The role and clinical implications of G6PI in experimental models of rheumatoid arthritis.

abstract：:Historically, the osteoblast has been considered the master cell in the control of osteoclast development and, therefore, bone resorption. Now the interactions between cells of the immune system and bone cells have redefined our thinking on the regulation of bone resorption. Moreover, the crosstalk between these cell ...

journal_title：Arthritis research & therapy

authors： Gillespie MT

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades adjacent cartilage and bone in rheumatoid arthritis (RA). The study was undertaken to determine the effect of interleukin-17 (IL-17) on the survival and/or proliferation of FLSs from RA patients and to investigate wh...

journal_title：Arthritis research & therapy

authors： Lee SY,Kwok SK,Son HJ,Ryu JG,Kim EK,Oh HJ,Cho ML,Ju JH,Park SH,Kim HY

更新日期：2013-02-20 00:00:00

abstract：INTRODUCTION:We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed arthritic joints. The objective of the present study was to ...

journal_title：Arthritis research & therapy

authors： Hughes C,Sette A,Seed M,D'Acquisto F,Manzo A,Vincent TL,Lim NH,Nissim A

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogenesis of AS. We aimed to define and compare the fecal microbiota composition in patients w...

journal_title：Arthritis research & therapy

authors： Klingberg E,Magnusson MK,Strid H,Deminger A,Ståhl A,Sundin J,Simrén M,Carlsten H,Öhman L,Forsblad-d'Elia H

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats-suggesting it may be a potent drug for rheumatoid arthritis (RA) therapy. We aimed to investigate its effect on the invasive property of fibroblast-like synoviocyte...

journal_title：Arthritis research & therapy

authors： Ma JD,Jing J,Wang JW,Yan T,Li QH,Mo YQ,Zheng DH,Gao JL,Nguyen KA,Dai L

更新日期：2019-06-24 00:00:00

abstract：INTRODUCTION:The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). METHODS:Peripheral blood from 42 GPA patients in remission and 29 age-matched healthy controls (HCs) were stimulated in vitro, and the frequencies of IL-21 p...

journal_title：Arthritis research & therapy

authors： Abdulahad WH,Lepse N,Stegeman CA,Huitema MG,Doornbos-van der Meer B,Tadema H,Rutgers A,Limburg PC,Kallenberg CG,Heeringa P

更新日期：2013-01-01 00:00:00

abstract：:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occu...

journal_title：Arthritis research & therapy

authors： Nowling TK,Gilkeson GS

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle. METHODS...

journal_title：Arthritis research & therapy

authors： Duijnisveld BJ,Bigot A,Beenakker KG,Portilho DM,Raz V,van der Heide HJ,Visser CP,Chaouch S,Mamchaoui K,Westendorp RG,Mouly V,Butler-Browne GS,Nelissen RG,Maier AB

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS:Fort...

journal_title：Arthritis research & therapy

authors： Vacca A,Montisci R,Garau P,Siotto P,Piga M,Cauli A,Ruscazio M,Meloni L,Iliceto S,Mathieu A

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) receiving an anti-rheumatic treatment. Obesity can be considered a low-grade, chronic systemic inflam...

journal_title：Arthritis research & therapy

authors： Lupoli R,Pizzicato P,Scalera A,Ambrosino P,Amato M,Peluso R,Di Minno MN

更新日期：2016-12-13 00:00:00

abstract：:Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or...

journal_title：Arthritis research & therapy

authors： Henrotin Y,Mobasheri A,Marty M

更新日期：2012-01-30 00:00:00

abstract：:The detection of autoantibodies in human sera is an important approach to the diagnosis and management of patients with autoimmune conditions. To meet market demands, manufacturers have developed a wide variety of easy to use and cost-effective diagnostic kits that are designed to detect a variety of human serum autoa...

journal_title：Arthritis research & therapy

authors： Fritzler MJ,Wiik A,Fritzler ML,Barr SG

更新日期：2003-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can o...

journal_title：Arthritis research & therapy

authors： Bode SF,Lehmberg K,Maul-Pavicic A,Vraetz T,Janka G,Stadt UZ,Ehl S

更新日期：2012-06-08 00:00:00

abstract：INTRODUCTION:The aim of this study was to test the naturally occurring organosulfur compound dipropyltetrasulfide (DPTTS), found in plants, which has antibiotic and anticancer properties, as a treatment for HOCl-induced systemic sclerosis in the mouse. METHODS:The prooxidative, antiproliferative, and cytotoxic effects...

journal_title：Arthritis research & therapy

authors： Marut W,Jamier V,Kavian N,Servettaz A,Winyard PG,Eggleton P,Anwar A,Nicco C,Jacob C,Chéreau C,Weill B,Batteux F

更新日期：2013-10-28 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

journal_title：Arthritis research & therapy

authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses. METHODS:A case-control study was co...

journal_title：Arthritis research & therapy

authors： Brink M,Lundquist A,Alexeyenko A,Lejon K,Rantapää-Dahlqvist S

更新日期：2019-12-16 00:00:00

abstract：INTRODUCTION:The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. METHODS:Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy co...

journal_title：Arthritis research & therapy

authors： Pleštilová L,Mann H,Andrés Cerezo L,Pecha O,Vencovský J,Šenolt L

更新日期：2014-10-31 00:00:00

abstract：INTRODUCTION:Autoantibodies in patients with polymyositis/dermatomyositis (PM/DM) are associated with unique subsets, clinical course and outcome. Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult...

journal_title：Arthritis research & therapy

authors： Ceribelli A,Fredi M,Taraborelli M,Cavazzana I,Franceschini F,Quinzanini M,Tincani A,Ross SJ,Chan JY,Pauley BA,Chan EK,Satoh M

更新日期：2012-04-30 00:00:00

abstract：BACKGROUND:Clinical remission can be maintained after the discontinuation of biological disease-modifying antirheumatic drugs (bDMARDs) in some patients with rheumatoid arthritis (RA) (bDMARD-free remission (BFR)). It is unknown which bDMARD is advantageous for achieving BFR or under which conditions BFR can be conside...

journal_title：Arthritis research & therapy

authors： Hashimoto M,Furu M,Yamamoto W,Fujimura T,Hara R,Katayama M,Ohnishi A,Akashi K,Yoshida S,Nagai K,Son Y,Amuro H,Hirano T,Ebina K,Uozumi R,Ito H,Tanaka M,Ohmura K,Fujii T,Mimori T

更新日期：2018-08-03 00:00:00

abstract：INTRODUCTION:There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-specific biologicals targeting the progressive phase of the disease, there is a need for relevant anim...

journal_title：Arthritis research & therapy

authors： Vierboom MP,Breedveld E,Kondova I,'t Hart BA

更新日期：2010-01-01 00:00:00

abstract：:Pegloticase is a powerful but underutilized weapon in the rheumatologist's armamentarium. The drug's immunogenicity leads to neutralizing antibody formation and rapid loss of efficacy in roughly one-half of all patients, which remains an impediment to broader use. New data, however, suggest that drug survival might im...

journal_title：Arthritis research & therapy

authors： Abeles AM

更新日期：2014-05-30 00:00:00

abstract：:The changes occurring in the field of rheumatoid arthritis (RA) over the past decade or two have encompassed new therapies and, in particular, a new look at the clinical characteristics of the disease in the context of therapeutic improvements. It has been shown that composite disease activity indices have special mer...

journal_title：Arthritis research & therapy

authors： Smolen JS,Aletaha D

更新日期：2009-01-01 00:00:00

abstract：:First identified by the Egyptians in 2640 BC, podagra (acute gout occurring in the first metatarsophalangeal joint) was later recognized by Hippocrates in the fifth century BC, who referred to it as 'the unwalkable disease'. The term is derived from the Latin word gutta (or 'drop'), and referred to the prevailing medi...

journal_title：Arthritis research & therapy

authors： Nuki G,Simkin PA

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Immunological studies of giant cell arteritis (GCA) suggest that a triggering antigen of unknown nature could generate a specific immune response. We thus decided to detect autoantibodies directed against endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in the serum of GCA patients and to i...

journal_title：Arthritis research & therapy

authors： Régent A,Dib H,Ly KH,Agard C,Tamby MC,Tamas N,Weksler B,Federici C,Broussard C,Guillevin L,Mouthon L

更新日期：2011-06-28 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and safety of mycophenolate sodium (MPS) in patients with primary Sjögren syndrome (pSS) refractory to other immunosuppressive agents. Eleven patients with pSS were treated with MPS up to 1,440 mg daily for an observation period of 6 months in this single-center, open...

journal_title：Arthritis research & therapy

authors： Willeke P,Schlüter B,Becker H,Schotte H,Domschke W,Gaubitz M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training could improve remodeling, we measured changes in inter-relationships of plasma galectin-3, skel...

journal_title：Arthritis research & therapy

authors： Andonian BJ,Bartlett DB,Huebner JL,Willis L,Hoselton A,Kraus VB,Kraus WE,Huffman KM

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthritis (RA). METHOD:RNA-sequencing-(RNA-seq)-based expression analysis of 377 genes from previously v...

journal_title：Arthritis research & therapy

authors： Shchetynsky K,Diaz-Gallo LM,Folkersen L,Hensvold AH,Catrina AI,Berg L,Klareskog L,Padyukov L

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). METHODS:Serum from patients with RA and osteoarthritis (OA), and healthy controls, and synov...

journal_title：Arthritis research & therapy

authors： Min HK,Won JY,Kim BM,Lee KA,Lee SJ,Lee SH,Kim HR,Kim KW

更新日期：2020-09-23 00:00:00

abstract：INTRODUCTION:The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize...

journal_title：Arthritis research & therapy

authors： Vitadello M,Doria A,Tarricone E,Ghirardello A,Gorza L

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00