

Arthritis Res Ther

authors

MacMullan PA,McCarthy GM

doi

10.1186/ar2993

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

116

issue

3

eissn

1478-6354

issn

1478-6362

pii

ar2993

journal_volume

12

pub_type

评论,社论
  • Pulmonary arterial hypertension in scleroderma: care gaps in screening.

    abstract::One in six patients with systemic sclerosis will develop pulmonary arterial hypertension (PAH). Screening with echocardiography and possibly pulmonary function testing (to determine the diffusing capacity of carbon monoxide) is recommended to detect PAH at a less severe stage. However, real-world screening programs ha...

    journal_title:Arthritis research & therapy

    pub_type: 社论

    doi:10.1186/s13075-017-1347-4

    authors: Pope JE

    更新日期:2017-06-06 00:00:00

  • Biology of platelet-rich plasma and its clinical application in cartilage repair.

    abstract::Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar4493

    authors: Xie X,Zhang C,Tuan RS

    更新日期:2014-02-25 00:00:00

  • AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year-a retrospective cohort study with 522 cases.

    abstract:OBJECTIVE:To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). PATIENTS AND METHODS:This was a retrospective cohort study, which included 522 patients with PM/DM-ILD whose...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02286-w

    authors: Li R,Zhu WJ,Wang F,Tang X,Luo F

    更新日期:2020-09-20 00:00:00

  • The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis.

    abstract:BACKGROUND:In recent decades, low-level laser therapy (LLLT) has been widely used to relieve pain caused by different musculoskeletal disorders. Though widely used, its reported therapeutic outcomes are varied and conflicting. Results similarly conflict regarding its usage in patients with nonspecific chronic low back ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s13075-015-0882-0

    authors: Huang Z,Ma J,Chen J,Shen B,Pei F,Kraus VB

    更新日期:2015-12-15 00:00:00

  • Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment.

    abstract:INTRODUCTION:Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar2992

    authors: Beck C,Morbach H,Beer M,Stenzel M,Tappe D,Gattenlöhner S,Hofmann U,Raab P,Girschick HJ

    更新日期:2010-01-01 00:00:00

  • Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles.

    abstract:OBJECTIVES:To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distinct subpopulation of patients can be identified. METHODS:We recruited patients with at least 1 SARD ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-1929-4

    authors: Reynolds JA,Briggs TA,Rice GI,Darmalinggam S,Bondet V,Bruce E,Khan M,Haque S,Chinoy H,Herrick AL,McCarthy EM,Zeef L,Hayes A,Duffy D,Parker B,Bruce IN

    更新日期:2019-06-14 00:00:00

  • Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study.

    abstract:INTRODUCTION:TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney. Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently intro...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1186/ar2816

    authors: Schwartz N,Rubinstein T,Burkly LC,Collins CE,Blanco I,Su L,Hojaili B,Mackay M,Aranow C,Stohl W,Rovin BH,Michaelson JS,Putterman C

    更新日期:2009-01-01 00:00:00

  • Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model.

    abstract:INTRODUCTION:Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with complex etiopathogenesis. Despite extensive studies to understand the disease process utilizing human and mouse models, the intersection between these species remains elusive. To address this gap, we utilized a novel systems biology appr...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4081

    authors: Horvath S,Nazmul-Hossain AN,Pollard RP,Kroese FG,Vissink A,Kallenberg CG,Spijkervet FK,Bootsma H,Michie SA,Gorr SU,Peck AB,Cai C,Zhou H,Wong DT

    更新日期:2012-11-01 00:00:00

  • An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.

    abstract:INTRODUCTION:The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for IVD degeneration. One such t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar2611

    authors: Le Maitre CL,Baird P,Freemont AJ,Hoyland JA

    更新日期:2009-01-01 00:00:00

  • Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine.

    abstract::The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the T...

    journal_title:Arthritis research & therapy

    pub_type: 评论,社论

    doi:10.1186/ar2524

    authors: Gaffo AL,Saag KG

    更新日期:2008-01-01 00:00:00

  • B cells in rheumatoid synovitis.

    abstract::In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B c...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar1737

    authors: Weyand CM,Seyler TM,Goronzy JJ

    更新日期:2005-01-01 00:00:00

  • Smoking, body mass index, disease activity, and the risk of rapid radiographic progression in patients with early rheumatoid arthritis.

    abstract:BACKGROUND:Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characte...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-018-1575-2

    authors: Rydell E,Forslind K,Nilsson JÅ,Jacobsson LTH,Turesson C

    更新日期:2018-05-02 00:00:00

  • Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency.

    abstract:BACKGROUND:The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP antibody and, thus, may ultimately develop RA. We retrospectively investigated whether anti-CCP-positi...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02351-4

    authors: Iwasaki T,Nakabo S,Terao C,Murakami K,Nakashima R,Hashimoto M,Imura Y,Yukawa N,Yoshifuji H,Miura Y,Yurugi K,Maekawa T,van Delft MAM,Trouw LA,Fujii T,Mimori T,Ohmura K

    更新日期:2020-10-19 00:00:00

  • Bone formation rather than inflammation reflects ankylosing spondylitis activity on PET-CT: a pilot study.

    abstract:INTRODUCTION:Positron Emission Tomography - Computer Tomography (PET-CT) is an interesting imaging technique to visualize Ankylosing Spondylitis (AS) activity using specific PET tracers. Previous studies have shown that the PET tracers [18F]FDG and [11C](R)PK11195 can target inflammation (synovitis) in rheumatoid arthr...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3792

    authors: Bruijnen ST,van der Weijden MA,Klein JP,Hoekstra OS,Boellaard R,van Denderen JC,Dijkmans BA,Voskuyl AE,van der Horst-Bruinsma IE,van der Laken CJ

    更新日期:2012-04-02 00:00:00

  • Elucidation of the potential roles of matrix metalloproteinases in skeletal biology.

    abstract::Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in...

    journal_title:Arthritis research & therapy

    pub_type: 评论,社论

    doi:10.1186/ar600

    authors: Krane SM

    更新日期:2003-01-01 00:00:00

  • Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration.

    abstract::Current evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those seen during ageing but appear to occur at an accelerated rate. We hypothesised that this is due to accelerate...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar2198

    authors: Le Maitre CL,Freemont AJ,Hoyland JA

    更新日期:2007-01-01 00:00:00

  • The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis.

    abstract::As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has be...

    journal_title:Arthritis research & therapy

    pub_type: 评论,社论

    doi:10.1186/ar1894

    authors: Pfander D,Swoboda B,Cramer T

    更新日期:2006-01-01 00:00:00

  • Significance of anti-neutrophil cytoplasmic antibodies in systemic sclerosis.

    abstract:BACKGROUND:Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the significance of ANCA in these patients is unclear. The aim of this study is to determine the prevalence of A...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,多中心研究

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    authors: Moxey J,Huq M,Proudman S,Sahhar J,Ngian GS,Walker J,Strickland G,Wilson M,Ross L,Major G,Roddy J,Stevens W,Nikpour M

    更新日期:2019-02-14 00:00:00

  • Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.

    abstract:BACKGROUND:The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies. It is unclear which pathways are involved in IIM, and the functional relationship between autoantib...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-016-1061-7

    authors: Parkes JE,Rothwell S,Day PJ,McHugh NJ,Betteridge ZE,Cooper RG,Ollier WE,Chinoy H,Lamb JA,Myositis Genetics Consortium (MYOGEN).

    更新日期:2016-07-07 00:00:00

  • The role of aldosterone blockade in murine lupus nephritis.

    abstract:BACKGROUND:The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB x NZW) F1 murine lupus model. METHODS:Female NZB/W F1 mice (11 weeks old) were treated daily with 25 or 50 mg/kg oral spironolactone or vehicle. Proteinuria...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar2353

    authors: Monrad SU,Killen PD,Anderson MR,Bradke A,Kaplan MJ

    更新日期:2008-01-01 00:00:00

  • Survivin but not Fms-like tyrosine kinase 3 ligand is up-regulated before the onset of rheumatoid arthritis: a pilot study.

    abstract:INTRODUCTION:Antibodies against citrullinated peptides (anti-CCP) and increased levels of cytokines precede the development of rheumatoid arthritis (RA) by several years. Recently, the proteins survivin and Fms-like tyrosine kinase 3 ligand (Flt3L) have been identified as biomarkers of RA associated with joint destruct...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4474

    authors: Bokarewa M,Brink M,Erlandsson M,Rantapää Dahlqvist S

    更新日期:2014-02-05 00:00:00

  • Post-traumatic osteoarthritis following ACL injury.

    abstract::Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest p...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s13075-020-02156-5

    authors: Wang LJ,Zeng N,Yan ZP,Li JT,Ni GX

    更新日期:2020-03-24 00:00:00

  • Hsa_circ_0123190 acts as a competitive endogenous RNA to regulate APLNR expression by sponging hsa-miR-483-3p in lupus nephritis.

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    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02404-8

    authors: Zhang C,Gao C,Di X,Cui S,Liang W,Sun W,Yao M,Liu S,Zheng Z

    更新日期:2021-01-13 00:00:00

  • Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms.

    abstract:BACKGROUND:Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects. Here, we investigate the role of PCSK9 in relation to the inflammatory activity in patients with rheumatoid arthritis (RA). METHODS:PCSK9-le...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02386-7

    authors: Frostegård J,Ahmed S,Hafström I,Ajeganova S,Rahman M

    更新日期:2021-01-19 00:00:00

  • The synovial proteome: analysis of fibroblast-like synoviocytes.

    abstract::The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar1153

    authors: Dasuri K,Antonovici M,Chen K,Wong K,Standing K,Ens W,El-Gabalawy H,Wilkins JA

    更新日期:2004-01-01 00:00:00

  • Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects.

    abstract:INTRODUCTION:There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study w...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4417

    authors: Flynn TJ,Phipps-Green A,Hollis-Moffatt JE,Merriman ME,Topless R,Montgomery G,Chapman B,Stamp LK,Dalbeth N,Merriman TR

    更新日期:2013-01-01 00:00:00

  • A subset of CD163+ macrophages displays mixed polarizations in discoid lupus skin.

    abstract:INTRODUCTION:Lesional skin of patients with discoid lupus erythematosus (DLE) contains macrophages, whose polarization has yet to be investigated. To test our hypothesis that M1 macrophages would be increased in DLE skin, we examined transcriptome alterations in immune cell gene expression and macrophage features in DL...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-015-0839-3

    authors: Chong BF,Tseng LC,Hosler GA,Teske NM,Zhang S,Karp DR,Olsen NJ,Mohan C

    更新日期:2015-11-13 00:00:00

  • Smoking in combination with antibodies to cyclic citrullinated peptides is associated with persistently high levels of survivin in early rheumatoid arthritis: a prospective cohort study.

    abstract:INTRODUCTION:High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor of joint damage and persistent disease activity. Survivin-positive patients are often poor responders to antirheumatic and biological treatment. The ai...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4438

    authors: Svensson B,Hafström I,Erlandsson MC,Forslind K,Bokarewa MI

    更新日期:2014-01-16 00:00:00

  • Association between acute phase reactants, interleukin-6, tumor necrosis factor-α, and disease activity in Takayasu's arteritis patients.

    abstract:BACKGROUND:To investigate the association between blood biomarkers and disease activity of Takayasu's arteritis (TAK) in a follow-up cohort. METHODS:Disease activity was assessed by clinical manifestations and repeated vascular Doppler examinations. The association between erythrocyte sedimentation rate (ESR), serum l...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02365-y

    authors: Li J,Wang Y,Wang Y,Wang Y,Yang Y,Zhao J,Li M,Tian X,Zeng X

    更新日期:2020-12-10 00:00:00

  • The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.

    abstract:INTRODUCTION:The goals of this study were to examine the oxemic regulation of Wnt signaling to explore whether Wnt signaling accelerates the age-related degeneration of nucleus pulposus cells, and if so, to define the mechanism underlying this effect. We investigated the expression of Klotho, a newly identified antiagi...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3830

    authors: Hiyama A,Arai F,Sakai D,Yokoyama K,Mochida J

    更新日期:2012-05-02 00:00:00