FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis.

abstract：INTRODUCTION:Rational selection of disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA) has many potential advantages, including rapid disease control, reduced long-term disability and reduced overall cost to the healthcare system. Inter-individual genetic differences are particularly at...

journal_title：Arthritis research & therapy

authors： Wiese MD,Schnabl M,O'Doherty C,Spargo LD,Sorich MJ,Cleland LG,Proudman SM

更新日期：2012-07-12 00:00:00

abstract：:Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation after tissue injury...

journal_title：Arthritis research & therapy

authors： Gilbane AJ,Denton CP,Holmes AM

更新日期：2013-01-01 00:00:00

abstract：:Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the ...

journal_title：Arthritis research & therapy

authors： Masi AT

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macrophages in the synovium. In the present study, we set out to investigate the impact of TLR stimulation ...

journal_title：Arthritis research & therapy

authors： Quero L,Hanser E,Manigold T,Tiaden AN,Kyburz D

更新日期：2017-11-02 00:00:00

abstract：:Ankylosing spondylitis (AS) is a member of the family of spondyloarthropathies, which are inflammatory arthritides largely involving the axial skeleton and commonly accompanied by peripheral arthritis. Genetic factors, particularly the presence of HLA-B27, are major contributors to the susceptibility for AS. Despite s...

journal_title：Arthritis research & therapy

authors： Peloso PM,Braun J

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Lesional skin of patients with discoid lupus erythematosus (DLE) contains macrophages, whose polarization has yet to be investigated. To test our hypothesis that M1 macrophages would be increased in DLE skin, we examined transcriptome alterations in immune cell gene expression and macrophage features in DL...

journal_title：Arthritis research & therapy

authors： Chong BF,Tseng LC,Hosler GA,Teske NM,Zhang S,Karp DR,Olsen NJ,Mohan C

更新日期：2015-11-13 00:00:00

abstract：INTRODUCTION:Human cytomegalovirus (HCMV) infection has been implicated in the development of autoimmunity, including systemic lupus erythematosus (SLE). Previously we reported that HCMV phosphoprotein 65 (pp65) could induce early onset of autoantibody and glomerulonephritis on lupus-prone NZB/W mice. This study furthe...

journal_title：Arthritis research & therapy

authors： Hsieh AH,Jhou YJ,Liang CT,Chang M,Wang SL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：INTRODUCTION:Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial cit...

journal_title：Arthritis research & therapy

authors： Makrygiannakis D,Revu S,Engström M,af Klint E,Nicholas AP,Pruijn GJ,Catrina AI

更新日期：2012-01-27 00:00:00

abstract：:Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/BxN mice, although some groups have reported that few healthy humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) is genetically regulated and has strong implications for the development of...

journal_title：Arthritis research & therapy

authors： Matsumoto I,Zhang H,Muraki Y,Hayashi T,Yasukochi T,Kori Y,Goto D,Ito S,Tsutsumi A,Sumida T

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease with complex etiopathogenesis. Despite extensive studies to understand the disease process utilizing human and mouse models, the intersection between these species remains elusive. To address this gap, we utilized a novel systems biology appr...

journal_title：Arthritis research & therapy

authors： Horvath S,Nazmul-Hossain AN,Pollard RP,Kroese FG,Vissink A,Kallenberg CG,Spijkervet FK,Bootsma H,Michie SA,Gorr SU,Peck AB,Cai C,Zhou H,Wong DT

更新日期：2012-11-01 00:00:00

abstract：:Anti-Sa antibodies are detected in the serum of 20-47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed th...

journal_title：Arthritis research & therapy

authors： El-Gabalawy HS,Wilkins JA

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. METHODS:T-cell receptor transgenic mice, in which nearly all CD4+ T cells recognize a single peptide of type II collagen, were immunized with collagen and obs...

journal_title：Arthritis research & therapy

authors： Lundy SK,Fox DA

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:C-reactive protein (CRP) is one of the biomarkers for the diagnosis and assessment of disease activity in rheumatoid arthritis (RA). CRP is not only the by-product of inflammatory response, but also plays proinflammatory and prothrombotic roles. The aim of this study was to determine the role of CRP on bon...

journal_title：Arthritis research & therapy

authors： Kim KW,Kim BM,Moon HW,Lee SH,Kim HR

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. METHODS:To generate expression of the CII-peptide sp...

journal_title：Arthritis research & therapy

authors： Andersson SE,Eneljung T,Tengvall S,Jirholt P,Stern A,Henningsson L,Liang B,Thorarinsdottir K,Kihlberg J,Holmdahl R,Mårtensson IL,Gustafsson K,Gjertsson I

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML). We aimed to investigate the expression of several AGEs and Glo-1 in human OA cartilage...

journal_title：Arthritis research & therapy

authors： Trellu S,Courties A,Jaisson S,Gorisse L,Gillery P,Kerdine-Römer S,Vaamonde-Garcia C,Houard X,Ekhirch FP,Sautet A,Friguet B,Jacques C,Berenbaum F,Sellam J

更新日期：2019-01-11 00:00:00

abstract：:Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines an...

journal_title：Arthritis research & therapy

authors： Raza K,Falciani F,Curnow SJ,Ross EJ,Lee CY,Akbar AN,Lord JM,Gordon C,Buckley CD,Salmon M

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Angiogenesis plays a critical role in synovial inflammation and joint destruction in rheumatoid arthritis (RA). Vascular endothelial growth factor A (VEGF-A) and angiopoietins are two important mediators of synovial angiogenesis. We have previously developed a novel chimeric decoy receptor, namely, double-...

journal_title：Arthritis research & therapy

authors： Hah YS,Koh YJ,Lim HS,Kim HO,Cheon YH,Noh HS,Jang KY,Lee SY,Lee GM,Koh GY,Lee SI

更新日期：2013-08-14 00:00:00

abstract：INTRODUCTION:A higher prevalence of metabolic syndrome (MetS) has been described in rheumatoid arthritis (RA), along with an association with disease activity. Objectives were to describe prevalence of MetS at RA diagnosis in a cohort of Mexican Mestizo early RA patients, and to define a causal association between MetS...

journal_title：Arthritis research & therapy

authors： Parra-Salcedo F,Contreras-Yáñez I,Elías-López D,Aguilar-Salinas CA,Pascual-Ramos V

更新日期：2015-02-20 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis. Pateclizumab (anti-lymphotoxin- alpha; MLTA3698A) is a humanized monoclonal antibody that blocks and depletes anti-LTα. This phase 2, randomized, head-to-head,...

journal_title：Arthritis research & therapy

authors： Kennedy WP,Simon JA,Offutt C,Horn P,Herman A,Townsend MJ,Tang MT,Grogan JL,Hsieh F,Davis JC

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND:Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of inclu...

journal_title：Arthritis research & therapy

authors： LaValley MP,Lo GH,Price LL,Driban JB,Eaton CB,McAlindon TE

更新日期：2017-05-16 00:00:00

abstract：BACKGROUND:It is currently impossible to predict the prognosis of patients with juvenile dermatomyositis (JDM). The aim of this study was to find clinical features most strongly associated with outcome variables in JDM as a first step towards tailor-made treatment. METHODS:In a large, prospectively followed, multicent...

journal_title：Arthritis research & therapy

authors： van Dijkhuizen EHP,De Iorio M,Wedderburn LR,Deakin CT,JDRG.

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicenter database. METHODS:We retrospectively reviewed baseline demographic, clinical and laboratory find...

journal_title：Arthritis research & therapy

authors： Sugiyama Y,Yoshimi R,Tamura M,Takeno M,Kunishita Y,Kishimoto D,Yoshioka Y,Kobayashi K,Takase-Minegishi K,Watanabe T,Hamada N,Nagai H,Tsuchida N,Soejima Y,Nakano H,Kamiyama R,Uehara T,Kirino Y,Sekiguchi A,Ihata A,O

更新日期：2018-01-11 00:00:00

abstract：INTRODUCTION:We designed OP3-4 (YCEIEFCYLIR), a cyclic peptide, to mimic the soluble osteoprotegerin (OPG), and was proven to bind to RANKL (receptor activator of NF-κB ligand), thereby inhibiting osteoclastogenesis. We recently found that another RANKL binding peptide, W9, could accelerate bone formation by affecting ...

journal_title：Arthritis research & therapy

authors： Kato G,Shimizu Y,Arai Y,Suzuki N,Sugamori Y,Maeda M,Takahashi M,Tamura Y,Wakabayashi N,Murali R,Ono T,Ohya K,Mise-Omata S,Aoki K

更新日期：2015-09-12 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities i...

journal_title：Arthritis research & therapy

authors： Jonsson MK,Hensvold AH,Hansson M,Aga AB,Sexton J,Mathsson-Alm L,Cornillet M,Serre G,Lillegraven S,Fevang BS,Catrina AI,Haavardsholm EA

更新日期：2018-07-13 00:00:00

abstract：:This prospective study examined the association between physical activity and the incidence of self-reported stiff or painful joints (SPJ) among mid-age women and older women over a 3-year period. Data were collected from cohorts of mid-age (48-55 years at Time 1; n = 4,780) and older women (72-79 years at Time 1; n =...

journal_title：Arthritis research & therapy

authors： Heesch KC,Miller YD,Brown WJ

更新日期：2007-01-01 00:00:00

abstract：:miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors. S...

journal_title：Arthritis research & therapy

authors： Luo X,Ranade K,Talker R,Jallal B,Shen N,Yao Y

更新日期：2013-04-09 00:00:00

abstract：BACKGROUND:To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome. METHODS:Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002...

journal_title：Arthritis research & therapy

authors： Heiligenhaus A,Klotsche J,Niewerth M,Horneff G,Ganser G,Haas JP,Minden K

更新日期：2020-04-15 00:00:00

abstract：INTRODUCTION:Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment. Dermal interstitial fluid sampling offers the potential to examine local mechanisms and identify proteins expressed withi...

journal_title：Arthritis research & therapy

authors： Clark KE,Lopez H,Abdi BA,Guerra SG,Shiwen X,Khan K,Etomi O,Martin GR,Abraham DJ,Denton CP,Stratton RJ

更新日期：2015-03-23 00:00:00

abstract：:Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the ...

journal_title：Arthritis research & therapy

authors： Betteridge ZE,Gunawardena H,McHugh NJ

更新日期：2011-03-18 00:00:00