microRNA-mediated regulation of innate immune response in rheumatic diseases.

abstract：:Macrophage activation syndrome (MAS) has been reported in association with many rheumatic diseases, most commonly in systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is similar to hemophagocytic lymphohistiocytosis (HLH), a genetic disorder with absent or depressed natural killer (NK) function. We have p...

journal_title：Arthritis research & therapy

authors： Villanueva J,Lee S,Giannini EH,Graham TB,Passo MH,Filipovich A,Grom AA

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthritis. Cytokine-induced JNK activation is strictly dependent on the mitogen-activated protein kinase ...

journal_title：Arthritis research & therapy

authors： Lee SI,Boyle DL,Berdeja A,Firestein GS

更新日期：2012-02-21 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselecte...

journal_title：Arthritis research & therapy

authors： Reiseter S,Molberg Ø,Gunnarsson R,Lund MB,Aalokken TM,Aukrust P,Ueland T,Garen T,Brunborg C,Michelsen A,Abraityte A,Hoffmann-Vold AM

更新日期：2015-08-28 00:00:00

abstract：INTRODUCTION:Cell therapy is a rapidly growing area of research for the treatment of osteoarthritis (OA). This work is aimed to investigate the efficacy of intra-articular adipose-derived stromal cell (ASC) injection in the healing process on cartilage, synovial membrane and menisci in an experimental rabbit model. ME...

journal_title：Arthritis research & therapy

authors： Desando G,Cavallo C,Sartoni F,Martini L,Parrilli A,Veronesi F,Fini M,Giardino R,Facchini A,Grigolo B

更新日期：2013-01-29 00:00:00

abstract：:Collagen-induced arthritis (CIA) is a chronic inflammatory disease bearing all the hallmarks of rheumatoid arthritis, e.g. polyarthritis, synovitis, and subsequent cartilage/bone erosions. One feature of the disease contributing to joint damage is synovial hyperplasia. The factors responsible for the hyperplasia are u...

journal_title：Arthritis research & therapy

authors： Tu-Rapp H,Hammermüller A,Mix E,Kreutzer HJ,Goerlich R,Köhler H,Nizze H,Thiesen HJ,Ibrahim SM

更新日期：2004-01-01 00:00:00

abstract：:Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding ...

journal_title：Arthritis research & therapy

authors： Youinou P,Putterman C

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS:Fort...

journal_title：Arthritis research & therapy

authors： Vacca A,Montisci R,Garau P,Siotto P,Piga M,Cauli A,Ruscazio M,Meloni L,Iliceto S,Mathieu A

更新日期：2013-01-09 00:00:00

abstract：:Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate the disease. Despite...

journal_title：Arthritis research & therapy

authors： Koike T

更新日期：2011-05-31 00:00:00

abstract：INTRODUCTION:Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a conti...

journal_title：Arthritis research & therapy

authors： Teichtahl AJ,Urquhart DM,Wang Y,Wluka AE,Heritier S,Cicuttini FM

更新日期：2015-10-23 00:00:00

abstract：:Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/BxN mice, although some groups have reported that few healthy humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) is genetically regulated and has strong implications for the development of...

journal_title：Arthritis research & therapy

authors： Matsumoto I,Zhang H,Muraki Y,Hayashi T,Yasukochi T,Kori Y,Goto D,Ito S,Tsutsumi A,Sumida T

更新日期：2005-01-01 00:00:00

abstract：:Glucocorticoids have successfully been used in the treatment of rheumatoid arthritis. Data suggest that 7alpha-hydroxy-dehydroepiandrosterone (7alpha-OH-DHEA), an immunostimulating metabolite of dehydroepiandrosterone, can block glucocorticoid-induced immune suppression. Formation of 7alpha-OH-DHEA is catalyzed by act...

journal_title：Arthritis research & therapy

authors： Dulos J,Kaptein A,Kavelaars A,Heijnen C,Boots A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the treatment response to RA. This study aimed to examine the relationship between the extent of PD and t...

journal_title：Arthritis research & therapy

authors： Tachibana M,Yonemoto Y,Okamura K,Suto T,Sakane H,Kaneko T,Dam TT,Okura C,Tajika T,Tsushima Y,Chikuda H

更新日期：2020-07-25 00:00:00

abstract：INTRODUCTION:An adjuvanted pandemic H1N1 influenza (pH1N1) vaccine (Pandemrix) was reported as highly immunogenic resulting in seroconversion in 77 to 94% of adults after administration of a single dose. The aim of the study was to investigate the impact of different anti-rheumatic treatments on antibody response to pH...

journal_title：Arthritis research & therapy

authors： Kapetanovic MC,Kristensen LE,Saxne T,Aktas T,Mörner A,Geborek P

更新日期：2014-01-02 00:00:00

abstract：:Antineutrophil antibodies are well recognized causes of neutropenia, producing both quantitative and qualitative defects in neutrophils and increased risk for infection. In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious in...

journal_title：Arthritis research & therapy

authors： Capsoni F,Sarzi-Puttini P,Zanella A

更新日期：2005-01-01 00:00:00

abstract：:Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification...

journal_title：Arthritis research & therapy

authors： MacMullan PA,McCarthy GM

更新日期：2010-01-01 00:00:00

abstract：:Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical assessment of signaling status has made it difficult to evaluate putative abnormalities completely using primary ...

journal_title：Arthritis research & therapy

authors： Grammer AC,Fischer R,Lee O,Zhang X,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：:Recent genome-wide association studies have implicated the tumor necrosis factor receptor-associated factor 3-interacting protein 2 (TRAF3IP2) gene and its product, nuclear factor-kappa-B activator 1 (Act1), in the development of psoriatic arthritis (PsA). The high level of sequence homology of the TRAF3IP2 (Act1) gen...

journal_title：Arthritis research & therapy

authors： Doyle MS,Collins ES,FitzGerald OM,Pennington SR

更新日期：2012-10-31 00:00:00

abstract：INTRODUCTION:Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of ...

journal_title：Arthritis research & therapy

authors： Dalbeth N,Pool B,Smith T,Callon KE,Lobo M,Taylor WJ,Jones PB,Cornish J,McQueen FM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic effects. Two isoforms have been identified: hematopoietic- and lipocalin-type PGDS (H-PGDS and L-PGDS, respectively). The aims of this study were to ...

journal_title：Arthritis research & therapy

authors： Zayed N,Li X,Chabane N,Benderdour M,Martel-Pelletier J,Pelletier JP,Duval N,Fahmi H

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleukin-17 (IL-17) on the survival and/or proliferation of FLSs from RA patients and to investigate wh...

journal_title：Arthritis research & therapy

authors： Lee SY,Kwok SK,Son HJ,Ryu JG,Kim EK,Oh HJ,Cho ML,Ju JH,Park SH,Kim HY

更新日期：2013-02-20 00:00:00

abstract：:Joint space width (JSW) and narrowing (JSN) measurements on radiographs are currently the best way to assess disease severity or progression in hip osteoarthritis, yet we lack data regarding the most accurate and sensitive measurement technique. This study was conducted to determine the optimal radiograph and number o...

journal_title：Arthritis research & therapy

authors： Maheu E,Cadet C,Marty M,Dougados M,Ghabri S,Kerloch I,Mazières B,Spector TD,Vignon E,Lequesne MG

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle. METHODS...

journal_title：Arthritis research & therapy

authors： Duijnisveld BJ,Bigot A,Beenakker KG,Portilho DM,Raz V,van der Heide HJ,Visser CP,Chaouch S,Mamchaoui K,Westendorp RG,Mouly V,Butler-Browne GS,Nelissen RG,Maier AB

更新日期：2011-01-01 00:00:00

abstract：:The objective of this study was to evaluate the safety and possible efficacy of IFN-beta-1a for the treatment of patients with rheumatoid arthritis (RA). Twenty-two patients with active RA were enrolled in a phase II randomized, double-blind, placebo-controlled trial of 30 microg IFN-beta-1a by weekly self-injection f...

journal_title：Arthritis research & therapy

authors： Genovese MC,Chakravarty EF,Krishnan E,Moreland LW

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED), which can lead to functional and morphological vascular abnormalities. Several non-invasive assessments of vascular function and morp...

journal_title：Arthritis research & therapy

authors： Sandoo A,Hodson J,Douglas KM,Smith JP,Kitas GD

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health record (EHR) technique to test for differences in comorbidities in African Americans compared to Cau...

journal_title：Arthritis research & therapy

authors： Barnado A,Carroll RJ,Casey C,Wheless L,Denny JC,Crofford LJ

更新日期：2018-04-10 00:00:00

abstract：INTRODUCTION:Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of ...

journal_title：Arthritis research & therapy

authors： Happonen KE,Saxne T,Geborek P,Andersson M,Bengtsson AA,Hesselstrand R,Heinegård D,Blom AM

更新日期：2012-01-20 00:00:00

abstract：: ...

journal_title：Arthritis research & therapy

authors： Sato S,Fujita Y,Shigemura T,Matoba H,Agematsu K,Sumichika Y,Yashiro M,Ono A,Kawasaki Y,Kobayashi H,Watanabe H,Koga T,Kawakami A,Migita K

更新日期：2018-12-10 00:00:00

abstract：:Current evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those seen during ageing but appear to occur at an accelerated rate. We hypothesised that this is due to accelerate...

journal_title：Arthritis research & therapy

authors： Le Maitre CL,Freemont AJ,Hoyland JA

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distinct subpopulation of patients can be identified. METHODS:We recruited patients with at least 1 SARD ...

journal_title：Arthritis research & therapy

authors： Reynolds JA,Briggs TA,Rice GI,Darmalinggam S,Bondet V,Bruce E,Khan M,Haque S,Chinoy H,Herrick AL,McCarthy EM,Zeef L,Hayes A,Duffy D,Parker B,Bruce IN

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the significance of ANCA in these patients is unclear. The aim of this study is to determine the prevalence of A...

journal_title：Arthritis research & therapy

authors： Moxey J,Huq M,Proudman S,Sahhar J,Ngian GS,Walker J,Strickland G,Wilson M,Ross L,Major G,Roddy J,Stevens W,Nikpour M

更新日期：2019-02-14 00:00:00