What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis?

abstract：BACKGROUND:In this study, we assessed whether clinical and ultrasonography (US)-based remission could be used to select patients with rheumatoid arthritis (RA) eligible to taper and discontinue anti-TNF-α therapy after achievement of remission, looking at disease relapse. METHODS:Forty-two patients with RA in sustaine...

journal_title：Arthritis research & therapy

authors： Alivernini S,Peluso G,Fedele AL,Tolusso B,Gremese E,Ferraccioli G

更新日期：2016-02-03 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin (a well recognized BMP inhibitor) and BMP-2 are expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin inhibition induces human mesenchymal stem cell...

journal_title：Arthritis research & therapy

authors： Heliotis M,Tsiridis E

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Gouty arthritis (gout) is primarily cared for in ambulatory care settings. Although the prevalence of gout in the US is thought to be increasing, there have been few data on this as well as temporal changes in gout medication use. METHODS:We analyzed annual visit and drug utilization data from national sa...

journal_title：Arthritis research & therapy

authors： Krishnan E,Chen L

更新日期：2013-11-06 00:00:00

abstract：:Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthritis and reported t...

journal_title：Arthritis research & therapy

authors： Kinderlerer AR,Steinberg R,Johns M,Harten SK,Lidington EA,Haskard DO,Maxwell PH,Mason JC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON). METHODS:Twenty-four female patients with FMS (54 ± 8 years) and 27 female CON (54 ± 9 years) were subjected to ...

journal_title：Arthritis research & therapy

authors： Ernberg M,Christidis N,Ghafouri B,Bileviciute-Ljungar I,Löfgren M,Larsson A,Palstam A,Bjersing J,Mannerkorpi K,Kosek E,Gerdle B

更新日期：2016-06-13 00:00:00

abstract：INTRODUCTION:During the progression of rheumatoid arthritis (RA), there are frequent but intermittent flares in which the joint becomes acutely inflamed and painful. Although a number of drug therapies are currently used to treat RA, their effectiveness is variable and side effects are common. Endocannabinoids have the...

journal_title：Arthritis research & therapy

authors： Krustev E,Reid A,McDougall JJ

更新日期：2014-09-27 00:00:00

abstract：:Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex ...

journal_title：Arthritis research & therapy

authors： Tveita A,Rekvig OP,Zykova SN

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with complex etiopathogenesis. Despite extensive studies to understand the disease process utilizing human and mouse models, the intersection between these species remains elusive. To address this gap, we utilized a novel systems biology appr...

journal_title：Arthritis research & therapy

authors： Horvath S,Nazmul-Hossain AN,Pollard RP,Kroese FG,Vissink A,Kallenberg CG,Spijkervet FK,Bootsma H,Michie SA,Gorr SU,Peck AB,Cai C,Zhou H,Wong DT

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:Bone morphogenetic proteins (BMPs) are critical growth factors in the osteogenic differentiation of progenitor cells during development in embryos and fracture repair in adults. Although recombinant BMPs are in use clinically, their clinical efficiency needs to be improved. The biological activities of BMP...

journal_title：Arthritis research & therapy

authors： Kwong FN,Richardson SM,Evans CH

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:A proliferation-inducing ligand (APRIL) from the TNF family, owing to its role in the generation and survival of plasma cells (PCs), is currently targeted for rheumatoid arthritis (RA) treatment. However, little is known about APRIL expression in RA lesions, hampering our understanding of the way APRIL may...

journal_title：Arthritis research & therapy

authors： Gabay C,Krenn V,Bosshard C,Seemayer CA,Chizzolini C,Huard B

更新日期：2009-01-01 00:00:00

abstract：:In a study published recently in Arthritis Research & Therapy, Woo and colleagues investigated the effects of pravastatin in combination with an apolipoprotein-AI (Apo-AI) mimetic peptide in a mouse model of lupus-accelerated atherosclerosis. Combination treatment resulted in a significant decrease in systemic inflamm...

journal_title：Arthritis research & therapy

authors： Mendez-Fernandez Y,Major A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:Disease-modifying antirheumatic drugs (DMARDs) have become the treatment standard for patients with rheumatoid arthritis (RA). Although several general-population studies document that a large population of patients diagnosed with RA do not use DMARDs, little is known about this group. We explored the char...

journal_title：Arthritis research & therapy

authors： Brown EM,Garneau KL,Tsao H,Solomon DH

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to certolizumab pegol (CZP) using data from the PREDICT trial. METHODS:Patients in PREDICT were randomiz...

journal_title：Arthritis research & therapy

authors： Curtis JR,Herrem C,Ndlovu 'N,O'Brien C,Yazici Y

更新日期：2017-09-29 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is characterized by progressive inflammation associated with rampantly proliferating synoviocytes and joint destruction due to oxidative stress. Recently, we described nuclear factor erythroid 2-related factor 2 (Nrf2) as a major requirement for limiting cartilage destruction. NF-...

journal_title：Arthritis research & therapy

authors： Fragoulis A,Laufs J,Müller S,Soppa U,Siegl S,Reiss LK,Tohidnezhad M,Rosen C,Tenbrock K,Varoga D,Lippross S,Pufe T,Wruck CJ

更新日期：2012-10-27 00:00:00

abstract：INTRODUCTION:Little is known about systemic B-cell activation in early rheumatoid arthritis (RA). We therefore evaluated the serum levels of markers of B-cell activation in patients included in the ESPOIR early arthritis cohort. METHODS:In the ESPOIR early arthritis cohort (at least 2 swollen joints for more than 6 we...

journal_title：Arthritis research & therapy

authors： Gottenberg JE,Miceli-Richard C,Ducot B,Goupille P,Combe B,Mariette X

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration modifies the therapeutic decision and improves the control of disease activity. METHODS:RA patie...

journal_title：Arthritis research & therapy

authors： Mulleman D,Méric JC,Paintaud G,Ducourau E,Magdelaine-Beuzelin C,Valat JP,Goupille P,Centre National de la Recherche Scientifique UMR 6239 GICC.

更新日期：2009-01-01 00:00:00

abstract：:Idiopathic CD4 lymphocytopenia (ICL) is a presumed heterogenous syndrome with key element low CD4 T-cell counts (below 300/mm³) without evidence of HIV infection or other known immunodeficiency. The etiology, pathogenesis, and management of ICL remain poorly understood and inadequately defined. The clinical presentati...

journal_title：Arthritis research & therapy

authors： Zonios D,Sheikh V,Sereti I

更新日期：2012-08-31 00:00:00

abstract：:Decreased number and impaired functions of endothelial progenitor cells (EPCs) leading to impaired vasculogenesis have been associated with rheumatoid arthritis (RA). Defective vasculogenesis has also been implicated in premature atherosclerosis in RA. Recently, early-outgrowth monocytic and late-outgrowth hemangiobla...

journal_title：Arthritis research & therapy

authors： Szekanecz Z,Koch AE

更新日期：2010-01-01 00:00:00

abstract：:The autoinflammatory diseases, also known as periodic fever syndromes, are disorders of innate immunity which can be inherited or acquired and which cause recurrent, self-limiting, seemingly spontaneous episodes of systemic inflammation and fever in the absence of autoantibody production or infection. There has been m...

journal_title：Arthritis research & therapy

authors： Lachmann HJ,Hawkins PN

更新日期：2009-01-01 00:00:00

abstract：:Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification...

journal_title：Arthritis research & therapy

authors： MacMullan PA,McCarthy GM

更新日期：2010-01-01 00:00:00

abstract：:An impaired differentiation of naive CD4+ T cells towards Th2 cells may contribute to the chronic tissue-destructive T-cell activity in rheumatoid arthritis (RA). The differentiation of naive CD4+ T cells into memory Th2 cells by IL-7 in comparison with that by IL-4 was studied in RA patients and in healthy controls. ...

journal_title：Arthritis research & therapy

authors： van Roon JA,Glaudemans CA,Bijlsma JW,Lafeber FP

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:In recent decades, low-level laser therapy (LLLT) has been widely used to relieve pain caused by different musculoskeletal disorders. Though widely used, its reported therapeutic outcomes are varied and conflicting. Results similarly conflict regarding its usage in patients with nonspecific chronic low back ...

journal_title：Arthritis research & therapy

authors： Huang Z,Ma J,Chen J,Shen B,Pei F,Kraus VB

更新日期：2015-12-15 00:00:00

abstract：INTRODUCTION:The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). METHODS:Clinical and radiographic data of 87 RA patients were r...

journal_title：Arthritis research & therapy

authors： Verstappen SM,Poole AR,Ionescu M,King LE,Abrahamowicz M,Hofman DM,Bijlsma JW,Lafeber FP,Utrecht Rheumatoid Arthritis Cohort Study group (SRU).

更新日期：2006-01-01 00:00:00

abstract：:The article by Seror et al. in Arthritis Research & Therapy reports data from the 15 French patients in the open-label BELISS (Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome, NCT01160666) study of belimumab in primary Sjögren's syndrome. The study identifies that higher baseline levels of...

journal_title：Arthritis research & therapy

authors： Bowman SJ,Fisher BA

更新日期：2015-12-07 00:00:00

abstract：:Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical assessment of signaling status has made it difficult to evaluate putative abnormalities completely using primary ...

journal_title：Arthritis research & therapy

authors： Grammer AC,Fischer R,Lee O,Zhang X,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distinct subpopulation of patients can be identified. METHODS:We recruited patients with at least 1 SARD ...

journal_title：Arthritis research & therapy

authors： Reynolds JA,Briggs TA,Rice GI,Darmalinggam S,Bondet V,Bruce E,Khan M,Haque S,Chinoy H,Herrick AL,McCarthy EM,Zeef L,Hayes A,Duffy D,Parker B,Bruce IN

更新日期：2019-06-14 00:00:00

abstract：:The mechanism of endothelin-1 (ET-1)-induced nitric oxide (NO) production, MMP-1 production and MMP-13 production was investigated in human osteoarthritis chondrocytes. The cells were isolated from human articular cartilage obtained at surgery and were cultured in the absence or presence of ET-1 with or without inhibi...

journal_title：Arthritis research & therapy

authors： Manacu CA,Martel-Pelletier J,Roy-Beaudry M,Pelletier JP,Fernandes JC,Shipkolye FS,Mitrovic DR,Moldovan F

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF b...

journal_title：Arthritis research & therapy

authors： Estelius J,Lengqvist J,Ossipova E,Idborg H,Le Maître E,Andersson MLA,Brundin L,Khademi M,Svenungsson E,Jakobsson PJ,Lampa J

更新日期：2019-02-15 00:00:00

abstract：:A growing body of literature has demonstrated that the multifunctional glycoprotein osteopontin (OPN), has a role in type I interferon (IFN) production and may be involved in systemic lupus erythematosus (SLE) pathogenesis. A recent report has provided further support for this, demonstrating an association between rai...

journal_title：Arthritis research & therapy

authors： Briggs TA

更新日期：2013-03-08 00:00:00