当前位置： SCI文献检索 > ARTHRITIS RESEARCH & THERAPY期刊下所有文献 > Disturbance of cytokine networks in Sjögren's syndrome.

Disturbance of cytokine networks in Sjögren's syndrome.

Abstract：

:The difficulty in predicting the consequences of interactions between different cytokine networks has increased with the expansion of the T helper (Th) cell universe and the discovery of numerous B lymphocyte-derived cytokines. Consequently, it is now difficult to conceptualize a straightforward view of the contribution of these disturbances to the pathogenesis of primary Sjögren's syndrome (SS). Th1 cells, which produce interferon-γ and IL-2, and Th17 cells, which make IL-17 and TNF-α, have been cast in the leading roles of the play. However, the complex role of T-cell subsets in SS is accentuated by the reciprocal effects of Th17 cells and regulatory T cells found in salivary glands of SS patients. Furthermore, B lymphocyte polarization into type-1 B effector (Be1) and Be2 cells and B-cell modulating factors of the TNF family, most notably the B-cell-activating factor (BAFF), and their prominent role in SS are additional complicating factors. Whereas Th17 cells orchestrate autoreactive germinal centers, local BAFF would repress the generation of Th17 cells. Such new insights into interconnected cytokines in primary SS may lead to new treatments for these patients.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Youinou P,Pers JO

doi

10.1186/ar3348

subject

Has Abstract

pub_date

2011-07-06 00:00:00

pages

227

issue

4

eissn

1478-6354

issn

1478-6362

pii

ar3348

journal_volume

13

pub_type

杂志文章,评审

相关文献

ARTHRITIS RESEARCH & THERAPY文献大全
  • Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial fibroblasts (RASFs) contribute significantly to disease progressi...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/s13075-015-0846-4

    authors： Chapoval SP

    更新日期：2015-11-06 00:00:00

  • Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage.

    abstract：INTRODUCTION:Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic effects. Two isoforms have been identified: hematopoietic- and lipocalin-type PGDS (H-PGDS and L-PGDS, respectively). The aims of this study were to ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2581

    authors： Zayed N,Li X,Chabane N,Benderdour M,Martel-Pelletier J,Pelletier JP,Duval N,Fahmi H

    更新日期：2008-01-01 00:00:00

  • Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis.

    abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including its ability to support...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3735

    authors： Sato M,Uchida K,Nakajima H,Miyazaki T,Guerrero AR,Watanabe S,Roberts S,Baba H

    更新日期：2012-02-07 00:00:00

  • Identification of kinectin as a novel Behçet's disease autoantigen.

    abstract：:There has been some evidence that Behçet's disease (BD) has a significant autoimmune component but the molecular identity of putative autoantigens has not been well characterized. In the initial analysis of the autoantibody profile in 39 Chinese BD patients, autoantibodies to cellular proteins were uncovered in 23% as...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1798

    authors： Lu Y,Ye P,Chen SL,Tan EM,Chan EK

    更新日期：2005-01-01 00:00:00

  • Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome.

    abstract：:Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the s...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar2005

    authors： Buskila D,Sarzi-Puttini P

    更新日期：2006-01-01 00:00:00

  • Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.

    abstract：BACKGROUND:Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenas...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2389

    authors： Chowdhury TT,Arghandawi S,Brand J,Akanji OO,Bader DL,Salter DM,Lee DA

    更新日期：2008-01-01 00:00:00

  • Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function.

    abstract：:With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a cen...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar2632

    authors： Walmsley SR,Chilvers ER,Whyte MK

    更新日期：2009-01-01 00:00:00

  • Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis.

    abstract：INTRODUCTION:The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. METHODS:T-cell receptor transgenic mice, in which nearly all CD4+ T cells recognize a single peptide of type II collagen, were immunized with collagen and obs...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2795

    authors： Lundy SK,Fox DA

    更新日期：2009-01-01 00:00:00

  • Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proin

    abstract：INTRODUCTION:The role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthritis (RA) in relation to the expression of vascular endothelial growth factor (VEGF) and matrix metal...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2844

    authors： Choi HM,Lee YA,Lee SH,Hong SJ,Hahm DH,Choi SY,Yang HI,Yoo MC,Kim KS

    更新日期：2009-01-01 00:00:00

  • Interferon alpha inhibits antigen-specific production of proinflammatory cytokines and enhances antigen-specific transforming growth factor beta production in antigen-induced arthritis.

    abstract：INTRODUCTION:Interferon alpha (IFN-α) has a complex role in autoimmunity, in that it may both enhance and prevent inflammation. We have previously shown that the presence of IFN-α at sensitization protects against subsequent antigen-triggered arthritis. To understand this tolerogenic mechanism, we performed a descripti...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4326

    authors： Chalise J,Narendra S,Paudyal B,Magnusson M

    更新日期：2013-10-03 00:00:00

  • The association between functional and morphological assessments of endothelial function in patients with rheumatoid arthritis: a cross-sectional study.

    abstract：INTRODUCTION:Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED), which can lead to functional and morphological vascular abnormalities. Several non-invasive assessments of vascular function and morp...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4287

    authors： Sandoo A,Hodson J,Douglas KM,Smith JP,Kitas GD

    更新日期：2013-01-01 00:00:00

  • Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological disease-modifying anti-rheumatic drugs.

    abstract：INTRODUCTION:Biological markers specifically reflecting pathological processes may add value in the assessment of inter-individual variations in the course of rheumatoid arthritis (RA). The current study was undertaken to investigate whether baseline serum levels of the chemokine CXCL13 might predict clinical and ultra...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3742

    authors： Bugatti S,Manzo A,Benaglio F,Klersy C,Vitolo B,Todoerti M,Sakellariou G,Montecucco C,Caporali R

    更新日期：2012-02-15 00:00:00

  • Tapering and discontinuation of TNF-α blockers without disease relapse using ultrasonography as a tool to identify patients with rheumatoid arthritis in clinical and histological remission.

    abstract：BACKGROUND:In this study, we assessed whether clinical and ultrasonography (US)-based remission could be used to select patients with rheumatoid arthritis (RA) eligible to taper and discontinue anti-TNF-α therapy after achievement of remission, looking at disease relapse. METHODS:Forty-two patients with RA in sustaine...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-016-0927-z

    authors： Alivernini S,Peluso G,Fedele AL,Tolusso B,Gremese E,Ferraccioli G

    更新日期：2016-02-03 00:00:00

  • Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.

    abstract：INTRODUCTION:The purpose of this study was to evaluate the effects of L-4F, an apolipoprotein A-1 mimetic peptide, alone or with pravastatin, in apoE-/-Fas-/-C57BL/6 mice that spontaneously develop immunoglobulin G (IgG) autoantibodies, glomerulonephritis, osteopenia, and atherosclerotic lesions on a normal chow diet. ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3020

    authors： Woo JM,Lin Z,Navab M,Van Dyck C,Trejo-Lopez Y,Woo KM,Li H,Castellani LW,Wang X,Iikuni N,Rullo OJ,Wu H,La Cava A,Fogelman AM,Lusis AJ,Tsao BP

    更新日期：2010-01-01 00:00:00

  • Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment.

    abstract：INTRODUCTION:Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2992

    authors： Beck C,Morbach H,Beer M,Stenzel M,Tappe D,Gattenlöhner S,Hofmann U,Raab P,Girschick HJ

    更新日期：2010-01-01 00:00:00

  • Fractional clearance of urate: validation of measurement in spot-urine samples in healthy subjects and gouty patients.

    abstract：INTRODUCTION:Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate. The fractional renal clearance of urate (FCU, renal clearance of urate/renal clearance of creatinine) has been proposed as a tool to identify subjects who manifest inefficient ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/ar4020

    authors： Kannangara DR,Ramasamy SN,Indraratna PL,Stocker SL,Graham GG,Jones G,Portek I,Williams KM,Day RO

    更新日期：2012-08-17 00:00:00

  • Altered signalling thresholds in T lymphocytes cause autoimmune arthritis.

    abstract：:The development of spontaneous autoimmunity in inbred strains of rodents has allowed us to investigate the molecular basis of chronic inflammatory disease in ways that would not be possible in humans. Recently, two new mouse models of autoimmune inflammatory polyarthritis have been reported that demonstrate how altera...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar1185

    authors： Cope AP

    更新日期：2004-01-01 00:00:00

  • Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure, processing, and resolution.

    abstract：:I comment on the well-designed trial by Alda and colleagues reported in a recent issue of Arthritis Research and Therapy which demonstrated some benefits of cognitive-behavioral therapy (CBT) for fibromyalgia (FM). CBT in this and other studies provides statistically significant but rather modest benefits for FM. This...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar3511

    authors： Lumley MA

    更新日期：2011-01-01 00:00:00

  • Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.

    abstract：INTRODUCTION:Rheumatoid synovial fibroblasts (RASFs) mediate joint inflammation and destruction in rheumatoid arthritis (RA). Endothelial protein C receptor (EPCR) is a specific receptor for the natural anticoagulant activated protein C (APC). It mediates the cytoprotective properties of APC and is expressed in rheumat...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4473

    authors： Xue M,Shen K,McKelvey K,Li J,Chan YK,Hatzis V,March L,Little CB,Tonkin M,Jackson CJ

    更新日期：2014-02-05 00:00:00

  • What can chronic arthritis pain teach about developing new analgesic drugs?

    abstract：:Chronic pain remains an important public health need with greater impact on the US economy than most other chronic conditions. Current pain management is largely limited to opioids and non-steroidal anti-inflammatory drugs, indicating a gap in the translation of new knowledge to the development of improved pain treatm...

    journal_title：Arthritis research & therapy

    pub_type： 社论

    doi：10.1186/ar1450

    authors： Witter J,Dionne RA

    更新日期：2004-01-01 00:00:00

  • A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease.

    abstract：BACKGROUND:Increased expression of toll-like receptor 4 (TLR4) and its endogenous ligands, is characteristic of rheumatoid arthritis (RA) synovitis. In this study, we evaluated how these TLR4 ligands may drive pathogenic processes and whether the fine profiling of anti-citrullinated protein antibodies (ACPA) based on t...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-016-1128-5

    authors： Hatterer E,Shang L,Simonet P,Herren S,Daubeuf B,Teixeira S,Reilly J,Elson G,Nelson R,Gabay C,Sokolove J,McInnes IB,Kosco-Vilbois M,Ferlin W,Monnet E,De Min C

    更新日期：2016-10-06 00:00:00

  • The autoimmune tautology.

    abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论,评审

    doi：10.1186/ar3175

    authors： Anaya JM

    更新日期：2010-01-01 00:00:00

  • Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes.

    abstract：INTRODUCTION:Rheumatoid arthritis (RA) is characterized by progressive inflammation associated with rampantly proliferating synoviocytes and joint destruction due to oxidative stress. Recently, we described nuclear factor erythroid 2-related factor 2 (Nrf2) as a major requirement for limiting cartilage destruction. NF-...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4059

    authors： Fragoulis A,Laufs J,Müller S,Soppa U,Siegl S,Reiss LK,Tohidnezhad M,Rosen C,Tenbrock K,Varoga D,Lippross S,Pufe T,Wruck CJ

    更新日期：2012-10-27 00:00:00

  • Rheumatoid arthritis patients on persistent moderate disease activity on biologics have adverse 5-year outcome compared to persistent low-remission status and represent a heterogeneous group.

    abstract：BACKGROUND:The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein, we analyzed the 5-year outcome of the pMDA group and assessed for within-group heterogeneity. MET...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02313-w

    authors： Genitsaridi I,Flouri I,Plexousakis D,Marias K,Boki K,Skopouli F,Drosos A,Bertsias G,Boumpas D,Sidiropoulos P

    更新日期：2020-09-29 00:00:00

  • The role and clinical implications of G6PI in experimental models of rheumatoid arthritis.

    abstract：:The antigens that trigger the pathogenic immune response in rheumatoid arthritis (RA) remain unknown. Until recently it was assumed that either viral or microbial antigens, or joint-specific antigens were the target of arthritogenic T and B lymphocytes in RA. Consequently, murine models of arthritis are induced by imm...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar1476

    authors： Kamradt T,Schubert D

    更新日期：2005-01-01 00:00:00

  • The lung as a possible target for the immune reaction in myositis.

    abstract：:Interstitial lung disease is a common manifestation of autoimmune myositis that confers significant morbidity and mortality. The vulnerability of the lung may offer insight into the etiology of this autoimmune disease. The frequency and patterns of lung injury vary based on the autoantibody. Antibodies against the ami...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3347

    authors： Danoff SK,Casciola-Rosen L

    更新日期：2011-07-13 00:00:00

  • Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia.

    abstract：BACKGROUND:This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON). METHODS:Twenty-four female patients with FMS (54 ± 8 years) and 27 female CON (54 ± 9 years) were subjected to ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s13075-016-1041-y

    authors： Ernberg M,Christidis N,Ghafouri B,Bileviciute-Ljungar I,Löfgren M,Larsson A,Palstam A,Bjersing J,Mannerkorpi K,Kosek E,Gerdle B

    更新日期：2016-06-13 00:00:00

  • The changing landscape of the clinical value of the PM/Scl autoantibody system.

    abstract：:Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibod...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar2646

    authors： Mahler M,Fritzler MJ

    更新日期：2009-01-01 00:00:00

  • Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis.

    abstract：:In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decrease in systemic inflamm...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar3115

    authors： Mendez-Fernandez Y,Major A

    更新日期：2010-01-01 00:00:00

  • The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts.

    abstract：INTRODUCTION:Previous studies have shown that the number of myoblastically differentiated fibroblasts known as myofibroblasts (MFs) is significantly increased in stiff joint capsules, indicating their crucial role in the pathogenesis of post-traumatic joint stiffness. Although the mode of MFs' function has been well de...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2902

    authors： Mattyasovszky SG,Hofmann A,Brochhausen C,Ritz U,Kuhn S,Wollstädter J,Schulze-Koops H,Müller LP,Watzer B,Rommens PM

    更新日期：2010-01-01 00:00:00