Detection of vascularity in wrist tenosynovitis: power doppler ultrasound compared with contrast-enhanced grey-scale ultrasound.

abstract：:Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the ...

journal_title：Arthritis research & therapy

authors： Masi AT

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia. METHODS:Using data from the Taiwanese National Health Insurance Research Database, we performed a propensity score-matched cohort study to analyze patients with fi...

journal_title：Arthritis research & therapy

authors： Wu MY,Huang MC,Chiang JH,Sun MF,Lee YC,Yen HR

更新日期：2017-02-28 00:00:00

abstract：:Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevated in the serum of patients with this disease and is expressed by the lymphocytes infiltrating the salivary gl...

journal_title：Arthritis research & therapy

authors： Scofield RH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD:Assessm...

journal_title：Arthritis research & therapy

authors： Coates LC,Wallman JK,McGonagle D,Schett GA,McInnes IB,Mease PJ,Rasouliyan L,Quebe-Fehling E,Asquith DL,Fasth AER,Pricop L,Gaillez C

更新日期：2019-12-04 00:00:00

abstract：:This review summarizes the immunological consequences of biological therapies used in juvenile idiopathic arthritis (JIA). For every frequently used biological agent the characteristics are clearly specified (molecular target, isotype, registered indication for JIA, route of administration, half-life, contraindication...

journal_title：Arthritis research & therapy

authors： Swart JF,de Roock S,Wulffraat NM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats-suggesting it may be a potent drug for rheumatoid arthritis (RA) therapy. We aimed to investigate its effect on the invasive property of fibroblast-like synoviocyte...

journal_title：Arthritis research & therapy

authors： Ma JD,Jing J,Wang JW,Yan T,Li QH,Mo YQ,Zheng DH,Gao JL,Nguyen KA,Dai L

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthritis (RA). METHOD:RNA-sequencing-(RNA-seq)-based expression analysis of 377 genes from previously v...

journal_title：Arthritis research & therapy

authors： Shchetynsky K,Diaz-Gallo LM,Folkersen L,Hensvold AH,Catrina AI,Berg L,Klareskog L,Padyukov L

更新日期：2017-02-02 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate...

journal_title：Arthritis research & therapy

authors： Moulton VR,Tsokos GC

更新日期：2011-03-17 00:00:00

abstract：:The field of biomarkers is a growing one, particularly in osteoarthritis (OA). OA is the most common disabling condition in older persons and a major cause of morbidity. While the debate continues about which of the involved tissues--cartilage, bone or synovium--is the most important in OA aetiology, there is no doubt...

journal_title：Arthritis research & therapy

authors： Williams FM

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Although the prevalence of arthritis dramatically increases with age, the great majority of preclinical studies concerning the mechanisms that drive arthritic joint pain have been performed in young animals. One mechanism hypothesized to contribute to arthritic pain is ectopic nerve sprouting; however, neu...

journal_title：Arthritis research & therapy

authors： Jimenez-Andrade JM,Mantyh PW

更新日期：2012-05-01 00:00:00

abstract：:Anti-Sa antibodies are detected in the serum of 20-47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed th...

journal_title：Arthritis research & therapy

authors： El-Gabalawy HS,Wilkins JA

更新日期：2004-01-01 00:00:00

abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

journal_title：Arthritis research & therapy

authors： van der Kraan PM

更新日期：2010-01-01 00:00:00

abstract：:Patients with lupus have a continuous production of IFNα and display an increased expression of IFNα-regulated genes. The reason for the ongoing IFNα synthesis in these patients seems to be an activation of plasmacytoid dendritic cells (pDCs) by immune complexes (ICs), consisting of autoantibodies in combination with ...

journal_title：Arthritis research & therapy

authors： Rönnblom L

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of i...

journal_title：Arthritis research & therapy

authors： Peterson JD,Labranche TP,Vasquez KO,Kossodo S,Melton M,Rader R,Listello JT,Abrams MA,Misko TP

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has bee...

journal_title：Arthritis research & therapy

authors： Zhang C,Gao C,Di X,Cui S,Liang W,Sun W,Yao M,Liu S,Zheng Z

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:The aim was to assess patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) treated with filgotinib during two phase 2b, 24-week, randomized, placebo-controlled studies. METHODS:Patients with moderate-to-severe active RA and an inadequate response to methotrexate (MTX) were randomized ...

journal_title：Arthritis research & therapy

authors： Genovese M,Westhovens R,Meuleners L,Van der Aa A,Harrison P,Tasset C,Kavanaugh A

更新日期：2018-03-23 00:00:00

abstract：INTRODUCTION:Hyperuricemia is the greatest risk factor for gout and is caused by an overproduction and/or inefficient renal clearance of urate. The fractional renal clearance of urate (FCU, renal clearance of urate/renal clearance of creatinine) has been proposed as a tool to identify subjects who manifest inefficient ...

journal_title：Arthritis research & therapy

authors： Kannangara DR,Ramasamy SN,Indraratna PL,Stocker SL,Graham GG,Jones G,Portek I,Williams KM,Day RO

更新日期：2012-08-17 00:00:00

abstract：BACKGROUND:Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allopurinol alone. Hence,...

journal_title：Arthritis research & therapy

authors： McWherter C,Choi YJ,Serrano RL,Mahata SK,Terkeltaub R,Liu-Bryan R

更新日期：2018-09-06 00:00:00

abstract：INTRODUCTION:Osteoporosis of the axial skeleton is a known complication of ankylosing spondylitis (AS), but bone loss affecting the peripheral skeleton is less studied. This study on volumetric bone mineral density (vBMD) and bone microarchitecture in AS was conducted to compare peripheral vBMD in AS patients with that...

journal_title：Arthritis research & therapy

authors： Klingberg E,Lorentzon M,Göthlin J,Mellström D,Geijer M,Ohlsson C,Atkinson EJ,Khosla S,Carlsten H,Forsblad-d'Elia H

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Soluble immune aggregates bearing intact Fc fragments are effective treatment for a variety of autoimmune disorders in mice. The better to understand the mechanisms by which Fc-bearing immune complexes suppress autoimmunity, and to develop a platform for clinical translation, we created a series of fully r...

journal_title：Arthritis research & therapy

authors： Jain A,Olsen HS,Vyzasatya R,Burch E,Sakoda Y,Mérigeon EY,Cai L,Lu C,Tan M,Tamada K,Schulze D,Block DS,Strome SE

更新日期：2012-08-20 00:00:00

abstract：INTRODUCTION:The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. METHODS:T-cell receptor transgenic mice, in which nearly all CD4+ T cells recognize a single peptide of type II collagen, were immunized with collagen and obs...

journal_title：Arthritis research & therapy

authors： Lundy SK,Fox DA

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to determine which genes' expression is related to atherosclerosis in SLE. METHODS:Monocytes were obtain...

journal_title：Arthritis research & therapy

authors： Korman BD,Huang CC,Skamra C,Wu P,Koessler R,Yao D,Huang QQ,Pearce W,Sutton-Tyrrell K,Kondos G,Edmundowicz D,Pope R,Ramsey-Goldman R

更新日期：2014-07-10 00:00:00

abstract：INTRODUCTION:Physical activity has been recommended to patients with knee osteoarthritis for improving their symptoms. However, it is still controversial if physical activity has effects on joint structures including cartilage volume. The aim of this study was to describe the associations between physical activity and ...

journal_title：Arthritis research & therapy

authors： Antony B,Venn A,Cicuttini F,March L,Blizzard L,Dwyer T,Cross M,Jones G,Ding C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00

abstract：:Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines an...

journal_title：Arthritis research & therapy

authors： Raza K,Falciani F,Curnow SJ,Ross EJ,Lee CY,Akbar AN,Lord JM,Gordon C,Buckley CD,Salmon M

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Properdin amplifies the alternative pathway of complement activation. In the present study, we evaluated its role in the development of collagen antibody-induced arthritis (CAIA). METHODS:Arthritis was induced by intraperitoneal injection of a collagen antibody cocktail into properdin-deficient (KO) and w...

journal_title：Arthritis research & therapy

authors： Dimitrova P,Ivanovska N,Belenska L,Milanova V,Schwaeble W,Stover C

更新日期：2012-07-25 00:00:00

abstract：BACKGROUND:The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in the intervertebral disc (IVD) has not been examined in detail. The purposes of this study were to ex...

journal_title：Arthritis research & therapy

authors： Takegami N,Akeda K,Yamada J,Sano T,Murata K,Huang J,Masuda K,Sudo A

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. METHODS:Eighty 10-week-old male C57BL/6 mice w...

journal_title：Arthritis research & therapy

authors： Li H,Ding X,Terkeltaub R,Lin H,Zhang Y,Zhou B,He K,Li K,Liu Z,Wei J,Yang Y,Xie H,Zeng C,Lei G

更新日期：2020-02-22 00:00:00

abstract：INTRODUCTION:Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic effects. Two isoforms have been identified: hematopoietic- and lipocalin-type PGDS (H-PGDS and L-PGDS, respectively). The aims of this study were to ...

journal_title：Arthritis research & therapy

authors： Zayed N,Li X,Chabane N,Benderdour M,Martel-Pelletier J,Pelletier JP,Duval N,Fahmi H

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:A number of occupational risk factors are discussed in relation to the development and progress of knee joint diseases (for example, working in a kneeling or squatting posture, lifting and carrying heavy weights). Besides the occupational factors, a number of individual risk factors are important. The dist...

journal_title：Arthritis research & therapy

authors： Klussmann A,Gebhardt H,Nübling M,Liebers F,Quirós Perea E,Cordier W,von Engelhardt LV,Schubert M,Dávid A,Bouillon B,Rieger MA

更新日期：2010-01-01 00:00:00