Post-traumatic osteoarthritis following ACL injury.

Abstract:

:Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest possible mechanisms thought to be responsible for PTOA, evaluate current diagnostic methods for detecting early OA, and discuss potential interventions to combat PTOA. We also identify important directions for future research. Although much work has been done, the incidence of PTOA among patients with a history of ACL injury remains high due to the complexity of ACL injury progression to PTOA, the lack of sensitive and easily accessible diagnostic methods to detect OA development, and the limitations of current treatments. A number of factors are thought to be involved in the underlying mechanism, including structural factors, biological factors, mechanical factors, and neuromuscular factor. Since there is a clear "start point" for PTOA, early detection and intervention is of great importance. Currently, imaging modalities and specific biomarkers allow early detection of PTOA. However, none of them is both sensitive and easily accessible. After ACL injury, many patients undergo surgical reconstruction of ACL to restore joint stability and prevent excessive loading. However, convincing evidence is still lacking for the superiority of ACL-R to conservative management in term of the incidence of PTOA. As for non-surgical treatment such as anti-cytokine and chemokine interventions, most of them are investigated in animal studies and have not been applied to humans. A complete understanding of mechanisms to stratify the patients into different subgroups on the basis of risk factors is critical. And the improvement of standardized and quantitative assessment techniques is necessary to guide intervention. Moreover, treatments targeted toward different pathogenic pathways may be crucial to the management of PTOA in the future.

journal_name

Arthritis Res Ther

authors

Wang LJ,Zeng N,Yan ZP,Li JT,Ni GX

doi

10.1186/s13075-020-02156-5

subject

Has Abstract

pub_date

2020-03-24 00:00:00

pages

57

issue

1

eissn

1478-6354

issn

1478-6362

pii

10.1186/s13075-020-02156-5

journal_volume

22

pub_type

杂志文章,评审
  • Children with oligoarticular juvenile idiopathic arthritis have skewed synovial monocyte polarization pattern with functional impairment-a distinct inflammatory pattern for oligoarticular juvenile arthritis.

    abstract:BACKGROUND:Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JI...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02279-9

    authors: Schmidt T,Berthold E,Arve-Butler S,Gullstrand B,Mossberg A,Kahn F,Bengtsson AA,Månsson B,Kahn R

    更新日期:2020-08-12 00:00:00

  • IgG anti-hinge antibodies against IgG4 F(ab')2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes.

    abstract:BACKGROUND:Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region at different sites. Moreover,...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02251-7

    authors: Ota T,Ota SI,Uchino A,Nagano S

    更新日期:2020-06-26 00:00:00

  • Blocking the janus-activated kinase pathway reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity by caspase-1 inhibition.

    abstract:INTRODUCTION:Our objective was to examine the role of the janus-activated kinase (JAK) pathway in the modulation of tumor necrosis factor-α (TNF)-induced-IL-18 bioactivity by reduction of caspase-1 function. METHODS:Caspase-1 expression in rheumatoid arthritis (RA) synovial fibroblasts treated with TNF was assessed by...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4551

    authors: Marotte H,Tsou PS,Fedorova T,Pinney AJ,Lewis B,Koch AE

    更新日期:2014-04-24 00:00:00

  • Incorporating assessment of the cervical facet joints in the modified Stoke ankylosing spondylitis spine score is of additional value in the evaluation of spinal radiographic outcome in ankylosing spondylitis.

    abstract:BACKGROUND:To aim was to investigate the additional value of incorporating the de Vlam cervical facet joint score in the modified ankylosing spondylitis (AS) spine score (mSASSS) for the evaluation of spinal radiographic outcome in AS. METHOD:Baseline and 4-year radiographs from 98 consecutive patients from the Gronin...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-017-1285-1

    authors: Maas F,Arends S,Brouwer E,Bootsma H,Bos R,Wink FR,Spoorenberg A

    更新日期:2017-04-26 00:00:00

  • Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis.

    abstract:INTRODUCTION:We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines ye...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3237

    authors: Kokkonen H,Mullazehi M,Berglin E,Hallmans G,Wadell G,Rönnelid J,Rantapää-Dahlqvist S

    更新日期:2011-02-03 00:00:00

  • Interleukin-32 in systemic sclerosis, a potential new biomarker for pulmonary arterial hypertension.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great v...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02218-8

    authors: Di Benedetto P,Guggino G,Manzi G,Ruscitti P,Berardicurti O,Panzera N,Grazia N,Badagliacca R,Riccieri V,Vizza CD,Radchenko G,Liakouli V,Ciccia F,Cipriani P,Giacomelli R

    更新日期:2020-06-01 00:00:00

  • Perspectives on epigenetic-based immune intervention for rheumatic diseases.

    abstract::Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lupus erythematosus an...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar4167

    authors: Gray SG

    更新日期:2013-03-14 00:00:00

  • Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial.

    abstract:INTRODUCTION:The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading. METHODS:Thirty-one female subjects with OA ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/ar3064

    authors: Helmark IC,Mikkelsen UR,Børglum J,Rothe A,Petersen MC,Andersen O,Langberg H,Kjaer M

    更新日期:2010-01-01 00:00:00

  • Fetal microchimerism in kidney biopsies of lupus nephritis patients may be associated with a beneficial effect.

    abstract:INTRODUCTION:Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the frequency of MFC in the renal tissue of patients with LN. METHODS:Twenty-seven renal biopsies we...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-015-0615-4

    authors: Florim GM,Caldas HC,de Melo JC,Baptista MA,Fernandes IM,Savoldi-Barbosa M,Goldman GH,Abbud-Filho M

    更新日期:2015-04-15 00:00:00

  • Spondyloarthritis Research Consortium of Canada sacroiliac joint inflammation and structural scores: change score reliability and recalibration utility in children.

    abstract:BACKGROUND:The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibration modules for the SIS and SSS and the reliability of their component change scores. METHODS:Chang...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02157-4

    authors: Weiss PF,Maksymowych WP,Xiao R,Biko DM,Francavilla ML,Lambert RG,Jaremko JL,Heshin-Bekenstein M,Brandon TG,Chauvin NA

    更新日期:2020-03-24 00:00:00

  • Treatment of Muckle-Wells syndrome: analysis of two IL-1-blocking regimens.

    abstract:OBJECTIVES:Muckle-Wells syndrome (MWS) is an autoinflammatory disease characterized by excessive interleukin-1 (IL-1) release, resulting in recurrent fevers, sensorineural hearing loss, and amyloidosis. IL-1 inhibition with anakinra, an IL-1 receptor antagonist, improves clinical symptoms and inflammatory markers. Subc...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4237

    authors: Kuemmerle-Deschner JB,Wittkowski H,Tyrrell PN,Koetter I,Lohse P,Ummenhofer K,Reess F,Hansmann S,Koitschev A,Deuter C,Bialkowski A,Foell D,Benseler SM

    更新日期:2013-01-01 00:00:00

  • Ultrasound of the hand is sufficient to detect subclinical inflammation in rheumatoid arthritis remission: a post hoc longitudinal study.

    abstract:BACKGROUND:Ultrasound (US) is a sensitive method for detecting joint/tendon inflammation in patients with rheumatoid arthritis (RA). Subclinical inflammation is often found in patients with RA in composite score remission. The purpose of the present study was to explore whether US of only the hands is sufficient to ide...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-017-1428-4

    authors: Hammer HB,Kvien TK,Terslev L

    更新日期:2017-10-04 00:00:00

  • Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus.

    abstract::Systematic lupus erythematosus (SLE) is a complex disease for which molecular diagnostics are limited and pathogenesis is not clearly understood. Important information is provided in this regard by identification and characterization of more specific molecular and cellular targets in SLE immune cells and target tissue...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar3701

    authors: Korte EA,Gaffney PM,Powell DW

    更新日期:2012-02-20 00:00:00

  • Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia.

    abstract:BACKGROUND:This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON). METHODS:Twenty-four female patients with FMS (54 ± 8 years) and 27 female CON (54 ± 9 years) were subjected to ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s13075-016-1041-y

    authors: Ernberg M,Christidis N,Ghafouri B,Bileviciute-Ljungar I,Löfgren M,Larsson A,Palstam A,Bjersing J,Mannerkorpi K,Kosek E,Gerdle B

    更新日期:2016-06-13 00:00:00

  • Mechanisms of tissue injury in lupus nephritis.

    abstract::Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occu...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar3528

    authors: Nowling TK,Gilkeson GS

    更新日期:2011-01-01 00:00:00

  • C/EBP homologous protein drives pro-catabolic responses in chondrocytes.

    abstract:INTRODUCTION:Excess C/EBP homologous protein (CHOP) expression is one feature of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress. Here, we focused on CHOP expression and function in chondrocytes. METHODS:We studied human knee osteoarthritis (OA) cartilage, bovine chondrocytes cultured in algin...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar4415

    authors: Husa M,Petursson F,Lotz M,Terkeltaub R,Liu-Bryan R

    更新日期:2013-01-01 00:00:00

  • A novel DNA/histone H4 peptide complex detects autoantibodies in systemic lupus erythematosus sera.

    abstract:BACKGROUND:The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (Crithidia Luciliae immunofluorescence test (CLIFT)). To overcom...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-016-1117-8

    authors: Panza F,Alcaro MC,Petrelli F,Angelotti F,Pratesi F,Rovero P,Migliorini P

    更新日期:2016-10-04 00:00:00

  • Secukinumab efficacy on resolution of enthesitis in psoriatic arthritis: pooled analysis of two phase 3 studies.

    abstract:BACKGROUND:Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD:Assessm...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s13075-019-2055-z

    authors: Coates LC,Wallman JK,McGonagle D,Schett GA,McInnes IB,Mease PJ,Rasouliyan L,Quebe-Fehling E,Asquith DL,Fasth AER,Pricop L,Gaillez C

    更新日期:2019-12-04 00:00:00

  • The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression.

    abstract:BACKGROUND:Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor, anti-citrullinated protein antibodies, and bone erosions. Current therapies can compromise immunity, leading to risk of infection. The interleukin-20 receptor (IL-20R) axis comprising IL-19, IL-20, and IL-24 and their shar...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s13075-016-0964-7

    authors: Kragstrup TW,Greisen SR,Nielsen MA,Rhodes C,Stengaard-Pedersen K,Hetland ML,Hørslev-Petersen K,Junker P,Østergaard M,Hvid M,Vorup-Jensen T,Robinson WH,Sokolove J,Deleuran B

    更新日期:2016-03-11 00:00:00

  • A subset of CD163+ macrophages displays mixed polarizations in discoid lupus skin.

    abstract:INTRODUCTION:Lesional skin of patients with discoid lupus erythematosus (DLE) contains macrophages, whose polarization has yet to be investigated. To test our hypothesis that M1 macrophages would be increased in DLE skin, we examined transcriptome alterations in immune cell gene expression and macrophage features in DL...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-015-0839-3

    authors: Chong BF,Tseng LC,Hosler GA,Teske NM,Zhang S,Karp DR,Olsen NJ,Mohan C

    更新日期:2015-11-13 00:00:00

  • The metastasis promoting protein S100A4 levels associate with disease activity rather than cancer development in patients with idiopathic inflammatory myopathies.

    abstract:INTRODUCTION:The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. METHODS:Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy co...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-014-0468-2

    authors: Pleštilová L,Mann H,Andrés Cerezo L,Pecha O,Vencovský J,Šenolt L

    更新日期:2014-10-31 00:00:00

  • The role and clinical implications of G6PI in experimental models of rheumatoid arthritis.

    abstract::The antigens that trigger the pathogenic immune response in rheumatoid arthritis (RA) remain unknown. Until recently it was assumed that either viral or microbial antigens, or joint-specific antigens were the target of arthritogenic T and B lymphocytes in RA. Consequently, murine models of arthritis are induced by imm...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar1476

    authors: Kamradt T,Schubert D

    更新日期:2005-01-01 00:00:00

  • Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection.

    abstract:INTRODUCTION:Intraarticular administration of autologous conditioned serum (ACS) recently demonstrated some clinical effectiveness in treatment of osteoarthritis (OA). The current study aims to evaluate the in vitro effects of ACS on cartilage proteoglycan (PG) metabolism, its composition and the effects on synovial fl...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3050

    authors: Rutgers M,Saris DB,Dhert WJ,Creemers LB

    更新日期:2010-01-01 00:00:00

  • Work outcome in yet undiagnosed patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis; results of a cross-sectional study among patients with chronic low back pain.

    abstract:BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-017-1333-x

    authors: van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

    更新日期:2017-06-17 00:00:00

  • Abnormalities of T cell signaling in systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/ar3251

    authors: Moulton VR,Tsokos GC

    更新日期:2011-03-17 00:00:00

  • Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ--prostaglandin E2 dependent proliferation of growth plate chondrocytes.

    abstract::Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential. We therefore examined the production of PGE2 in cultured growth plate chondr...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar1948

    authors: Brochhausen C,Neuland P,Kirkpatrick CJ,Nüsing RM,Klaus G

    更新日期:2006-01-01 00:00:00

  • Sensory and sympathetic nerve fibers undergo sprouting and neuroma formation in the painful arthritic joint of geriatric mice.

    abstract:INTRODUCTION:Although the prevalence of arthritis dramatically increases with age, the great majority of preclinical studies concerning the mechanisms that drive arthritic joint pain have been performed in young animals. One mechanism hypothesized to contribute to arthritic pain is ectopic nerve sprouting; however, neu...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3826

    authors: Jimenez-Andrade JM,Mantyh PW

    更新日期:2012-05-01 00:00:00

  • Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis.

    abstract:INTRODUCTION:Rational selection of disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA) has many potential advantages, including rapid disease control, reduced long-term disability and reduced overall cost to the healthcare system. Inter-individual genetic differences are particularly at...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3911

    authors: Wiese MD,Schnabl M,O'Doherty C,Spargo LD,Sorich MJ,Cleland LG,Proudman SM

    更新日期:2012-07-12 00:00:00

  • Individual and occupational risk factors for knee osteoarthritis: results of a case-control study in Germany.

    abstract:INTRODUCTION:A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weights). Besides the occupational factors, a number of individual risk factors are important. The dist...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/ar3015

    authors: Klussmann A,Gebhardt H,Nübling M,Liebers F,Quirós Perea E,Cordier W,von Engelhardt LV,Schubert M,Dávid A,Bouillon B,Rieger MA

    更新日期:2010-01-01 00:00:00

  • Smoking, body mass index, disease activity, and the risk of rapid radiographic progression in patients with early rheumatoid arthritis.

    abstract:BACKGROUND:Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characte...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-018-1575-2

    authors: Rydell E,Forslind K,Nilsson JÅ,Jacobsson LTH,Turesson C

    更新日期:2018-05-02 00:00:00