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New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options.

Abstract：

:Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding and causes posttraumatic joint inflammation. Although the acute symptoms resolve and some of the lesions can be surgically repaired, joint injury triggers a chronic remodeling process in cartilage and other joint tissues that ultimately manifests as osteoarthritis in a majority of cases. The objective of the present review is to summarize information on pathogenetic mechanisms involved in the acute and chronic consequences of joint trauma and discuss potential pharmacological interventions. The focus of the review is on the early events that follow joint trauma since therapies for posttraumatic joint inflammation are not available and this represents a unique window of opportunity to limit chronic consequences.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Lotz MK,Kraus VB

doi

10.1186/ar3046

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

211

issue

3

eissn

1478-6354

issn

1478-6362

pii

ar3046

journal_volume

12

pub_type

杂志文章,评审

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