当前位置： SCI文献检索 > ARTHRITIS RESEARCH & THERAPY期刊下所有文献 > Developments in the clinical understanding of rheumatoid arthritis.

Developments in the clinical understanding of rheumatoid arthritis.

Abstract：

:The changes occurring in the field of rheumatoid arthritis (RA) over the past decade or two have encompassed new therapies and, in particular, a new look at the clinical characteristics of the disease in the context of therapeutic improvements. It has been shown that composite disease activity indices have special merits in following patients, that disease activity governs the evolution of joint damage, and that disability can be dissected into several components--among them disease activity and joint damage. It has also been revealed that aiming at any disease activity state other than remission (or, at worst, low disease activity) is associated with significant progression of joint destruction, that early recognition and appropriate therapy of RA are important facets of the overall strategy of optimal clinical control of the disease, and that tight control employing composite scores supports the optimization of the therapeutic approaches. Finally, with the advent of novel therapies, remission has become a reality and the treatment algorithms encompassing all of the above-mentioned aspects will allow us to achieve the rigorous aspirations of today and tomorrow.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Smolen JS,Aletaha D

doi

10.1186/ar2535

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

204

issue

1

eissn

1478-6354

issn

1478-6362

pii

ar2535

journal_volume

11

pub_type

杂志文章,评审

相关文献

ARTHRITIS RESEARCH & THERAPY文献大全
  • Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA).

    abstract：INTRODUCTION:The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). METHODS:Peripheral blood from 42 GPA patients in remission and 29 age-matched healthy controls (HCs) were stimulated in vitro, and the frequencies of IL-21 p...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4247

    authors： Abdulahad WH,Lepse N,Stegeman CA,Huitema MG,Doornbos-van der Meer B,Tadema H,Rutgers A,Limburg PC,Kallenberg CG,Heeringa P

    更新日期：2013-01-01 00:00:00

  • Synovial tissues concentrate secreted APRIL.

    abstract：INTRODUCTION:A proliferation-inducing ligand (APRIL) from the TNF family, owing to its role in the generation and survival of plasma cells (PCs), is currently targeted for rheumatoid arthritis (RA) treatment. However, little is known about APRIL expression in RA lesions, hampering our understanding of the way APRIL may...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2817

    authors： Gabay C,Krenn V,Bosshard C,Seemayer CA,Chizzolini C,Huard B

    更新日期：2009-01-01 00:00:00

  • Progressive structural bone changes and their relationship with treatment in patients with psoriatic arthritis: a longitudinal HR-pQCT study.

    abstract：BACKGROUND:Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitative computed tomography (HR-pQCT) have been reported, no studies have investigated the long-term stru...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2043-3

    authors： Wu D,Griffith JF,Lam SHM,Wong PCH,Shi L,Li EK,Cheng IT,Li TK,Hung VW,Qin L,Tam LS

    更新日期：2019-12-04 00:00:00

  • The role of anti-alpha-actinin antibodies in the pathogenesis and monitoring of lupus nephritis.

    abstract：:Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding ...

    journal_title：Arthritis research & therapy

    pub_type： 社论

    doi：10.1186/ar2869

    authors： Youinou P,Putterman C

    更新日期：2009-01-01 00:00:00

  • Heterogeneity of psychophysiological stress responses in fibromyalgia syndrome patients.

    abstract：:Dysregulated psychophysiological responses have been observed in patients with fibromyalgia syndrome (FMS), although the results are inconsistent. Surface electromyographic (EMG), systolic and diastolic blood pressure, heart rate (HR), and skin conductance levels (SCLs) were continuously recorded at baseline, and duri...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1863

    authors： Thieme K,Turk DC

    更新日期：2006-01-01 00:00:00

  • The meniscus, calcification and osteoarthritis: a pathologic team.

    abstract：:Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar2993

    authors： MacMullan PA,McCarthy GM

    更新日期：2010-01-01 00:00:00

  • C/EBP homologous protein drives pro-catabolic responses in chondrocytes.

    abstract：INTRODUCTION:Excess C/EBP homologous protein (CHOP) expression is one feature of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress. Here, we focused on CHOP expression and function in chondrocytes. METHODS:We studied human knee osteoarthritis (OA) cartilage, bovine chondrocytes cultured in algin...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4415

    authors： Husa M,Petursson F,Lotz M,Terkeltaub R,Liu-Bryan R

    更新日期：2013-01-01 00:00:00

  • Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.

    abstract：BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02412-8

    authors： Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

    更新日期：2021-01-19 00:00:00

  • Association between acute phase reactants, interleukin-6, tumor necrosis factor-α, and disease activity in Takayasu's arteritis patients.

    abstract：BACKGROUND:To investigate the association between blood biomarkers and disease activity of Takayasu's arteritis (TAK) in a follow-up cohort. METHODS:Disease activity was assessed by clinical manifestations and repeated vascular Doppler examinations. The association between erythrocyte sedimentation rate (ESR), serum l...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02365-y

    authors： Li J,Wang Y,Wang Y,Wang Y,Yang Y,Zhao J,Li M,Tian X,Zeng X

    更新日期：2020-12-10 00:00:00

  • Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs.

    abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3459

    authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

    更新日期：2011-01-01 00:00:00

  • Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register.

    abstract：OBJECTIVES:To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA). METHODS:All patients in the BIOBADASER registry diagnosed with RA, AS, and PsA,...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02231-x

    authors： Vela P,Sanchez-Piedra C,Perez-Garcia C,Castro-Villegas MC,Freire M,Mateo L,Díaz-Torné C,Bohorquez C,Blanco-Madrigal JM,Ros-Vilamajo I,Gómez S,Caño R,Sánchez-Alonso F,Díaz-González F,Gómez-Reino JJ

    更新日期：2020-06-15 00:00:00

  • Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine.

    abstract：:The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the T...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar2524

    authors： Gaffo AL,Saag KG

    更新日期：2008-01-01 00:00:00

  • Bone formation rather than inflammation reflects ankylosing spondylitis activity on PET-CT: a pilot study.

    abstract：INTRODUCTION:Positron Emission Tomography - Computer Tomography (PET-CT) is an interesting imaging technique to visualize Ankylosing Spondylitis (AS) activity using specific PET tracers. Previous studies have shown that the PET tracers [18F]FDG and [11C](R)PK11195 can target inflammation (synovitis) in rheumatoid arthr...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3792

    authors： Bruijnen ST,van der Weijden MA,Klein JP,Hoekstra OS,Boellaard R,van Denderen JC,Dijkmans BA,Voskuyl AE,van der Horst-Bruinsma IE,van der Laken CJ

    更新日期：2012-04-02 00:00:00

  • Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis.

    abstract：BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-020-02261-5

    authors： Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

    更新日期：2020-07-16 00:00:00

  • Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis.

    abstract：BACKGROUND:Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses. METHODS:A case-control study was co...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2066-9

    authors： Brink M,Lundquist A,Alexeyenko A,Lejon K,Rantapää-Dahlqvist S

    更新日期：2019-12-16 00:00:00

  • Rule-based and machine learning algorithms identify patients with systemic sclerosis accurately in the electronic health record.

    abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated methods are needed. We developed and validated EHR-based algorithms that incorporate billing codes ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-019-2092-7

    authors： Jamian L,Wheless L,Crofford LJ,Barnado A

    更新日期：2019-12-30 00:00:00

  • Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.

    abstract：BACKGROUND:Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenas...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2389

    authors： Chowdhury TT,Arghandawi S,Brand J,Akanji OO,Bader DL,Salter DM,Lee DA

    更新日期：2008-01-01 00:00:00

  • The metastasis promoting protein S100A4 levels associate with disease activity rather than cancer development in patients with idiopathic inflammatory myopathies.

    abstract：INTRODUCTION:The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. METHODS:Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy co...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/s13075-014-0468-2

    authors： Pleštilová L,Mann H,Andrés Cerezo L,Pecha O,Vencovský J,Šenolt L

    更新日期：2014-10-31 00:00:00

  • Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain.

    abstract：INTRODUCTION:The Vβ12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) β-chain and consequently displays an ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3108

    authors： Merky P,Batsalova T,Bockermann R,Dzhambazov B,Sehnert B,Burkhardt H,Bäcklund J

    更新日期：2010-01-01 00:00:00

  • Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis.

    abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation ...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3098

    authors： Mohanty ST,Kottam L,Gambardella A,Nicklin MJ,Coulton L,Hughes D,Wilson AG,Croucher PI,Bellantuono I

    更新日期：2010-01-01 00:00:00

  • Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study.

    abstract：INTRODUCTION:The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS:The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3033

    authors： Franklin J,Ingvarsson T,Englund M,Lohmander S

    更新日期：2010-01-01 00:00:00

  • The synovial proteome: analysis of fibroblast-like synoviocytes.

    abstract：:The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar1153

    authors： Dasuri K,Antonovici M,Chen K,Wong K,Standing K,Ens W,El-Gabalawy H,Wilkins JA

    更新日期：2004-01-01 00:00:00

  • The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.

    abstract：INTRODUCTION:The goals of this study were to examine the oxemic regulation of Wnt signaling to explore whether Wnt signaling accelerates the age-related degeneration of nucleus pulposus cells, and if so, to define the mechanism underlying this effect. We investigated the expression of Klotho, a newly identified antiagi...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar3830

    authors： Hiyama A,Arai F,Sakai D,Yokoyama K,Mochida J

    更新日期：2012-05-02 00:00:00

  • Pulmonary arterial hypertension in scleroderma: care gaps in screening.

    abstract：:One in six patients with systemic sclerosis will develop pulmonary arterial hypertension (PAH). Screening with echocardiography and possibly pulmonary function testing (to determine the diffusing capacity of carbon monoxide) is recommended to detect PAH at a less severe stage. However, real-world screening programs ha...

    journal_title：Arthritis research & therapy

    pub_type： 社论

    doi：10.1186/s13075-017-1347-4

    authors： Pope JE

    更新日期：2017-06-06 00:00:00

  • The changing landscape of the clinical value of the PM/Scl autoantibody system.

    abstract：:Autoantibodies to the polymyositis/scleroderma (PM/Scl) complex have been associated with systemic sclerosis and PM/Scl overlap syndrome. The report of Hanke and colleagues in a recent issue of Arthritis Research and Therapy is the first to describe the separate evaluation of anti-PM/Scl-75c and PM/Scl-100 autoantibod...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar2646

    authors： Mahler M,Fritzler MJ

    更新日期：2009-01-01 00:00:00

  • B cells in rheumatoid synovitis.

    abstract：:In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B c...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,评审

    doi：10.1186/ar1737

    authors： Weyand CM,Seyler TM,Goronzy JJ

    更新日期：2005-01-01 00:00:00

  • Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials.

    abstract：INTRODUCTION:The efficacy and the optimal type and volume of aerobic exercise (AE) in fibromyalgia syndrome (FMS) are not established. We therefore assessed the efficacy of different types and volumes of AE in FMS. METHODS:The Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDISCUS (through April 2009) and the re...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/ar3002

    authors： Häuser W,Klose P,Langhorst J,Moradi B,Steinbach M,Schiltenwolf M,Busch A

    更新日期：2010-01-01 00:00:00

  • Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies.

    abstract：INTRODUCTION:There is a suspicion of increased risk of Epstein-Barr virus (EBV)-associated lymphoproliferations in patients with inflammatory arthritides receiving immunosuppressive drugs. We investigated the EBV load and EBV-specific T-cell response in patients treated with methotrexate (MTX) or anti-TNF therapy. MET...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar2708

    authors： Miceli-Richard C,Gestermann N,Amiel C,Sellam J,Ittah M,Pavy S,Urrutia A,Girauld I,Carcelain G,Venet A,Mariette X

    更新日期：2009-01-01 00:00:00

  • Inflammatory expression profiles in monocyte-to-macrophage differentiation in patients with systemic lupus erythematosus and relationship with atherosclerosis.

    abstract：INTRODUCTION:Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. METHODS:Monocytes were obtain...

    journal_title：Arthritis research & therapy

    pub_type： 杂志文章

    doi：10.1186/ar4609

    authors： Korman BD,Huang CC,Skamra C,Wu P,Koessler R,Yao D,Huang QQ,Pearce W,Sutton-Tyrrell K,Kondos G,Edmundowicz D,Pope R,Ramsey-Goldman R

    更新日期：2014-07-10 00:00:00

  • Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model.

    abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

    journal_title：Arthritis research & therapy

    pub_type： 评论,社论

    doi：10.1186/ar3082

    authors： van der Kraan PM

    更新日期：2010-01-01 00:00:00