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abstract：BACKGROUND:To investigate the association between knee pain and risk factors including low back pain and to develop a score to predict new knee pain in an older population, using population-based longitudinal cohort data. METHODS:We collected a questionnaire on self-reported knee pain and demographic data in a systema...

journal_title：Arthritis research & therapy

authors： Ito H,Tominari S,Tabara Y,Nakayama T,Furu M,Kawata T,Azukizawa M,Setoh K,Kawaguchi T,Matsuda F,Matsuda S,Nagahama Study group.

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great v...

journal_title：Arthritis research & therapy

authors： Di Benedetto P,Guggino G,Manzi G,Ruscitti P,Berardicurti O,Panzera N,Grazia N,Badagliacca R,Riccieri V,Vizza CD,Radchenko G,Liakouli V,Ciccia F,Cipriani P,Giacomelli R

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune system. Once activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and procaspase-1 to form a large protein complex termed inflammasome. Although some ...

journal_title：Arthritis research & therapy

authors： Ito S,Hara Y,Kubota T

更新日期：2014-02-12 00:00:00

abstract：:The objective of this study was to evaluate the safety and possible efficacy of IFN-beta-1a for the treatment of patients with rheumatoid arthritis (RA). Twenty-two patients with active RA were enrolled in a phase II randomized, double-blind, placebo-controlled trial of 30 microg IFN-beta-1a by weekly self-injection f...

journal_title：Arthritis research & therapy

authors： Genovese MC,Chakravarty EF,Krishnan E,Moreland LW

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Although the prevalence of arthritis dramatically increases with age, the great majority of preclinical studies concerning the mechanisms that drive arthritic joint pain have been performed in young animals. One mechanism hypothesized to contribute to arthritic pain is ectopic nerve sprouting; however, neu...

journal_title：Arthritis research & therapy

authors： Jimenez-Andrade JM,Mantyh PW

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) antagonists reduce the signs and symptoms of spondyloarthritides, including ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Our objective was to evaluate the effectiveness and safety of adalimumab, 40 mg every other week, for patients with AS or PsA and prior treatmen...

journal_title：Arthritis research & therapy

authors： Rudwaleit M,Van den Bosch F,Kron M,Kary S,Kupper H

更新日期：2010-01-01 00:00:00

abstract：:The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the T...

journal_title：Arthritis research & therapy

authors： Gaffo AL,Saag KG

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

journal_title：Arthritis research & therapy

authors： Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Established rheumatoid arthritis (RA) patients display differentially expressed genes coding for cytokine/chemokine-mediated immunity compared to healthy controls. It is unclear, however, if in the pre-arthritis phase of clinically suspect arthralgia (CSA) expression of immune genes differ between patients w...

journal_title：Arthritis research & therapy

authors： Niemantsverdriet E,van den Akker EB,Boeters DM,van den Eeden SJF,Geluk A,van der Helm-van Mil AHM

更新日期：2020-11-09 00:00:00

abstract：INTRODUCTION:Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or...

journal_title：Arthritis research & therapy

authors： Sato M,Kuroda S,Mansjur KQ,Khaliunaa G,Nagata K,Horiuchi S,Inubushi T,Yamamura Y,Azuma M,Tanaka E

更新日期：2015-10-07 00:00:00

abstract：INTRODUCTION:Broad-range rDNA PCR provides an alternative, cultivation-independent approach for identifying bacterial DNA in reactive and other form of arthritis. The aim of this study was to use broad-range rDNA PCR targeting the 16S rRNA gene in patients with reactive and other forms of arthritis and to screen for th...

journal_title：Arthritis research & therapy

authors： Siala M,Gdoura R,Fourati H,Rihl M,Jaulhac B,Younes M,Sibilia J,Baklouti S,Bargaoui N,Sellami S,Sghir A,Hammami A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The immunoregulatory function of interleukin (IL)-29 has recently been recognized. However, little is known about the involvement of IL-29 in the pathogenesis of rheumatoid arthritis (RA). This study aimed to examine the expression profiles of IL-29 in blood, synovial fluid (SF) and synovium in RA patients...

journal_title：Arthritis research & therapy

authors： Wang F,Xu L,Feng X,Guo D,Tan W,Zhang M

更新日期：2012-10-19 00:00:00

abstract：INTRODUCTION:The purpose of this study was to examine the diagnostic performance of autoantibodies against citrullinated peptides/proteins (ACPA) and to determine the prevalence of HLA-DRB1 shared epitope alleles (SE) in African patients with rheumatoid arthritis (RA). METHODS:Serum levels of anti-cyclic citrullinated...

journal_title：Arthritis research & therapy

authors： Singwe-Ngandeu M,Finckh A,Bas S,Tiercy JM,Gabay C

更新日期：2010-01-01 00:00:00

abstract：:Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms (that is, autoimmune tautology). First, clinical evidence highlights the co-occurrence of distinct autoimmune...

journal_title：Arthritis research & therapy

authors： Anaya JM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weights). Besides the occupational factors, a number of individual risk factors are important. The dist...

journal_title：Arthritis research & therapy

authors： Klussmann A,Gebhardt H,Nübling M,Liebers F,Quirós Perea E,Cordier W,von Engelhardt LV,Schubert M,Dávid A,Bouillon B,Rieger MA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) has been known to be associated with increased risk of cardiovascular disease (CVD). The aim of this study was to investigate the effects of Tai Chi exercise on CVD risk in elderly women with RA. METHOD:In total, 56 female patients with RA were assigned to either a Tai Chi exercise...

journal_title：Arthritis research & therapy

authors： Shin JH,Lee Y,Kim SG,Choi BY,Lee HS,Bang SY

更新日期：2015-12-24 00:00:00

abstract：BACKGROUND:Interleukin-17A (IL-17A) plays a pathogenic role in several rheumatic diseases including spondyloarthritis and, paradoxically, has been described to both promote and protect from bone formation. We therefore examined the effects of IL-17A on osteoblast differentiation in vitro and on periosteal bone formatio...

journal_title：Arthritis research & therapy

authors： Shaw AT,Maeda Y,Gravallese EM

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma cell/plasmablast depletion mechanism by daratumumab in the treatment of patien...

journal_title：Arthritis research & therapy

authors： Cole S,Walsh A,Yin X,Wechalekar MD,Smith MD,Proudman SM,Veale DJ,Fearon U,Pitzalis C,Humby F,Bombardieri M,Axel A,Adams H 3rd,Chiu C,Sharp M,Alvarez J,Anderson I,Madakamutil L,Nagpal S,Guo Y

更新日期：2018-05-02 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived growth factor receptor (PDGFR) activation promote collagen I (Col I) production, leading to fibrosis in SSc. Lipoic acid (LA) and its active metabolite...

journal_title：Arthritis research & therapy

authors： Tsou PS,Balogh B,Pinney AJ,Zakhem G,Lozier A,Amin MA,Stinson WA,Schiopu E,Khanna D,Fox DA,Koch AE

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:To investigate the association between blood biomarkers and disease activity of Takayasu's arteritis (TAK) in a follow-up cohort. METHODS:Disease activity was assessed by clinical manifestations and repeated vascular Doppler examinations. The association between erythrocyte sedimentation rate (ESR), serum l...

journal_title：Arthritis research & therapy

authors： Li J,Wang Y,Wang Y,Wang Y,Yang Y,Zhao J,Li M,Tian X,Zeng X

更新日期：2020-12-10 00:00:00

abstract：INTRODUCTION:TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney. Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently intro...

journal_title：Arthritis research & therapy

authors： Schwartz N,Rubinstein T,Burkly LC,Collins CE,Blanco I,Su L,Hojaili B,Mackay M,Aranow C,Stohl W,Rovin BH,Michaelson JS,Putterman C

更新日期：2009-01-01 00:00:00

abstract：:Pegloticase is a powerful but underutilized weapon in the rheumatologist's armamentarium. The drug's immunogenicity leads to neutralizing antibody formation and rapid loss of efficacy in roughly one-half of all patients, which remains an impediment to broader use. New data, however, suggest that drug survival might im...

journal_title：Arthritis research & therapy

authors： Abeles AM

更新日期：2014-05-30 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential. We therefore examined the production of PGE2 in cultured growth plate chondr...

journal_title：Arthritis research & therapy

authors： Brochhausen C,Neuland P,Kirkpatrick CJ,Nüsing RM,Klaus G

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Dual-energy computed tomography (DECT) has potential for monitoring urate deposition in patients with gout. The aim of this prospective longitudinal study was to analyse measurement error of DECT urate volume measurement in clinically stable patients with tophaceous gout. METHODS:Seventy-three patients wi...

journal_title：Arthritis research & therapy

authors： Rajan A,Aati O,Kalluru R,Gamble GD,Horne A,Doyle AJ,McQueen FM,Dalbeth N

更新日期：2013-10-23 00:00:00

abstract：INTRODUCTION:miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The aim of this study is to identify a molecular target of miR-146a, thereby elucidating its function in chondrocytes during OA pathogenesis....

journal_title：Arthritis research & therapy

authors： Li J,Huang J,Dai L,Yu D,Chen Q,Zhang X,Dai K

更新日期：2012-04-16 00:00:00

abstract：:Chemokines play an essential role in the progression of rheumatoid arthritis (RA). In the present study we examined the expression and regulatory mechanisms of IFN-gamma inducible protein (IP)-10 in RA synovitis. RA synovial fluid contained greater amounts of IP-10 than did synovial fluid from patients with osteoarthr...

journal_title：Arthritis research & therapy

authors： Hanaoka R,Kasama T,Muramatsu M,Yajima N,Shiozawa F,Miwa Y,Negishi M,Ide H,Miyaoka H,Uchida H,Adachi M

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization have be...

journal_title：Arthritis research & therapy

authors： Roubille C,Raynauld JP,Abram F,Paiement P,Dorais M,Delorme P,Bessette L,Beaulieu AD,Martel-Pelletier J,Pelletier JP

更新日期：2014-12-14 00:00:00

abstract：BACKGROUND:Differences in the expression of variants across ethnic groups in the systemic lupus erythematosus (SLE) patients have been well documented. However, the genetic architecture in the Thai population has not been thoroughly examined. In this study, we carried out genome-wide association study (GWAS) in the Tha...

journal_title：Arthritis research & therapy

authors： Tangtanatakul P,Thumarat C,Satproedprai N,Kunhapan P,Chaiyasung T,Klinchanhom S,Wang YF,Wei W,Wongshinsri J,Chiewchengchol D,Rodsaward P,Ngamjanyaporn P,Suangtamai T,Mahasirimongkol S,Pisitkun P,Hirankarn N

更新日期：2020-08-08 00:00:00

abstract：:Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary gl...

journal_title：Arthritis research & therapy

authors： Scofield RH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4+ T cells of patients with early rheumatoid arthritis (RA) is associated with treatment response to synthetic disease-modifying antirheumatic drugs (DMARDs). This prompted us to study the...

journal_title：Arthritis research & therapy

authors： Kuuliala K,Kuuliala A,Koivuniemi R,Kautiainen H,Repo H,Leirisalo-Repo M

更新日期：2017-04-11 00:00:00