The effect of nicotinamide adenine dinucleotide phosphate oxidase 4 on migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.

abstract：BACKGROUND:Differences in the expression of variants across ethnic groups in the systemic lupus erythematosus (SLE) patients have been well documented. However, the genetic architecture in the Thai population has not been thoroughly examined. In this study, we carried out genome-wide association study (GWAS) in the Tha...

journal_title：Arthritis research & therapy

authors： Tangtanatakul P,Thumarat C,Satproedprai N,Kunhapan P,Chaiyasung T,Klinchanhom S,Wang YF,Wei W,Wongshinsri J,Chiewchengchol D,Rodsaward P,Ngamjanyaporn P,Suangtamai T,Mahasirimongkol S,Pisitkun P,Hirankarn N

更新日期：2020-08-08 00:00:00

abstract：INTRODUCTION:The aim of the study was to determine whether Olf1/EBF associated zinc finger protein (OAZ), a transcription factor encoded by a positional systemic lupus erythematosus (SLE) candidate gene, plays a functional role in the pathogenesis in SLE. METHODS:Gene expression levels in peripheral blood cells (PBLs)...

journal_title：Arthritis research & therapy

authors： Feng X,Li R,Huang J,Zhang H,Zhu L,Hua B,Tsao BP,Sun L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Nucleus pulposus (NP) cells have a phenotype similar to articular cartilage (AC) cells. However, the matrix of the NP is clearly different to that of AC suggesting that specific cell phenotypes exist. The aim of this study was to identify novel genes that could be used to distinguish bovine NP cells from A...

journal_title：Arthritis research & therapy

authors： Minogue BM,Richardson SM,Zeef LA,Freemont AJ,Hoyland JA

更新日期：2010-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is an immunosuppressant drug being used for induction and maintenance of remission of lupus nephritis in systemic lupus erythematosus. Evidence about its use was sought from full publications and abstracts of randomised trials and cohort studies by using a variety of search strategies. Effi...

journal_title：Arthritis research & therapy

authors： Moore RA,Derry S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. METHODS:Peripheral blood mononuclear cells from healthy donors were incubated with different JAKis, levels of phosphorylated signal transd...

journal_title：Arthritis research & therapy

authors： McInnes IB,Byers NL,Higgs RE,Lee J,Macias WL,Na S,Ortmann RA,Rocha G,Rooney TP,Wehrman T,Zhang X,Zuckerman SH,Taylor PC

更新日期：2019-08-02 00:00:00

abstract：INTRODUCTION:Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled cri...

journal_title：Arthritis research & therapy

authors： De Rooy DP,Willemze A,Mertens B,Huizinga TW,Van der Helm-van Mil AH

更新日期：2011-01-01 00:00:00

abstract：:The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular thrombosis or miscarriages but includes additional manifestations that cannot be explained solely by a thrombophilic state. Anti-cardiolipin, anti-beta₂ glycoprotein I (anti-β₂GPI) and lupus anticoagulant (LA) assays are not only ...

journal_title：Arthritis research & therapy

authors： Meroni PL,Chighizola CB,Rovelli F,Gerosa M

更新日期：2014-01-01 00:00:00

abstract：:The transcription factor STAT-1 (signal transducer and activator of transcription-1) plays a pivotal role in the expression of inflammatory gene products involved in the pathogenesis of arthritis such as various cytokines and the CD40/CD40 ligand (CD40/CD40L) receptor-ligand dyad. The therapeutic efficacy of a synthet...

journal_title：Arthritis research & therapy

authors： Hückel M,Schurigt U,Wagner AH,Stöckigt R,Petrow PK,Thoss K,Gajda M,Henzgen S,Hecker M,Bräuer R

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The aims of this study were to evaluate the diagnostic accuracy of blood B-cell subset profiling and immune-system activation marker assays in primary Sjögren's syndrome (pSS) and to assess whether adding these tools to the current laboratory item would improve the American-European Consensus Group (AECG) ...

journal_title：Arthritis research & therapy

authors： Cornec D,Saraux A,Pers JO,Jousse-Joulin S,Marhadour T,Roguedas-Contios AM,Genestet S,Renaudineau Y,Devauchelle-Pensec V

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. METHODS:Eighty 10-week-old male C57BL/6 mice w...

journal_title：Arthritis research & therapy

authors： Li H,Ding X,Terkeltaub R,Lin H,Zhang Y,Zhou B,He K,Li K,Liu Z,Wei J,Yang Y,Xie H,Zeng C,Lei G

更新日期：2020-02-22 00:00:00

abstract：BACKGROUND:With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivity to first-line biologic disease-modifying anti-rheumatic drugs (bDMARD) is becoming a significant ...

journal_title：Arthritis research & therapy

authors： Ochi S,Saito K,Mizoguchi F,Kato S,Tanaka Y

更新日期：2020-03-04 00:00:00

abstract：:The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the T...

journal_title：Arthritis research & therapy

authors： Gaffo AL,Saag KG

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Brain-derived neurotrophic factor (BDNF) was first identified in the intervertebral disc (IVD) when its molecular upregulation was observed in sections of nucleus pulposus cultured under conditions of increased osmolarity. BDNF is now known to be involved in a number of biologic functions, including regula...

journal_title：Arthritis research & therapy

authors： Gruber HE,Ingram JA,Hoelscher G,Zinchenko N,Norton HJ,Hanley EN Jr

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:We aimed to understand the changes in cartilage lubricin expression and immunolocalisation in responsed to treadmill running with different intensities in a rat model. METHODS:A total of 24 male Wistar rats were randomly assigned into groups of control (CON), low-intensity running (LIR), moderate-intensit...

journal_title：Arthritis research & therapy

authors： Ni GX,Lei L,Zhou YZ

更新日期：2012-11-24 00:00:00

abstract：INTRODUCTION:C-reactive protein (CRP) is one of the biomarkers for the diagnosis and assessment of disease activity in rheumatoid arthritis (RA). CRP is not only the by-product of inflammatory response, but also plays proinflammatory and prothrombotic roles. The aim of this study was to determine the role of CRP on bon...

journal_title：Arthritis research & therapy

authors： Kim KW,Kim BM,Moon HW,Lee SH,Kim HR

更新日期：2015-03-04 00:00:00

abstract：INTRODUCTION:Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or...

journal_title：Arthritis research & therapy

authors： Sato M,Kuroda S,Mansjur KQ,Khaliunaa G,Nagata K,Horiuchi S,Inubushi T,Yamamura Y,Azuma M,Tanaka E

更新日期：2015-10-07 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects. Here, we investigate the role of PCSK9 in relation to the inflammatory activity in patients with rheumatoid arthritis (RA). METHODS:PCSK9-le...

journal_title：Arthritis research & therapy

authors： Frostegård J,Ahmed S,Hafström I,Ajeganova S,Rahman M

更新日期：2021-01-19 00:00:00

abstract：:Advanced imaging techniques may enable early diagnosis and monitoring of therapy in various rheumatic diseases. To prevent irreversible tissue damage, inflammatory rheumatic disease must be diagnosed and treated in pre-clinical stages, requiring highly sensitive detection techniques. Positron emission tomography (PET)...

journal_title：Arthritis research & therapy

authors： Yamashita H,Kubota K,Mimori A

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate. The fractional renal clearance of urate (FCU, renal clearance of urate/renal clearance of creatinine) has been proposed as a tool to identify subjects who manifest inefficient ...

journal_title：Arthritis research & therapy

authors： Kannangara DR,Ramasamy SN,Indraratna PL,Stocker SL,Graham GG,Jones G,Portek I,Williams KM,Day RO

更新日期：2012-08-17 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

journal_title：Arthritis research & therapy

authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H2S) has been implicated in mineralization but has never been studied in OA. Here, we investigated t...

journal_title：Arthritis research & therapy

authors： Nasi S,Ehirchiou D,Chatzianastasiou A,Nagahara N,Papapetropoulos A,Bertrand J,Cirino G,So A,Busso N

更新日期：2020-03-17 00:00:00

abstract：INTRODUCTION:Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment. Dermal interstitial fluid sampling offers the potential to examine local mechanisms and identify proteins expressed withi...

journal_title：Arthritis research & therapy

authors： Clark KE,Lopez H,Abdi BA,Guerra SG,Shiwen X,Khan K,Etomi O,Martin GR,Abraham DJ,Denton CP,Stratton RJ

更新日期：2015-03-23 00:00:00

abstract：:Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthritis and reported t...

journal_title：Arthritis research & therapy

authors： Kinderlerer AR,Steinberg R,Johns M,Harten SK,Lidington EA,Haskard DO,Maxwell PH,Mason JC

更新日期：2006-01-01 00:00:00

abstract：:The accumulation of T cells in the synovial membrane is the crucial step in the pathophysiology of the inflammatory processes characterizing juvenile idiopathic arthritis (JIA). In this study, we evaluated the expression and the pathogenetic role in oligoarticular JIA of a CXC chemokine involved in the directional mig...

journal_title：Arthritis research & therapy

authors： Martini G,Zulian F,Calabrese F,Bortoli M,Facco M,Cabrelle A,Valente M,Zacchello F,Agostini C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PC...

journal_title：Arthritis research & therapy

authors： Hutcheson J,Vanarsa K,Bashmakov A,Grewal S,Sajitharan D,Chang BY,Buggy JJ,Zhou XJ,Du Y,Satterthwaite AB,Mohan C

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF b...

journal_title：Arthritis research & therapy

authors： Estelius J,Lengqvist J,Ossipova E,Idborg H,Le Maître E,Andersson MLA,Brundin L,Khademi M,Svenungsson E,Jakobsson PJ,Lampa J

更新日期：2019-02-15 00:00:00

abstract：:Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

journal_title：Arthritis research & therapy

authors： Xie X,Zhang C,Tuan RS

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:During pregnancy, many patients with rheumatoid arthritis (RA) experience disease improvement, whereas patients with ankylosing spondylitis often suffer from persistent active disease. Here we investigated whether pregnancy-related changes in disease activity were associated with changes in the proportion an...

journal_title：Arthritis research & therapy

authors： Tham M,Schlör GR,Yerly D,Mueller C,Surbek D,Villiger PM,Förger F

更新日期：2016-01-22 00:00:00

abstract：INTRODUCTION:The interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis. METHODS:Human CD14+ cells were isolated fro...

journal_title：Arthritis research & therapy

authors： Adamopoulos IE,Chao CC,Geissler R,Laface D,Blumenschein W,Iwakura Y,McClanahan T,Bowman EP

更新日期：2010-01-01 00:00:00