Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function.

abstract：BACKGROUND:To investigate the association between knee pain and risk factors including low back pain and to develop a score to predict new knee pain in an older population, using population-based longitudinal cohort data. METHODS:We collected a questionnaire on self-reported knee pain and demographic data in a systema...

journal_title：Arthritis research & therapy

authors： Ito H,Tominari S,Tabara Y,Nakayama T,Furu M,Kawata T,Azukizawa M,Setoh K,Kawaguchi T,Matsuda F,Matsuda S,Nagahama Study group.

更新日期：2019-04-15 00:00:00

abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

journal_title：Arthritis research & therapy

authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

更新日期：2011-01-01 00:00:00

abstract：:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occu...

journal_title：Arthritis research & therapy

authors： Nowling TK,Gilkeson GS

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Mutations in the NLRP3 gene are associated with the dominantly inherited cryopyrin-associated periodic syndrome (CAPS). The significance of the V198M variant is unclear; it has been reported in association with various CAPS phenotypes and as a variant of uncertain consequence. The aim of this study was to ...

journal_title：Arthritis research & therapy

authors： Rowczenio DM,Trojer H,Russell T,Baginska A,Lane T,Stewart NM,Gillmore JD,Hawkins PN,Woo P,Mikoluc B,Lachmann HJ

更新日期：2013-02-19 00:00:00

abstract：:Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical assessment of signaling status has made it difficult to evaluate putative abnormalities completely using primary ...

journal_title：Arthritis research & therapy

authors： Grammer AC,Fischer R,Lee O,Zhang X,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Methotrexate (MTX) is a cornerstone of treatment in a wide variety of inflammatory conditions, including juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM). However, owing to its narrow therapeutic index and the considerable interpatient variability in clinical response, monitoring of a...

journal_title：Arthritis research & therapy

authors： Hawwa AF,AlBawab A,Rooney M,Wedderburn LR,Beresford MW,McElnay JC

更新日期：2015-10-22 00:00:00

abstract：INTRODUCTION:TNFα is a proinflammatory cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of certolizumab pegol, a TNFα blocker, on endothelial cell function and angiogenesis. METHODS:Human dermal microvascular endothelial cells (HMVECs) were stimulated wit...

journal_title：Arthritis research & therapy

authors： Shu Q,Amin MA,Ruth JH,Campbell PL,Koch AE

更新日期：2012-04-25 00:00:00

abstract：RESULTS:Anti-CarP antibodies were detected in 117 patients with RA (37.9%), ACPA in 190 patients (61.4%) and RF in 202 patients (65.3%). Two (2.04%) of the NHS were positive for anti-CarP, one NHS (1.02%) was positive for ACPA and three NHS were positive for RF (3.06%). Among disease controls, anti-CarP antibodies were...

journal_title：Arthritis research & therapy

authors： Pecani A,Alessandri C,Spinelli FR,Priori R,Riccieri V,Di Franco M,Ceccarelli F,Colasanti T,Pendolino M,Mancini R,Truglia S,Barbati C,Vomero M,Sabatinelli D,Morello F,Valesini G,Conti F

更新日期：2016-12-16 00:00:00

abstract：:Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and ...

journal_title：Arthritis research & therapy

authors： McQueen FM

更新日期：2012-09-28 00:00:00

abstract：INTRODUCTION:Although the prevalence of arthritis dramatically increases with age, the great majority of preclinical studies concerning the mechanisms that drive arthritic joint pain have been performed in young animals. One mechanism hypothesized to contribute to arthritic pain is ectopic nerve sprouting; however, neu...

journal_title：Arthritis research & therapy

authors： Jimenez-Andrade JM,Mantyh PW

更新日期：2012-05-01 00:00:00

abstract：:The initiation of an immune response requires that professional antigen-presenting cells, such as dendritic cells, physically interact with antigen-specific T cells within the complex environment of the lymph node. Although the way in which antigen is presented to T cells and in particular the cellular associations in...

journal_title：Arthritis research & therapy

authors： Scheinecker C

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines ye...

journal_title：Arthritis research & therapy

authors： Kokkonen H,Mullazehi M,Berglin E,Hallmans G,Wadell G,Rönnelid J,Rantapää-Dahlqvist S

更新日期：2011-02-03 00:00:00

abstract：BACKGROUND:Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of long-term outcomes, and the impact of psoriatic arthritis (PsA) on patients' lives. The objective...

journal_title：Arthritis research & therapy

authors： Queiro R,Cañete JD,Montoro M,Gómez S,Cábez A,MAAPS study group.

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:The information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance of cystatin C (CysC) and complement component 1q (C1q) for LN. METHODS:A case-control study that in...

journal_title：Arthritis research & therapy

authors： Xu B,Zhang YM,Yang YW,Liu YS,Feng JF

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has bee...

journal_title：Arthritis research & therapy

authors： Zhang C,Gao C,Di X,Cui S,Liang W,Sun W,Yao M,Liu S,Zheng Z

更新日期：2021-01-13 00:00:00

abstract：INTRODUCTION:Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment. Dermal interstitial fluid sampling offers the potential to examine local mechanisms and identify proteins expressed withi...

journal_title：Arthritis research & therapy

authors： Clark KE,Lopez H,Abdi BA,Guerra SG,Shiwen X,Khan K,Etomi O,Martin GR,Abraham DJ,Denton CP,Stratton RJ

更新日期：2015-03-23 00:00:00

abstract：INTRODUCTION:The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). METHODS:Clinical and radiographic data of 87 RA patients were r...

journal_title：Arthritis research & therapy

authors： Verstappen SM,Poole AR,Ionescu M,King LE,Abrahamowicz M,Hofman DM,Bijlsma JW,Lafeber FP,Utrecht Rheumatoid Arthritis Cohort Study group (SRU).

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:In this study, we aimed to determine the relationship between flow-mediated endothelium-dependent vasodilatation (FMD) and carotid artery intima-media wall thickness (IMT), two surrogate markers of atherosclerosis, in a series of Spanish patients with rheumatoid arthritis (RA) without clinically evident ca...

journal_title：Arthritis research & therapy

authors： González-Juanatey C,Llorca J,González-Gay MA

更新日期：2011-06-22 00:00:00

abstract：INTRODUCTION:The arthritis-specific Work Productivity Survey (WPS) was developed to evaluate productivity limitations associated with arthritis within and outside the home. There is an unmet need for an instrument assessing similar productivity limitations in axial spondyloarthritis (axSpA), including nonradiographic a...

journal_title：Arthritis research & therapy

authors： Osterhaus JT,Purcaru O

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To investigate dependencies in more detail, we compared IgG hypogalactosylation between patients with RA,...

journal_title：Arthritis research & therapy

authors： Schwedler C,Häupl T,Kalus U,Blanchard V,Burmester GR,Poddubnyy D,Hoppe B

更新日期：2018-03-14 00:00:00

abstract：INTRODUCTION:Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment of disease activity. We hypothesize that augmented pain processing, fibromyalgic features, poorer menta...

journal_title：Arthritis research & therapy

authors： Joharatnam N,McWilliams DF,Wilson D,Wheeler M,Pande I,Walsh DA

更新日期：2015-01-20 00:00:00

abstract：BACKGROUND:The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibration modules for the SIS and SSS and the reliability of their component change scores. METHODS:Chang...

journal_title：Arthritis research & therapy

authors： Weiss PF,Maksymowych WP,Xiao R,Biko DM,Francavilla ML,Lambert RG,Jaremko JL,Heshin-Bekenstein M,Brandon TG,Chauvin NA

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:The Vβ12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) β-chain and consequently displays an ...

journal_title：Arthritis research & therapy

authors： Merky P,Batsalova T,Bockermann R,Dzhambazov B,Sehnert B,Burkhardt H,Bäcklund J

更新日期：2010-01-01 00:00:00

abstract：:The difficulty in predicting the consequences of interactions between different cytokine networks has increased with the expansion of the T helper (Th) cell universe and the discovery of numerous B lymphocyte-derived cytokines. Consequently, it is now difficult to conceptualize a straightforward view of the contributi...

journal_title：Arthritis research & therapy

authors： Youinou P,Pers JO

更新日期：2011-07-06 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

journal_title：Arthritis research & therapy

authors： Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

更新日期：2020-07-16 00:00:00

abstract：INTRODUCTION:We aimed to understand the changes in cartilage lubricin expression and immunolocalisation in responsed to treadmill running with different intensities in a rat model. METHODS:A total of 24 male Wistar rats were randomly assigned into groups of control (CON), low-intensity running (LIR), moderate-intensit...

journal_title：Arthritis research & therapy

authors： Ni GX,Lei L,Zhou YZ

更新日期：2012-11-24 00:00:00

abstract：:Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the ...

journal_title：Arthritis research & therapy

authors： Masi AT

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with complex etiopathogenesis. Despite extensive studies to understand the disease process utilizing human and mouse models, the intersection between these species remains elusive. To address this gap, we utilized a novel systems biology appr...

journal_title：Arthritis research & therapy

authors： Horvath S,Nazmul-Hossain AN,Pollard RP,Kroese FG,Vissink A,Kallenberg CG,Spijkervet FK,Bootsma H,Michie SA,Gorr SU,Peck AB,Cai C,Zhou H,Wong DT

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humanized monoclonal antibody that blocks and depletes anti-LTα. This phase 2, randomized, head-to-head,...

journal_title：Arthritis research & therapy

authors： Kennedy WP,Simon JA,Offutt C,Horn P,Herman A,Townsend MJ,Tang MT,Grogan JL,Hsieh F,Davis JC

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND:To aim was to investigate the additional value of incorporating the de Vlam cervical facet joint score in the modified ankylosing spondylitis (AS) spine score (mSASSS) for the evaluation of spinal radiographic outcome in AS. METHOD:Baseline and 4-year radiographs from 98 consecutive patients from the Gronin...

journal_title：Arthritis research & therapy

authors： Maas F,Arends S,Brouwer E,Bootsma H,Bos R,Wink FR,Spoorenberg A

更新日期：2017-04-26 00:00:00