IL-21 and Sjögren's syndrome.

abstract：BACKGROUND:Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. SKG mice develop not only arthritis but also an ILD resembling RA-ILD. We previously reported that tofacitinib, a JAK inhibitor, facilitates the expansion of myeloid-derived suppres...

journal_title：Arthritis research & therapy

authors： Sendo S,Saegusa J,Yamada H,Nishimura K,Morinobu A

更新日期：2019-08-06 00:00:00

abstract：:miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors. S...

journal_title：Arthritis research & therapy

authors： Luo X,Ranade K,Talker R,Jallal B,Shen N,Yao Y

更新日期：2013-04-09 00:00:00

abstract：:Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in...

journal_title：Arthritis research & therapy

authors： Krane SM

更新日期：2003-01-01 00:00:00

abstract：:Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest p...

journal_title：Arthritis research & therapy

authors： Wang LJ,Zeng N,Yan ZP,Li JT,Ni GX

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macrophages in the synovium. In the present study, we set out to investigate the impact of TLR stimulation ...

journal_title：Arthritis research & therapy

authors： Quero L,Hanser E,Manigold T,Tiaden AN,Kyburz D

更新日期：2017-11-02 00:00:00

abstract：:Recent genome-wide association studies have implicated the tumor necrosis factor receptor-associated factor 3-interacting protein 2 (TRAF3IP2) gene and its product, nuclear factor-kappa-B activator 1 (Act1), in the development of psoriatic arthritis (PsA). The high level of sequence homology of the TRAF3IP2 (Act1) gen...

journal_title：Arthritis research & therapy

authors： Doyle MS,Collins ES,FitzGerald OM,Pennington SR

更新日期：2012-10-31 00:00:00

abstract：INTRODUCTION:Enhanced B cell activity, particularly memory B cells have gained interest in evaluating response during therapies with biologics. CD27-IgD- double-negative (DN) B cells lacking the conventional memory marker CD27 are reported to be part of the memory compartment, however, only scarce data is available for...

journal_title：Arthritis research & therapy

authors： Mahmood Z,Muhammad K,Schmalzing M,Roll P,Dörner T,Tony HP

更新日期：2015-03-14 00:00:00

abstract：:Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the s...

journal_title：Arthritis research & therapy

authors： Buskila D,Sarzi-Puttini P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Brain-derived neurotrophic factor (BDNF) was first identified in the intervertebral disc (IVD) when its molecular upregulation was observed in sections of nucleus pulposus cultured under conditions of increased osmolarity. BDNF is now known to be involved in a number of biologic functions, including regula...

journal_title：Arthritis research & therapy

authors： Gruber HE,Ingram JA,Hoelscher G,Zinchenko N,Norton HJ,Hanley EN Jr

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) frequently involves the loss of tolerance to citrullinated antigens, which may play a role in pathogenicity. Citrullinated fibrinogen is commonly found in inflamed synovial tissue and is a frequent target of autoantibodies in RA patients. To obtain insight into the B-cell response...

journal_title：Arthritis research & therapy

authors： van Beers JJ,Raijmakers R,Alexander LE,Stammen-Vogelzangs J,Lokate AM,Heck AJ,Schasfoort RB,Pruijn GJ

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The Vβ12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) β-chain and consequently displays an ...

journal_title：Arthritis research & therapy

authors： Merky P,Batsalova T,Bockermann R,Dzhambazov B,Sehnert B,Burkhardt H,Bäcklund J

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders. METHODS:RNA microarray analyses (Agilent Human 1A(V2) 20K oligo arrays) were used to quantify gene ex...

journal_title：Arthritis research & therapy

authors： O'Hanlon TP,Rider LG,Gan L,Fannin R,Paules RS,Umbach DM,Weinberg CR,Shah RR,Mav D,Gourley MF,Miller FW

更新日期：2011-04-26 00:00:00

abstract：INTRODUCTION:High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor of joint damage and persistent disease activity. Survivin-positive patients are often poor responders to antirheumatic and biological treatment. The ai...

journal_title：Arthritis research & therapy

authors： Svensson B,Hafström I,Erlandsson MC,Forslind K,Bokarewa MI

更新日期：2014-01-16 00:00:00

abstract：INTRODUCTION:Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. METHODS:In total, 394 older men and women (mean age, 63 years; range, 52 ...

journal_title：Arthritis research & therapy

authors： Doré D,de Hoog J,Giles G,Ding C,Cicuttini F,Jones G

更新日期：2012-01-18 00:00:00

abstract：BACKGROUND:Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD:Assessm...

journal_title：Arthritis research & therapy

authors： Coates LC,Wallman JK,McGonagle D,Schett GA,McInnes IB,Mease PJ,Rasouliyan L,Quebe-Fehling E,Asquith DL,Fasth AER,Pricop L,Gaillez C

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients w...

journal_title：Arthritis research & therapy

authors： Klingberg E,Magnusson MK,Strid H,Deminger A,Ståhl A,Sundin J,Simrén M,Carlsten H,Öhman L,Forsblad-d'Elia H

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines.We have observed that sera from rheumatoid arthritis (RA) patients recogniz...

journal_title：Arthritis research & therapy

authors： Charpin C,Martin M,Balandraud N,Roudier J,Auger I

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that is activated in the synovium in rheumatoid arthritis (RA) and promotes expression of various matrix metalloproteinases. In this study, we examined whether C/EBPβ mediates the expression of receptor activator of nuclear factor-kappa-B ...

journal_title：Arthritis research & therapy

authors： Tsushima H,Okazaki K,Ishihara K,Ushijima T,Iwamoto Y

更新日期：2015-02-17 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PC...

journal_title：Arthritis research & therapy

authors： Hutcheson J,Vanarsa K,Bashmakov A,Grewal S,Sajitharan D,Chang BY,Buggy JJ,Zhou XJ,Du Y,Satterthwaite AB,Mohan C

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is a part of the compensatory response that maintains the necessary resident nucleus pulposus (NP) cell proliferation to repla...

journal_title：Arthritis research & therapy

authors： Long J,Wang X,Du X,Pan H,Wang J,Li Z,Liu H,Li X,Zheng Z

更新日期：2019-10-16 00:00:00

abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

journal_title：Arthritis research & therapy

authors： Betteridge ZE,Gunawardena H,McHugh NJ

更新日期：2011-03-18 00:00:00

abstract：INTRODUCTION:There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island people have higher serum urate and more severe gout than European people. The aim of this study w...

journal_title：Arthritis research & therapy

authors： Flynn TJ,Phipps-Green A,Hollis-Moffatt JE,Merriman ME,Topless R,Montgomery G,Chapman B,Stamp LK,Dalbeth N,Merriman TR

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. METHODS:Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy co...

journal_title：Arthritis research & therapy

authors： Pleštilová L,Mann H,Andrés Cerezo L,Pecha O,Vencovský J,Šenolt L

更新日期：2014-10-31 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche in the RA synovium could adversely affect MSC function. This study was designed to investigate biologic and immunologic properties of synovium-derived MSCs (SMSCs) in RA, with partic...

journal_title：Arthritis research & therapy

authors： Zhang Z,Ding Y,Li W,Song B,Yang R

更新日期：2013-10-29 00:00:00

abstract：INTRODUCTION:Recent advances suggest that the cellular redox state may play a significant role in the progression of fibrosis in systemic sclerosis (SSc). Another, and as yet poorly accounted for, feature of SSc is its overlap with thyroid abnormalities. Previous reports demonstrate that hypothyroidism reduces oxidant ...

journal_title：Arthritis research & therapy

authors： Bagnato G,Bitto A,Irrera N,Pizzino G,Sangari D,Cinquegrani M,Roberts W,Atteritano M,Altavilla D,Squadrito F,Bagnato G,Saitta A

更新日期：2013-09-16 00:00:00

abstract：:TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients suffer from periodic bouts of severe abdominal pain, localised inflammation, migratory rashes, and fever. More than 40 individual mutations have been identified,...

journal_title：Arthritis research & therapy

authors： Kimberley FC,Lobito AA,Siegel RM,Screaton GR

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The high-affinity receptor for IgG Fcgamma/CD64 is critical for the development of lupus nephritis (LN). Cross-linking Fc receptor on recruited monocytes by IgG-containing immune complexes is a key step in immune-complex-mediated nephritis in systemic lupus erythematosus (SLE). The goal of this study was t...

journal_title：Arthritis research & therapy

authors： Li Y,Lee PY,Sobel ES,Narain S,Satoh M,Segal MS,Reeves WH,Richards HB

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement ('hypocomplementaemia') is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosis (SSc) is unknown. We sought to determine the frequency, clinical associations and relationship to ...

journal_title：Arthritis research & therapy

authors： Esposito J,Brown Z,Stevens W,Sahhar J,Rabusa C,Zochling J,Roddy J,Walker J,Proudman SM,Nikpour M

更新日期：2016-10-22 00:00:00

abstract：:Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial h...

journal_title：Arthritis research & therapy

authors： Bauer K,Knipper A,Tu-Rapp H,Koczan D,Kreutzer HJ,Nizze H,Mix E,Thiesen HJ,Holmdahl R,Ibrahim SM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. METHODS:Peripheral blood mononuclear cells from healthy donors were incubated with different JAKis, levels of phosphorylated signal transd...

journal_title：Arthritis research & therapy

authors： McInnes IB,Byers NL,Higgs RE,Lee J,Macias WL,Na S,Ortmann RA,Rocha G,Rooney TP,Wehrman T,Zhang X,Zuckerman SH,Taylor PC

更新日期：2019-08-02 00:00:00