Elucidation of the potential roles of matrix metalloproteinases in skeletal biology.

Abstract:

:Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in proteolysis of joint collagens in arthritis. These approaches include identifying spontaneous genetic disorders of the enzymes and substrates in humans and animals, as well as engineering mutations in the genes that encode these proteins in mice. Insights gained from such studies can be used to design new therapies to interrupt these catabolic events.

journal_name

Arthritis Res Ther

authors

Krane SM

doi

10.1186/ar600

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

2-4

issue

1

eissn

1478-6354

issn

1478-6362

journal_volume

5

pub_type

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