The role of baseline BLyS levels and type 1 interferon-inducible gene signature status in determining belimumab response in systemic lupus erythematosus: a post hoc meta-analysis.

abstract：:Dysregulated psychophysiological responses have been observed in patients with fibromyalgia syndrome (FMS), although the results are inconsistent. Surface electromyographic (EMG), systolic and diastolic blood pressure, heart rate (HR), and skin conductance levels (SCLs) were continuously recorded at baseline, and duri...

journal_title：Arthritis research & therapy

authors： Thieme K,Turk DC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00

abstract：INTRODUCTION:Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with complex etiopathogenesis. Despite extensive studies to understand the disease process utilizing human and mouse models, the intersection between these species remains elusive. To address this gap, we utilized a novel systems biology appr...

journal_title：Arthritis research & therapy

authors： Horvath S,Nazmul-Hossain AN,Pollard RP,Kroese FG,Vissink A,Kallenberg CG,Spijkervet FK,Bootsma H,Michie SA,Gorr SU,Peck AB,Cai C,Zhou H,Wong DT

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitative computed tomography (HR-pQCT) have been reported, no studies have investigated the long-term stru...

journal_title：Arthritis research & therapy

authors： Wu D,Griffith JF,Lam SHM,Wong PCH,Shi L,Li EK,Cheng IT,Li TK,Hung VW,Qin L,Tam LS

更新日期：2019-12-04 00:00:00

abstract：INTRODUCTION:Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of ...

journal_title：Arthritis research & therapy

authors： Happonen KE,Saxne T,Geborek P,Andersson M,Bengtsson AA,Hesselstrand R,Heinegård D,Blom AM

更新日期：2012-01-20 00:00:00

abstract：INTRODUCTION:Patients with rheumatoid arthritis (RA) are at an increased risk of malignancies compared with the general population. This has raised concerns regarding these patients, particularly with the widespread use of immunomodulating therapies, including biologic disease-modifying antirheumatic drugs (DMARDs). We...

journal_title：Arthritis research & therapy

authors： Simon TA,Thompson A,Gandhi KK,Hochberg MC,Suissa S

更新日期：2015-08-15 00:00:00

abstract：INTRODUCTION:Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of i...

journal_title：Arthritis research & therapy

authors： Peterson JD,Labranche TP,Vasquez KO,Kossodo S,Melton M,Rader R,Listello JT,Abrams MA,Misko TP

更新日期：2010-01-01 00:00:00

abstract：:An impaired differentiation of naive CD4+ T cells towards Th2 cells may contribute to the chronic tissue-destructive T-cell activity in rheumatoid arthritis (RA). The differentiation of naive CD4+ T cells into memory Th2 cells by IL-7 in comparison with that by IL-4 was studied in RA patients and in healthy controls. ...

journal_title：Arthritis research & therapy

authors： van Roon JA,Glaudemans CA,Bijlsma JW,Lafeber FP

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Pain is one of the most important domains affecting health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Secukinumab has demonstrated rapid and sustained improvements in signs and symptoms, including HRQoL, among patients with active PsA. This analysis evaluates the effect of se...

journal_title：Arthritis research & therapy

authors： McInnes IB,Mease PJ,Schett G,Kirkham B,Strand V,Williams N,Fox T,Pricop L,Jugl SM,Gandhi KK,FUTURE 2 Study Group.

更新日期：2018-06-07 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

journal_title：Arthritis research & therapy

authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:To aim was to investigate the additional value of incorporating the de Vlam cervical facet joint score in the modified ankylosing spondylitis (AS) spine score (mSASSS) for the evaluation of spinal radiographic outcome in AS. METHOD:Baseline and 4-year radiographs from 98 consecutive patients from the Gronin...

journal_title：Arthritis research & therapy

authors： Maas F,Arends S,Brouwer E,Bootsma H,Bos R,Wink FR,Spoorenberg A

更新日期：2017-04-26 00:00:00

abstract：:The development of spontaneous autoimmunity in inbred strains of rodents has allowed us to investigate the molecular basis of chronic inflammatory disease in ways that would not be possible in humans. Recently, two new mouse models of autoimmune inflammatory polyarthritis have been reported that demonstrate how altera...

journal_title：Arthritis research & therapy

authors： Cope AP

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:During the progression of rheumatoid arthritis (RA), there are frequent but intermittent flares in which the joint becomes acutely inflamed and painful. Although a number of drug therapies are currently used to treat RA, their effectiveness is variable and side effects are common. Endocannabinoids have the...

journal_title：Arthritis research & therapy

authors： Krustev E,Reid A,McDougall JJ

更新日期：2014-09-27 00:00:00

abstract：INTRODUCTION:Dual-energy computed tomography (DECT) has potential for monitoring urate deposition in patients with gout. The aim of this prospective longitudinal study was to analyse measurement error of DECT urate volume measurement in clinically stable patients with tophaceous gout. METHODS:Seventy-three patients wi...

journal_title：Arthritis research & therapy

authors： Rajan A,Aati O,Kalluru R,Gamble GD,Horne A,Doyle AJ,McQueen FM,Dalbeth N

更新日期：2013-10-23 00:00:00

abstract：INTRODUCTION:In this study, we sought to address changes in blood lymphocyte subpopulations and labial salivary gland (LSG) inflammation after belimumab treatment in patients with primary Sjögren's syndrome (pSS) and to identify predictors of response to treatment. METHODS:Sequential blood lymphocyte subsets and LSG b...

journal_title：Arthritis research & therapy

authors： Seror R,Nocturne G,Lazure T,Hendel-Chavez H,Desmoulins F,Belkhir R,Ravaud P,Benbijja M,Poirier-Colame V,Taoufik Y,Mariette X

更新日期：2015-09-04 00:00:00

abstract：:Chronic pain remains an important public health need with greater impact on the US economy than most other chronic conditions. Current pain management is largely limited to opioids and non-steroidal anti-inflammatory drugs, indicating a gap in the translation of new knowledge to the development of improved pain treatm...

journal_title：Arthritis research & therapy

authors： Witter J,Dionne RA

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the frequency of MFC in the renal tissue of patients with LN. METHODS:Twenty-seven renal biopsies we...

journal_title：Arthritis research & therapy

authors： Florim GM,Caldas HC,de Melo JC,Baptista MA,Fernandes IM,Savoldi-Barbosa M,Goldman GH,Abbud-Filho M

更新日期：2015-04-15 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis is an autoimmune arthritis characterized by joint destruction. Anti-citrullinated protein antibodies are pathologic in rheumatoid arthritis, but the role of the citrullinated proteins themselves is much less clear. Citrullination is the conversion of the arginine residues of a protein ...

journal_title：Arthritis research & therapy

authors： Shelef MA,Bennin DA,Mosher DF,Huttenlocher A

更新日期：2012-11-05 00:00:00

abstract：INTRODUCTION:Antibodies against citrullinated peptides (anti-CCP) and increased levels of cytokines precede the development of rheumatoid arthritis (RA) by several years. Recently, the proteins survivin and Fms-like tyrosine kinase 3 ligand (Flt3L) have been identified as biomarkers of RA associated with joint destruct...

journal_title：Arthritis research & therapy

authors： Bokarewa M,Brink M,Erlandsson M,Rantapää Dahlqvist S

更新日期：2014-02-05 00:00:00

abstract：:Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification...

journal_title：Arthritis research & therapy

authors： MacMullan PA,McCarthy GM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Lack of adequate self-care, frequent admissions, and poor quality of life are common and serious problems in adult patients with systemic lupus erythematosus (SLE). Some studies have revealed that transitional care is effective in improving self-care and quality of life as well as reducing rehospitalization ...

journal_title：Arthritis research & therapy

authors： Xie X,Song Y,Yang H,Nie A,Chen H,Li JP

更新日期：2018-08-16 00:00:00

abstract：INTRODUCTION:The interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis. METHODS:Human CD14+ cells were isolated fro...

journal_title：Arthritis research & therapy

authors： Adamopoulos IE,Chao CC,Geissler R,Laface D,Blumenschein W,Iwakura Y,McClanahan T,Bowman EP

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Ultrasound (US) is a sensitive method for detecting joint/tendon inflammation in patients with rheumatoid arthritis (RA). Subclinical inflammation is often found in patients with RA in composite score remission. The purpose of the present study was to explore whether US of only the hands is sufficient to ide...

journal_title：Arthritis research & therapy

authors： Hammer HB,Kvien TK,Terslev L

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) patients are treated with a mean of 3-4 conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) with or without glucocorticoids (GCs), before the first biologic prescription. The main reasons for change are inefficacy in 30-40 % of patients, and toxicity ≈ 10 %. Thus...

journal_title：Arthritis research & therapy

authors： Hernández-Cruz B,Márquez-Saavedra E,Caliz-Caliz R,Navarro-Sarabia F

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region at different sites. Moreover,...

journal_title：Arthritis research & therapy

authors： Ota T,Ota SI,Uchino A,Nagano S

更新日期：2020-06-26 00:00:00

abstract：:It has long been recognized that laboratory tests are useful in the diagnosis of disease and to monitor treatment outcome. Their performance has become even more demanding with the development of personalized medicine. In patients with rheumatoid arthritis (RA) the standard biochemical tests measure serological marker...

journal_title：Arthritis research & therapy

authors： van de Loo FA

更新日期：2011-04-27 00:00:00

abstract：BACKGROUND:Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenas...

journal_title：Arthritis research & therapy

authors： Chowdhury TT,Arghandawi S,Brand J,Akanji OO,Bader DL,Salter DM,Lee DA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health record (EHR) technique to test for differences in comorbidities in African Americans compared to Cau...

journal_title：Arthritis research & therapy

authors： Barnado A,Carroll RJ,Casey C,Wheless L,Denny JC,Crofford LJ

更新日期：2018-04-10 00:00:00

abstract：:Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding and causes posttraumatic joint inflammation. Although the acute symptoms resolve and some of the lesions can b...

journal_title：Arthritis research & therapy

authors： Lotz MK,Kraus VB

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Rational selection of disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA) has many potential advantages, including rapid disease control, reduced long-term disability and reduced overall cost to the healthcare system. Inter-individual genetic differences are particularly at...

journal_title：Arthritis research & therapy

authors： Wiese MD,Schnabl M,O'Doherty C,Spargo LD,Sorich MJ,Cleland LG,Proudman SM

更新日期：2012-07-12 00:00:00