A novel mechanism for the regulation of IFN-gamma inducible protein-10 expression in rheumatoid arthritis.

abstract：INTRODUCTION:Notable weakness of the quadriceps muscles is typically observed as a consequence of knee joint arthritis, knee surgery and knee injury. This is partly due to ongoing neural inhibition that prevents the central nervous system from fully activating the quadriceps, a process known as arthrogenic muscle inhib...

journal_title：Arthritis research & therapy

authors： Rice DA,Graven-Nielsen T,Lewis GN,McNair PJ,Dalbeth N

更新日期：2015-08-12 00:00:00

abstract：:Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. The production of a variety ...

journal_title：Arthritis research & therapy

authors： Hirohata S,Kikuchi H

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Although rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persistence. To explore mechanisms underlying RA-persistence, we performed a candidate gene study. We hypo...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Ruyssen-Witrand A,Huizinga TW,Cantagrel A,Berenbaum F,van der Helm-van Mil AH

更新日期：2015-09-08 00:00:00

abstract：:Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect. ...

journal_title：Arthritis research & therapy

authors： Drivelegka P,Sigurdardottir V,Svärd A,Jacobsson LTH,Dehlin M

更新日期：2018-09-10 00:00:00

abstract：:Magnetic resonance imaging bone marrow edema is an imaging feature that has been described in many conditions, including osteomyelitis, overuse syndromes, avascular necrosis, trauma, and inflammatory arthritides. In rheumatoid arthritis (RA), bone edema has special significance as it has been shown to be a common and ...

journal_title：Arthritis research & therapy

authors： McQueen FM

更新日期：2012-09-28 00:00:00

abstract：INTRODUCTION:A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weights). Besides the occupational factors, a number of individual risk factors are important. The dist...

journal_title：Arthritis research & therapy

authors： Klussmann A,Gebhardt H,Nübling M,Liebers F,Quirós Perea E,Cordier W,von Engelhardt LV,Schubert M,Dávid A,Bouillon B,Rieger MA

更新日期：2010-01-01 00:00:00

abstract：:Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary gl...

journal_title：Arthritis research & therapy

authors： Scofield RH

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Nucleus pulposus (NP) cells have a phenotype similar to articular cartilage (AC) cells. However, the matrix of the NP is clearly different to that of AC suggesting that specific cell phenotypes exist. The aim of this study was to identify novel genes that could be used to distinguish bovine NP cells from A...

journal_title：Arthritis research & therapy

authors： Minogue BM,Richardson SM,Zeef LA,Freemont AJ,Hoyland JA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliorate progression of SSc-ILD. Data on everyday IS prescription patterns and clinical courses of lung fu...

journal_title：Arthritis research & therapy

authors： Adler S,Huscher D,Siegert E,Allanore Y,Czirják L,DelGaldo F,Denton CP,Distler O,Frerix M,Matucci-Cerinic M,Mueller-Ladner U,Tarner IH,Valentini G,Walker UA,Villiger PM,Riemekasten G,EUSTAR co-workers on behalf of the DeSS

更新日期：2018-01-30 00:00:00

abstract：INTRODUCTION:Angiogenesis plays a critical role in synovial inflammation and joint destruction in rheumatoid arthritis (RA). Vascular endothelial growth factor A (VEGF-A) and angiopoietins are two important mediators of synovial angiogenesis. We have previously developed a novel chimeric decoy receptor, namely, double-...

journal_title：Arthritis research & therapy

authors： Hah YS,Koh YJ,Lim HS,Kim HO,Cheon YH,Noh HS,Jang KY,Lee SY,Lee GM,Koh GY,Lee SI

更新日期：2013-08-14 00:00:00

abstract：BACKGROUND:Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allopurinol alone. Hence,...

journal_title：Arthritis research & therapy

authors： McWherter C,Choi YJ,Serrano RL,Mahata SK,Terkeltaub R,Liu-Bryan R

更新日期：2018-09-06 00:00:00

abstract：INTRODUCTION:Our objective was to examine the role of the janus-activated kinase (JAK) pathway in the modulation of tumor necrosis factor-α (TNF)-induced-IL-18 bioactivity by reduction of caspase-1 function. METHODS:Caspase-1 expression in rheumatoid arthritis (RA) synovial fibroblasts treated with TNF was assessed by...

journal_title：Arthritis research & therapy

authors： Marotte H,Tsou PS,Fedorova T,Pinney AJ,Lewis B,Koch AE

更新日期：2014-04-24 00:00:00

abstract：:It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of th...

journal_title：Arthritis research & therapy

authors： Sherlock JP,Filer AD,Isaacs JD,Buckley CD

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED), which can lead to functional and morphological vascular abnormalities. Several non-invasive assessments of vascular function and morp...

journal_title：Arthritis research & therapy

authors： Sandoo A,Hodson J,Douglas KM,Smith JP,Kitas GD

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients w...

journal_title：Arthritis research & therapy

authors： Klingberg E,Magnusson MK,Strid H,Deminger A,Ståhl A,Sundin J,Simrén M,Carlsten H,Öhman L,Forsblad-d'Elia H

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). METHODS:Peripheral blood from 42 GPA patients in remission and 29 age-matched healthy controls (HCs) were stimulated in vitro, and the frequencies of IL-21 p...

journal_title：Arthritis research & therapy

authors： Abdulahad WH,Lepse N,Stegeman CA,Huitema MG,Doornbos-van der Meer B,Tadema H,Rutgers A,Limburg PC,Kallenberg CG,Heeringa P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies. OBJECTIVE:To investigate FOI for treatment monitoring in a homogenous cohort of patients with early (disease duration < 2 years) and active ...

journal_title：Arthritis research & therapy

authors： Glimm AM,Sprenger LI,Haugen IK,Mansmann U,Hermann S,Häupl T,Hoff P,Burmester GR,Backhaus M,Le L,Ohrndorf S

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Stem cell therapy is considered as a promising alternative to treat intervertebral disc degeneration (IDD). Extensive work had been done on identifying and comparing different types of candidate stem cells, both in vivo and in vitro. However, few studies have shed light on degenerative nucleus pulposus cells...

journal_title：Arthritis research & therapy

authors： Han Z,Wang J,Gao L,Wang Q,Wu J

更新日期：2018-08-16 00:00:00

abstract：INTRODUCTION:We performed a systematic review of prognostic factors for the progression of symptomatic knee osteoarthritis (OA), defined as increase in pain, decline in physical function or total joint replacement. METHOD:We searched for available observational studies up to January 2015 in Medline and Embase accordin...

journal_title：Arthritis research & therapy

authors： Bastick AN,Runhaar J,Belo JN,Bierma-Zeinstra SM

更新日期：2015-06-08 00:00:00

abstract：:Synovial biomarker analysis in rheumatoid arthritis can be used to evaluate drug effect in clinical trials of novel therapeutic agents. Previous studies of synovial gene expression for these studies have mainly relied on histological methods including immunohistochemistry and in situ hybridization. To increase the rel...

journal_title：Arthritis research & therapy

authors： Boyle DL,Rosengren S,Bugbee W,Kavanaugh A,Firestein GS

更新日期：2003-01-01 00:00:00

abstract：:The field of biomarkers is a growing one, particularly in osteoarthritis (OA). OA is the most common disabling condition in older persons and a major cause of morbidity. While the debate continues about which of the involved tissues--cartilage, bone or synovium--is the most important in OA aetiology, there is no doubt...

journal_title：Arthritis research & therapy

authors： Williams FM

更新日期：2009-01-01 00:00:00

abstract：:The accumulation of T cells in the synovial membrane is the crucial step in the pathophysiology of the inflammatory processes characterizing juvenile idiopathic arthritis (JIA). In this study, we evaluated the expression and the pathogenetic role in oligoarticular JIA of a CXC chemokine involved in the directional mig...

journal_title：Arthritis research & therapy

authors： Martini G,Zulian F,Calabrese F,Bortoli M,Facco M,Cabrelle A,Valente M,Zacchello F,Agostini C

更新日期：2005-01-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is an immunosuppressant drug being used for induction and maintenance of remission of lupus nephritis in systemic lupus erythematosus. Evidence about its use was sought from full publications and abstracts of randomised trials and cohort studies by using a variety of search strategies. Effi...

journal_title：Arthritis research & therapy

authors： Moore RA,Derry S

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or...

journal_title：Arthritis research & therapy

authors： Sato M,Kuroda S,Mansjur KQ,Khaliunaa G,Nagata K,Horiuchi S,Inubushi T,Yamamura Y,Azuma M,Tanaka E

更新日期：2015-10-07 00:00:00

abstract：:Adverse events of opioids may restrict their use in non-cancer pain. Analysis of the incidence of common adverse events in trials conducted in non-cancer pain has usually been limited to opioids used to treat severe pain according to the WHO three-step ladder. To examine the incidence of common adverse events of opioi...

journal_title：Arthritis research & therapy

authors： Moore RA,McQuay HJ

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Rheumatic diseases are among the most common and debilitating health problems in the United States. These diseases are chronic, can result in severe decrements of physical and psychosocial functioning and affect patients' overall quality of life. A consensus regarding the best patient outcomes to be measur...

journal_title：Arthritis research & therapy

authors： Wallen GR,Middleton KR,Rivera-Goba MV,Mittleman BB

更新日期：2011-01-05 00:00:00

abstract：INTRODUCTION:High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor of joint damage and persistent disease activity. Survivin-positive patients are often poor responders to antirheumatic and biological treatment. The ai...

journal_title：Arthritis research & therapy

authors： Svensson B,Hafström I,Erlandsson MC,Forslind K,Bokarewa MI

更新日期：2014-01-16 00:00:00

abstract：INTRODUCTION:Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the frequency of MFC in the renal tissue of patients with LN. METHODS:Twenty-seven renal biopsies we...

journal_title：Arthritis research & therapy

authors： Florim GM,Caldas HC,de Melo JC,Baptista MA,Fernandes IM,Savoldi-Barbosa M,Goldman GH,Abbud-Filho M

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Lack of adequate self-care, frequent admissions, and poor quality of life are common and serious problems in adult patients with systemic lupus erythematosus (SLE). Some studies have revealed that transitional care is effective in improving self-care and quality of life as well as reducing rehospitalization ...

journal_title：Arthritis research & therapy

authors： Xie X,Song Y,Yang H,Nie A,Chen H,Li JP

更新日期：2018-08-16 00:00:00

abstract：:Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review ...

journal_title：Arthritis research & therapy

authors： Ramiro S,Machado P,Singh JA,Landewé RB,da Silva JA

更新日期：2010-01-01 00:00:00