Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?

abstract：INTRODUCTION:Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as a possible biomarker in primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and ...

journal_title：Arthritis research & therapy

authors： Sellam J,Proulle V,Jüngel A,Ittah M,Miceli Richard C,Gottenberg JE,Toti F,Benessiano J,Gay S,Freyssinet JM,Mariette X

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Despite the substantial prevalence of gout in the ageing female population, female hormonal influence has not been comprehensively examined. We evaluated and quantified the potential independent association between menopause, postmenopausal hormone use and serum uric acid levels in a nationally representat...

journal_title：Arthritis research & therapy

authors： Hak AE,Choi HK

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post hoc meta-analysis of BLISS-52 and BLISS-76 explored the relationship between base...

journal_title：Arthritis research & therapy

authors： Wilkinson C,Henderson RB,Jones-Leone AR,Flint SM,Lennon M,Levy RA,Ji B,Bass DL,Roth D

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF b...

journal_title：Arthritis research & therapy

authors： Estelius J,Lengqvist J,Ossipova E,Idborg H,Le Maître E,Andersson MLA,Brundin L,Khademi M,Svenungsson E,Jakobsson PJ,Lampa J

更新日期：2019-02-15 00:00:00

abstract：INTRODUCTION:Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome. METHODS:Fort...

journal_title：Arthritis research & therapy

authors： Vacca A,Montisci R,Garau P,Siotto P,Piga M,Cauli A,Ruscazio M,Meloni L,Iliceto S,Mathieu A

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of inclu...

journal_title：Arthritis research & therapy

authors： LaValley MP,Lo GH,Price LL,Driban JB,Eaton CB,McAlindon TE

更新日期：2017-05-16 00:00:00

abstract：BACKGROUND:BoneXpert (BX) is a newly developed medical device based on digital X-ray radiogrammetry to measure human cortical bone thickness. The aim of this study was to quantify cortical bone loss of the metacarpals in patients with psoriatic arthritis (PsA) and compare these findings with other radiological scoring ...

journal_title：Arthritis research & therapy

authors： Pfeil A,Krojniak L,Renz DM,Reinhardt L,Franz M,Oelzner P,Wolf G,Böttcher J

更新日期：2016-10-25 00:00:00

abstract：INTRODUCTION:Notable weakness of the quadriceps muscles is typically observed as a consequence of knee joint arthritis, knee surgery and knee injury. This is partly due to ongoing neural inhibition that prevents the central nervous system from fully activating the quadriceps, a process known as arthrogenic muscle inhib...

journal_title：Arthritis research & therapy

authors： Rice DA,Graven-Nielsen T,Lewis GN,McNair PJ,Dalbeth N

更新日期：2015-08-12 00:00:00

abstract：INTRODUCTION:Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats-suggesting it may be a potent drug for rheumatoid arthritis (RA) therapy. We aimed to investigate its effect on the invasive property of fibroblast-like synoviocyte...

journal_title：Arthritis research & therapy

authors： Ma JD,Jing J,Wang JW,Yan T,Li QH,Mo YQ,Zheng DH,Gao JL,Nguyen KA,Dai L

更新日期：2019-06-24 00:00:00

abstract：INTRODUCTION:We sought to assess vascularity in wrist tenosynovitis by using power Doppler ultrasound (PDUS) and to compare detection of intra- and peritendinous vascularity with that of contrast-enhanced grey-scale ultrasound (CEUS). METHODS:Twenty-six tendons of 24 patients (nine men, 15 women; mean age ± SD, 54.4 ±...

journal_title：Arthritis research & therapy

authors： Klauser AS,Franz M,Arora R,Feuchtner GM,Gruber J,Schirmer M,Jaschke WR,Gabl MF

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a conti...

journal_title：Arthritis research & therapy

authors： Teichtahl AJ,Urquhart DM,Wang Y,Wluka AE,Heritier S,Cicuttini FM

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. METHODS:Eighty 10-week-old male C57BL/6 mice w...

journal_title：Arthritis research & therapy

authors： Li H,Ding X,Terkeltaub R,Lin H,Zhang Y,Zhou B,He K,Li K,Liu Z,Wei J,Yang Y,Xie H,Zeng C,Lei G

更新日期：2020-02-22 00:00:00

abstract：BACKGROUND:Biologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawal of the bDMARD. Results from published studies indicate that some patients will maintain remission;...

journal_title：Arthritis research & therapy

authors： Tanaka Y,Smolen JS,Jones H,Szumski A,Marshall L,Emery P

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:In osteoarthritis, chondrocytes adopt an abnormal hypertrophic morphology and upregulate the expression of the extracellular matrix-degrading enzymes, MMP-13 and ADAMTS-5. The activation of the hedgehog signalling pathway has been established in osteoarthritis and is thought to influence both of these proces...

journal_title：Arthritis research & therapy

authors： Thompson CL,Patel R,Kelly TA,Wann AK,Hung CT,Chapple JP,Knight MM

更新日期：2015-12-24 00:00:00

abstract：INTRODUCTION:Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms could explain part of the remaining heritability. Multiple interactions have been reported, but only the share...

journal_title：Arthritis research & therapy

authors： Ferreiro-Iglesias A,Calaza M,Perez-Pampin E,Lopez Longo FJ,Marenco JL,Blanco FJ,Narvaez J,Navarro F,Cañete JD,de la Serna AR,Gonzalez-Alvaro I,Herrero-Beaumont G,Pablos JL,Balsa A,Fernandez-Gutierrez B,Caliz R,Gomez-Reino

更新日期：2014-09-27 00:00:00

abstract：:In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decrease in systemic inflamm...

journal_title：Arthritis research & therapy

authors： Mendez-Fernandez Y,Major A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and prevention of gene transcription. Sources of Id1 production in rheumatoid arthritis synovial tissue (RA ST) and its range of functional effects in RA rem...

journal_title：Arthritis research & therapy

authors： Edhayan G,Ohara RA,Stinson WA,Amin MA,Isozaki T,Ha CM,Haines GK 3rd,Morgan R,Campbell PL,Arbab AS,Friday SC,Fox DA,Ruth JH

更新日期：2016-04-12 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and safety of mycophenolate sodium (MPS) in patients with primary Sjögren syndrome (pSS) refractory to other immunosuppressive agents. Eleven patients with pSS were treated with MPS up to 1,440 mg daily for an observation period of 6 months in this single-center, open...

journal_title：Arthritis research & therapy

authors： Willeke P,Schlüter B,Becker H,Schotte H,Domschke W,Gaubitz M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00

abstract：:A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature ...

journal_title：Arthritis research & therapy

authors： Abraham D,Distler O

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The arthritis-specific Work Productivity Survey (WPS) was developed to evaluate productivity limitations associated with arthritis within and outside the home. There is an unmet need for an instrument assessing similar productivity limitations in axial spondyloarthritis (axSpA), including nonradiographic a...

journal_title：Arthritis research & therapy

authors： Osterhaus JT,Purcaru O

更新日期：2014-08-06 00:00:00

abstract：INTRODUCTION:Methotrexate (MTX) is a cornerstone of treatment in a wide variety of inflammatory conditions, including juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM). However, owing to its narrow therapeutic index and the considerable interpatient variability in clinical response, monitoring of a...

journal_title：Arthritis research & therapy

authors： Hawwa AF,AlBawab A,Rooney M,Wedderburn LR,Beresford MW,McElnay JC

更新日期：2015-10-22 00:00:00

abstract：INTRODUCTION:TNFα is a proinflammatory cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of certolizumab pegol, a TNFα blocker, on endothelial cell function and angiogenesis. METHODS:Human dermal microvascular endothelial cells (HMVECs) were stimulated wit...

journal_title：Arthritis research & therapy

authors： Shu Q,Amin MA,Ruth JH,Campbell PL,Koch AE

更新日期：2012-04-25 00:00:00

abstract：:Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lupus erythematosus an...

journal_title：Arthritis research & therapy

authors： Gray SG

更新日期：2013-03-14 00:00:00

abstract：INTRODUCTION:HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Because PBMCs from lcSSc-PAH patients are also characteri...

journal_title：Arthritis research & therapy

authors： Lenna S,Assassi S,Farina GA,Mantero JC,Scorza R,Lafyatis R,Farber HW,Trojanowska M

更新日期：2015-12-16 00:00:00

abstract：INTRODUCTION:Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease ...

journal_title：Arthritis research & therapy

authors： Rastogi A,Kim H,Twomey JD,Hsieh AH

更新日期：2013-04-27 00:00:00

abstract：OBJECTIVE:To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). PATIENTS AND METHODS:This was a retrospective cohort study, which included 522 patients with PM/DM-ILD whose...

journal_title：Arthritis research & therapy

authors： Li R,Zhu WJ,Wang F,Tang X,Luo F

更新日期：2020-09-20 00:00:00

abstract：RESULTS:Anti-CarP antibodies were detected in 117 patients with RA (37.9%), ACPA in 190 patients (61.4%) and RF in 202 patients (65.3%). Two (2.04%) of the NHS were positive for anti-CarP, one NHS (1.02%) was positive for ACPA and three NHS were positive for RF (3.06%). Among disease controls, anti-CarP antibodies were...

journal_title：Arthritis research & therapy

authors： Pecani A,Alessandri C,Spinelli FR,Priori R,Riccieri V,Di Franco M,Ceccarelli F,Colasanti T,Pendolino M,Mancini R,Truglia S,Barbati C,Vomero M,Sabatinelli D,Morello F,Valesini G,Conti F

更新日期：2016-12-16 00:00:00

abstract：INTRODUCTION:Properdin amplifies the alternative pathway of complement activation. In the present study, we evaluated its role in the development of collagen antibody-induced arthritis (CAIA). METHODS:Arthritis was induced by intraperitoneal injection of a collagen antibody cocktail into properdin-deficient (KO) and w...

journal_title：Arthritis research & therapy

authors： Dimitrova P,Ivanovska N,Belenska L,Milanova V,Schwaeble W,Stover C

更新日期：2012-07-25 00:00:00

abstract：:The transcription factor STAT-1 (signal transducer and activator of transcription-1) plays a pivotal role in the expression of inflammatory gene products involved in the pathogenesis of arthritis such as various cytokines and the CD40/CD40 ligand (CD40/CD40L) receptor-ligand dyad. The therapeutic efficacy of a synthet...

journal_title：Arthritis research & therapy

authors： Hückel M,Schurigt U,Wagner AH,Stöckigt R,Petrow PK,Thoss K,Gajda M,Henzgen S,Hecker M,Bräuer R

更新日期：2006-01-01 00:00:00