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Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis.

Abstract：

INTRODUCTION:Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration modifies the therapeutic decision and improves the control of disease activity. METHODS:RA patients routinely treated with infliximab were included in an observational open-label study. On visit 1 (V1), according to the disease activity, a preliminary therapeutic decision was selected among four therapeutic options and a blood sample was collected to measure trough serum infliximab concentration. The final therapeutic decision, based on both disease activity and serum infliximab concentration assessed at V1, was applied at the following infusion (V2). Clinical and biological evaluations were performed at V3 and V4 and compared with those at V1. RESULTS:We included 24 patients. The final therapeutic decision differed from the preliminary decision for 12 patients (50%). For patients with increased infliximab dosage at V2, mean disease activity score for 28 joints (DAS28) decreased by about 20% at V3 or V4 as compared with V1 (P < 0.05). Decreased DAS28 was correlated with increased serum infliximab concentration (P < 0.02). CONCLUSIONS:The measurement of infliximab trough concentration modifies the therapeutic decision for RA patients and helps improve control of disease activity. Therapeutic drug monitoring of infliximab in RA may be useful for individual dosage adjustment.

journal_name

Arthritis Res Ther

journal_title

Arthritis research & therapy

authors

Mulleman D,Méric JC,Paintaud G,Ducourau E,Magdelaine-Beuzelin C,Valat JP,Goupille P,Centre National de la Recherche Scientifique UMR 6239 GICC.

doi

10.1186/ar2867

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

R178

issue

6

eissn

1478-6354

issn

1478-6362

pii

ar2867

journal_volume

11

pub_type

临床试验,杂志文章

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