Factors associated with the achievement of biological disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: the ANSWER cohort study.

abstract：:Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis. As proteinases their substrates include the von Willebrand factor precursor and extracellular matrix components such as procollagen, ...

journal_title：Arthritis research & therapy

authors： Jones GC,Riley GP

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The non-histone nuclear protein high mobility group box protein-1 (HMGB1) is typically associated with nucleosomes, but may shuttle between the nucleus and the cytoplasm, and under some conditions also be released extracellularly and participate in systemic inflammation. Monoclonal HMGB1-targeting antibodi...

journal_title：Arthritis research & therapy

authors： Wirestam L,Schierbeck H,Skogh T,Gunnarsson I,Ottosson L,Erlandsson-Harris H,Wetterö J,Sjöwall C

更新日期：2015-11-23 00:00:00

abstract：:Pleiotropic effects are now described for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammat...

journal_title：Arthritis research & therapy

authors： McCarey DW,Sattar N,McInnes IB

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma cell/plasmablast depletion mechanism by daratumumab in the treatment of patien...

journal_title：Arthritis research & therapy

authors： Cole S,Walsh A,Yin X,Wechalekar MD,Smith MD,Proudman SM,Veale DJ,Fearon U,Pitzalis C,Humby F,Bombardieri M,Axel A,Adams H 3rd,Chiu C,Sharp M,Alvarez J,Anderson I,Madakamutil L,Nagpal S,Guo Y

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein, we analyzed the 5-year outcome of the pMDA group and assessed for within-group heterogeneity. MET...

journal_title：Arthritis research & therapy

authors： Genitsaridi I,Flouri I,Plexousakis D,Marias K,Boki K,Skopouli F,Drosos A,Bertsias G,Boumpas D,Sidiropoulos P

更新日期：2020-09-29 00:00:00

abstract：:Adverse events of opioids may restrict their use in non-cancer pain. Analysis of the incidence of common adverse events in trials conducted in non-cancer pain has usually been limited to opioids used to treat severe pain according to the WHO three-step ladder. To examine the incidence of common adverse events of opioi...

journal_title：Arthritis research & therapy

authors： Moore RA,McQuay HJ

更新日期：2005-01-01 00:00:00

abstract：:Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/BxN mice, although some groups have reported that few healthy humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) is genetically regulated and has strong implications for the development of...

journal_title：Arthritis research & therapy

authors： Matsumoto I,Zhang H,Muraki Y,Hayashi T,Yasukochi T,Kori Y,Goto D,Ito S,Tsutsumi A,Sumida T

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

journal_title：Arthritis research & therapy

authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

journal_title：Arthritis research & therapy

authors： Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

更新日期：2021-01-19 00:00:00

abstract：INTRODUCTION:The role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthritis (RA) in relation to the expression of vascular endothelial growth factor (VEGF) and matrix metal...

journal_title：Arthritis research & therapy

authors： Choi HM,Lee YA,Lee SH,Hong SJ,Hahm DH,Choi SY,Yang HI,Yoo MC,Kim KS

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Lesional skin of patients with discoid lupus erythematosus (DLE) contains macrophages, whose polarization has yet to be investigated. To test our hypothesis that M1 macrophages would be increased in DLE skin, we examined transcriptome alterations in immune cell gene expression and macrophage features in DL...

journal_title：Arthritis research & therapy

authors： Chong BF,Tseng LC,Hosler GA,Teske NM,Zhang S,Karp DR,Olsen NJ,Mohan C

更新日期：2015-11-13 00:00:00

abstract：BACKGROUND:Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training could improve remodeling, we measured changes in inter-relationships of plasma galectin-3, skel...

journal_title：Arthritis research & therapy

authors： Andonian BJ,Bartlett DB,Huebner JL,Willis L,Hoselton A,Kraus VB,Kraus WE,Huffman KM

更新日期：2018-12-27 00:00:00

abstract：INTRODUCTION:Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the associatio...

journal_title：Arthritis research & therapy

authors： Schipper LG,Fransen J,den Broeder AA,Van Riel PL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises ...

journal_title：Arthritis research & therapy

authors： Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

更新日期：2012-01-08 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is a tightly orchestrated process dependent on several factors, including the balance between receptor acti...

journal_title：Arthritis research & therapy

authors： Carmona-Fernandes D,Santos MJ,Perpétuo IP,Fonseca JE,Canhão H

更新日期：2011-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is an autologous concentrated cocktail of growth factors and inflammatory mediators, and has been considered to be potentially effective for cartilage repair. In addition, the fibrinogen in PRP may be activated to form a fibrin matrix to fill cartilage lesions, fulfilling the initial require...

journal_title：Arthritis research & therapy

authors： Xie X,Zhang C,Tuan RS

更新日期：2014-02-25 00:00:00

abstract：:Patients with lupus have a continuous production of IFNα and display an increased expression of IFNα-regulated genes. The reason for the ongoing IFNα synthesis in these patients seems to be an activation of plasmacytoid dendritic cells (pDCs) by immune complexes (ICs), consisting of autoantibodies in combination with ...

journal_title：Arthritis research & therapy

authors： Rönnblom L

更新日期：2010-01-01 00:00:00

abstract：:B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex formation and complement activation in the joints. B cells are also very efficient antigen-presenting cells, ...

journal_title：Arthritis research & therapy

authors： Silverman GJ,Carson DA

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:The FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis plays a fundamental role in proliferation and differentiation of dendritic cells (DCs). As DCs play an important role in rheumatoid arthritis (RA) immunopathology we studied in detail the Flt3L/CD135 axis in RA patients. METHODS:The levels of Flt...

journal_title：Arthritis research & therapy

authors： Ramos MI,Perez SG,Aarrass S,Helder B,Broekstra P,Gerlag DM,Reedquist KA,Tak PP,Lebre MC

更新日期：2013-01-01 00:00:00

abstract：:Mammalian immune responses are intended to eradicate microbial pathogens and thus protect individuals from the harmful effects of such infections. However, unresolved inflammation can be devastating to the host and cause tissue damage and organ malfunction. Immune responses can even mistakenly target self-antigens and...

journal_title：Arthritis research & therapy

authors： Hu R,O'Connell RM

更新日期：2013-01-25 00:00:00

abstract：INTRODUCTION:Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with complex etiopathogenesis. Despite extensive studies to understand the disease process utilizing human and mouse models, the intersection between these species remains elusive. To address this gap, we utilized a novel systems biology appr...

journal_title：Arthritis research & therapy

authors： Horvath S,Nazmul-Hossain AN,Pollard RP,Kroese FG,Vissink A,Kallenberg CG,Spijkervet FK,Bootsma H,Michie SA,Gorr SU,Peck AB,Cai C,Zhou H,Wong DT

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA). METHODS:This was a non-randomised, single-centre, pro...

journal_title：Arthritis research & therapy

authors： Salomon S,Guignant C,Morel P,Flahaut G,Brault C,Gourguechon C,Fardellone P,Marolleau JP,Gubler B,Goëb V

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). METHODS:Clinical and radiographic data of 87 RA patients were r...

journal_title：Arthritis research & therapy

authors： Verstappen SM,Poole AR,Ionescu M,King LE,Abrahamowicz M,Hofman DM,Bijlsma JW,Lafeber FP,Utrecht Rheumatoid Arthritis Cohort Study group (SRU).

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Pain remains the most important problem for people with rheumatoid arthritis (RA). Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment of disease activity. We hypothesize that augmented pain processing, fibromyalgic features, poorer menta...

journal_title：Arthritis research & therapy

authors： Joharatnam N,McWilliams DF,Wilson D,Wheeler M,Pande I,Walsh DA

更新日期：2015-01-20 00:00:00

abstract：INTRODUCTION:Soluble immune aggregates bearing intact Fc fragments are effective treatment for a variety of autoimmune disorders in mice. The better to understand the mechanisms by which Fc-bearing immune complexes suppress autoimmunity, and to develop a platform for clinical translation, we created a series of fully r...

journal_title：Arthritis research & therapy

authors： Jain A,Olsen HS,Vyzasatya R,Burch E,Sakoda Y,Mérigeon EY,Cai L,Lu C,Tan M,Tamada K,Schulze D,Block DS,Strome SE

更新日期：2012-08-20 00:00:00

abstract：: ...

journal_title：Arthritis research & therapy

authors： Sato S,Fujita Y,Shigemura T,Matoba H,Agematsu K,Sumichika Y,Yashiro M,Ono A,Kawasaki Y,Kobayashi H,Watanabe H,Koga T,Kawakami A,Migita K

更新日期：2018-12-10 00:00:00

abstract：INTRODUCTION:In this study, we aimed to determine the relationship between flow-mediated endothelium-dependent vasodilatation (FMD) and carotid artery intima-media wall thickness (IMT), two surrogate markers of atherosclerosis, in a series of Spanish patients with rheumatoid arthritis (RA) without clinically evident ca...

journal_title：Arthritis research & therapy

authors： González-Juanatey C,Llorca J,González-Gay MA

更新日期：2011-06-22 00:00:00

abstract：INTRODUCTION:Despite growing evidence that large intergenic noncoding RNAs (lincRNAs) can regulate gene expression and widely take part in normal physiological and disease conditions, our knowledge of systemic lupus erythematosus (SLE)-related lincRNAs remains limited. The aim of this study was to detect the levels of ...

journal_title：Arthritis research & therapy

authors： Wu Y,Zhang F,Ma J,Zhang X,Wu L,Qu B,Xia S,Chen S,Tang Y,Shen N

更新日期：2015-05-21 00:00:00

abstract：:Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lupus erythematosus an...

journal_title：Arthritis research & therapy

authors： Gray SG

更新日期：2013-03-14 00:00:00

abstract：:Although it is generally accepted that osteoarthritis is a degenerative condition of the cartilage, other tissues such as synovium in which immunological and inflammatory reactions occur contribute to the development of joint pathology. This sheds new light on the potential mechanism of action of mesenchymal stem cell...

journal_title：Arthritis research & therapy

authors： van Lent PL,van den Berg WB

更新日期：2013-03-20 00:00:00