Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms.

abstract：INTRODUCTION:Broad-range rDNA PCR provides an alternative, cultivation-independent approach for identifying bacterial DNA in reactive and other form of arthritis. The aim of this study was to use broad-range rDNA PCR targeting the 16S rRNA gene in patients with reactive and other forms of arthritis and to screen for th...

journal_title：Arthritis research & therapy

authors： Siala M,Gdoura R,Fourati H,Rihl M,Jaulhac B,Younes M,Sibilia J,Baklouti S,Bargaoui N,Sellami S,Sghir A,Hammami A

更新日期：2009-01-01 00:00:00

abstract：:Cardiovascular event rates are markedly increased in rheumatoid arthritis (RA), and RA atherogenesis remains poorly understood. The relative contributions of traditional and nontraditional risk factors to cardiovascular disease in RA await elucidation. The present study comprises three components. First, we compared b...

journal_title：Arthritis research & therapy

authors： Dessein PH,Joffe BI,Singh S

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Recent advances suggest that the cellular redox state may play a significant role in the progression of fibrosis in systemic sclerosis (SSc). Another, and as yet poorly accounted for, feature of SSc is its overlap with thyroid abnormalities. Previous reports demonstrate that hypothyroidism reduces oxidant ...

journal_title：Arthritis research & therapy

authors： Bagnato G,Bitto A,Irrera N,Pizzino G,Sangari D,Cinquegrani M,Roberts W,Atteritano M,Altavilla D,Squadrito F,Bagnato G,Saitta A

更新日期：2013-09-16 00:00:00

abstract：:The difficulty in predicting the consequences of interactions between different cytokine networks has increased with the expansion of the T helper (Th) cell universe and the discovery of numerous B lymphocyte-derived cytokines. Consequently, it is now difficult to conceptualize a straightforward view of the contributi...

journal_title：Arthritis research & therapy

authors： Youinou P,Pers JO

更新日期：2011-07-06 00:00:00

abstract：:Macrophage activation syndrome (MAS) has been reported in association with many rheumatic diseases, most commonly in systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is similar to hemophagocytic lymphohistiocytosis (HLH), a genetic disorder with absent or depressed natural killer (NK) function. We have p...

journal_title：Arthritis research & therapy

authors： Villanueva J,Lee S,Giannini EH,Graham TB,Passo MH,Filipovich A,Grom AA

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize...

journal_title：Arthritis research & therapy

authors： Vitadello M,Doria A,Tarricone E,Ghirardello A,Gorza L

更新日期：2010-01-01 00:00:00

abstract：:The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the T...

journal_title：Arthritis research & therapy

authors： Gaffo AL,Saag KG

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Methotrexate (MTX) is a cornerstone of treatment in a wide variety of inflammatory conditions, including juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM). However, owing to its narrow therapeutic index and the considerable interpatient variability in clinical response, monitoring of a...

journal_title：Arthritis research & therapy

authors： Hawwa AF,AlBawab A,Rooney M,Wedderburn LR,Beresford MW,McElnay JC

更新日期：2015-10-22 00:00:00

abstract：INTRODUCTION:Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fl...

journal_title：Arthritis research & therapy

authors： Rutgers M,Saris DB,Dhert WJ,Creemers LB

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor, anti-citrullinated protein antibodies, and bone erosions. Current therapies can compromise immunity, leading to risk of infection. The interleukin-20 receptor (IL-20R) axis comprising IL-19, IL-20, and IL-24 and their shar...

journal_title：Arthritis research & therapy

authors： Kragstrup TW,Greisen SR,Nielsen MA,Rhodes C,Stengaard-Pedersen K,Hetland ML,Hørslev-Petersen K,Junker P,Østergaard M,Hvid M,Vorup-Jensen T,Robinson WH,Sokolove J,Deleuran B

更新日期：2016-03-11 00:00:00

abstract：INTRODUCTION:Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease ...

journal_title：Arthritis research & therapy

authors： Rastogi A,Kim H,Twomey JD,Hsieh AH

更新日期：2013-04-27 00:00:00

abstract：:It has long been recognized that laboratory tests are useful in the diagnosis of disease and to monitor treatment outcome. Their performance has become even more demanding with the development of personalized medicine. In patients with rheumatoid arthritis (RA) the standard biochemical tests measure serological marker...

journal_title：Arthritis research & therapy

authors： van de Loo FA

更新日期：2011-04-27 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

journal_title：Arthritis research & therapy

authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health record (EHR) technique to test for differences in comorbidities in African Americans compared to Cau...

journal_title：Arthritis research & therapy

authors： Barnado A,Carroll RJ,Casey C,Wheless L,Denny JC,Crofford LJ

更新日期：2018-04-10 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin (a well recognized BMP inhibitor) and BMP-2 are expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin inhibition induces human mesenchymal stem cell...

journal_title：Arthritis research & therapy

authors： Heliotis M,Tsiridis E

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the effect of aldosterone receptor blockade on the immunopathogenesis and progression of nephritis in the (NZB x NZW) F1 murine lupus model. METHODS:Female NZB/W F1 mice (11 weeks old) were treated daily with 25 or 50 mg/kg oral spironolactone or vehicle. Proteinuria...

journal_title：Arthritis research & therapy

authors： Monrad SU,Killen PD,Anderson MR,Bradke A,Kaplan MJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great v...

journal_title：Arthritis research & therapy

authors： Di Benedetto P,Guggino G,Manzi G,Ruscitti P,Berardicurti O,Panzera N,Grazia N,Badagliacca R,Riccieri V,Vizza CD,Radchenko G,Liakouli V,Ciccia F,Cipriani P,Giacomelli R

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Disease-modifying antirheumatic drugs (DMARDs) have become the treatment standard for patients with rheumatoid arthritis (RA). Although several general-population studies document that a large population of patients diagnosed with RA do not use DMARDs, little is known about this group. We explored the char...

journal_title：Arthritis research & therapy

authors： Brown EM,Garneau KL,Tsao H,Solomon DH

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein, we analyzed the 5-year outcome of the pMDA group and assessed for within-group heterogeneity. MET...

journal_title：Arthritis research & therapy

authors： Genitsaridi I,Flouri I,Plexousakis D,Marias K,Boki K,Skopouli F,Drosos A,Bertsias G,Boumpas D,Sidiropoulos P

更新日期：2020-09-29 00:00:00

abstract：INTRODUCTION:Studies in the spontaneous ankylosis model in aging male DBA/1 mice and in patients with ankylosing spondylitis provide evidence that inflammation and new tissue formation leading to joint or spine ankylosis are likely linked but largely uncoupled processes. We previously proposed the 'entheseal stress' hy...

journal_title：Arthritis research & therapy

authors： Braem K,Deroose CM,Luyten FP,Lories RJ

更新日期：2012-03-12 00:00:00

abstract：BACKGROUND:With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivity to first-line biologic disease-modifying anti-rheumatic drugs (bDMARD) is becoming a significant ...

journal_title：Arthritis research & therapy

authors： Ochi S,Saito K,Mizoguchi F,Kato S,Tanaka Y

更新日期：2020-03-04 00:00:00

abstract：INTRODUCTION:Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted to assess the safety, tolerability, < NOTE: For clarity and per AMA/S-W ...

journal_title：Arthritis research & therapy

authors： Emu B,Luca D,Offutt C,Grogan JL,Rojkovich B,Williams MB,Tang MT,Xiao J,Lee JH,Davis JC

更新日期：2012-01-08 00:00:00

abstract：BACKGROUND:Established rheumatoid arthritis (RA) patients display differentially expressed genes coding for cytokine/chemokine-mediated immunity compared to healthy controls. It is unclear, however, if in the pre-arthritis phase of clinically suspect arthralgia (CSA) expression of immune genes differ between patients w...

journal_title：Arthritis research & therapy

authors： Niemantsverdriet E,van den Akker EB,Boeters DM,van den Eeden SJF,Geluk A,van der Helm-van Mil AHM

更新日期：2020-11-09 00:00:00

abstract：:The article by Seror et al. in Arthritis Research & Therapy reports data from the 15 French patients in the open-label BELISS (Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome, NCT01160666) study of belimumab in primary Sjögren's syndrome. The study identifies that higher baseline levels of...

journal_title：Arthritis research & therapy

authors： Bowman SJ,Fisher BA

更新日期：2015-12-07 00:00:00

abstract：INTRODUCTION:The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. METHODS:Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy co...

journal_title：Arthritis research & therapy

authors： Pleštilová L,Mann H,Andrés Cerezo L,Pecha O,Vencovský J,Šenolt L

更新日期：2014-10-31 00:00:00

abstract：:Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-related restructuring of the immune system and age-induced remodeling of the vascular wall. Immunosenescence results in shrinkage of the naïve T-cell pool, contraction of T-cell diversity, and impairment of innate immunity. ...

journal_title：Arthritis research & therapy

authors： Mohan SV,Liao YJ,Kim JW,Goronzy JJ,Weyand CM

更新日期：2011-08-02 00:00:00

abstract：INTRODUCTION:Monocytic cells play a central role in the aetiology of rheumatoid arthritis, and manipulation of the activation of these cells is an approach currently under investigation to discover new therapies for this and associated diseases. CD148 is a transmembrane tyrosine phosphatase that is highly expressed in ...

journal_title：Arthritis research & therapy

authors： Dave RK,Naylor AJ,Young SP,Bayley R,Hardie DL,Haworth O,Rider DA,Cook AD,Buckley CD,Kellie S

更新日期：2013-01-01 00:00:00

abstract：:The autoinflammatory diseases, also known as periodic fever syndromes, are disorders of innate immunity which can be inherited or acquired and which cause recurrent, self-limiting, seemingly spontaneous episodes of systemic inflammation and fever in the absence of autoantibody production or infection. There has been m...

journal_title：Arthritis research & therapy

authors： Lachmann HJ,Hawkins PN

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block activation of inflammation through nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), subchondral bone changes through receptor activator of nu...

journal_title：Arthritis research & therapy

authors： TenBroek EM,Yunker L,Nies MF,Bendele AM

更新日期：2016-01-21 00:00:00

abstract：:As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has be...

journal_title：Arthritis research & therapy

authors： Pfander D,Swoboda B,Cramer T

更新日期：2006-01-01 00:00:00