Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion.

abstract：BACKGROUND:Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post hoc meta-analysis of BLISS-52 and BLISS-76 explored the relationship between base...

journal_title：Arthritis research & therapy

authors： Wilkinson C,Henderson RB,Jones-Leone AR,Flint SM,Lennon M,Levy RA,Ji B,Bass DL,Roth D

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Autophagy induction is an effective approach for OA therapy. IL-1β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destruction. The objective of this study was to decipher the link between autophagy and regulatory mechanism o...

journal_title：Arthritis research & therapy

authors： Wang F,Liu J,Chen X,Zheng X,Qu N,Zhang B,Xia C

更新日期：2019-07-10 00:00:00

abstract：:TNF receptor-associated periodic syndrome (TRAPS) is a dominantly inherited disease caused by missense mutations in the TNF receptor 1 (TNFR1) gene. Patients suffer from periodic bouts of severe abdominal pain, localised inflammation, migratory rashes, and fever. More than 40 individual mutations have been identified,...

journal_title：Arthritis research & therapy

authors： Kimberley FC,Lobito AA,Siegel RM,Screaton GR

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor Activator for Nuclear Factor κ B Ligand) to RANK results in the activation of TRAF6 (tumor necros...

journal_title：Arthritis research & therapy

authors： Knevel R,de Rooy DP,Saxne T,Lindqvist E,Leijsma MK,Daha NA,Koeleman BP,Tsonaka R,Houwing-Duistermaat JJ,Schonkeren JJ,Toes RE,Huizinga TW,Brouwer E,Wilson AG,van der Helm-van Mil AH

更新日期：2014-05-07 00:00:00

abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

journal_title：Arthritis research & therapy

authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Vagus nerve stimulation (VNS) exerts beneficial anti-inflammatory effects in various animal models of inflammation, including collagen-induced arthritis, and is implicated in representing a novel therapy for rheumatoid arthritis. However, evidence of anti-inflammatory effects of VNS in humans is very scarc...

journal_title：Arthritis research & therapy

authors： Kox M,van Eijk LT,Verhaak T,Frenzel T,Kiers HD,Gerretsen J,van der Hoeven JG,Kornet L,Scheiner A,Pickkers P

更新日期：2015-06-07 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Autoreactive B cells are crucial players in the pathogenesis of rheumatoid arthritis (RA). Autoantibodies specific for citrullinated proteins (ACPA), present in the serum of approximately 60-70 % of patients, have a pathogenic role in the disease. B cell depleting therapies may result in a transient immunosu...

journal_title：Arthritis research & therapy

authors： Pozsgay J,Babos F,Uray K,Magyar A,Gyulai G,Kiss É,Nagy G,Rojkovich B,Hudecz F,Sármay G

更新日期：2016-01-16 00:00:00

abstract：:The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by...

journal_title：Arthritis research & therapy

authors： Dasuri K,Antonovici M,Chen K,Wong K,Standing K,Ens W,El-Gabalawy H,Wilkins JA

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment of cartilage injury. Therefore, in this study we tested whether gene delivery of the growth factor Indian hedgehog (IHH) was able to induce chondrogenesis in huma...

journal_title：Arthritis research & therapy

authors： Steinert AF,Weissenberger M,Kunz M,Gilbert F,Ghivizzani SC,Göbel S,Jakob F,Nöth U,Rudert M

更新日期：2012-07-20 00:00:00

abstract：INTRODUCTION:Since current treatment options for patients suffering from active rheumatoid arthritis (RA) remain inadequate, especially for those unresponsive to disease-modifying antirheumatic drugs (DMARDs), new and improved medication is needed. This study evaluates the safety and efficacy of masitinib (AB1010), a p...

journal_title：Arthritis research & therapy

authors： Tebib J,Mariette X,Bourgeois P,Flipo RM,Gaudin P,Le Loët X,Gineste P,Guy L,Mansfield CD,Moussy A,Dubreuil P,Hermine O,Sibilia J

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Disease-modifying antirheumatic drugs (DMARDs) have become the treatment standard for patients with rheumatoid arthritis (RA). Although several general-population studies document that a large population of patients diagnosed with RA do not use DMARDs, little is known about this group. We explored the char...

journal_title：Arthritis research & therapy

authors： Brown EM,Garneau KL,Tsao H,Solomon DH

更新日期：2014-01-29 00:00:00

abstract：INTRODUCTION:Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived growth factor receptor (PDGFR) activation promote collagen I (Col I) production, leading to fibrosis in SSc. Lipoic acid (LA) and its active metabolite...

journal_title：Arthritis research & therapy

authors： Tsou PS,Balogh B,Pinney AJ,Zakhem G,Lozier A,Amin MA,Stinson WA,Schiopu E,Khanna D,Fox DA,Koch AE

更新日期：2014-01-01 00:00:00

abstract：:Cartilage damage in osteoarthritis (OA) is considered an imbalance between catabolic and anabolic factors, favoring the catabolic side. We assessed whether adenoviral overexpression of transforming growth factor-beta (TGFbeta) enhanced cartilage repair and whether TGFbeta-induced fibrosis was blocked by local expressi...

journal_title：Arthritis research & therapy

authors： Blaney Davidson EN,Vitters EL,van den Berg WB,van der Kraan PM

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Although rheumatoid arthritis (RA) is generally a chronic disease, a proportion of RA-patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission, reflecting loss of disease-persistence. To explore mechanisms underlying RA-persistence, we performed a candidate gene study. We hypo...

journal_title：Arthritis research & therapy

authors： van Steenbergen HW,van Nies JA,Ruyssen-Witrand A,Huizinga TW,Cantagrel A,Berenbaum F,van der Helm-van Mil AH

更新日期：2015-09-08 00:00:00

abstract：:Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex ...

journal_title：Arthritis research & therapy

authors： Tveita A,Rekvig OP,Zykova SN

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Nucleus pulposus (NP) cells have a phenotype similar to articular cartilage (AC) cells. However, the matrix of the NP is clearly different to that of AC suggesting that specific cell phenotypes exist. The aim of this study was to identify novel genes that could be used to distinguish bovine NP cells from A...

journal_title：Arthritis research & therapy

authors： Minogue BM,Richardson SM,Zeef LA,Freemont AJ,Hoyland JA

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for IVD degeneration. One such t...

journal_title：Arthritis research & therapy

authors： Le Maitre CL,Baird P,Freemont AJ,Hoyland JA

更新日期：2009-01-01 00:00:00

abstract：:The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the T...

journal_title：Arthritis research & therapy

authors： Gaffo AL,Saag KG

更新日期：2008-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：INTRODUCTION:Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypothesize that it does. We compared the occurrence of 30-day postoperative complications and mortali...

journal_title：Arthritis research & therapy

authors： Michaud K,Fehringer EV,Garvin K,O'Dell JR,Mikuls TR

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The major histocompatibility complex (H-2d) and non-major histocompatibility complex genetic backgrounds make the BALB/c strain highly susceptible to inflammatory arthritis and spondylitis. Although different BALB/c colonies develop proteoglycan-induced arthritis and proteoglycan-induced spondylitis in res...

journal_title：Arthritis research & therapy

authors： Farkas B,Boldizsar F,Tarjanyi O,Laszlo A,Lin SM,Hutas G,Tryniszewska B,Mangold A,Nagyeri G,Rosenzweig HL,Finnegan A,Mikecz K,Glant TT

更新日期：2009-01-01 00:00:00

abstract：:Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells, such as L-selectin (CD62L), can also be detected on some memory T cells. Moreover, a fraction of CD45RO+ (positive for the short human isoform of CD45) memory T cells reverts to the CD45RA+ (pos...

journal_title：Arthritis research & therapy

authors： Lamprecht P,Erdmann A,Mueller A,Csernok E,Reinhold-Keller E,Holl-Ulrich K,Feller AC,Bruehl H,Gross WL

更新日期：2003-01-01 00:00:00

abstract：:In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B c...

journal_title：Arthritis research & therapy

authors： Weyand CM,Seyler TM,Goronzy JJ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Interleukin-17A (IL-17A) plays a pathogenic role in several rheumatic diseases including spondyloarthritis and, paradoxically, has been described to both promote and protect from bone formation. We therefore examined the effects of IL-17A on osteoblast differentiation in vitro and on periosteal bone formatio...

journal_title：Arthritis research & therapy

authors： Shaw AT,Maeda Y,Gravallese EM

更新日期：2016-05-10 00:00:00

abstract：INTRODUCTION:Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic effects. Two isoforms have been identified: hematopoietic- and lipocalin-type PGDS (H-PGDS and L-PGDS, respectively). The aims of this study were to ...

journal_title：Arthritis research & therapy

authors： Zayed N,Li X,Chabane N,Benderdour M,Martel-Pelletier J,Pelletier JP,Duval N,Fahmi H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

journal_title：Arthritis research & therapy

authors： Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

更新日期：2020-10-15 00:00:00

abstract：INTRODUCTION:TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney. Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently intro...

journal_title：Arthritis research & therapy

authors： Schwartz N,Rubinstein T,Burkly LC,Collins CE,Blanco I,Su L,Hojaili B,Mackay M,Aranow C,Stohl W,Rovin BH,Michaelson JS,Putterman C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with RA who responded to TNFi therapy and those who did not. METHODS:For this retrospective cohort analys...

journal_title：Arthritis research & therapy

authors： Grabner M,Boytsov NN,Huang Q,Zhang X,Yan T,Curtis JR

更新日期：2017-05-15 00:00:00

abstract：INTRODUCTION:We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines ye...

journal_title：Arthritis research & therapy

authors： Kokkonen H,Mullazehi M,Berglin E,Hallmans G,Wadell G,Rönnelid J,Rantapää-Dahlqvist S

更新日期：2011-02-03 00:00:00