Abstract:
INTRODUCTION:The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). METHODS:Clinical and radiographic data of 87 RA patients were recorded 1 year after disease onset and then annually up to four years. Serum concentrations of four cartilage biomarkers were determined at these time points: a neoepitope formed by collagenase cleavage of type II collagen (C2C), a neoepitope formed by collagenase cleavage of type II collagen as well as type I collagen (C1,2C), a carboxy propeptide of type II procollagen formed during synthesis (CPII), and a cartilage proteoglycan aggrecan turnover epitope (CS846-epitope). Biomarker concentrations between patients with rapid radiographic progression (>7.3 Sharp/van der Heijde units per year) and those with slow radiographic progression (<2.3 units per year) were compared. In addition, we evaluated the long-term and short-term predictive value of each biomarker for progression of radiographic damage. RESULTS:Patients with rapid radiographic progression had higher C2C, higher C1,2C, and higher CS846-epitope levels than slow progressors. CPII levels showed no differences. Most importantly, the long-term radiographic progression for C2C, for C1,2C, and for CS846-epitope can be predicted by the biomarker value at year 1 after disease onset. C2C was also a predictor for joint space narrowing and annual radiographic damage during the subsequent year. CONCLUSION:This study shows that the concentration of serum biomarkers of cartilage collagen breakdown and proteoglycan turnover, but not of collagen synthesis, are related to joint destruction in RA. The use of these biomarkers may be of value when studying progression of joint damage in patients with RA.
journal_name
Arthritis Res Therjournal_title
Arthritis research & therapyauthors
Verstappen SM,Poole AR,Ionescu M,King LE,Abrahamowicz M,Hofman DM,Bijlsma JW,Lafeber FP,Utrecht Rheumatoid Arthritis Cohort Study group (SRU).doi
10.1186/ar1882keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
R31issue
1eissn
1478-6354issn
1478-6362pii
ar1882journal_volume
8pub_type
杂志文章abstract:BACKGROUND:During pregnancy, many patients with rheumatoid arthritis (RA) experience disease improvement, whereas patients with ankylosing spondylitis often suffer from persistent active disease. Here we investigated whether pregnancy-related changes in disease activity were associated with changes in the proportion an...
journal_title:Arthritis research & therapy
pub_type: 杂志文章
doi:10.1186/s13075-016-0925-1
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abstract:INTRODUCTION:Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as a possible biomarker in primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and ...
journal_title:Arthritis research & therapy
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journal_title:Arthritis research & therapy
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doi:10.1186/ar3087
更新日期:2010-01-01 00:00:00
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journal_title:Arthritis research & therapy
pub_type: 杂志文章,多中心研究
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journal_title:Arthritis research & therapy
pub_type: 已发布勘误
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更新日期:2016-12-16 00:00:00
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pub_type: 评论,社论
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journal_title:Arthritis research & therapy
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journal_title:Arthritis research & therapy
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journal_title:Arthritis research & therapy
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journal_title:Arthritis research & therapy
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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doi:10.1186/s13075-016-0915-3
更新日期:2016-01-19 00:00:00
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pub_type: 杂志文章
doi:10.1186/s13075-014-0411-6
更新日期:2014-01-01 00:00:00
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journal_title:Arthritis research & therapy
pub_type: 杂志文章
doi:10.1186/ar3823
更新日期:2012-04-30 00:00:00
abstract:INTRODUCTION:We designed OP3-4 (YCEIEFCYLIR), a cyclic peptide, to mimic the soluble osteoprotegerin (OPG), and was proven to bind to RANKL (receptor activator of NF-κB ligand), thereby inhibiting osteoclastogenesis. We recently found that another RANKL binding peptide, W9, could accelerate bone formation by affecting ...
journal_title:Arthritis research & therapy
pub_type: 杂志文章
doi:10.1186/s13075-015-0753-8
更新日期:2015-09-12 00:00:00
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journal_title:Arthritis research & therapy
pub_type: 评论,社论
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更新日期:2009-01-01 00:00:00
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journal_title:Arthritis research & therapy
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更新日期:2012-05-02 00:00:00
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