The increased cardiovascular risk in rheumatoid arthritis: when does it start?

abstract：BACKGROUND:Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliorate progression of SSc-ILD. Data on everyday IS prescription patterns and clinical courses of lung fu...

journal_title：Arthritis research & therapy

authors： Adler S,Huscher D,Siegert E,Allanore Y,Czirják L,DelGaldo F,Denton CP,Distler O,Frerix M,Matucci-Cerinic M,Mueller-Ladner U,Tarner IH,Valentini G,Walker UA,Villiger PM,Riemekasten G,EUSTAR co-workers on behalf of the DeSS

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:As an initial step in the development of a local therapeutic to treat osteoarthritis (OA), a number of agents were tested for their ability to block activation of inflammation through nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), subchondral bone changes through receptor activator of nu...

journal_title：Arthritis research & therapy

authors： TenBroek EM,Yunker L,Nies MF,Bendele AM

更新日期：2016-01-21 00:00:00

abstract：INTRODUCTION:The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS:Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM...

journal_title：Arthritis research & therapy

authors： Ramachandran M,Achan P,Salter DM,Bader DL,Chowdhury TT

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure. METHODS:The Treato platform was used to analyze all publicly available social media data including Facebook, blogs, and discussion boards for posts mentioning inflammatory ar...

journal_title：Arthritis research & therapy

authors： Curtis JR,Chen L,Higginbotham P,Nowell WB,Gal-Levy R,Willig J,Safford M,Coe J,O'Hara K,Sa'adon R

更新日期：2017-03-07 00:00:00

abstract：INTRODUCTION:CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that is activated in the synovium in rheumatoid arthritis (RA) and promotes expression of various matrix metalloproteinases. In this study, we examined whether C/EBPβ mediates the expression of receptor activator of nuclear factor-kappa-B ...

journal_title：Arthritis research & therapy

authors： Tsushima H,Okazaki K,Ishihara K,Ushijima T,Iwamoto Y

更新日期：2015-02-17 00:00:00

abstract：:We investigated the therapeutic potential and mechanism of action of IFN-beta protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, mice were given daily injections of recombinant mouse IFN-beta or saline for 7 days. Disease...

journal_title：Arthritis research & therapy

authors： van Holten J,Reedquist K,Sattonet-Roche P,Smeets TJ,Plater-Zyberk C,Vervoordeldonk MJ,Tak PP

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma membrane potassium channel. Blocking KCa1.1 reduces the invasive phenotype of RA-FLS and attenua...

journal_title：Arthritis research & therapy

authors： Pethő Z,Tanner MR,Tajhya RB,Huq R,Laragione T,Panyi G,Gulko PS,Beeton C

更新日期：2016-05-10 00:00:00

abstract：:Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest p...

journal_title：Arthritis research & therapy

authors： Wang LJ,Zeng N,Yan ZP,Li JT,Ni GX

更新日期：2020-03-24 00:00:00

abstract：:This article is about risk. Risk is probably the most misunderstood component in determining therapeutic intervention; however, it is probably the most relevant issue to consider in the context of expected benefit. The rarity of quantitative risk-benefit assessment and the lack of comparative risk-benefit when alterna...

journal_title：Arthritis research & therapy

authors： Goldkind L,Simon LS

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post hoc meta-analysis of BLISS-52 and BLISS-76 explored the relationship between base...

journal_title：Arthritis research & therapy

authors： Wilkinson C,Henderson RB,Jones-Leone AR,Flint SM,Lennon M,Levy RA,Ji B,Bass DL,Roth D

更新日期：2020-05-04 00:00:00

abstract：INTRODUCTION:Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and ...

journal_title：Arthritis research & therapy

authors： Beck C,Morbach H,Beer M,Stenzel M,Tappe D,Gattenlöhner S,Hofmann U,Raab P,Girschick HJ

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms could explain part of the remaining heritability. Multiple interactions have been reported, but only the share...

journal_title：Arthritis research & therapy

authors： Ferreiro-Iglesias A,Calaza M,Perez-Pampin E,Lopez Longo FJ,Marenco JL,Blanco FJ,Narvaez J,Navarro F,Cañete JD,de la Serna AR,Gonzalez-Alvaro I,Herrero-Beaumont G,Pablos JL,Balsa A,Fernandez-Gutierrez B,Caliz R,Gomez-Reino

更新日期：2014-09-27 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies and immune complex deposition in various organs. Aberrations in the T lymphocyte compartment and dysregulated cytokine production are key features of SLE pathogenesis and disease progression. Recently...

journal_title：Arthritis research & therapy

authors： Puwipirom H,Hirankarn N,Sodsai P,Avihingsanon Y,Wongpiyabovorn J,Palaga T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Nitric oxide and prostaglandin E2 (PGE2play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1beta and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iNOS) and cyclo-oxygenas...

journal_title：Arthritis research & therapy

authors： Chowdhury TT,Arghandawi S,Brand J,Akanji OO,Bader DL,Salter DM,Lee DA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of i...

journal_title：Arthritis research & therapy

authors： Peterson JD,Labranche TP,Vasquez KO,Kossodo S,Melton M,Rader R,Listello JT,Abrams MA,Misko TP

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Lesional skin of patients with discoid lupus erythematosus (DLE) contains macrophages, whose polarization has yet to be investigated. To test our hypothesis that M1 macrophages would be increased in DLE skin, we examined transcriptome alterations in immune cell gene expression and macrophage features in DL...

journal_title：Arthritis research & therapy

authors： Chong BF,Tseng LC,Hosler GA,Teske NM,Zhang S,Karp DR,Olsen NJ,Mohan C

更新日期：2015-11-13 00:00:00

abstract：:The accumulation of T cells in the synovial membrane is the crucial step in the pathophysiology of the inflammatory processes characterizing juvenile idiopathic arthritis (JIA). In this study, we evaluated the expression and the pathogenetic role in oligoarticular JIA of a CXC chemokine involved in the directional mig...

journal_title：Arthritis research & therapy

authors： Martini G,Zulian F,Calabrese F,Bortoli M,Facco M,Cabrelle A,Valente M,Zacchello F,Agostini C

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate the effects of L-4F, an apolipoprotein A-1 mimetic peptide, alone or with pravastatin, in apoE-/-Fas-/-C57BL/6 mice that spontaneously develop immunoglobulin G (IgG) autoantibodies, glomerulonephritis, osteopenia, and atherosclerotic lesions on a normal chow diet. ...

journal_title：Arthritis research & therapy

authors： Woo JM,Lin Z,Navab M,Van Dyck C,Trejo-Lopez Y,Woo KM,Li H,Castellani LW,Wang X,Iikuni N,Rullo OJ,Wu H,La Cava A,Fogelman AM,Lusis AJ,Tsao BP

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Physical activity has been recommended to patients with knee osteoarthritis for improving their symptoms. However, it is still controversial if physical activity has effects on joint structures including cartilage volume. The aim of this study was to describe the associations between physical activity and ...

journal_title：Arthritis research & therapy

authors： Antony B,Venn A,Cicuttini F,March L,Blizzard L,Dwyer T,Cross M,Jones G,Ding C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:Persistence of biologic therapy in psoriatic arthritis (PsA) patients is an important factor in individualized patient treatment planning and healthcare policy and guideline development. OBJECTIVE:To estimate the persistence of biologic agents prescribed to PsA patients in a real-life setting as well as fac...

journal_title：Arthritis research & therapy

authors： Haddad A,Gazitt T,Feldhamer I,Feld J,Cohen AD,Lavi I,Tatour F,Bergman I,Zisman D

更新日期：2021-01-29 00:00:00

abstract：:Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and ...

journal_title：Arthritis research & therapy

authors： van der Kraan PM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Stem cell therapy is considered as a promising alternative to treat intervertebral disc degeneration (IDD). Extensive work had been done on identifying and comparing different types of candidate stem cells, both in vivo and in vitro. However, few studies have shed light on degenerative nucleus pulposus cells...

journal_title：Arthritis research & therapy

authors： Han Z,Wang J,Gao L,Wang Q,Wu J

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：INTRODUCTION:TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney. Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently intro...

journal_title：Arthritis research & therapy

authors： Schwartz N,Rubinstein T,Burkly LC,Collins CE,Blanco I,Su L,Hojaili B,Mackay M,Aranow C,Stohl W,Rovin BH,Michaelson JS,Putterman C

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis plays a fundamental role in proliferation and differentiation of dendritic cells (DCs). As DCs play an important role in rheumatoid arthritis (RA) immunopathology we studied in detail the Flt3L/CD135 axis in RA patients. METHODS:The levels of Flt...

journal_title：Arthritis research & therapy

authors： Ramos MI,Perez SG,Aarrass S,Helder B,Broekstra P,Gerlag DM,Reedquist KA,Tak PP,Lebre MC

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the various human leucocyte antigen (HLA)-DRB1 alleles. The purpose of this study was to investigate SE ...

journal_title：Arthritis research & therapy

authors： Meyer PW,Hodkinson B,Ally M,Musenge E,Wadee AA,Fickl H,Tikly M,Anderson R

更新日期：2011-01-01 00:00:00

abstract：:Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines an...

journal_title：Arthritis research & therapy

authors： Raza K,Falciani F,Curnow SJ,Ross EJ,Lee CY,Akbar AN,Lord JM,Gordon C,Buckley CD,Salmon M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor, anti-citrullinated protein antibodies, and bone erosions. Current therapies can compromise immunity, leading to risk of infection. The interleukin-20 receptor (IL-20R) axis comprising IL-19, IL-20, and IL-24 and their shar...

journal_title：Arthritis research & therapy

authors： Kragstrup TW,Greisen SR,Nielsen MA,Rhodes C,Stengaard-Pedersen K,Hetland ML,Hørslev-Petersen K,Junker P,Østergaard M,Hvid M,Vorup-Jensen T,Robinson WH,Sokolove J,Deleuran B

更新日期：2016-03-11 00:00:00

abstract：INTRODUCTION:Early degeneration of the intervertebral disc (IVD) involves a change in cellular differentiation from notochordal cells (NCs) in the nucleus pulposus (NP) to chondrocyte-like cells (CLCs). The purpose of this study was to investigate the gene expression profiles involved in this process using NP tissue fr...

journal_title：Arthritis research & therapy

authors： Smolders LA,Meij BP,Onis D,Riemers FM,Bergknut N,Wubbolts R,Grinwis GC,Houweling M,Groot Koerkamp MJ,van Leenen D,Holstege FC,Hazewinkel HA,Creemers LB,Penning LC,Tryfonidou MA

更新日期：2013-01-29 00:00:00

abstract：:Chemokines play an essential role in the progression of rheumatoid arthritis (RA). In the present study we examined the expression and regulatory mechanisms of IFN-gamma inducible protein (IP)-10 in RA synovitis. RA synovial fluid contained greater amounts of IP-10 than did synovial fluid from patients with osteoarthr...

journal_title：Arthritis research & therapy

authors： Hanaoka R,Kasama T,Muramatsu M,Yajima N,Shiozawa F,Miwa Y,Negishi M,Ide H,Miyaoka H,Uchida H,Adachi M

更新日期：2003-01-01 00:00:00