当前位置： SCI文献检索 > ARTHRITIS RESEARCH & THERAPY期刊下所有文献 > Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis.

Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis.

Abstract：

:Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial fibroblasts (RASFs) contribute significantly to disease progression by initiating and regulating many pathways of joint destruction. Detailed molecular insights into RASF biology may lead to identification of important therapeutic targets. The discovery of common molecular targets for joint resident and inflammatory cells may help to develop the most effective therapeutic strategy. One such pathway includes semaphorin 4A as reported in a recent article in Arthritis Research & Therapy.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Chapoval SP

doi

10.1186/s13075-015-0846-4

subject

Has Abstract

pub_date

2015-11-06 00:00:00

pages

313

eissn

1478-6354

issn

1478-6362

pii

10.1186/s13075-015-0846-4

journal_volume

17

pub_type

评论,社论

相关文献

ARTHRITIS RESEARCH & THERAPY文献大全
  • Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis.

    abstract：BACKGROUND:The information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance of cystatin C (CysC) and complement component 1q (C1q) for LN. METHODS:A case-control study that in...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2065-x

    authors： Xu B,Zhang YM,Yang YW,Liu YS,Feng JF

    更新日期：2019-12-04 00:00:00

  • A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee.

    abstract：INTRODUCTION:Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. METHODS:In total, 394 older men and women (mean age, 63 years; range, 52 ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3689

    authors： Doré D,de Hoog J,Giles G,Ding C,Cicuttini F,Jones G

    更新日期：2012-01-18 00:00:00

  • Expanding the armamentarium for the spondyloarthropathies.

    abstract：:Ankylosing spondylitis (AS) is a member of the family of spondyloarthropathies, which are inflammatory arthritides largely involving the axial skeleton and commonly accompanied by peripheral arthritis. Genetic factors, particularly the presence of HLA-B27, are major contributors to the susceptibility for AS. Despite s...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar1012

    authors： Peloso PM,Braun J

    更新日期：2004-01-01 00:00:00

  • The schedule of administration of canakinumab in cryopyrin associated periodic syndrome is driven by the phenotype severity rather than the age.

    abstract：INTRODUCTION:Interleukin-1 (IL-1) blockade is the treatment of choice of cryopyrin associated periodic syndromes (CAPS). Anti-IL-1 monoclonal antibody (canakinumab) was recently registered. However no clear data are available on the optimal schedule of administration of this drug. The aim of the present study was to an...

    journal_title：Arthritis research & therapy

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1186/ar4184

    authors： Caorsi R,Lepore L,Zulian F,Alessio M,Stabile A,Insalaco A,Finetti M,Battagliese A,Martini G,Bibalo C,Martini A,Gattorno M

    更新日期：2013-02-26 00:00:00

  • Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial.

    abstract：INTRODUCTION:Pateclizumab (MLTA3698A) is a humanized mAb against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis. This study was conducted to assess the safety, tolerability, < NOTE: For clarity and per AMA/S-W ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/ar3554

    authors： Emu B,Luca D,Offutt C,Grogan JL,Rojkovich B,Williams MB,Tang MT,Xiao J,Lee JH,Davis JC

    更新日期：2012-01-08 00:00:00

  • Inducing articular cartilage phenotype in costochondral cells.

    abstract：INTRODUCTION:Costochondral cells may be isolated with minimal donor site morbidity and are unaffected by pathologies of the diarthrodial joints. Identification of optimal exogenous stimuli will allow abundant and robust hyaline articular cartilage to be formed from this cell source. METHODS:In a three factor, two leve...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4409

    authors： Murphy MK,DuRaine GD,Reddi A,Hu JC,Athanasiou KA

    更新日期：2013-01-01 00:00:00

  • Correction to: Comorbidity in gout at the time of first diagnosis: sex differences that may have implications for dosing of urate lowering therapy.

    abstract：:Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect. ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,已发布勘误

    doi：10.1186/s13075-018-1700-2

    authors： Drivelegka P,Sigurdardottir V,Svärd A,Jacobsson LTH,Dehlin M

    更新日期：2018-09-10 00:00:00

  • New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options.

    abstract：:Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding and causes posttraumatic joint inflammation. Although the acute symptoms resolve and some of the lesions can b...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar3046

    authors： Lotz MK,Kraus VB

    更新日期：2010-01-01 00:00:00

  • The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation.

    abstract：INTRODUCTION:The purpose of this study was to evaluate the effects of risedronate (Ris) in the modulation of bone formation in rats with glucocorticoid (GC)-induced osteoporosis by histomorphometric, immunohistochemical and gene expression analyses. METHODS:We analyzed structure, turnover and microarchitecture, cycloo...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3122

    authors： Valenti MT,Giannini S,Donatelli L,Zanatta M,Bertoldo F,Sella S,Vilei MT,Ossi E,Realdi G,Lo Cascio V,Dalle Carbonare L

    更新日期：2010-01-01 00:00:00

  • Clinical signs and symptoms in a joint model of four disease activity parameters in juvenile dermatomyositis: a prospective, longitudinal, multicenter cohort study.

    abstract：BACKGROUND:It is currently impossible to predict the prognosis of patients with juvenile dermatomyositis (JDM). The aim of this study was to find clinical features most strongly associated with outcome variables in JDM as a first step towards tailor-made treatment. METHODS:In a large, prospectively followed, multicent...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s13075-018-1687-8

    authors： van Dijkhuizen EHP,De Iorio M,Wedderburn LR,Deakin CT,JDRG.

    更新日期：2018-08-15 00:00:00

  • Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study.

    abstract：:Human T cell leukaemia virus type I (HTLV-I) is known to be involved in late-onset chronic polyarthritis as HTLV-I-associated arthropathy. However, it is unclear whether HTLV-I infection could modify the pathophysiology of osteoarthritis (OA). In this study we compared several inflammatory cytokines, such as C-termina...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1193

    authors： Yoshihara Y,Tsukazaki T,Osaki M,Nakashima M,Hasui K,Shindo H

    更新日期：2004-01-01 00:00:00

  • A concise history of gout and hyperuricemia and their treatment.

    abstract：:First identified by the Egyptians in 2640 BC, podagra (acute gout occurring in the first metatarsophalangeal joint) was later recognized by Hippocrates in the fifth century BC, who referred to it as 'the unwalkable disease'. The term is derived from the Latin word gutta (or 'drop'), and referred to the prevailing medi...

    journal_title：Arthritis research & therapy

    pub_type： 历史文章,杂志文章,评审

    doi：10.1186/ar1906

    authors： Nuki G,Simkin PA

    更新日期：2006-01-01 00:00:00

  • Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis.

    abstract：INTRODUCTION:There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-specific biologicals targeting the progressive phase of the disease, there is a need for relevant anim...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3172

    authors： Vierboom MP,Breedveld E,Kondova I,'t Hart BA

    更新日期：2010-01-01 00:00:00

  • CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis.

    abstract：INTRODUCTION:Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is available for...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-015-0580-y

    authors： Mahmood Z,Muhammad K,Schmalzing M,Roll P,Dörner T,Tony HP

    更新日期：2015-03-14 00:00:00

  • The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis.

    abstract：BACKGROUND:In recent decades, low-level laser therapy (LLLT) has been widely used to relieve pain caused by different musculoskeletal disorders. Though widely used, its reported therapeutic outcomes are varied and conflicting. Results similarly conflict regarding its usage in patients with nonspecific chronic low back ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/s13075-015-0882-0

    authors： Huang Z,Ma J,Chen J,Shen B,Pei F,Kraus VB

    更新日期：2015-12-15 00:00:00

  • Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.

    abstract：:Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthritis and reported t...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2019

    authors： Kinderlerer AR,Steinberg R,Johns M,Harten SK,Lidington EA,Haskard DO,Maxwell PH,Mason JC

    更新日期：2006-01-01 00:00:00

  • Primary and secondary autoimmune neutropenia.

    abstract：:Antineutrophil antibodies are well recognized causes of neutropenia, producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious in...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar1803

    authors： Capsoni F,Sarzi-Puttini P,Zanella A

    更新日期：2005-01-01 00:00:00

  • Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20).

    abstract：: ...

    journal_title：Arthritis research & therapy

    pub_type： 信件

    doi：10.1186/s13075-018-1766-x

    authors： Sato S,Fujita Y,Shigemura T,Matoba H,Agematsu K,Sumichika Y,Yashiro M,Ono A,Kawasaki Y,Kobayashi H,Watanabe H,Koga T,Kawakami A,Migita K

    更新日期：2018-12-10 00:00:00

  • The use and abuse of commercial kits used to detect autoantibodies.

    abstract：:The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoa...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar782

    authors： Fritzler MJ,Wiik A,Fritzler ML,Barr SG

    更新日期：2003-01-01 00:00:00

  • Trends in physician diagnosed gout and gout therapies in the US: results from the national ambulatory health care surveys 1993 to 2009.

    abstract：INTRODUCTION:Gouty arthritis (gout) is primarily cared for in ambulatory care settings. Although the prevalence of gout in the US is thought to be increasing, there have been few data on this as well as temporal changes in gout medication use. METHODS:We analyzed annual visit and drug utilization data from national sa...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4370

    authors： Krishnan E,Chen L

    更新日期：2013-11-06 00:00:00

  • Class-switched B cells display response to therapeutic B-cell depletion in rheumatoid arthritis.

    abstract：INTRODUCTION:Reconstitution of peripheral blood (PB) B cells after therapeutic depletion with the chimeric anti-CD20 antibody rituximab (RTX) mimics lymphatic ontogeny. In this situation, the repletion kinetics and migratory properties of distinct developmental B-cell stages and their correlation to disease activity mi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2686

    authors： Möller B,Aeberli D,Eggli S,Fuhrer M,Vajtai I,Vögelin E,Ziswiler HR,Dahinden CA,Villiger PM

    更新日期：2009-01-01 00:00:00

  • Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study.

    abstract：BACKGROUND:We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction. METHODS:Arthroscopic assessment of articular cartilage damage was performed twice ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1471-1

    authors： Sobue Y,Kojima T,Kurokouchi K,Takahashi S,Yoshida H,Poole R,Ishiguro N

    更新日期：2017-12-06 00:00:00

  • Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis.

    abstract：BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02261-5

    authors： Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

    更新日期：2020-07-16 00:00:00

  • PEG-ing down (and preventing?) the cause of pegloticase failure.

    abstract：:Pegloticase is a powerful but underutilized weapon in the rheumatologist's armamentarium. The drug's immunogenicity leads to neutralizing antibody formation and rapid loss of efficacy in roughly one-half of all patients, which remains an impediment to broader use. New data, however, suggest that drug survival might im...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar4572

    authors： Abeles AM

    更新日期：2014-05-30 00:00:00

  • Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice.

    abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3481

    authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

    更新日期：2011-01-01 00:00:00

  • Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis.

    abstract：INTRODUCTION:We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines ye...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3237

    authors： Kokkonen H,Mullazehi M,Berglin E,Hallmans G,Wadell G,Rönnelid J,Rantapää-Dahlqvist S

    更新日期：2011-02-03 00:00:00

  • Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects.

    abstract：INTRODUCTION:There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study w...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4417

    authors： Flynn TJ,Phipps-Green A,Hollis-Moffatt JE,Merriman ME,Topless R,Montgomery G,Chapman B,Stamp LK,Dalbeth N,Merriman TR

    更新日期：2013-01-01 00:00:00

  • Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example.

    abstract：BACKGROUND:The presence of autoantibodies is considered an important characteristic of rheumatoid arthritis (RA); therefore, both anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are included in the 2010 classification criteria for rheumatoid arthritis (RA). However, a considerable number of RA pa...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-018-1591-2

    authors： Boeters DM,Trouw LA,van der Helm-van Mil AHM,van Steenbergen HW

    更新日期：2018-05-03 00:00:00

  • Scleroderma-polymyositis overlap syndrome versus idiopathic polymyositis and systemic sclerosis: a descriptive study on clinical features and myopathology.

    abstract：INTRODUCTION:The objective was to characterize the clinical and myopathologic features of patients with scleroderma-polymyositis (SSc-PM) overlap compared with a population of patients with systemic sclerosis (SSc) and polymyositis (PM). METHODS:A three-way comparison of patients with SSc-PM overlap (n = 25) with pati...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4562

    authors： Bhansing KJ,Lammens M,Knaapen HK,van Riel PL,van Engelen BG,Vonk MC

    更新日期：2014-05-13 00:00:00

  • Acupuncture decreased the risk of coronary heart disease in patients with fibromyalgia in Taiwan: a nationwide matched cohort study.

    abstract：BACKGROUND:The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia. METHODS:Using data from the Taiwanese National Health Insurance Research Database, we performed a propensity score-matched cohort study to analyze patients with fi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-017-1239-7

    authors： Wu MY,Huang MC,Chiang JH,Sun MF,Lee YC,Yen HR

    更新日期：2017-02-28 00:00:00